Dr Tatiana Novoselova, MBBS, MD, PhD Molecular Cellular Neuroscience, FHEA

Profile

Tatiana is a lecturer in Medical Sciences at the IHSE and is co-lead for the Metabolism in Phase 1. She is involved in teaching on the “Metabolism” and “Brain and Behaviour” modules of Year 1 and Year 2 MBBS as well as the Graduate Entry Program students. She is also Senior Internal Examiner (SIE) for Year 2 Paper B.

She combines clinical education with a strong background in neuroscience and metabolic regulation. Tatiana graduated from one of the top medical schools in Russia and then moved to the UK to study Molecular and Cellular Neuroscience as a PhD student at UCL. After her PhD, she joined QMUL as a postdoctoral researcher to work on the central regulation of metabolism, the physiology of the adrenal gland as well as ataxia. After nine years at QMUL, Tatiana joined Middlesex University London as a Lecturer and then Senior Lecturer in Neuroscience. She undertook program leadership for the MSc Computational Neuroscience program and was teaching level 4-7 students leading six neuroscience-based modules. Along with teaching, Tatiana was involved in research activities by supervising MSc and PhD students as well as in academic leadership as an early career researcher by contributing to the faculty REF2021 submission, departmental RKE and the Ethics committees

Teaching

Year 1 Metabolism 
Year 2 Metabolism
Year 1 Brain and Behaviour
Year 2 Brain and Behaviour 
GEP (Graduate Entry Programme) Year 1 Digestion, Metabolism & Growth
GEP (Graduate Entry Programme) Year 1 Brain & Behaviour
Senior Tutor (MBBS) 
Academic Adviser (MBBS)

Research

Research Interests:

Tatiana has a strong interest in molecular and cellular mechanisms of neurodegenerative disorders as well as ataxias; further interests include central regulation of the metabolic function, mechanisms of obesity and adrenal gland physiology. 

