Archive

17th Dec
Vahitha Abdul Salam 
Proteomics approaches in Pulmonary Arterial Hypertension (PAH) - The CLIC story

10th Dec
no seminar due to meeting clash

3rd Dec
Suchita Nadkarni 
A role for maternal inflammatory immune cells in abnormal embryonic heart development

26th Nov 
Qadeer Aziz
The role of ATP-sensitive potassium channels in cardiovascular (patho)physiology

19th Nov
Barts Community Smiles  (PPAG Team)
Alcohol and the Body

12th Nov
Marilena Crescente
Profiling the eicosanoid networks that underlie aspirin’s action in the cardiovascular system

5th Nov
James Whiteford 
Novel syndecan derived therapeutics for treating neovascular and fibrotic diseases

29th Oct
Mary Walker
13-series resolvins in regulating vascular inflammation during arthritis

22nd Oct
Paul Armstrong
Platelet-monocyte complexes in thrombo-inflammatory cardiovascular diseases

15th Oct 
Helen Warren
Genetic Analyses for Pharmacogenetic Response of Blood Pressure to Anti-Hypertensive Drugs: Using ASCOT and other datasets
Slides Helen Warren 15th Oct [PDF 266KB]

8th Oct
Ajay Gupta
Lipid-lowering therapy: the Good, the Bad, and the Fake

1st Oct
Matthew Traylor
Genetic studies in cerebrovascular disease 

24th Sept
Harriet Allan
Platelet ageing is associated with changes in composition and function

17th Sept
Deepti Gurdasani 
Population History and Genomic Discovery in East Africa

10^th Sept
Claudio Raimondi
Neuropilin-1 and ATP-binding-cassette family member 8 (ABCB8) promote mitochondrial and endothelial cell homeostasis

3rd Sept
Dan Jones
High Thrombus Burden in Patients with COVID-19 Presenting with ST-Elevation Myocardial Infarction​

20^th Aug 
Qingbo Xu
Application of Single Cell RNA-sequencing for the Study of Vascular Disease

12th March  
NEW SPEAKER
Michael Shattock, King's   
FXYD1 phosphorylation regulates vascular tone, blood pressure and hypertension in mice and man

Cancelled: Due to outbreak of Coronavirus
Takaaki Akaike, Tohoku University (Sendai, Japan)   
Emerging sulfur biology innovating vascular signaling and disease control             

5th March 
Jillian Simon, University of Oxford
Novel mechanisms of PKA-dependent calcium regulation

27th Feb  
Mariana Fernandez Caggiano
Mitochondrial pyruvate carrier abundance mediates pathological cardiac hypertrophy
Sebastian Gremer
Classical and oxidative activation of PKGIa in the cardiovascular systems - Brothers in arms or opposing players?

9th Dec
Prof Lisa Heather (University of Oxford)
The battle between hypoxia and diabetes- targeting HIF to improve the diabetic heart

25th Nov
Edward T. Chouchani (Harvard Medical School)
Mechanisms of metabolite regulation over health and disease

18th Nov
Prof Pawel Swietach (University of Oxford)
An alkaline milieu is conducive for cardiac contraction and hypertrophy

11th Nov
Andrea de la Fuente-Alonso, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain
Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO

28th Oct
Mark Ranek (Johns Hopkins University)
Treating Cardiac Proteinopathies with Protein Kinase G Activators

21st Oct
Caroline Roney
Predicting atrial fibrillation recurrence: combining population data and patient-specific biophysical models

14th Oct
Prof Anja Karlstaedt (Smidt Heart Institute)
Cardio-Oncology: Metabolic interactions between cancer and the heart

23rd Sept
Miriam Cortese-Krott  (University of Dusseldorf)
Red blood cells and regulation of blood pressure

16th Sept
Christian Oeing (University Medicine Berlin)
Redox-dependent mTOR signaling in Heart Failure

9th Sept
Paul S. Brookes
Methylglyoxal Metabolism and Cardiac Ischemia

29th Jul
Kyle McCommis
Remodeling and reverse-remodeling the MPC-deficient heart

22nd Jul
Sruti Shiva (University of Pittsburgh)
Platelet mitochondria – a cardiovascular signaling hub

15th Jul
Thomas Krieg (University of Cambridge)
Succinate Dehydrogenase as a therapeutical target

8th Jul
Prof Johannes Backs (Heidelberg University)
Class IIa histone deacetylases in cardiac homeostasis and disease

1st Jul
Prof Cristina Basso (University of Padua Medical School)
Inflammation in myocardial diseases: the pathologist perspective

17th Jun
Mirela Delibegovic (University of Aberdeen)
Targeting PTP1B for treatment of cardiovascular disease and diabetes

