IUBMB Enzyme Nomenclature

EC 4.2.1.182

Accepted name: phosphomevalonate dehydratase

Reaction: (R)-5-phosphomevalonate = (2E)--3-methyl-5-phosphooxypent-2-enoate + H2O

Glossary:(2E)-3-methyl-5-phosphooxypent-2-enoate = trans-anhydromevalonate 5-phosphate

Systematic name: (R)-5-phosphomevalonate hydro-lyase

Comments: The enzyme catalyses a step in an archaeal prenyl diphosphate biosynthesis pathway. It belongs to the aconitase X family, and contains a [4Fe-4S] cluster.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:

References:

1. Hayakawa, H., Motoyama, K., Sobue, F., Ito, T., Kawaide, H., Yoshimura, T. and Hemmi, H. Modified mevalonate pathway of the archaeon Aeropyrum pernix proceeds via trans-anhydromevalonate 5-phosphate. Proc. Natl. Acad. Sci. USA 115 (2018) 10034–10039. [PMID: 30224495]

2. Yoshida, R., Yoshimura, T. and Hemmi, H. Reconstruction of the "archaeal" mevalonate pathway from the methanogenic archaeon Methanosarcina mazei in Escherichia coli cells. Appl. Environ. Microbiol. 86 (2020) e02889-19. [PMID: 31924615]

3. Komeyama, M., Kanno, K., Mino, H., Yasuno, Y., Shinada, T., Ito, T. and Hemmi, H. A [4Fe-4S] cluster resides at the active center of phosphomevalonate dehydratase, a key enzyme in the archaeal modified mevalonate pathway. Front Microbiol. 14 (2023) 1150353. [PMID: 36992929]

[EC 4.2.1.182 created 2023]


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