Our Projects
Currently recruiting...
Targeted heart rate control using the funny current inhibitor ivabradine to reduce morbidity in patients undergoing non-cardiac surgery: a phase IIa, triple blind, placebo controlled randomised trial
Selective heart rate lowering to reduce morbidity after non-cardiac surgery.
Optimising Shared decision-makIng for high-RIsk major Surgery (OSIRIS)
To understand and improve the shared decision making process for patients at high risk of medical complications as they contemplate major surgery.
Epidural-related maternal fever (EPIFEVER-2): personalised genomic medicine to guide labour analgesia
To determine whether polymorphisms in interleukin-1 receptor antagonist gene promotes fever in labouring women receiving epidural analgesia.
Email / EPIFEVER protocol [PDF 418KB]
Completed...
Stopping Perioperative Angiotensin II Converting Enzyme inhibitors and/or receptor blockers in major non-cardiac surgery (SPACE)
Patients on chronic ACEi/ARB therapy will have them either continued or stopped immediately prior to elective surgery.
OPtimisation of Peri-operaTive CardIovascular Management to Improve Surgical outcomE II (OPTIMISE II)
Using a cardiac output monitor to deliver goal-directed haemodynamic therapy intra-op and four hours post-op.
Alternative Substrates in the Critically Ill Subject (ASICS)
Investigate the feasibility of administrating alternative substrates to ICU patients.
Email / Clinical Trials Register
Prevention of Respiratory Insufficiency after Surgical Management (PRISM)
Early postoperative CPAP to reduce atelectasis and the incidence of subsequent respiratory complications.
PRISM Trial Paper - The Lancet Respiratory Medicine / Website
Enhanced Peri-Operative Care for High-risk patients (EPOCH)
A stepped wedge cluster randomised trial of a quality improvement intervention for patients undergoing emergency laparotomy.
EPOCH Trial Paper - The Lancet / Website
International Surgical Outcomes Study (ISOS)
International observational cohort study of complications following elective surgery.
ISOS Trial Paper - British Journal of Anaesthesia / Website
OPtimisation of Peri-operaTive CardIovascular Management to Improve Surgical outcomE (OPTIMISE)
To evaluate the clinical effectiveness of a perioperative, cardiac output–guided hemodynamic therapy algorithm.
OPTIMISE Trial Paper - JAMA Network
European Surgical Outcomes Study (EuSOS)
Multi-centre international cohort study of perioperative care and clinical outcomes for patients undergoing non-cardiac surgery.
EuSOS Trial Paper - The Lancet