3rd Jun
Junichi Sadoshima (Rutgers New Jersey Medical School)
The role of the Hippo signaling in cardiac disease

10th Jun
Sakthivel Sadayappan
Diastolic Dysfunction of South Asian (Dosa study)   

27th May
Bradford Hill (University of Louisville)
Metabolic mechanisms of cardiac remodeling

20th May
Jamie Timmons
Strategies for using genomics for drug repurposing in metabolic disease

13th May - BHF Accelerator Award Seminar
Pilar Alcaide
T cell immune responses in heart inflammation and failure

6th May
Sarah De Val (University of Oxford)
Understanding regulatory pathways controlling blood vessel behaviour throughout development and during cardiac injury

29th April
Mairi Brittan (University of Edinburgh)
Understanding endogenous mechanisms of vascular regeneration in the heart.

22nd April
Gareth Purvis (University of Oxford)
New insights into Bruton's tyrosine kinase (BTK): Macrophages in obesity and atherosclerosis

15th April - BHF Accelerator Award Seminar
Gabriele Schiattarella
Cardiometabolic Alterations in Heart Failure with Preserved Ejection Fraction

1st April
Gabrielle Fredman (Albany Medical College)
Dysregulation of resolution in atherosclerosis

25th Mar
Prof Ralf Brandes (Goethe University Frankfurt)
Long non-coding RNAs in endothelial function

18th Mar
Prof Sean Davidson (UCL)
Exosomes - a promising therapeutic agent for myocardial infarction

4th Mar - BHF Accelerator Award Seminar
Marinos Kallikourdis 
Roles of T cells and their consequences for cardiovascular pathology

25th Feb
Will Fuller (University of Glasgow)
New tricks for old ion transporters: palmitoylation and the regulation of cardiac function 

18th Feb
Prof Jesmond Dalli
Resolution pathways as novel targets in cardiovascular diseases

4th Feb
Christos Bourantas
Implications of the local hemodynamic forces on atherosclerotic evolution. From bench to bedside.

28th Jan
Rebecca Charles
Soluble epoxide hydrolase activation by intra-protein disulfide bond formation contributes to angiotensin II induced hypertension

21st Jan
Friederike Cuello (University of Hamburg)
Molecular pathomechanisms in humans with mutations in Protein Kinase G I that cause cardiovascular disease

 

7th July

Dr Dianne Cooper (QMUL)

Cardiac dysfunction in rheumatoid arthritis: the role of inflammation

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14th July

Dr Nicola Smart (University of Oxford)

Mechanisms of vascular protection and repair: insights from the developing embryo

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 21st July

Prof Jojo (Judith) Haendeler & Dr Yogi Altschmied (Heinrich Heine University)

The hitchhiker's guide to mitochondrial Telomerase Reverse Transcriptase in the cardiovascular system

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28th July

Prof Sir Mark Caulfield (QMUL)

Cardiovascular Genomics

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1st September

Dr Patrick Pagano (University of Pittsburgh School of Medicine)

Redox signalling and NOX1 rheostat in vascular phenotype modulation and disease

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8th September

Dr Ivan Kadurin (QMUL)

Modulation of voltage-gated calcium channels in excitable cells

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22nd September

Dr Nikolaos Frangogiannis (Albert Einstein College of Medicine)

Cardiac fibrosis

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29th September 

Dr Anja Hofman (University Hospital Dresden)

NOX4 is protective in carotid artery stenois

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6th October

Dr Elena Goncharova (University of California Davis School of Medicine)

A 'tail' of two pathways: targeting HIPPO signalling in pulmonary hypertension

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13th October

Dr David Thomas (Imperial College London)

EROS: A selective chaperone that controls reactive oxygen species and inflammasome activation

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20th October

Prof Mauro Giacca (King's College London)

RNA therapies for cardiac regeneration and gene editing

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10th November

Jane Batchelor & Dr David Collier (QMUL)

TBA

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17th November

Prof Matthias Nahrendorf (MGH Research Institute / Harvard Medical School)

Myeloid cells in cardiovascular health

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1st December

Associate Prof Benjamin L Prosser (University of Pennsylvania, Perelman School of Medicine)

Cytoskeletal control of cardiac growth and mechanics

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8th December

Dr Angeliki Asimaki (St George's, University of London)

Arrythmogenic cardiomyopathy; shifting the needle from intuitive to precision medicine

12th January

Dr Katja Gehmlich (University of Birmingham)

The role of Z-disc proteins in cardiomyopathy

 

9th February

Professor Tomasz Guzik (University of Edinburgh)

Targeting inflammation in hypertension and associated vascular dysfunction

 