Publications

1. Sladen P.E, Jovanovic K, Guarascio R, Ottaviani D, Salsbury G, Novoselova T, Chapple J.P, Yu-Wai-Man P, Cheetham M.E. Modelling autosomal dominant optic atrophy associated with OPA1 variants in iPSC-derived retinal ganglion cells, Human Molecular Genetics, 2022
2. Romano LEL, Aw WY, Hixson KM, Novoselova TV, Havener TM, Howell S, Taylor-Blake B, Hall CL, Xing L, Beri J, Nethisinghe S, Perna L, Hatimy A, Altadonna GC, Graves LM, Herring LE, Hickey AJ, Thalassinos K, Chapple JP, Wolter JM. Multi-omic profiling reveals the ataxia protein sacsin is required for integrin trafficking and synaptic organization. Cell Rep. 2022 Nov 1;41(5):111580. 
3. Sladen PE, Perdigão PRL, Salsbury G, Novoselova TV, van der Spuy J, Chapple JP, Yu-Wai-Man P, Cheetham ME. CRISPR-Cas9 correction of OPA1 c.1334G>A: p.R445H restores mitochondrial homeostasis in dominant optic atrophy patient-derived iPSCs. Mol Ther Nucleic Acids. Aug 19; 26:432-443, 2021
4. Novoselova TV, King PJ, Guasti L, Metherell LA, Clark AJL, Chan LF. ACTH signalling and resistance: lessons from mouse models. Endocrine Connections, EC-19-0190, 2019
5. Maharaj A, Maudhoo A, Chan LF, Novoselova TV, Prasad R, Metherell LA, Guasti L. Isolated glucocorticoid deficiency: Genetic causes and animal models. J Steroid Biochem and Mol Biol; Vol 189, 73-80, 2019
6. O’Toole SM, Watson DS, Novoselova TV, Romano LEL, King PJ, Bradshaw TY, Thompson CL, Knight MM, Sharp TV, Barnes MR, Srirangalingam U, Drake WM Chapple JP. Oncometabolite induced primary cilia loss in pheochromocytomas. Endocrine-Related Cancer, Jan 1;26(1):165-180, 2019
7. Novoselova TV, Hussain M, King PJ, Guasti L, Metherell LA, Charalambous M, Clark AJL, Chan LF. MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation. FASEB J, Jun 7, 2018
8. Novoselova TV, Chan LF, Clark AJL. Pathophysiology of melanocortin receptors and their accessory proteins. Best Pract Res Clin Endocrinol Metab, Apr;32(2):93-106; 2018
9. Samuelsson AMS, Mullier A, Maicas N, Oosterhuis NR, Bae SE, NovoselovaTV, Chan LF, Pombo J, Taylor P, Joles JA, Coen CW, Balthasar N, Poston L. A central role for melanocortin-4 receptors in offspring hypertension arising from maternal obesity. PNAS October 6, 2016
10. Novoselova TV, Larder R, Rimmington D, Lelliott C, Wynn EH, Gorrigan R,Guasti L, The Sanger Mouse Genetics Project, O'Rahilly S, Clark AJL, Logan DW, Coll AP, Chan LF. Loss of Mrap2 is associated with Sim1 deficiency and increased circulating cholesterol. J Endocrinol, Apr 22, 2016
11. Chan LF, Campbell DC, Novoselova TV, Clark AJ, Metherell LA. Whole-Exome Sequencing in the Differential Diagnosis of Primary Adrenal Insufficiency in Children. Front Endocrinol (Lausanne), Aug 5;6:113, 2015
12. Novoselova TV, Rath SR, Carpenter K, Pachter N, Dickinson JE, Price G,Chan LF, Choong CS, Metherell LA. NNT Pseudoexon Activation as a Novel Mechanism for Disease in Two Siblings with Familial Glucocorticoid Deficiency. J Clin Endo Metab, Dec 2, 2014
13. Asai M, Ramachandrappa S, Joachim M, Shen Y, Zhang R, Nuthalapati N, Ramanathan V, Strochlic DE, Ferket P, Linhart K, Ho C, Novoselova TV, Garg S, Ridderstråle M, Marcus C, Hirschhorn JN, Keogh JM, O'Rahilly S, Chan LF, Clark AJ, Farooqi IS, Majzoub JA. Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity. Science, Jul 19;341(6143):275-8, 2013
14. Novoselova TV, Jackson D, Campbell DC, Clark AJ, Chan LF. Melanocortin receptor accessory proteins in adrenal gland physiology and beyond. J Endocrinol, Mar 19;217(1):R1-11, 2013
15. Novoselova TV, Rose RS, Marks HM, Sullivan JA. SUMOylation regulates the homologous to E6-AP carboxyl terminus (HECT) ubiquitin ligase Rsp5p. J Biol Chem, Apr 12;288(15):10308-17, 2013
16. Novoselova TV, Zahira K, Rose RS, Sullivan JA. 2012. The Bul proteins, a nonredundant, antagonistic family of ubiquitin ligase regulatory proteins. Eukaryot Cell, Feb 3, 2012
17. Schwarz N*, Novoselova TV*, Wait R., Hardcastle AJ, Cheetham ME. 2011. The X- linked retinitis pigmentosa protein RP2 facilitates G protein traffic. Hum Mol Genet, 21: 863-873, 2012 * Equal contribution
18. Kosmaoglou M, Novoselova TV, and Cheetham, ME. The role of chaperones and co-chaperones in retinal degenerative diseases. Heat ShocProteins And The Brain: Implications For Neurodegenerative Diseases And Neuroprotection. Eds. Brown I and Azea, AA. Springer. Pg 109-124. ISBN 978-1- 4020-8230-6, 2007
19. Novoselova TV, Margulis BA, Novoselov SS, Sapozhnikov AM, van der Spuy J, Cheetham ME, Guzhova IV. Treatment with extracellular Hsp70 protein can reduce polyglutamine toxicity and aggregation. J Neurochem, 94 (3):597-606, 2005
20. Novoselov SS, Novoselova TV, Verbova MV, Margulis BA, Guzhova IV. The balance between Hsp70 and its cochaperones Hdj1 and Bag1 determines its substrate-binding activity. Tsitologiia, 47 (3): 220-229, 2005
21. Novoselov SS, Novoselova TV, Moskaleva OS, Margulis BA, Guzhova IV. Dynamics of chaperone complex Hdj1-Hsp70-Bag1 as a response of erythroleukemia K562 cells to heat stress. Tsitologiia, 46(7): 620-627, 2004

Educational content production 

22. Carlson NR and Birkett M. Physiology of Behaviour, 13/e (2021) - Pearson Global Editions. Content replacement, revision questions, end of chapter multiple choice questions
23. Carlson NR and Birkett M. Foundations of Behavioural Neuroscience, 10/e, (2020) Pearson Global Editions. End of chapter multiple choice questions