Dr Lesley Bergmeier, PhD CBiol, MRSB, PGCAP, FHEA

Profile

Dr Bergmeier was appointed non-clinical Senior Lecturer in Applied Mucosal Immunology in the Centre for Clinical and Diagnostic Oral Sciences in 2006. Prior to this she held an appointment as Lecturer in Applied Mucosal Immunology at the Dental Institute of King's College London. Dr Bergmeier carried out her PhD studies on the devlopment of novel vaccines for HIV/SIV. She has published extensively in the immunology field (more than 65 peer reviewed papers). She is a reviewer for several journals including Immunology, Clinical and Experimental Immunology  and Vaccine and has reviewed  several grants for both the MRC and the Canadian Foundation for Inovation. Dr Bergmeier is a Fellow of the Higher Education Academy and has considerable experience in teaching both undergraduate and post graduatesand was awarded the Drapers Prize for Excellence in Teaching in 2012. She is course organizer for the MSc in Experimental Oral pathology (Oral Sciences) and has developed the course to include an interactive Journal club and Practical Portfolio in support of the experimental research project module. She also contributes Immunology teaching to the Diploma in Dental Clinical Sciences and Oral Biology MSc and teaches an Immunology module to 2nd year BDS students and an introduction to Immunology to 1st year BDS. She currently supervises 2 PhD students. Of the MSc students she has supervised  more than half have achieved either distinction or merit.

Research

Research Interests:

Dr Bergmeiers' research is positioned within the Immune and Inflammatory Disease research group and within the programmes of Mucosal Biology.

Dr Bergmeiers' career has been spent entirely in the field of Mucosal Immunology, initially in the field of dental caries and later in the development of vaccine candidates against HIV and SIV with special reference to vaccine applied to the mucosal immune system. The SIV work expanded to investigate the innate and cognate responses to a novel adjuvant- Heat shock protein (HSP) - in relation to viral proteins and the HIV co-receptor CCR5.

Investigation of the properties of HSP has also evolved into studies of their involvement in Behçet's and Crohn's disease. These studies have been presented both nationally and internationally.

Her current research focuses on understanding the role of heat shock proteins as chaperokines in health and oral mucosal diseases including Behcet's Disease, Sjögrens Syndrome and Recurrent Aphthous Stomatitis.

Dr Bergmeier was instrumental in initiating investigations into the expression of Suppressor of Cytokine Signalling (SOCS) in Behcet's disease as a PhD project in 2009. Areas of research include the interface between innate and adaptive immunity and the cross talk between the mucosal and systemic compartments.

Current projects include the investigation of the control of pro-inflammatory cytokine induction and the investigation of auto-immune and auto-inflammatory aspects of oral disease and how the homeostasis of the oral cavity influences systemic disease.

Dr Bergmeier has published over 65 peer reviewed papers and additionally has written several reviews, book chapters and conference proceedings. She been an invited speaker both internationally and nationally and has recently chaired a workshop on Heat Shock Proteins in health and disease.

Publications

Key Publications

1: Ryan PL, Sumaria N, Holland CJ, Bradford CM, Izotova N, Grandjean CL, Jawad
AS, Bergmeier LA, Pennington DJ. Heterogeneous yet stable Vδ2(+) T-cell profiles
define distinct cytotoxic effector potentials in healthy human individuals. Proc
Natl Acad Sci U S A. 2016 Dec 13;113(50):14378-14383. PubMed PMID: 27911793;
PubMed Central PMCID: PMC5167212.

2: Moftah H, Dias K, Apu EH, Liu L, Uttagomol J, Bergmeier L, Kermorgant S, Wan
H. Desmoglein 3 regulates membrane trafficking of cadherins, an implication in
cell-cell adhesion. Cell Adh Migr. 2016 Jun 2:1-22. [Epub ahead of print] PubMed
PMID: 27254775.

3: Hasan MS, Bergmeier LA, Petrushkin H, Fortune F. Gamma Delta (γδ) T Cells and
Their Involvement in Behçet's Disease. J Immunol Res. 2015; 2015:705831. doi:
10.1155/2015/705831. Review. PubMed PMID: 26539557; PubMed Central PMCID:
PMC4619955.

4: Senusi A, Seoudi N, Bergmeier LA, Fortune F. Genital ulcer severity score and
genital health quality of life in Behçet's disease. Orphanet J Rare Dis. 2015 Sep
22; 10:117. doi: 10.1186/s13023-015-0341-7. PubMed PMID: 26394620; PubMed Central
PMCID: PMC4579635.

