Identification of autoantigens and their potential post-translational modification in EGPA and Severe Eosinophilic Asthma (IDEA)

[IRAS Project ID 274097] [REC Ref. No 20/PR/0004] 

Status: Closed for recruitment

This is a laboratory-based research study using blood and sputum samples from healthy controls and patients with eosinophilic granulomatous polyangiitis (EGPA), severe eosinophilic asthma, and other eosinophilic diseases. The aim is to determine the presence, or not, of auto-antibodies to self-peptides in severe eosinophilic asthma and EGPA, and to characterise whether they may be a useful diagnostic marker in such diseases.

IDEA Bio & Data-Resource Metrics

The study recruited 120 participants. Samples of blood and sputum (phlegm) was collected. From these samples, we isolated antibodies and immune cells that we studied further and compared to clinical measures of the disease.

Publications

• Frontiers | Identification of autoantigens and their potential post-translational modification in EGPA and severe eosinophilic asthma (frontiersin.org)

Supported by NIHR Barts Biomedical Research Centre