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Genetic causes of pituitary adenomas
While pituitary adenomas are not so rare, one patient for every 1000 people in the general population, familial cases are only occasionally seen. However, these cases are often more severe, start in childhood and more challenging to manage. We have now shown that follow-up of these families can reduce the number of interventions and can lead to better outcome for those whose disease has been discovered during the follow-up.
We also believe that a background genetic predisposition exists for the development of pituitary tumours. This has been seen in many diseases, such as type 2 diabetes, and this may also explain some of the familial cases, where single genes cannot be identified.
One of the key aim of our laboratory to find the players in the genetic predisposition for pituitary adenomas.
If you are a patient with pituitary adenoma or a colleague with patients with pituitary adenomas, please get in contact and help us to discover the genetic background of pituitary adenomas.
Important: We are a purely research-based group and therefore all genetic diagnoses may have to be validated by an NHS or nationally accredited facility.