Zabet Lab
We are multidisciplinary lab that combines computational biology, machine learning, AI and molecular biology to decode the contribution of epigenetics (DNA methylation and histone modifications), enhancers, transcription factors and 3D genome organisation to gene regulation. Our focus in on both human diseases (including cancer), but also on normal development.
Selected Publications
Pop RT, Pisante A, Nagy D, Martin PCN, Mikheeva LA, Hayat A, Ficz G, Zabet NR (2023) "Identification of mammalian transcription factors that bind to inaccessible chromatin", Nucleic Acids Research, 51:8480-95 (PMID: 37486787)
Chathoth KT, Mikheeva LA, Crevel G, Wolfe JC, Hunter I, Beckett-Doyle S, Cotterill S, Dai H, Harrison A, Zabet NR (2022) "The role of insulators and transcription in 3D chromatin organisation of flies", Genome Research, 32:682-98 (PMID: 35354608)
Grant OA, Wang Y, Kumari M, Zabet NR, Schalkwyk LC (2022) "Characterising sex differences of autosomal DNA methylation in whole blood using the Illumina EPIC array", Clinical Epigenetics, 14:62 (PMID: 35568878)
Wolfe JC, Mikheeva LA, Hagras H, Zabet NR (2021) "An explainable artificial intelligence approach for decoding the enhancer histone modifications code and identification of novel enhancers in Drosophila", Genome Biology, 22:308 (PMID: 34749786)
Chathoth KT, Zabet NR (2019) "Chromatin architecture reorganisation during neuronal cell differentiation in Drosophila genome", Genome Research, 29:613-25 (PMID: 30709849)
Catoni M, Tsang JMF, Greco AP, Zabet NR (2018) "DMRcaller: a versatile R/Bioconductor package for detection and visualization of differentially methylated regions in CpG and non-CpG contexts", Nucleic Acids Research, 46:e114 (PMID: 29986099)Group Members
Dr. Duarte Polvora BrandãoInes Hofer
Khizra Maqsood
Alexandra Hadaway
Caitlin Mellor
Ziba Shadman Zanjani
