We combine computational and experimental approaches, including single-cell omics and genetic engineering, to study how the genetic and epigenetic state of a cell influences molecular, cellular and tissue behaviour during cancer development. The ability to causally link these alterations to their functional consequences will improve strategies to target cancer cells.
Hodis E*, Torlai Triglia E*, Kwon JYH, Biancalani T, Zakka LR, Parkar S, Hütter JC, Buffoni L, Delorey TM, Phillips D, Dionne D, Nguyen LT, Schapiro D, Maliga Z, Jacobson CA, Hendel A, Rozenblatt- Rosen O, Mihm MC, Garraway LA, Regev A (2022) "Stepwise-edited, human melanoma models reveal mutations’ effect on tumor and microenvironment", Science, 376:eabi8175 (PMID: 35482859)
Bielecki P*, Riesenfeld SJ*, Hütter JC*, Torlai Triglia E*, Kowalczyk MS, Ricardo-Gonzalez RR, Amezcua Vesely MC, Kroehling L, Slyper M, Muus C, Ludwig LS, Christian E, Tao L, Kedaigle AJ, Steach HR, York AG, Skadow MH, Yaghoubi P, Dionne D, Jarret A, McGee HM, Porter CBM, Licona-Limón P, Bailis W, Jackson RP, Gagliani N, Locksley RM, Regev A, Flavell RA (2021) "Skin-resident innate lymphoid cells converge on a pathogenic effector state", Nature, 592:128-32 (PMID: 33536623)
Muus C*, Luecken MD*, Eraslan G*, Sikkema L*, Waghray A*, Heimberg G*, Kobayashi Y*, Dhaval Vaishnav E*, Subramanian A*, Smilie C*, Jagadeesh K*, Thu Duong E*, Fiskin E*, Torlai Triglia E*, Ansari M*, Cai P*, Lin B*, Buchanan J*, Chen S*, Shu J*, Haber AL*, Chung H*, Montoro DT* [..], NHLBI LungMAP, Human Cell Atlas Lung Biological Network (2021) "Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics", Nature Medicine, 27:546-59 (PMID: 33654293)
Skourti-Stathaki K, Torlai Triglia E, Warburton M, Voigt P, Bird A, Pombo A (2019) "R-Loops enhance Polycomb Repression at a subset of developmental regulator genes", Molecular Cell, 73:930-45 (PMID: 30709709)
Ferrai C*, Torlai Triglia E*, Risner-Janiczek JR, Rito T, Rackham OJL, de Santiago I, Kukalev A, Nicodemi M, Akalin A, Li M, Ungless MA, Pombo A (2017) "RNA polymerase II primes Polycomb-repressed developmental genes throughout terminal neuronal differentiation", Molecular Systems Biology, 13:946 (PMID: 29038337)
Kar G, Kim JK, Kolodziejczyk AA, Natarajan KN, Torlai Triglia E, Mifsud B, Elderkin S, Marioni JC, Pombo A, Teichmann SA (2017) "Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression", Nature Communications, 8:36 (PMID: 28652613)
*Shared first authorship