Professor Mangala Patel, PhD (Lond),MSc, BSc(Hons)

Profile

Professor Mangala Patel was awarded a BSc degree with honours in Chemistry, followed by an MSc in Synthetic Organic Chemistry. She then successfully completed a PhD on heterocyclic methacrylates for dental and clinical applications, in the Department of Biomaterials in Relation to Dentistry, at the former London Hospital Medical College, now named Dental Physical Sciences Unit (DPSU), at QMUL.

Professor Patel's research centres on the development of novel polymeric dental and related biomaterials, for the delivery of therapeutic (active) species, locally within the oral cavity and in the body, aimed at treating a range of pathological conditions.

From 2011- early 2019, Professor Patel chaired the Institute of Dentistry (IoD) Athena SWAN Self-Assessment Team (SAT). Under her leadership, the IoD successfully gained the Athena SWAN Bronze Award in 2013, renewed in 2015, followed by the Silver Award in November 2018, thus demonstrating the impact of her actions, in fostering a positive, inclusive environment in which all staff and students can flourish. She continues to mentor numerous staff and students to reach their career goals.

As an experienced Dental Materials (DM) tutor, Professor Patel has led on the development of both undergraduate and postgraduate dental materials teaching to stimulate students’ interest. 

Currently she is Centre Lead for Oral Bioengineering, one of the four research active centres within the Institute of Dentistry.

Centre: Oral Bioengineering

Teaching

Professor Mangala Patel has extensive experience in teaching Dental Materials Science and Biomaterials for clinical applications, to both undergraduate and postgraduate students. To enhance student experience, she has actively designed the dental materials component of the 2012 undergraduate curriculum, which runs across all five years of the degree. Professor Patel delivers Dental Materials Science teaching that underpins the materials clinical use(s). She also examines several PhDs, MSc/ Doctors in Clinical Dentistry (DClinDent) and BEng / BSc projects. Professor Patel is a module convenor for 1 DClinDent and 2 MSc modules, which she has designed and developed to provide students with in-depth, evidence-based knowledge of the subject, to attain optimum clinical results when using these materials.

Research

Research Interests:

Professor Patel's research centres on the development of novel polymeric dental and related biomaterials for the delivery of therapeutic (active) species, locally within the oral cavity and in the body, aimed at treating a range of pathological conditions. An example includes proteins across oral mucosa and dermal sites.

The detailed kinetics of water absorption and diffusion processes associated with drug release are central to the clinical performance of these systems. This area of research has benefitted from interdisciplinary research, international / national collaborations, patents, and success in external / internal funding. A further example is the development of a self-disinfecting dental alginate impression material, that is effective against some oral bacteria and viruses. 

Innovative research areas also include iontophoretic drug delivery via the buccal mucosa, drug delivery systems for potentially treating oral Recurrent Aphthous Stomatitis (ulcers), and the development of materials useful in addressing orthodontic white spot lesions. The outcomes of a recent project area foresee an impact on reducing early-stage caries.  This research includes materials containing Layered Double Hydroxide (LDHs), that are capable of absorbing and releasing therapeutic levels of fluoride (and other beneficial ions). 

Publications

Key Publications

Tameeza Hassanali Tejani, Alex Milosevic, Mangala Patel, David Gillam (2021). The effect of layered double hydroxide on fluoride release and recharge from a commercial and an experimental resin varnish. Dental Materials (article in press) Available online 8 November 2021

Agha A, Parker S, Parkinson EK, Patel M (2021). Characteristics of experimental resin-modified glass-ionomer cements, containing alternate monomers to HEMA. Dental Materials2021 Oct;37(10):1542-1552.  10.1016/j.dental.2021.08.003

Ud Din S, Parker S, Braden M, Patel M ( 2021 ). Improved water absorption behaviour of experimental hydrophilic vinyl polysiloxane (VPS) impression materials incorporating a crosslinking agent and a novel surfactant. Dental Materials vol. 37 , ( 6 ) 1054 - 1065 .
10.1016/j.dental.2021.03.019

Hoxha, A., Karpukhina, N., Gillam, G., Bushby, A., Patel, M., (2020). Fluoride Rechargeable Layered Double Hydroxide Powders for Dental Applications. Applied Clay Sciences Volume 200, Jan 2021 1005863  https://doi.org/10.1016/j.clay.2020.105863

Hoxha A, Gillam DG, Agha A, Karpukhina N, Bushby AJ, Patel MP (2020). Novel fluoride rechargeable dental composites containing MgAl and CaAl layered double hydroxide (LDH). Dental Materials Volume 36, Issue 8, August 2020, 973-986
10.1016/j.dental.2020.04.011

Hoxha A, Gillam DG, Bushby AJ, Agha A, Patel MP (2019). Layered Double Hydroxide Fluoride Release in Dental Applications: A Systematic Review. Dent J (Basel) vol. 7, (3)
10.3390/dj7030087