5: Seoudi N, Bergmeier LA, Hagi-Pavli E, Bibby D, Fortune F. The seroprevalence
and salivary shedding of herpesviruses in Behçet's syndrome and recurrent
aphthous stomatitis. J Oral Microbiol. 2015 Jun 5;7: 27156. doi:
10.3402/jom. v7.27156. PubMed PMID: 26051327; PubMed Central PMCID: PMC4458513.

6: Seoudi N, Bergmeier LA, Drobniewski F, Paster B, Fortune F. The oral mucosal
and salivary microbial community of Behçet's syndrome and recurrent aphthous
stomatitis. J Oral Microbiol. 2015 Jun 1;7: 27150. doi: 10.3402/jom. v7.27150.
PubMed PMID: 26037240; PubMed Central PMCID: PMC4452653.

7: Hamedi M, Bergmeier LA, Hagi-Pavli E, Vartoukian SR, Fortune F. Differential
expression of suppressor of cytokine signalling proteins in Behçet's disease.
Scand J Immunol. 2014 Nov;80(5):369-76. doi: 10.1111/sji.12211. PubMed PMID:
25207681.

8: Vartoukian SR, Tilakaratne WM, Seoudi N, Bombardieri M, Bergmeier L, Tappuni
AR, Fortune F. Dysregulation of the suppressor of cytokine signalling 3-signal
transducer and activator of transcription-3 pathway in the aetiopathogenesis of
Sjögren's syndrome. Clin Exp Immunol. 2014 Sep;177(3):618-29. doi:
10.1111/cei.12377. PubMed PMID: 24827536; PubMed Central PMCID: PMC4137846.

9: Seoudi N, Bergmeier LA, Hagi-Pavli E, Bibby D, Curtis MA, Fortune F. The role
of TLR2 and 4 in Behçet's disease pathogenesis. Innate Immun. 2014
May;20(4):412-22. doi: 10.1177/1753425913498042. PubMed PMID: 23940075.

10: Wang Y, Whittall T, Rahman D, Bunnik EM, Vaughan R, Schøller J, Bergmeier LA,
Montefiori D, Singh M, Schuitemaker H, Lehner T. The role of innate APOBEC3G and
adaptive AID immune responses in HLA-HIV/SIV immunized SHIV infected macaques.
PLoS One. 2012;7(4): e34433. doi: 10.1371/journal.pone.0034433. PubMed PMID:
22514633; PubMed Central PMCID: PMC3326050.

11: Yang GB, Wang Y, Babaahmady K, Schøller J, Rahman D, Bunnik E, Spallek R,
Zong CM, Duan JZ, Qin C, Jiang H, Singh M, Vaughan R, Bergmeier LA, Schuitemaker
H, Shao Y, Lehner T. Immunization with recombinant macaque major
histocompatibility complex class I and II and human immunodeficiency virus gp140
inhibits simian-human immunodeficiency virus infection in macaques. J Gen Virol.
2012 Jul;93(Pt 7):1506-18. doi: 10.1099/vir.0.041061-0. PubMed PMID: 22492918.

12: Mörner A, Jansson M, Bunnik EM, Schøller J, Vaughan R, Wang Y, Montefiori DC,
Otting N, Bontrop R, Bergmeier LA, Singh M, Wyatt RT, Schuitemaker H, Biberfeld
G, Thorstensson R, Lehner T. Immunization with recombinant HLA classes I and II,
HIV-1 gp140, and SIV p27 elicits protection against heterologous SHIV infection
in rhesus macaques. J Virol. 2011 Jul;85(13):6442-52. doi: 10.1128/JVI.00129-11.
PubMed PMID: 21490092; PubMed Central PMCID: PMC3126489.

13: Schøller J, Singh M, Bergmeier L, Brunstedt K, Wang Y, Whittall T, Rahman D,
Pido-Lopez J, Lehner T. A recombinant human HLA-class I antigen linked to dextran
elicits innate and adaptive immune responses. J Immunol Methods. 2010 Aug
31;360(1-2):1-9. doi: 10.1016/j.jim.2010.05.008. PubMed PMID: 20542039.

