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Centre for Epigenetics
  1. Centre for Epigenetics
  2. About us
  3. Bochukova

Bochukova Lab

Our laboratory is interested in the biology underlying human genetic obesity and related metabolic and neuropsychiatric traits. We apply gene discovery in understudied South Asian populations, and study obesity-associated genome variation using stem cell-derived genome-edited models and genomics technologies for mechanistic insights.

Photo of members of the Bochukova lab next to a microscopy image of a cell

Selected Publications

Ogunkolade BW, Adaikalakoteswari A, Cardoso SR, Lowe R, Patel N, Rakyan V, Finer S, Wabitsch M, Saravanan P, Tripathi G, Bochukova E, Hitman GA (2022) "An integrative epi-transcriptomic approach identifies the human cartilage chitinase 3-like protein 2 (CHI3L2) as a potential mediator of B12 deficiency in adipocytes", Epigenetics, 10:1219-33 (PMID: 34818986)

Lam BYH, Williamson A, Finer S, et al. (2021) "MC3R links nutritional state to childhood growth and the timing of puberty", Nature, 599:436-41 (PMID: 34732894)

Bochukova EG, Lower K, Croizier S, Keogh J, Patel N, Strohbehn G, Lo KK, Humphrey J, Hokken-Koelega A, Damen L, Donz S, Bouret SG, Plagnol V, Farooqi IS (2018) "A transcriptomic signature of the hypothalamic response to fasting and BDNF deficiency in Prader-Willi syndrome", Cell Reports, 22:3401-8 (PMID: 29590610)

Wheeler E*, Bochukova EG*, Huang N*, Keogh JM, Lindsay S, Garg S, Henning E, Blackburn H, Loos RJ, Wareham NJ, O'Rahilly S, Hurles ME, Barroso I, Farooqi IS (2013) "Genome-wide SNP and CNV analysis identifies novel common and low frequency variants associated with severe early obesity", Nature Genetics, 45:513-7 (PMID: 23563609)

Bochukova EG*, Schoenmakers N*, Agostini M, Schoenmakers E, […], Vargha-Khadem F, Dattani M, Farooqi IS, Gurnell M, Chatterjee K (2012) "A mutation in the thyroid hormone receptor alpha gene", New England Journal of Medicine, 366:243-9 (PMID: 22168587)

Bochukova EG, Huang N, Keogh J, Henning E, Purmann C, Blaszczyk K, Saeed S, Hamilton-Shield J, Clayton-Smith J, O'Rahilly S, Hurles ME, Farooqi IS (2010) "Large, rare chromosomal deletions associated with severe early-onset obesity", Nature, 463:666-70 (PMID: 19966786)

Group Members

Rachel Wilson
Cecilia San Vicente Huizar
Dr. Xiaoyang Dai
Dr. Sadaf Ambreen

Links

QMUL webpage

 

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