Dr Christopher R JonesSenior LecturerEmail: c.jones@qmul.ac.ukTelephone: +44 (0)20 7882 6631Room Number: Room 1.07, Joseph Priestley BuildingProfileTeachingResearchPublicationsSupervisionProfileChris is a Senior Lecturer at Queen Mary University of London. He read Natural Sciences at the University of Cambridge (MSci Hons, 2005), where he later obtained his PhD in organic chemistry under the supervision of Professor Martin D. Smith (University of Cambridge, 2009). He then moved to the University of Oxford as a Junior Research Fellow to work with Professor Timothy J. Donohoe. He joined QMUL in 2013 as a Ramsay Memorial Research Fellow and in 2015 was awarded an EPSRC Early Career Fellowship. His research interests are based on the development of new synthetic organic methods, with a particular focus on aryne chemistry and related applications in functional carbon nanomaterial preparation.Undergraduate Teaching CHE100 Essential Skills for Chemists (tutorials) CHE102B Fundamentals of Organic Chemistry (MO) CHE202A Structure and Reactivity in Organic Chemistry CHE210 Essential Skills for Chemists II (tutorials) CHE211 Practical Chemistry (MO) CHE600/1 Chemistry Project CHE700 Chemical Research Project CHE410 Advanced Topics in Chemistry (MO) ResearchResearch Interests:We are a synthetic organic chemistry group, interested in developing new methods that have the potential to impact upon contemporary socioeconomic issues such as new drug discovery and the need to find more sustainable chemical feedstocks. As such, we aim to harness the high levels of reactivity of arynes, carbenes and radicals (“reactive intermediates”), as they afford unique and powerful opportunities to control challenging new chemical and biological processes. In our group we are particularly focused on exploiting aryne reactivity for the development of new synthetic strategies, including direct Csp3-Csp2 bond formation and aliphatic C-H bond functionalisation, that will enable cheap and abundant hydrocarbon sources to be utilised and therefore reducing our reliance upon more limited and heavily functionalised starting materials. Find out more on the Jones Chemistry website Research department Chemistry Publications Browse a list of publications by Dr Christopher Jones View Dr Jones' Google Scholar profile Li Q, Xu Y, Pedersen A et al. (publicationYear). Investigating the Role of Fe‐Pyrrolic N4 Configuration in the Oxygen Reduction Reaction via Covalently Bound Porphyrin Functionalized Carbon Nanotubes. nameOfConference DOI: 10.1002/adfm.202311086 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/93732 Xu Y, Xie R, Li Q et al. (2023). Pyridine Functionalized Carbon Nanotubes: Unveiling the Role of External Pyridinic Nitrogen Sites for Oxygen Reduction Reaction. nameOfConference DOI: 10.1002/smll.202302795 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/91208 Idiris FIM, Jones CR (2023). Rarely used strained molecules step up for organic synthesis. nameOfConference DOI: 10.1038/d41586-023-01935-9 QMRO: qmroHref Sun W, Uttendorfer M, Idiris FIM et al. (2023). Selective access to dihydrophenanthridines and phenanthridinones via cyclisation of aryl amines onto N -tethered arynes. nameOfConference DOI: 10.1039/d3cc03027j QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/91301 Cao Y, Xu Y, Li Q et al. (2022). Corrosion Inhibition and Disinfection of Heating and Cooling Water Systems Using In Situ Generated Hydrogen Peroxide. nameOfConference DOI: 10.1039/d2nj03806d QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/80695 Yang Y, Jones CR (2022). The Aryne Ene Reaction. nameOfConference DOI: 10.1055/a-1827-2987 QMRO: qmroHref Fang L, Crespo-Otero R, Jones CR et al. (2021). Protect to detect: A Golgi apparatus targeted probe to image mobile zinc through the use of a lipophilic cell-labile protecting group strategy. nameOfConference DOI: 10.1016/j.snb.2021.129850 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/73603 Neal EA, Werling AYR, Jones CR (2021). A simple Hückel model-driven strategy to overcome electronic barriers to retro-Brook silylation relevant to aryne and bisaryne precursor synthesis.. nameOfConference DOI: 10.1039/d0cc08283j QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/70258 Fang L, Trigiante G, Crespo-Otero R et al. (2019). An alternative modular 'click-SNAr-click' approach to develop subcellular localised fluorescent probes to image mobile Zn2+ .. nameOfConference DOI: 10.1039/c9ob01855g QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/60986 Fang L, Trigiante G, Crespo-Otero R et al. (2019). Endoplasmic reticulum targeting fluorescent probes to image mobile Zn2+. nameOfConference DOI: 10.1039/c9sc04300d QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/60990 Yang Y, Xu