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Centre for Epigenetics
  1. Centre for Epigenetics
  2. About us
  3. de Mendoza

de Mendoza Lab

Our group is interested in the evolution of gene regulation and its impact on organismal complexity, with a bias for DNA methylation. Furthermore, we are interested in the co-evolution of transposable elements and host epigenomes. We study these topics through comparative epigenomics of non-traditional model species across the tree of life of eukaryotes.

Photo of members of the de Mendoza lab next to an image of an Amoebidium

Selected Publications

Sarre LA, Kim IV, Ovchinnikov V, Olivetta M, Suga H, Dudin O, Sebé-Pedrós A, de Mendoza A (2024) “DNA methylation enables recurrent endogenization of giant viruses in an animal relative”, BioRxiv, 2024.01. 08.574619

Guynes K, Sarre LA, Carrillo-Baltodano AM, Davies BE, Xu L, Liang Y, Martin-Zamora FM, Hurd PJ, de Mendoza A, Martin-Duran JM (2023) “Annelid methylomes reveal ancestral developmental and ageing-associated epigenetic erosion across Bilateria”, BioRxiv, 2023.12. 21.572802

de Mendoza A, Nguyen TV, Ford E, Poppe D, Buckberry S, Pflueger J, Grimmer MR, Stolzenburg S, Bogdanovic O, Oshlack A, Farnham PJ, Blancafort P,  Lister R (2023) “Large-scale manipulation of promoter DNA methylation reveals context-specific transcriptional responses and stability”, Genome Biology, 23:163 (PMID: 35883107)

de Mendoza A, Poppe D, Buckberry S, Pflueger J, Albertin CB, Daish T, Bertrand S, de la Calle-Mustienes E, Gomez-Skarmeta JL, Nery JR, Ecker JR, Baer B, Ragsdale CW, Grützner F, Escriva H, Venkatesh B, Bogdanovic O, Lister R (2021) “The emergence of the brain non-CpG methylation system in vertebrates”,  Nature Ecology and Evolution, 5:369–378 (PMID: 33462491)

Group Members

Luke A. Sarre
Dr. Lan Xu
Pedro Romero Charria
Benjamin Tapon
Giselle Gastellou Peralta

Links

Lab website

 

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