Mangala Patel and Sandra Parker
In memoriam of Professor Michael Braden 6th September 1928–22nd November 2017. Dental Materials, 35, 2019, 1-2.
https://doi.org/10.1016/j.dental.2018.11.020

Ud Din S, Parker S, Braden M, Patel, M.P. (2018). The effects of cross-linking agent and surfactant on the tear strength of novel vinyl polysiloxane impression materials. Dental Materials Vol.34 Issue 12, pages e334-e343. DOI: 10.1016/j.dental.2018.09.010

Taha, A.A., Fleming, P.S., Hill, R.G, Patel, M.P. (August 2018) Enamel Remineralisation with Novel Bioactive Glass Air Abrasion. J Dent Res, Vol 97, Issue 13, https://journals.sagepub.com/doi/10.1177/0022034518792048

Ud Din, S., Hassan, M., Khalid, S., Zafar, Sohail., Ahmed, B., Patel, M. (2018) Effects of surfactant's molecular weight on the wettability of vinyl polysiloxane impression materials after immersion disinfection. "Materials Express" Journal. Mater. Express, Vol 8, No. 1, 2018; doi: 10.1166/mex.2018.1413

Toprani, D., Patel, M.P., Mordan, D., Gillam, D.G. (2017) Comparison of Two Tricalcium Phosphate Varnishes and a Comparator Fluoride Varnish on Tubular Occlusion. BAOJ Dentistry, 3(2);036 (Open Access)

Taha, A.A., Patel, M.P., Hill, R.G., Fleming, P.S. (2017) The effect of bioactive glasses on enamel remineralisation: A systematic review. J Dent 2017 Dec; 67:9-17. doi: 10.1016/j.dent.2017.09.007 Epub Sep 20. 

Agha A, Parker S, Patel MP. (2017) The properties of experimental resin-modified glass-ionomer luting cements (RMGICs) containing novel monomers. Dent Mater; 33(12):1331-1339. doi: 10.1016/j.dental.2017.08.189. Epub Sep 20.

Taha, A.A., Hill, R.G., Fleming, P.S., Patel, M.P. (2017) Development of a novel bioactive glass for air-abrasion to selectively remove orthodontic adhesives. Clinical Oral Investigations, Nov 28. doi: 10.1007/s00784-017-2279-8. [Epub ahead of print]

Patel J, Granger C, Parker S, Patel MP (2017) The effect of instrument lubricant on the diametral tensile strength and water uptake of posterior composite restorative material. Journal of Dentistry, 56, 33-38. 10.1016/j.dent.2016.10.006

Ud Din S, Parker S, Braden M, Tomlins P, Patel MP (2017). Experimental hydrophilic vinyl polysiloxane (VPS) impression materials incorporating a novel surfactant compared with commercial VPS. Dental Materials. 33(8): e301-e309. Epub (2017) May 20. 

Ud Din S, Hassan M, Parker S, Patel MP (2016) Setting characteristics of three commercial vinyl polysiloxane impression materials measured by an oscillating rheometer. Pakistan Oral & Dental Journal Vol 36, No. 3.

Agha A, Parker S, Patel MP (2016) Development of experimental resin modified glass ionomer cements (RMGICs) with reduced water uptake and dimensional change. Dent Mater. 32(6):713-22. 10.1016/j.dental.2016.03.004.

Abdulmohsen B, Parker S, Braden M, Patel MP (2016) A study to investigate and compare the physicomechanical properties of experimental and commercial temporary crown and bridge materials. Dent Mater. 32(2):200-10. 10.1016/j.dental.2015.11.025

Nallamuthu NA, Braden M, Oxford J, Williams D, Patel MP (2015) Modification of pH Conferring Virucidal Activity on Dental Alginates. Materials, 8, 1966.1975.10.3390/ma8041966 (Open Access)

Mustaza TA, Braden M and Patel MP (2014) Comparison of various properties of a Silorane Based Dental Composite with Two Methacrylate Based Dental Composites. GSTF International Journal of Advances in Medical Research (JAMR) Vol.1(1),78-83 doi: 10.7603/s40782-014-0012-y

Patel MP, Churchman ST, Cruchley AT, Braden M and Williams DM (2013). Electrically induced transport of macromolecules through oral buccal mucosa. Dent Mater, 29(6): 674-681; 10.1016/j.dental.2013.03.016

Patel MP, Churchman ST, Cruchley AT, Braden M and Williams DM (2013). Delivery of macromolecules across oral mucosa from polymeric hydrogels is enhanced by electrophoresis (iontophoresis). Dent Mater, 29(11): e299-e307; 10.1016/j.dental.2013.09.00

Nallamuthu NA, Braden M, Patel MP (2012). Some aspects of the formulation of alginate dental impression materials - setting characteristics and mechanical properties. Dent Mater, 28(7); 756-762. 