14: Bergmeier LA, Babaahmady K, Pido-Lopez J, Heesom KJ, Kelly CG, Lehner T.
Cytoskeletal proteins bound to heat-shock protein 70 may elicit resistance to
simian immunodeficiency virus infection of CD4(+) T cells. Immunology. 2010
Apr;129(4):506-15. doi: 10.1111/j.1365-2567.2009.03202. x. PubMed PMID: 20002211;
PubMed Central PMCID: PMC2842497.

15: Wang Y, Bergmeier LA, Stebbings R, Seidl T, Whittall T, Singh M, Berry N,
Almond N, Lehner T. Mucosal immunization in macaques upregulates the innate
APOBEC 3G anti-viral factor in CD4(+) memory T cells. Vaccine. 2009 Feb
5;27(6):870-81. doi: 10.1016/j.vaccine.2008.11.084. PubMed PMID: 19084567; PubMed
Central PMCID: PMC2744409.

16: Lewis SM, Treacher DF, Bergmeier L, Brain SD, Chambers DJ, Pearson JD, Brown
KA. Plasma from patients with sepsis up-regulates the expression of CD49d and
CD64 on blood neutrophils. Am J Respir Cell Mol Biol. 2009 Jun;40(6):724-32. doi:
10.1165/rcmb.2008-0252OC. PubMed PMID: 19011162.

17: Babaahmady K, Bergmeier LA, Lehner T. Combining human antisera to human
leukocyte antigens, HIVgp120 and 70 kDa heat shock protein results in broadly
neutralizing activity to HIV-1. AIDS. 2008 Jul 11;22(11):1267-76. doi:
10.1097/QAD.0b013e328304b3a6. PubMed PMID: 18580605.

18: Lehner T, Wang Y, Pido-Lopez J, Whittall T, Bergmeier LA, Babaahmady K. The
emerging role of innate immunity in protection against HIV-1 infection. Vaccine.
2008 Jun 6;26(24):2997-3001. doi: 10.1016/j.vaccine.2007.11.060. Review. PubMed
PMID: 18180080.

19: Bergmeier L. Animal welfare is not just another bureaucratic hoop. Nature.
2007 Jul 19;448(7151):251. PubMed PMID: 17637639.

20: Pido-Lopez J, Whittall T, Wang Y, Bergmeier LA, Babaahmady K, Singh M, Lehner
T. Stimulation of cell surface CCR5 and CD40 molecules by their ligands or by
HSP70 up-regulates APOBEC3G expression in CD4(+) T cells and dendritic cells. J
Immunol. 2007 Feb 1;178(3):1671-9. PubMed PMID: 17237417.

21: Whittall T, Wang Y, Younson J, Kelly C, Bergmeier L, Peters B, Singh M,
Lehner T. Interaction between the CCR5 chemokine receptors and microbial HSP70.
Eur J Immunol. 2006 Sep;36(9):2304-14. PubMed PMID: 16909434.

22: Bergmeier LA, Lehner T. Innate and adaptive mucosal immunity in protection
against HIV infection. Adv Dent Res. 2006 Apr 1;19(1):21-8. PubMed PMID:
16672545.

23: Whittall T, Wang Y, Kelly CG, Thompson R, Sanderson J, Lomer M, Soon SY,
Bergmeier LA, Singh M, Lehner T. Tumour necrosis factor-alpha production
stimulated by heat shock protein 70 and its inhibition in circulating dendritic
cells and cells eluted from mucosal tissues in Crohn's disease. Clin Exp Immunol.
2006 Mar;143(3):550-9. PubMed PMID: 16487255; PubMed Central PMCID: PMC1809607.

24: Bergmeier LA, Babaahmady K, Wang Y, Lehner T. Mucosal alloimmunization
elicits T-cell proliferation, CC chemokines, CCR5 antibodies and inhibition of
simian immunodeficiency virus infectivity. J Gen Virol. 2005 Aug;86(Pt 8):2231-8.
PubMed PMID: 16033970.

25: Wang Y, Whittall T, McGowan E, Younson J, Kelly C, Bergmeier LA, Singh M,
Lehner T. Identification of stimulating and inhibitory epitopes within the heat
shock protein 70 molecule that modulate cytokine production and maturation of
dendritic cells. J Immunol. 2005 Mar 15;174(6):3306-16. PubMed PMID: 15749862.

26: Bogers WM, Bergmeier LA, Oostermeijer H, ten Haaft P, Wang Y, Kelly CG, Singh
M, Heeney JL, Lehner T. CCR5 targeted SIV vaccination strategy preventing or
inhibiting SIV infection. Vaccine. 2004 Aug 13;22(23-24):2974-84. PubMed PMID:
15356916.

