Peer reviewed articles

Role of plasma extracellular vesicles in prediction of cardiovascular risk and alterations in response to statin therapy in hypertensive patients. Oggero S, Godec T, van Gorp R, Pinto L. Adreia, Schurgers JL, Reutelingsperger C, Sever P, Norling LV, Perretti M, Gupta A. J Hypertension 2022 Jun 22

Adhesion of leukocytes to cerebral venules precedes neuronal cell death and is sufficient to trigger tissue damage after cerebral ischemia. Sienel RI, Kataoka H, Kim S-W, Seker FB and Plesnila N. Front. Neurol., 2022, 12:807658

Design, synthesis, and biological evaluation of novel pyrrolidinone small-molecule Formyl peptide receptor 2 agonists. Maciuszek M, Ortega-Gomez, A, Maas SL, Garrido-Mesa J, Ferraro B, Perretti M, Merritt A, Nicolaes GAF, Soehnlein O, Chapman TM. Eur J Med Chem, 2021, 226, 113805.

Synthesis and evaluation of novel cyclopentane urea FPR2 agonists and their potential application in the treatment of cardiovascular inflammation. Maciuszek M, Ortega-Gomez A, Maas SL, Perretti M, Merritt A, Soehnlein O, Chapman TM. Eur J Med Chem, 2021, 214, 113194.

Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque reactivity. Oggero, S., de Gaetano, M., Marcone, S., Fitzsimons, S., Pinto, A. L., Ikramova, D., Barry, M., Burke, D., Montero‐Melendez, T., Cooper, D., Burgoyne, T., Belton, O., Norling, L. V., Brennan, E. P., Godson, C., & Perretti, M. (2021) J. Extracell. Vesicles, 10:, e12084.

Germ-free mice are not protected against diet-induced obesity and metabolic dysfunction. Moretti CH, Schiffer TA, Li X, Weitzberg E, Carlström M, Lundberg JO. Acta Physiol (Oxf). 2020 Nov 22:e13581.

Dietary nitrite extends lifespan and prevents age-related locomotor decline in the fruit fly. Moretti CH, Schiffer TA, Montenegro MF, Larsen FJ, Tsarouhas V, Carlström M, Samakovlis C, Weitzberg E, Lundberg JO. Free Radic Biol Med. 2020 Nov 20;160:860-870.

Head-to-head comparison of inorganic nitrate and metformin in a mouse model of cardiometabolic disease. Cordero-Herrera I, Guimarães DD, Moretti C, Zhuge Z, Han H, McCann Haworth S, Uribe Gonzalez AE, Andersson DC, Weitzberg E, Lundberg JO, Carlström M. Nitric Oxide. 2020 Apr 1;97:48-56

The obligatory role of host microbiota in bioactivation of dietary nitrate. Moretti C, Zhuge Z, Zhang G, McCann Haworth S, Paulo LL, Guimarães DD, Cruz JC, Montenegro MF, Cordero-Herrera I, Braga VA, Weitzberg E, Carlström M and Lundberg JO. Free Radical Biology and Medicine, Dec 2019, 145:342-348

Pro-Angiogenic Macrophage Phenotype to Promote Myocardial Repair. Ferraro B, Leoni G, Hinkel R, Ormanns S, Paulin N, Ortega-Gomez A, Viola JR, de Jong R, Bongiovanni D, Bozoglu T, Maas SL, D'Amico M, Kessler T, Zeller T, Hristov M, Reutelingsperger C, Sager HB, Döring Y, Nahrendorf M, Kupatt C, Soehnlein O. J Am Coll Cardiol. 2019 Jun 18;73(23):2990-3002

AMP-activated protein kinase activation and NADPH oxidase inhibition by inorganic nitrate and nitrite prevent liver steatosis. Cordero-Herrera I, Kozyra M, Zhuge Z, McCann Haworth Z, Moretti C, Peleli M, Caldeira-Dias M, Jahandideh A, Huirong H, de Campos Cruz J, Kleschyov AL, Montenegro MF, Ingelman-Sundberg M, Weitzberg E, Lundberg JO, and Carlstrom M. PNAS January 2, 2019 116 (1) 217-226.

Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms). de Gaetano M, Butler E, Gahan K, Zanetti A, Marai M, Chen J, Cacace A, Hams E, Maingot C, McLoughlin A, Brennan E, Leroy X, Loscher CE, Fallon P, Perretti M, Godson C, Guiry PJ. Eur J Med Chem. 2018 Oct 23;162:80-108.

Double-Strand DNA Sensing Aim2 Inflammasome Regulates Atherosclerotic Plaque Vulnerability. Paulin N, Viola JR, Maas SL, de Jong R, Fernandes-Alnemri T, Weber C, Drechsler M, Döring Y and Soehnlein O Circulation. 2018 Jul 17;138(3):321-323

Deletion of MFGE8 Inhibits Neointima Formation upon Arterial Damage. Viola JR, Lemnitzer P, Paulin N, Drechsler M, Nazari-Jahantigh M, Maas SL, De Jong R, Winter J, Schober A, Weber C, Atabai K, Soehnlein O. Thromb Haemost. 2018 Jul;118(7):1340-1342

Reviews

Vascular Smooth Muscle Cell Neutral Sphingomyelinase 2 in the Release of Exosomes and Vascular Calcification. Pavlic A, Bahram Sangani N, Kerins J, Nicolaes G, Schurgers L, Reutelingsperger C. International Journal of Molecular Sciences. 2022; 23(16):9178.

Recent advances in the design and development of formyl peptide receptor 2 (FPR2/ALX) agonists as pro-resolving agents with diverse therapeutic potential. Maciuszek M, Cacace A, Brennan E, Godson C, Chapman TM. Eur J Med Chem, 2021, 213, 113167.

Microbiota, diet and the generation of reactive nitrogen compounds. Carlström M, Moretti CH, Weitzberg E, Lundberg JO. Free Radic Biol Med. 2020;161(October):321–5

Symbiotic bacteria enhance exercise performance. Lundberg JO, Moretti C, Benjamin N, Weitzberg E. Br J Sports Med. 2020 May 23:bjsports-2020-102094.

The Contrasting Role of Extracellular Vesicles in Vascular Inflammation and Tissue Repair. Oggero S, Austin-Williams S and Norling LV. Front. Pharmacol. 2019 Dec 17;10:1479.

Role of Vascular Smooth Muscle Cell Phenotypic Switching and Calcification in Aortic Aneurysm Formation. Petsophonsakul P, Furmanik M, Forsythe R, Dweck M, Schurink GW, Natour E, Reutelingsperger C, Jacobs M, Mees B, Schurgers L. Arterioscler Thromb Vasc Biol. 2019 Jul;39(7):1351-1368.

Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease. Halder M, Petsophonsakul P, Akbulut AC, Pavlic A, Bohan F, Anderson E, Maresz K, Kramann R, Schurgers L. Int. J. Mol. Sci. 2019, 20(4):896.

Specialized Pro-resolving Lipid Mediators: Modulation of Diabetes-Associated Cardio-, Reno-, and Retino-Vascular Complications. de Gaetano M, McEvoy C, Andrews D, Cacace A, Hunter J, Brennan E and Godson C. Front. Pharmacol., 19 December 2018

Organ-Specific Mechanisms of Transendothelial Neutrophil Migration in the Lung, Liver, Kidney, and Aorta. Maas SL,  Soehnlein O, and Viola JR. Front. Immunol., 27 November 2018

Eicosanoids in platelets and the effect of their modulation by aspirin in the cardiovascular system (and beyond). Crescente M, Menke L, Chan MV, Armstrong PC, Warner TD. Br J Pharmacol. 2018 Mar 7. doi: 10.1111/bph.14196.

Heterogeneity of atherosclerotic plaque macrophage origin, phenotype and functions: Implications for treatment.  Nagenborg J, Goossens P, Biessen EAL, Donners MMPC,  European Journal of Pharmacology, Dec 5 2017; 816: 14-24.

Specialized pro-resolving mediators in renal fibrosis, Brennan EP, Cacace A and Godson C. Mol Aspects Med. 2017 May 11.