Profile
I graduated in Medicine from the University of Cambridge with a distinction in 2009, subsequently undertaking paediatric and then haematology specialty training in North-East London. I completed a PhD as part of an MRC Clinical Training Research Fellowship at the Weatherall Institute of Molecular Medicine, University of Oxford (2017-2020) under the supervision of Professors Doug Higgs and James Davies. My project involved the study of the cis-regulatory control of the human alpha-globin genes by their main enhancer, as well as the development of novel genome engineering strategies to ameliorate beta-thalassaemia. I was appointed Senior Clinical Lecturer and Consultant in Paediatric Haematology at the Blizard Institute and the Royal London Hospital respectively in August 2024.
To refer a patient to the bone marrow failure clinic please email me at m.badat@nhs.net. We welcome referrals from throughout the UK.
Research
Research Interests:
My current research involves the study of the inherited bone marrow failure syndromes. These rare often life-threatening disorders arise through the perturbation of fundamental cellular processes in haematopoiesis. Our group aims to identify the genomic causes of these conditions, particularly the Telomere Biology Disorders, and characterise the precise molecular mechanisms that lead to disease, We thereby hope to advance our knowledge of molecular biology as well as develop novel and improved treatment strategies for our patients.
Research group: Telomere Biology Disorder lab
To refer a patient to the bone marrow failure clinic please email me at m.badat@nhs.net. We welcome referrals from throughout the UK.
Publications
Key Publications
The evolving genetic landscape of dyskeratosis congenita (DC) and DC-like disorders
Hemanth Tummala, Amanda J Walne, Mohsin Badat, Manthan Patel, Jenna Alnajar, Chi Ching Chow Ibtehal Albursan, Jennifer Frost, David Ballard, Sally Killick, Hernan Sabio, Judith Marsh, Maria Angelica Fernandez Barbieri, Jacques de Blic, Peter Szitanyi, Ann Kelly, Alan Warren, Manoj Raghavan, Corrina Powell, Reinier Raymakers, Tony Todd, Fusun Arda, Edmond Ma Elpis Mantadakis, Sophia Polychronopoulou, Cynthia Toze, Anna Kochin, Nikolas Pontikos, Tianyi Liao, Pradeep M Madapura, Upal Hossain, Tom Vulliamy, and Inderjeet Dokal.
EMBO Molecular Medicine 2024 Aug 28. doi: 10.1038/s44321-024-00118-x
Direct correction of haemoglobin E/β-thalassaemia using base editors
Badat M, Ejaz A, Hua P, Rice S, Zhang W, Hentges LD, Fisher CA, Denny N, Schwessinger R, Yasara N, Roy NBA, Issa F, Roy A, Telfer P, Hughes J, Mettananda S, Higgs DR, Davies JOJ.
Nature Communications 2023 Apr 19;14(1):2238. doi: 10.1038/s41467-023-37604-8
Defining genome architecture at base-pair resolution
Hua P, Badat M, Hanssen LLP, Hentges LD, Crump N, Downes DJ, Jeziorska DM, Oudelaar AM, Schwessinger R, Taylor S, Milne TA, Hughes JR, Higgs DR, Davies JOJ.
Nature 2021 Jul;595(7865):125-129. doi: 10.1038/s41586-021-03639-4
A remarkable case of HbH disease illustrates the relative contributions of the α-globin enhancers to gene expression
Badat M, Davies JOJ, Fisher CA, Downes DJ, Rose A, Glenthøj AB, van Beers EJ, Harteveld CL, Higgs DR.
Blood 2021 Jan 28;137(4):572-575. doi: 10.1182/blood.2020006680
Editing an α-globin enhancer in primary, long-term repopulating human hematopoietic stem cells: a new approach to therapy for β-thalassemia. Mettananda S, Fisher CA, Hay D, Badat M, Quek L, Clark K, Hublitz P, Downes D, Kerry J, Gosden M, Telenius J, Sloane-Stanley JA, Faustino P, Coelho A, Doondeea J, Usukhbayar B, Sopp P, Sharpe JA, Hughes JR, Vyas P, Gibbons RJ, Higgs DR. Nature Communications 2017 Sep 4;8(1):424. doi: 10.1038/s41467-017-00479-7
All Publications