27: Stanford M, Whittall T, Bergmeier LA, Lindblad M, Lundin S, Shinnick T,
Mizushima Y, Holmgren J, Lehner T. Oral tolerization with peptide 336-351 linked
to cholera toxin B subunit in preventing relapses of uveitis in Behcet's disease.
Clin Exp Immunol. 2004 Jul;137(1):201-8. PubMed PMID: 15196263; PubMed Central
PMCID: PMC1809095.

28: Bogers WM, Bergmeier LA, Ma J, Oostermeijer H, Wang Y, Kelly CG, Ten Haaft P,
Singh M, Heeney JL, Lehner T. A novel HIV-CCR5 receptor vaccine strategy in the
control of mucosal SIV/HIV infection. AIDS. 2004 Jan 2;18(1):25-36. PubMed PMID:
15090826.

29: Wang Y, Kelly CG, Singh M, McGowan EG, Carrara AS, Bergmeier LA, Lehner T.
Stimulation of Th1-polarizing cytokines, C-C chemokines, maturation of dendritic
cells, and adjuvant function by the peptide binding fragment of heat shock
protein 70. J Immunol. 2002 Sep 1;169(5):2422-9. PubMed PMID: 12193710.

30: Babaahmady K, Bergmeier LA, Whittall T, Singh M, Wang Y, Lehner T. A
comparative investigation of CC chemokines and SIV suppressor factors generated
by CD8+ and CD4+ T cells and CD14+ monocytes. J Immunol Methods. 2002 Jun
1;264(1-2):1-10. PubMed PMID: 12191503.

31: Bergmeier LA, Wang Y, Lehner T. The role of immunity in protection from
mucosal SIV infection in macaques. Oral Dis. 2002;8 Suppl 2:63-8. Review. PubMed
PMID: 12164663.

32: Wang Y, Kelly CG, Karttunen JT, Whittall T, Lehner PJ, Duncan L, MacAry P,
Younson JS, Singh M, Oehlmann W, Cheng G, Bergmeier L, Lehner T. CD40 is a
cellular receptor mediating mycobacterial heat shock protein 70 stimulation of
CC-chemokines. Immunity. 2001 Dec;15(6):971-83. PubMed PMID: 11754818.

33: Lehner T, Doyle C, Wang Y, Babaahmady K, Whittall T, Tao L, Bergmeier L,
Kelly C. Immunogenicity of the extracellular domains of C-C chemokine receptor 5
and the in vitro effects on simian immunodeficiency virus or HIV infectivity. J
Immunol. 2001 Jun 15;166(12):7446-55. PubMed PMID: 11390497.

34: Polyanskaya N, Bergmeier LA, Sharpe SA, Cook N, Leech S, Hall G, Dennis M,
ten Haaft P, Heeney J, Manca F, Lehner T, Cranage MP. Mucosal exposure to
subinfectious doses of SIV primes gut-associated antibody-secreting cells and T
cells: lack of enhancement by nonneutralizing antibody. Virology. 2001 Jan
20;279(2):527-38. PubMed PMID: 11162808.

35: Lehner T, Mitchell E, Bergmeier L, Singh M, Spallek R, Cranage M, Hall G,
Dennis M, Villinger F, Wang Y. The role of gammadelta T cells in generating
antiviral factors and beta-chemokines in protection against mucosal simian
immunodeficiency virus infection. Eur J Immunol. 2000 Aug;30(8):2245-56. PubMed
PMID: 10940916.

36: Lehner T, Wang Y, Cranage M, Tao L, Mitchell E, Bravery C, Doyle C, Pratt K,
Hall G, Dennis M, Villinger L, Bergmeier L. Up-regulation of beta-chemokines and
down-modulation of CCR5 co-receptors inhibit simian immunodeficiency virus
transmission in non-human primates. Immunology. 2000 Apr;99(4):569-77. PubMed
PMID: 10792505; PubMed Central PMCID: PMC2327186.

37: Lehner T, Bergmeier LA, Wang Y, Tao L, Sing M, Spallek R, van der Zee R. Heat
shock proteins generate beta-chemokines which function as innate adjuvants
enhancing adaptive immunity. Eur J Immunol. 2000 Feb;30(2):594-603. PubMed PMID:
10671216.

