Our research aims to understand the epigenetic regulation of transposable elements and how their dysregulation contributes to the generation and development of cancer. Using an integrative approach, combining functional and computational genomics, our team focuses on their roles as gene regulators and as triggers of anti-tumor immunity.
Deniz Ö, Ahmed M, Todd CD, Rio-Machin A, Dawson MA, Branco MR (2020) "Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia", Nature Communications, 11:3506 (PMID: 32665538)
Carrillo-Jimenez A, Deniz Ö, Niklison-Chirou MV, Ruiz R, Bezerra-Salomão K, Stratoulias V, Amouroux R, Yip PK, Vilalta A, Cheray M, Scott-Egerton AM, Rivas E, Tayara K, García-Domínguez I, Garcia-Revilla J, Fernandez-Martin JC, Espinosa-Oliva AM, Shen X, St George-Hyslop P, Brown GC, Hajkova P, Joseph B, Venero JL, Branco MR, Burguillos MA (2019) "TET2 regulates the neuroinflammatory response in microglia", Cell Reports, 29:697-713 (PMID: 31618637)
Deniz Ö, de la Rica L, Cheng KCL, Spensberger D, Branco MR (2018) "SETDB1 prevents TET2-dependent activation of IAP retroelements in naive embryonic stem cells", Genome Biology, 19:6 (PMID: 29351814)