Siddiqui A, Braden M, Patel MP, Parker S.  An experimental and theoretical study of the effect of sample thickness on the shore hardness of elastomers. Dent Mater, 26(6): 560-4, (2010)

Methananda I, Parker S, Patel MP, Braden M.  the relationship between shore A hardness of elastomeric dental materials and Young’s Modulus.  Dent Mater, 25: 956-959, (2009)

Darr JA, Gong K, Braden M, Patel MP, Rehman IU, Zhang D. Controlled release of chlorhexidine diacetate from a porous methacrylate system: supercritical fluid assisted foaming and impregnation. J.Pharm.Sci 96: (2007)

Anderson P, Ahmed Y, Patel MP, Davis GR, Braden M. X-ray microtomographic studies of novel radio-opaque polymeric materials for dental applications. Materials Science and Technology 22: 1094-1097. (2006)

Nallamuthu, N, Braden M, Patel MP. Dimensional changes of alginate dental impression materials. J.Mater.Sci: Mater Med.17: 1205-1210 (2006)

Braden M, Latham D, Patel MP. Observations on the swelling of cross-linked poly(dimethyl siloxane) networks by solvents. European Polymer Journal 41: 3069-3071 (2005)

Forrester-Baker L, Seymour KG, Samarawickrama D, Zou L, Patel M. A comparison of dimensional accuracy between three different addition cured silicone impression materials. Eur. J. Prosthodont. Res. Dent., 13:No2, 69-74 (2005)

Rahman FF, Bonfield W, Cameron RE, Patel MP, Braden M, Pearson GJ, Tavakoli S.M Water uptake of poly(ethyl methacrylate) tetrahydrofurfuryl methacrylate polymer systems modified with tricalcium phosphate and hydroxyapatite. Bioceramics 16: 513-516; (Key Engineering Materials 254-256), (2004).

Chowdbury M, Hill DJT, Whittaker AK, Braden M, Patel M.P. NMR imaging of water diffusion into PEMP/P(HEMA-co-THFMA) semi-IPN Matrices. Polymer Preprints 45: 517 (2004)

Chowdhury MA, Hill DJT, Whittaker AK, Braden M, Patel MP. NMR Imaging of water diffusion at 310K into semi -IPN's of PEM and Poly(HEMA-c- THFM) with and without chlorhexidine diacetate. Biomacromolecules 5: 1405-1411, (2004)

Scott G, Patel M P, Braden M. Use of prepolymerised cement spacers to augment the femoral component in revision total knee arthroplasty. Journal of Arthroplasty 18: 769-774, (2003)

Patel, M.P., Pavlovic, P., Hughes, F.J., King, G.N., Cruchley, A. and Braden, M. Release of recombinant human bone morphogenetic protein-2 from heterocyclic methacrylate polymer systems. 22: 2081-2086, (2001).

Nazhat, S.N., Parker, S., Patel, M.P. and Braden, M. Isoprene-styrene copolymer elastomer and terahydrofurfuryl methacrylate mixtures for soft prosthetic applications. Biomaterials, 22(17), 2411-2416, (2001).

Patel, M.P., Cruchley, A.T., Coleman, D.C., Swai, H., Braden, M. and Williams, D.M. A polymeric system for the intra-oral delivery of an antifungal agent. Biomaterials, 22(17), 2319-2324, (2001).

Riggs, P.D., Kinchesh, P., Braden, M. and Patel, M.P. Nuclear magnetic imaging of an osmotic water uptake and delivery process. Biomaterials 22, (No 5), 419-427, (2001).

Riggs, P.D., Clough, A.S., Jenneson, P.M., Braden, M. and Patel, M.P. 3He ion-beam analysis of water uptake and drug delivery. Journal of Controlled Release, 61, 165-174, (1999).

Patel, M. P., Pearson, G. J., Braden, M. and Mirza, M. A. Fluoride ion release from two methacrylate polymer systems. Biomaterials, 19, 1911-1917, (1998).

Downes, S., Archer, R. S., Kayser, M. V., Patel, M. P. and Braden, M. The regeneration of articular cartilage using a new polymer system. J. Mater. Sci., Mater. Med., 5, 88-95, (1994).

Patel, M.P., Braden, M. and Davy, K.W.M., Polymerisation shrinkage of methacrylate esters, Biomaterials, 8, 53-56, (1987).

Patents

Bhusate, M. and Braden, M.  Low shrinkage monomer/polymer curable compositions useful in biomedical applications. U.K. Patent, G.B. 2, 107, 341B, 1985.

Braden, M., Downes, S., Patel, M.P. and Davy, K.W.M. The use of biomaterials for tissue repair. UK Patent Appl. GB210734.1 (1992), European Application. 92923088.6, PCT/GB92/02128, US No5,468,787, 1995

Braden, M., Patel, M. P.and Pearson, G. J.  Fluoride releasing biomaterials.  UK granted, European Patent Appl., 96300314.0, 1996, US Patent No: 5,718,924, 1998

Pearson, G.J., Williams, J., Todhunter, R., Clements, D., Patel, M.P. and Braden, M. Polymerisable resin compositions for use in dentistry.  European Patent Appl, 2001, US Patent No: US 7,166,652 B2, 2007