38: Lehner T, Bergmeier L, Wang Y, Tao L, Mitchell E. A rational basis for
mucosal vaccination against HIV infection. Immunol Rev. 1999 Aug; 170:183-96.
Review. PubMed PMID: 10566151.

39: Lehner T, Wang Y, Doyle C, Tao L, Bergmeier LA, Mitchell E, Bogers WM, Heeney
J, Kelly CG. Induction of inhibitory antibodies to the CCR5 chemokine receptor
and their complementary role in preventing SIV infection in macaques. Eur J
Immunol. 1999 Aug;29(8):2427-35. PubMed PMID: 10458756.

40: Wang Y, Tao L, Mitchell E, Bergmeier L, Doyle C, Lehner T. The effect of
immunization on chemokines and CCR5 and CXCR4 coreceptor functions in SIV binding
and chemotaxis. Vaccine. 1999 Apr 9;17(15-16):1826-36. PubMed PMID: 10217580.

41: Lehner T, Wang Y, Tao L, Bergmeier LA, Mitchell E, Doyle C. CD8-suppressor
factor and beta-chemokine function as a complementary mechanism to cognate
immunity. Immunol Lett. 1999 Mar;66(1-3):171-6. PubMed PMID: 10203051.

42: Lehner T, Wang Y, Ping L, Bergmeier L, Mitchell E, Cranage M, Hall G, Dennis
M, Cook N, Doyle C, Jones I. The effect of route of immunization on mucosal
immunity and protection. J Infect Dis. 1999 May;179 Suppl 3:S489-92. Review.
PubMed PMID: 10099126.

43: Mitchell EA, Bergmeier LA, Doyle C, Brookes R, Hussain LA, Wang Y, Lehner T.
Homing of mononuclear cells from iliac lymph nodes to the genital and rectal
mucosa in non-human primates. Eur J Immunol. 1998 Oct;28(10):3066-74. PubMed
PMID: 9808175.

44: Bergmeier LA, Mitchell EA, Hall G, Cranage MP, Cook N, Dennis M, Lehner T.
Antibody-secreting cells specific for simian immunodeficiency virus antigens in
lymphoid and mucosal tissues of immunized macaques. AIDS. 1998 Jul
9;12(10):1139-47. PubMed PMID: 9677162.

45: Wang Y, Tao L, Mitchell E, Bogers WM, Doyle C, Bravery CA, Bergmeier LA,
Kelly CG, Heeney JL, Lehner T. Generation of CD8 suppressor factor and beta
chemokines, induced by xenogeneic immunization, in the prevention of simian
immunodeficiency virus infection in macaques. Proc Natl Acad Sci U S A. 1998 Apr
28;95(9):5223-8. PubMed PMID: 9560257; PubMed Central PMCID: PMC20242.

46: Lehner T, Wang Y, Cranage M, Bergmeier LA, Mitchell E, Tao L, Hall G, Dennis
M, Cook N, Jones I, Doyle C. Protective mucosal immunity elicited by targeted
lymph node immunization with a subunit SIV envelope and core vaccine in macaques.
Dev Biol Stand. 1998; 92:225-35. PubMed PMID: 9554279.

47: Klavinskis LS, Bergmeier LA, Gao L, Mitchell E, Ward RG, Layton G, Brookes R,
Meyers NJ, Lehner T. Mucosal or targeted lymph node immunization of macaques with
a particulate SIVp27 protein elicits virus-specific CTL in the genito-rectal
mucosa and draining lymph nodes. J Immunol. 1996 Sep 15;157(6):2521-7. PubMed
PMID: 8805653.

48: Lehner T, Wang Y, Cranage M, Bergmeier LA, Mitchell E, Tao L, Hall G, Dennis
M, Cook N, Brookes R, Klavinskis L, Jones I, Doyle C, Ward R. Protective mucosal
immunity elicited by targeted iliac lymph node immunization with a subunit SIV
envelope and core vaccine in macaques. Nat Med. 1996 Jul;2(7):767-75. PubMed
PMID: 8673922.

49: Lehner T, Bergmeier L, Tao L, Brookes R, Hussain L, Klavinskis L, Mitchell E.
Mucosal receptors and T- and B-cell immunity. Antibiot Chemother (1971).
1996; 48:21-9. Review. PubMed PMID: 8726502.