Y, Jones C (2019). A Ring Expansion Route to Benzofused N-Heterocycles via Aryne Insertion into 1,3-Diaza-heterocycles. nameOfConference DOI: 10.1002/ejoc.201900570 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/57784 Clement P, Trinchera P, Cervantes-Salguero K et al. (2019). One‐step chemical strategy for the formation of carbon nanotube junctions in aqueous solution: The Reaction of DNA‐WrappedCarbon Nanotubes with Diazonium Salts. nameOfConference DOI: 10.1002/cplu.201900151 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/57723 JONES CR, TRINCHERA P, SUN W et al. (2018). Aryne-Mediated Arylation of Hantzsch Esters: Access to Highly Substituted Aryl-dihydropyridines, Aryl-tetrahydropyridines and Spiro[benzocyclobutene-1,1′-(3′,4′-dihydropyridines)]. nameOfConference DOI: 10.1055/s-0037-1611065 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/49943 JONES CR, IDIRIS F, Majesté C et al. (2018). Intramolecular hydride transfer onto arynes: redox-neutral and transition metal-free C(sp3)-H functionalization of amines. nameOfConference DOI: 10.1039/C8SC00181B QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/33651 JONES CR, Idiris FIM (publicationYear). Recent advances in fluoride-free aryne generation from arene precursors. nameOfConference DOI: 10.1039/c7ob01947e QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/28553 JONES CR, Trinchera P, Sun W et al. (2017). Intermolecular Aryne Ene Reaction of Hantzsch Esters: Stable Co-valent Ene Adducts from a 1,4-Dihydropyridine Reaction. nameOfConference DOI: 10.1021/acs.orglett.7b02272 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/25450 Ferguson MD, Donohoe TJ, Jones CR (publicationYear). Lithium 4,4′‐Di‐tert‐butylbiphenylide. nameOfConference DOI: 10.1002/047084289x.rl088.pub2 QMRO: qmroHref Donohoe TJ, Jones CR, Kornahrens AF et al. (2014). ChemInform Abstract: Total Synthesis of the Antitumor Antibiotic (.+‐.)‐Streptonigrin: First‐ and Second‐Generation Routes for de Novo Pyridine Formation Using Ring‐Closing Metathesis.. nameOfConference DOI: 10.1002/chin.201421241 QMRO: qmroHref Donohoe TJ, Jones CR, Winter C (2014). 8.22 Partial and Complete Reduction of Pyrroles, Furans, Thiophenes, and their Benzo Analogs, Heterocycles Containing More Than One Heteroatom. nameOfConference DOI: 10.1016/b978-0-08-097742-3.00824-7 QMRO: qmroHref Donohoe TJ, Jones CR, Kornahrens AF et al. (2013). Total synthesis of the antitumor antibiotic (±)-streptonigrin: first- and second-generation routes for de novo pyridine formation using ring-closing metathesis.. nameOfConference DOI: 10.1021/jo402388f QMRO: qmroHref Donohoe TJ, O’Riordan TJC, Peifer M et al. (2012). Asymmetric Synthesis of the Fully Elaborated Pyrrolidinone Core of Oxazolomycin A. nameOfConference DOI: 10.1021/ol302541j QMRO: qmroHref Jones CR, Baruah PK, Thompson AL et al. (2012). Can a C-H•••O interaction be a determinant of conformation?. nameOfConference DOI: 10.1021/ja301318a QMRO: qmroHref Neier R, Journot G, R. Jones C et al. (2012). The Hydrogenation of Heterocyclic Calix[4]arenes, a Transformation Leading to Novel Macrocyclic Ligands. nameOfConference DOI: 10.3987/rev-11-sr(p)8 QMRO: qmroHref Donohoe TJ, Jones CR, Barbosa LCA (2011). Total Synthesis of (±)-Streptonigrin: De Novo Construction of a Pentasubstituted Pyridine using Ring-Closing Metathesis. nameOfConference DOI: 10.1021/ja207835w QMRO: qmroHref Jones CR, Dan Panto G, Morrison AJ et al. (2009). Plagiarizing proteins: enhancing efficiency in asymmetric hydrogenbonding catalysis through positive cooperativity. nameOfConference DOI: 10.1002/anie.200903063 QMRO: qmroHref Jones CR, Pantoş GD, Morrison AJ et al. (2009). Plagiarizing Proteins: Enhancing Efficiency in Asymmetric Hydrogen‐Bonding Catalysis through Positive Cooperativity. nameOfConference DOI: 10.1002/ange.200903063 QMRO: qmroHref Jones CR, Qureshi MKN, Truscott FR et al. (2008). A nonpeptidic reverse turn that promotes parallel sheet structure stabilized by C-H⋯O hydrogen bonds in a cyclopropane γ-peptide. nameOfConference DOI: 10.1002/anie.200802648 QMRO: qmroHref Jones CR, Qureshi MKN, Truscott FR et al. (2008). A Nonpeptidic Reverse Turn that Promotes Parallel Sheet Structure Stabilized by CH⋅⋅⋅O Hydrogen Bonds in a Cyclopropane γ‐Peptide. nameOfConference DOI: 10.1002/ange.200802648 QMRO: qmroHref SupervisionCurrent PhD opportunities Aryne-mediated metal-free C(sp3)-H bond functionalisation Aryne-mediated synthesis of biologically active heterocycles Diversity Oriented Synthesis via the Harnessing of Multiple Reactive Intermediates PhD supervision Qi Li Haseeb Ur-Rehman Shah Mi Zhang Peter Lock Khushal Siddiq Zainab Shafique Eleanor Mathias (50:50 with Stellios) Kaicheng Zhang (50:50 with Stellios) Yibing Chen (50:50 with Stellios)