We employ functional (epi)genomics to understand the mechanisms that mediate interactions between the genome and environment. Using the honey bee as a model organism, we integrate molecular biology, biochemistry, proteomics, metabolomics and (epi)genomic tools, combined with hands-on apiculture, to understand how nutrition dictates the development of three phenotypically distinct organisms from a single genome.
Kucharski R, Ellis N, Hurd PJ*, Maleszka R* (2023) "The PWWP domain and the evolution of unique DNA methylation toolkits in Hymenoptera", iScience, 26:108193 (PMID: 37920666)
Lowe R, Wojciechowki M, Ellis N, Hurd PJ (2022) "Chromatin accessibility-based characterisation of brain gene regulatory networks in three distinct honey bee polyphenisms", Nucleic Acids Research, 50:11550 (PMID: 36330958)
Hurd PJ, Grùˆbel C, Wojciechowsk M, Maleszka R, Rössler W (2021) "A novel structure in the nuclei of Kenyon cells in honey bee brain revealed by immunostaining', Scientific Reports, 11:6852 (PMID: 33767244)
Wojciechowski M, Lowe R, Maleszka J, Conn D, Maleszka R, Hurd PJ (2018) "Phenotypically distinct female castes in honey bees are defined by alternative chromatin states during larval development", Genome Research, 28:1532 (PMID: 30135090)
Dickman MJ, Kucharski R, Maleszka R, Hurd PJ (2013) "Extensive histone post-translational modification in the honey bee", Insect Biochemistry and Molecular Biology, 43:125 (PMID: 23174121)
Hurd PJ, Bannister AJ, Halls K, Dawson MA, Vermeulen M, Olsen JV, Ismail H, Somers J, Mann M, Owen-Hughes T, Gout I, Kouzarides T (2009) "Phosphorylation of histone H3 Thr-45 is linked to apoptosis", Journal of Biological Chemistry, 284:16575 (PMID: 19363025)