Hypothalamic-pituitary- growth axis
In the Barts Pituitary Centre, our current research project is:
‘Unravelling genetic causes of isolated and syndromic congenital hypopituitarism.’
In this project we aim to find new genetic causes of congenital hypopituitarism, either isolated GH deficiency or multiple pituitary hormone deficiencies, using next generation sequencing techniques and state of the art wet lab techniques for functional analysis of identified genetic variants.
We are especially interested in pituitary abnormalities due to variants in ARID1B (Coffin Siris Syndrome), MSX2 (open foramen parietale syndrome) and SOX10 (Van Waardenburg syndrome and PCWH (peripheral demyelinating neuropathy, central dysmyelinating leukodystrophy, Waardenburg syndrome, Hirschprung), as well as Noonan syndrome.
This project is in collaboration with Dr Carles Gaston-Massuet and Prof Dattani.
Dr Gevers forms a clinician scientist – basic scientist partnership with Dr Carles Gaston-Massuet in the Pituitary Centre.
Dr Gevers has co-supervised a PhD student (Dr Nikolina Kyprianou) with Dr Carles Gaston-Massuet in a project on craniopharyngioma, setting up a clinical international database of patients with craniopharyngioma allowing for prediction of recurrence using pre-and post-surgical parameters, and this is currently being taken forward in a follow up project.