In the context of a perceptual decision-making task, this research aims to investigate the neural transformations linking visual inputs to motor behaviours, focusing on both feedforward (FF) and feedback (FB) signalling components as well as the plasticity of the underlying neural representations. For effective decision-making, the coupling of sensory information with motor actions requires plastic changes in neural circuits so that subsequent experiences in similar contexts result in beneficial (to the organism) motor outputs. Using the mouse animal model and combining cutting-edge imaging and optogenetic technologies, the study will employ a closed-loop system that integrates two-photon calcium imaging for real-time monitoring of neural activity with computer-generated holographic optogenetics for precise manipulation of specific neural circuits. This approach will enable a detailed exploration of how dynamic patterns of neural activity contribute to decision-making processes and adaptive behaviour.
The PhD position offers the unique opportunity to be co-supervised by two experienced neuroscientists with unique skillsets used to investigate the brain mechanisms by which animals relate sensory information with adaptive motor actions. The PhD candidate will be trained in systems neuroscience techniques spanning from 1) immunocytochemical approaches for identifying neurochemical distinct neuronal cell-types and their projections 2) rodent behavioural paradigms and analysis of reach-to-grasp kinematics 3) advanced imaging and holographic neuro-manipulation techniques and corresponding analysis of the data. The student will be supported with regular data talks and journal clubs and access to the world-renowned London systems neuroscience community.
Find out more about the School of Biological and Behavioural Sciences on our website.
We are looking for candidates to have or expecting to receive a first or upper-second class honours degree and a Master’s degree in an area relevant to the project such as Neuroscience or related areas (Psychology combined with Biology).
Some programming skills will be necessary for completing the PhD work and previous experience with some neuroscience-related experimental methods (e.g., rodent behaviour, electrophysiology or imaging) are preferred.
You must meet the IELTS requirements for your course and upload evidence before CSC’s application deadline, ideally by 1st March 2025. You are therefore strongly advised to sit an approved English Language test as soon as possible, where your IELTS test must still be valid when you enrol for the programme.
Please find further details on our English Language requirements page.
Formal applications must be submitted through our online form by 29th January 2025 for consideration. Please identify yourself as a ‘CSC Scholar’ in the funding section of the application.
Applicants are required to submit the following documents:
Find out more about our application process on our SBBS website.
Informal enquiries about the project can be sent to Prof Andrea Benucci and Dr John Apergis-Schoute AT a.benucci@qmul.ac.uk and j.apergis-schoute@qmul.ac.uk
Admissions-related queries can be sent to sbbs-pgadmissions@qmul.ac.uk
Shortlisted applicants will be invited for a formal interview by the supervisor. If you are successful in your QMUL application, then you will be issued an QMUL Offer Letter, conditional on securing a CSC scholarship along with academic conditions still required to meet our entry requirements.
Once applicants have obtained their QMUL Offer Letter, they should then apply to CSC for the scholarship with the support of the supervisor.
For further information, please go to the QMUL China Scholarship Council webpage.
Apply Online