Our mission is to advance the science of fracture healing through discovery, innovation and collaboration to transform outcomes.
Our group is dedicated to addressing the unique needs of trauma patients, particularly in the underserved population of East London. Managing complex fractures in this demographic presents significant challenges due to various factors, including socio-economic disparities, cultural diversity, and limited access to specialised care. Through this cluster we will improve outcomes and enhance the quality of care for trauma patients in East London and beyond.
Together, our group combines expertise in bioengineering, biomedical materials, mechanobiology, dentistry, regenerative medicine, neuroscience, orthopaedic surgery, and plastic surgery. We collaborate across disciplines to address the unique challenges in complex fracture management and improve outcomes for trauma patients.
Led by Professor Xavier Griffin, Chair of Bone and Joint Health, our group comprises a diverse team of academics, clinical academics and clinicians across institutes at Queen Mary University of London and Barts Health NHS Trust.
Our research explores optimising fracture healing through biomechanics, in vitro modeling, graft materials, cellular dynamics, clinical challenges, failure mechanisms, regenerative processes, and intraoperative assessment, aiming to enhance trauma fracture management.
Investigating the biomechanical factors that influence fracture healing to elucidate the optimal mechanical conditions for effective bone regeneration.
Developing sophisticated in vitro models that replicate the biomechanical and biological complexities of fractures to enhance our understanding of the healing process.
Utilising these models for pharmacological studies to assess the efficacy of various drugs in promoting fracture repair and regeneration.
Engineering graft materials with structural integrity and osteoinductive properties for clinical use, aiming to enhance bone regeneration and integration.
Investigating the cellular and molecular changes occurring at fracture sites to decipher the underlying mechanisms driving bone healing processes.
Investigating the clinical challenges and limitations associated with tibia grafting procedures to identify factors contributing to suboptimal outcomes.
Analysing the underlying causes of bone graft failures to improve grafting techniques and outcomes in clinical practice.
Examining the biological mechanisms involved in bone regeneration during distraction histogenesis to optimise clinical approaches for limb lengthening procedures.
Developing novel techniques and tools for the intraoperative assessment of bone contamination, aiming to improve surgical decision-making and outcomes.