50: Brookes R, Bergmeier LA, Mitchell E, Walker J, Tao L, Klavinskis L, Meyers
NJ, Layton G, Adams SE, Lehner T. Generation of diversity in the hierarchy of
T-cell epitope responses following different routes of immunization with simian
immunodeficiency virus protein. AIDS. 1995 Sep;9(9):1017-24. PubMed PMID:
8527073.

51: Lehner T, Panagiotidi C, Bergmeier LA, Tao L, Brookes R, Gearing A, Adams S.
Genital-associated lymphoid tissue in female non-human primates. Adv Exp Med
Biol. 1995;371A:357-65. PubMed PMID: 8525944.

52: Panagiotidi C, Bergmeier LA, Gearing AJ, Adams SE, Lehner T. T cell responses
in macaques after vaginal immunization with particulate SIV p27 antigen. Adv Exp
Med Biol. 1995;371B:1575-80. PubMed PMID: 7502859.

53: Bergmeier LA, Tao L, Gearing AJ, Adams S, Lehner T. Induction of IgA and IgG
antibodies in vaginal fluid, serum and saliva following immunization of genital
and gut associated lymphoid tissue. Adv Exp Med Biol. 1995;371B:1567-73. PubMed
PMID: 7502858.

54: Bergmeier LA, Walker J, Tao L, Cranage M, Lehner T. Antibodies to human and
non-human primate cellular and culture medium components in macaques vaccinated
with the simian immunodeficiency virus. Immunology. 1994 Oct;83(2):213-20. PubMed
PMID: 7835937; PubMed Central PMCID: PMC1414951.

55: Lehner T, Bergmeier LA, Tao L, Panagiotidi C, Klavinskis LS, Hussain L, Ward
RG, Meyers N, Adams SE, Gearing AJ, et al. Targeted lymph node immunization with
simian immunodeficiency virus p27 antigen to elicit genital, rectal, and urinary
immune responses in nonhuman primates. J Immunol. 1994 Aug 15;153(4):1858-68.
PubMed PMID: 7519218.

56: Lehner T, Tao L, Panagiotidi C, Klavinskis LS, Brookes R, Hussain L, Meyers
N, Adams SE, Gearing AJ, Bergmeier LA. Mucosal model of genital immunization in
male rhesus macaques with a recombinant simian immunodeficiency virus p27
antigen. J Virol. 1994 Mar;68(3):1624-32. PubMed PMID: 8107223; PubMed Central
PMCID: PMC236620.

57: Bergmeier LA. Unreconstructed man. Nature. 1993 Jan 14;361(6408):108. PubMed
PMID: 8481191.

58: Lehner T, Bergmeier LA, Panagiotidi C, Tao L, Brookes R, Klavinskis LS,
Walker P, Walker J, Ward RG, Hussain L, et al. Induction of mucosal and systemic
immunity to a recombinant simian immunodeficiency viral protein. Science. 1992
Nov 20;258(5086):1365-9. PubMed PMID: 1360702.

59: Brookes RH, Rayfield LS, Bergmeier LA, Shepherd PS. Isolation of a human T
cell line specific for a streptococcal cell surface antigen. FEMS Microbiol
Immunol. 1991 Jun;3(3):177-83. PubMed PMID: 1715178.

60: Kelly C, Evans P, Ma JK, Bergmeier LA, Taylor W, Brady LJ, Lee SF, Bleiweis
AS, Lehner T. Sequencing and characterization of the 185 kDa cell surface antigen
of Streptococcus mutans. Arch Oral Biol. 1990;35 Suppl:33S-38S. PubMed PMID:
1982405.

61: Lehner T, Walker P, Smerdon R, Childerstone A, Bergmeier LA, Haron J.
Identification of T- and B-cell epitopes in synthetic peptides derived from a
Streptococcus mutans protein and characterization of their antigenicity and
immunogenicity. Arch Oral Biol. 1990;35 Suppl:39S-45S. PubMed PMID: 1708230.

62: Kelly C, Evans P, Bergmeier L, Lee SF, Progulske-Fox A, Harris AC, Aitken A,
Bleiweis AS, Lehner T. Sequence analysis of the cloned streptococcal cell surface
antigen I/II. FEBS Lett. 1989 Nov 20;258(1):127-32. PubMed PMID: 2687020.

63: Lehner T, Walker P, Bergmeier LA, Haron JA. Immunogenicity of synthetic
peptides derived from the sequences of a Streptococcus mutans cell surface
antigen in nonhuman primates. J Immunol. 1989 Oct 15;143(8):2699-705. PubMed
PMID: 2477455.

