Based in Blizard Institute, Pradeepa Madapura's lab research focuses on the role of histone acetyltransferases, histone acetylations and reader proteins of acetylations and their role in development and disease. We use human and mouse stem cell differentiation system, neurodevelopmental, pregnancy disorder, and cancer.
Sundarraj J, Patel M, Aziz H, Brooke G, Tummala H, Pradeepa MM (2024) "PSIP1/LEDGF reduces R-loops at transcription sites to maintain genome integrity", Nature Communications, 15:361 (PMID: 38191578)
Pal D, Patel M, Boulet F, Sundarraj J, Grant OA, Branco MR, Basu S, Santos S, Zabet NR, Scaffidi P, Pradeepa, MM (2023) "H4K16ac activates the transcription of transposable elements and contributes to their cis-regulatory function", Nature Struct. Mol. Biol., 30:935 (PMID: 37308596)
Patel MB, Maniati E, Atanur SS, Pal D, Rio-Machin A, Heward J, Fitzgibbon J, Pradeepa MM*, Wang J* (2023) "Non-coding mutations at enhancer clusters contribute to pancreatic ductal adenocarcinoma", BioRxiv, 2023.06.28.546873
De Vas MG, Boulet F, Garstang MG, Joshi SS, Khan TN, Atla G, Parry D, Moore D, Cebola I, Zhang S, Cui W, Lampe AK, Lam WW, Genomics England Consortium, Ferrer J, Pradeepa MM*, Atanur SS* (2023) "Regulatory de novo mutations underlying intellectual disability", Life Science Alliance, 6:e202201843, (PMID: 36854624)
Olley G, Pradeepa MM, Grimes GR, Piquet S, Polo SE, FitzPatrick DR, Bickmore WA, Boumendil C (2021) "Cornelia de Lange syndrome-associated mutations cause a DNA damage signalling and repair defect", Nat Commun., 12:3127 (PMID: 34035299)
Olley G, Ansari M, Bengani H, Grimes GR, Rhodes J, Kriegsheim AV, Blatnik A, Stewart F J, Ross A, Bickmore WA*, Pradeepa MM, FitzPatrick DR (2018) "BRD4 interacts with NIPBL and is mutated in a Cornelia de Lange-like syndrome", Nature Genet., 50:329-32 (PMID: 29379197)