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Centre for Epigenetics
  1. Centre for Epigenetics
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Branco Lab

Our research focuses on the regulation of mammalian transposable elements, which have played a major role in genome evolution. We aim to elucidate the impact that transposable elements have in the contexts of development and disease.

Photo of members of the Branco lab next to an image of a blastocyst made up of corn kernels.

Selected Publications

Frost JM, Amante SM, Okae H, Jones EM, Ashely B, Lewis RM, Cleal JK, Caley MP, Arima T, Maffucci T, Branco MR (2023) “Regulation of human trophoblast gene expression by endogenous retroviruses”, Nat Struct Mol Biol, 30:527-38 (PMID: 37012406)

Taylor D, Lowe R, Philippe C, Cheng KCL, Grant OA, Zabet NR, Cristofari G, Branco MR (2022) “Locus-specific chromatin profiling of evolutionarily young transposable elements”, Nucleic Acids Research, 50:e33 (PMID: 34908129)

Deniz O, Ahmed M, Todd CD, Rio-Machin A, Dawson MA, Branco MR (2020) “Endogenous retroviruses are a source of oncogenic enhancers in acute myeloid leukemia”, Nature Communications, 11:3506 (PMID: 32665538)

Todd CD, Deniz O, Taylor D, Branco MR (2019) “Functional evaluation of transposable elements as transcriptional enhancers in mouse embryonic and trophoblast stem cells”, eLife, 8:e44344 (PMID: 31012843)

Deniz O, de la Rica L, Cheng KC, Spensberger D, Branco MR (2018) “SETDB1 prevents TET2-dependent activation of IAP retroelements in naïve embryonic stem cells”, Genome Biology, 19:6 (PMID: 29351814)

de la Rica L, Deniz O, Cheng KC, Todd CD, Cruz C, Houseley J, Branco MR (2016) “TET-dependent regulation of retrotransposable elements in mouse embryonic stem cells”, Genome Biology, 17:234 (PMID: 27863519)

Group Members

Dr. Samuele Amante
Aldo Juárez-Miranda
Jessica Li
Diane Vaz

Links

Lab website
@BrancoLab
@brancolab.bsky.social

 

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