64: Lehner T, Haron J, Bergmeier LA, Mehlert A, Beard R, Dodd M, Mielnik B, Moore
S. Local oral immunization with synthetic peptides induces a dual mucosal IgG and
salivary IgA antibody response and prevents colonization of Streptococcus mutans.
Immunology. 1989 Jul;67(3):419-24. PubMed PMID: 2759661; PubMed Central PMCID:
PMC1385363.

65: Rayfield LS, Smith TA, Andrews SJ, Bergmeier LA. Induction of experimental
autoimmune thyroiditis in B cell-depleted mice. Immunol Lett. 1989 Jan
15;20(1):21-7. PubMed PMID: 2785490.

66: Bergmeier LA, Lehner T. Separation and characterization of a 14,000-dalton
cyanogen bromide-generated peptide from a 185,000-dalton streptococcal antigen.
Infect Immun. 1988 Sep;56(9):2424-9. PubMed PMID: 3410545; PubMed Central PMCID:
PMC259583.

67: Fellowes R, Fortune F, Bergmeier LA, Lehner T. The effect of immunization
with a 14-kDa streptococcal antigen on primate T cell and B cell responses. Eur J
Immunol. 1988 Apr;18(4):559-64. PubMed PMID: 3259185.

68: Challacombe SJ, Bergmeier LA, Czerkinsky C, Rees AS. Natural antibodies in
man to Streptococcus mutans: specificity and quantification. Immunology. 1984
May;52(1):143-50. PubMed PMID: 6715017; PubMed Central PMCID: PMC1454598.

69: Challacombe SJ, Bergmeier LA, Rees AS. Natural antibodies in man to a protein
antigen from the bacterium Streptococcus mutans related to dental caries
experience. Arch Oral Biol. 1984;29(3):179-84. PubMed PMID: 6203506.

70: Czerkinsky C, Rees AS, Bergmeier LA, Challacombe SJ. The detection and
specificity of class specific antibodies to whole bacterial cells using a solid
phase radioimmunoassay. Clin Exp Immunol. 1983 Jul;53(1):192-200. PubMed PMID:
6872327; PubMed Central PMCID: PMC1535533.

71: Bergmeier LA, Lehner T. Lack of antibodies to human heart tissue in sera of
rhesus monkeys immunized with Streptococcus mutans antigens and comparative study
with rabbit antisera. Infect Immun. 1983 Jun;40(3):1075-82. PubMed PMID: 6852912;
PubMed Central PMCID: PMC348160.

72: Russell MW, Zanders ED, Bergmeier LA, Lehner T. Affinity purification and
characterization of protease-susceptible antigen I of Streptococcus mutans.
Infect Immun. 1980 Sep;29(3):999-1006. PubMed PMID: 7000709; PubMed Central
PMCID: PMC551230.

73: Russell MW, Bergmeier LA, Zanders ED, Lehner T. Protein antigens of
Streptococcus mutans: purification and properties of a double antigen and its
protease-resistant component. Infect Immun. 1980 May;28(2):486-93. PubMed PMID:
6995311; PubMed Central PMCID: PMC550961.

74: Challacombe SJ, Russell MW, Hawkes JE, Bergmeier LA, Lehner T. Passage of
immunoglobulins from plasma to the oral cavity in rhesus monkeys. Immunology.
1978 Dec;35(6):923-31. PubMed PMID: 104924; PubMed Central PMCID: PMC1457446.

Other publications

Bergmeier LA (2008) AIDS: A mucosal approach to a mucosal infection. In. AIDS Vaccines, HIV receptors and AIDS research. Ed Kendroe LB. Nova Science Publishers Inc. ISBN 978-1-60692-074-9

Lehner T and  Bergmeier LA. (2005). Mucosal Infection and immune response to simian immunodeficiency virus. In: Mucosal Immunology. 3rd Edition. Chapter 66 Vol. 2 pp1179-1197. Eds: Mestecky, Lamm, Strober, Bienenstock, McGhee and Mayer. Elsevier. Academic Press. New York. (ISBN

Lehner T, Wang Y, Whittall T and Bergmeier LA (2005). Heat shock proteins, their cell surface receptors and effects on the immune system. In: Molecular Chaperones and Cell Signalling. Eds.  Henderson and Pockley. Chapter 10.  Cambridge University Press (ISBN 0521836549).