Professor Laura Green, MBBS FRCP FRCPath MD(Res)

Profile

ORCID ID: 0000-0003-4063-9768

Laura Green is a Professor of Haemostasis and Transfusion Medicine at the Blizard Institute (Faculty of Medicine and Dentistry), and a Principal Investigator at NHS Blood and transplant (NHSBT). Her clinical practice is based at NHSBT and Barts Health NHS Trust. Laura leads multi-centre national and international clinical research in haemostasis and blood transfusion, with a focus on improving the evidence on the appropriate use of blood components for the treatment of a range of acquired bleeding disorders (trauma, cardiac surgery, obstetrics etc.) and developing new blood components and products that can improve the management of bleeding disorders nationally and internationally.

Professor Laura Green did her specialist training in Haematology at Kings College Hospital in 2004 and between 2009 – 2011 undertook research in Haemostasis and Thrombosis at University College London, leading to the award of an MD(Res) degree. In 2011 she was ap-pointed a Consultant in Haemostasis and Transfusion Medicine, jointly at NHS Blood and Transplant (NHSBT) and Barts Health Trust. In 2020 she was appointed as Principal Investigator at NHSBT leading clinical research in blood components. Laura was promoted to Professor of Haemostasis and Transfusion Medicine at Queen Mary University of London in 2024.

Research

Research Interests:

I lead the Transfusion Academic Unit at the Blizard Institute, Queen Mary University of London (QMUL), whose remit is to drive clinical research in haemostasis and transfusion medicine. My research focus is on enhancing and developing blood components for the treatment of bleeding disorders (e.g., trauma and surgery) by bringing together laboratory services and clinical research at NHS Blood and Transplant, Barts Health Trust and QMUL. I have led several past and ongoing multi-centre randomised controlled trials and national epidemiological studies which have made a significant impact on improving the management of patients with major bleeding, both in the UK and internationally. Examples include the ORANGE study, PROPHESY 1 and 2 trials, the Whole Blood Programme (incorporating the Red Cell Plasma study and its successor, the SWiFT trial) etc.

Publications

Key Publications

Ross Davenport, Nicola Curry, Erin E. Fox, Helen Thomas, Joanne Lucas, Amy Eans, Shaminie Shanmugaranjan, Rupa Sharma, Alison Deary, Antoinette Edwards,  Laura Green, Charles E. Wade, Jonathan R. Benger, Bryan A. Cotton, Simon J. Stanworth, Karim Brohi, for the CRYOSTAT-2 Principal Investigators. Early and empirical high-dose cryoprecipitate for hemorrhage after traumatic injury: the CRYOSTAT-2 ran-domized clinical trial. JAMA. 2023;330(19):1882-1891.

Harriet Tucker, Karim Brohi, Joachim Tan, Christopher Aylwin, Roger Bloomer, Rebecca Cardigan, Ross Davenport, Edward D Davies, Phillip Godfrey, Rachel Hawes, Richard Lyon, Josephine McCullagh, Simon Stanworth, Julian Thompson, James Uprichard, Simon Walsh, Anne Weaver, Laura Green. Association of red blood cells and plasma transfusion versus red blood cell transfusion only with survival for treatment of major traumatic hemorrhage in prehospital setting in England. Critical Care 2023: 27 (1), 1-10. 

L. Green, J. Daru, F. J. Gonzalez Carreras, D. Lanz, M. C. Pardo, T. Perez, S. Philip, T. Tanqueray, K. S. Khan,and collaborators. Early cryoprecipitate transfusion versus standard care in severe postpartum haemorrhage: a pilot cluster-randomised trial. Anaesthesia, 2022; 77 (2), 175-184. 

Laura Green, Neil Roberts, Jackie Cooper, Jane Field, Ravi Gill, Andrew Klein, Seema Agarwal, Simon Stanworth, Atholl Johnston, Vivienne Monk, Ben O’Brien. Prothrombin complex concentrate vs. fresh frozen plasma in adult patients undergoing heart surgery – a pilot randomised controlled trial (PROPHESY trial). Anaesthesia 2021; 76, (7) 892 - 901. 

L Green, M Knight, FM Seeney, C Hopkinson, Peter W Collins, RE Collis, NAB Simpson, A Weeks, SS Stanworth. The epidemiology and outcomes of women with postpartum haemorrhage requiring massive transfusion with eight or more units of red cells: A national cross‐sectional study. BJOG. 2016: 123, (13) 2164 – 2170.

All Publications

Supervision

Current

• Dr Harriet Tucker, PhD (2019 – 2024)
• Ms Florence Oyekan, PhD (2022 – 2026)
• Dr Chibuzo Mowete, PhD (2023 – 2027) 

Completed

• Dr Andrea Rossetto, PhD (2024)
• Dr Suzanne Forbes, MD (2024)
• Dr Josephine McCullagh, DClinSci (2022)
• Dr Ruchika Kohli, MD (2021)