Dr Yung-Yao Lin, PhD, FHEA
Senior Lecturer
Centre: Centre for Genomics and Child Health
Email: yy.lin@qmul.ac.uk
Telephone: 020 7882 2339
Website: https://uk.linkedin.com/in/yung-yao-lin-496074202
Twitter: @yungyaolin
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Dr Yung-Yao Lin got his BSc from National Taiwan University and did his PhD in the Department of Genetics, University of Cambridge.
His most important research contributions to date are elucidating pathological mechanisms of previously unexplained neuromuscular disorders and developing disease models that can facilitate therapeutic development. His postdoctoral work at Wellcome Sanger Institute brought novel insights into the pathological mechanisms underlying a group of neuromuscular disorders, referred to as dystroglycanopathies and contributed to the complete elucidation of a novel pathway of laminin-binding glycan on α-dystroglycan.
At the Blizard Institute, the Lin group have been developing human-relevant microphysiological models that can elucidate pathological mechanisms and facilitate therapeutic innovation. With expertise in human pluripotent stem cells (hPSCs), CRISPR-mediated genome engineering and bioengineering technologies, the Lin group generated isogenic pairs of hPSC-based microphysiological systems for modelling neuromuscular disorders and skeletal muscle regeneration, as well as testing potential drug candidates. The isogenic pairs of patient-derived and CRISPR-corrected hPSC lines in the Lin laboratory provide an invaluable resource for many research projects. Dr Lin has obtained substantial research funding (>£2M) from industry, patient charities and the NC3Rs to exploit human-relevant microphysiological systems for disease modelling, drug discovery and regenerative medicine. Recently, the Lin group developed a novel hydrogel-based transplantation procedure that improves animal welfare (3Rs impact - Refinement) and enables long-term engraftment of human myogenic cells.