The principal research interest of Professor Inderjeet Dokal and Dr Tom Vulliamy is bone marrow failure (BMF) focusing on the genetics of the inherited BMF syndromes, particularly dyskeratosis congenita (DC). Their research has highlighted the important role of telomeres in humans and the consequences of telomere dysfunction including dysregulated human development, premature ageing, increased risk of BMF and cancer. Current research is focused on elucidating the biology of the many uncharacterized cases of DC, BMF, familial myelodysplasia/leukaemia (with Professors Jude Fitzgibbon and Jamie Cavenagh) as well as studies aimed at correction of the cell defect with the long term aim of developing new therapies for this group of patients.
Research Group
Professor Inderjeet Dokal
Dr Tom Vulliamy
Dr Amanda J Walne
Dr Hemanth Tummala
Laura Collopy
Shirleny Cardoso
Alicia Ellison
Ana Rio-Machin
Alumni
Dr Anna Marrone Dr Philip J Mason
David Stevens
Dr Michael Kirwan
Dr Richard Breswick
Dr Stuart Knight