Our group is interested in the evolution of gene regulation and its impact on organismal complexity, with a bias for DNA methylation. Furthermore, we are interested in the co-evolution of transposable elements and host epigenomes. We study these topics through comparative epigenomics of non-traditional model species across the tree of life of eukaryotes.
Sarre LA, Kim IV, Ovchinnikov V, Olivetta M, Suga H, Dudin O, Sebé-Pedrós A, de Mendoza A (2024) “DNA methylation enables recurrent endogenization of giant viruses in an animal relative”, BioRxiv, 2024.01. 08.574619
Guynes K, Sarre LA, Carrillo-Baltodano AM, Davies BE, Xu L, Liang Y, Martin-Zamora FM, Hurd PJ, de Mendoza A, Martin-Duran JM (2023) “Annelid methylomes reveal ancestral developmental and ageing-associated epigenetic erosion across Bilateria”, BioRxiv, 2023.12. 21.572802
de Mendoza A, Nguyen TV, Ford E, Poppe D, Buckberry S, Pflueger J, Grimmer MR, Stolzenburg S, Bogdanovic O, Oshlack A, Farnham PJ, Blancafort P, Lister R (2023) “Large-scale manipulation of promoter DNA methylation reveals context-specific transcriptional responses and stability”, Genome Biology, 23:163 (PMID: 35883107)