Dr Damian Smedley

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Damian holds a B.Sc. in Biochemistry from Bristol University and PhD in Biochemistry from Cambridge University. Following postdoctoral research as a Kay Kendall Research Fellow at the Institute of Cancer Research and Imperial College, involving identification and characterisation of chromosomal translocations in haematological cancers, he pursued a new, purely computational research career via a M.Sc. in Bioinformatics from Birbeck College. At the European Bioinformatics Institute (EBI) he contributed to the BioMart software system evolving from the advanced query interface of Ensembl to a federated, data management system used by multiple resources worldwide. He then founded and led the mouse informatics team at the EBI before a 3 year spell at the Sanger Institute as a senior manager leading a team of computational biologists linking human disease to the emerging data from the Mouse Genetics Programme and the International Mouse Phenotyping Consortium (IMPC). In 2016 Damian joined the William Harvey Research Institute (WHRI) as a Senior Lecturer where his research team continues to work on the IMPC as well as development of the popular Exomiser package for phenotype-aware analysis of rare disease genomes. He is also seconded full time to Genomics England as Director of Genomic Interpretation for Genomics England where he is helping to deliver the clinical analysis of rare disease and cancer samples in the 100,000 Genomes Project.

Group Leader at C4TB

Team members

• Dr Pilar Cacheiro
• Dr Valentina Cipriani
• Dr Thomasz Konopka
• Dr Julius Jacobsen

Research