23rd February

Dr Aleksandar Ivetic (King's College London)

Endothelial cell permeability: from a novel mechanism to a druggable target

 

9th March

Professor Iain Scott (University of Pittsburgh)

Dysregulated mitochondrial lysine acetylation in cardiometabolic disease

 

23rd March

Professor Damian Tyler (University of Oxford)

Hyperpolarized magnetic resonance imaging - A novel technique to assess cardiac metabolism

 

4th May

Professor Costantino Iadecola (Feil Family Brain and Mind Research Institute)

Neurovascular determinants of brain health: bench to bedside

 

18th May

Professor Albert van der Vliet (University of Vermont)

DUOX1 in lung remodeling during chronic lung disease. A unique role in macrophages

 

1st June

Dr Ketaki Mhatre (University of Washington)

Functional and metabolic benefits of deoxy ATP cell therapy against chronic heart failure

 

22nd June

Professor Lea Delbridge (University of Melbourne)

Heart failure with preserved ejection fraction...is there something special about women?

 

29th June

Dr Chi Fung Lee (OMRF)

Mitochondrial and NAD metabolism in cardiometabolic disease

 

27th July

Dr Melanie Madhani (University of Birmingham)

Role of nitrite and persulfides in cardiovascular health and disease

 

7th September

Dr Evan DeVallance (West Virginia University)

Redox-mediated epigenetics in the vasculature following toxicant inhalation: Role of endothelial bound xanthine oxidase

 

21st September

Dr Javier Barallobre Barreiro (King's College London)

The landscape of human heart failure; studying the effect of mutations, medications and comorbidities

 

5th October

Dr George Robinson (UCL)

Lipid metabolism and inflammation in juvenile lupus: mechanisms of early atherosclerosis 

 

12th October

Professor Paul Evans (QMUL)

Endothelial responses to stress in atherosclerosis 

 

2nd November 

Heartfelt stories: why public engagement and involvement matters

 

30th November

Dr Oleksandra Prysyazhna (QMUL)

Blood pressure is regulated by RSK1/2 redox state - opportunities for a new class of anti-hypertensives

 

11th January

Professor Laurent Yvan-Charvet (INSERM, France)

Artery wall remodelling by local and distal glutamine metabolism 

 

18th January

Professor Steven Niederer (Imperial College)

A multi-scale patient-specific modelling approach to cardiac physiology, pathology and care

 

25th January

Dr Alessandra Ghigo (University of Turin)

Transcriptional and metabolic adaptations to cardiotoxic anticancer therapies

 

8th February

Dr Jan Dudek (University Clinic Wurzburg)

Activation of the integrated stress response rewires cardiac metabolism in Barth Syndrome

 

15th February

Dr Jan Miljkovic (University of Cambridge)

Chemical biology of H2S and implication of cross-talk with NO cardiovascular physiology

 

7th March

Dr Sarah Schumacher (Cleveland Clinic Lerner College of Medicine)

Cardiac GRK2 peptide as a tool to understand sexual dimorphism in heart failure and cardiometabolism

 

14th March

Dr Florian Weinberger (CNIC)

Pluripotent stem cell derived cardiomyocytes for cardiac repair - pharmacological considerations

 

21st March

Professor Kristina Lorenz (University of Würzburg)

Interfering with ERK dimerization and autophosphorylation as therapeutic strategy in heart failure

 

4th April

Dr Giancarlo Forte (King's College of London)

The different layers of mechanosensing in the failing heart

 

18th April 

Dr Gustavo Ramos (University Hospital Wurzburg)

Exploring the cardio-immune crosstalk across the full aging spectrum

 

2nd May

Dr Anna Zoccarato (King's College)

NRF2 activation in the heart induces glucose metabolic reprogramming and mediates cardioprotection via unregulation of the pentose phosphate pathway

 

9th May

Dr Juma El-Awaisi (University of Birmingham)

Getting to the heart of the matter: advancing cardiopulmonary disease research with in vivo and ex vivo imaging techniques

 

16th May

Dr Hiran Prag (University of Cambridge)

Targeting succinate metabolism to treat cardiac ischemia/reperfusion injury

 

30th May

Professor Pasquale Maffia (University of Glasgow)

Immune dysregulation in cardiovascular disease - from novel mechanisms to therapeutic targeting

 

13th June

Dr Marie Jost (UKE, Hamburg)

Unravelling the precise molecular pathomechanisms of how mutations PRKG1 cause thoratic aneurysm and dissection

 

27th June

Professor Norata Giuseppe Danilo (University of Milan)

Cholesterol and lipoprotein metabolism as immunometabolic checkpoints in the adaptive immune response

 

11th July

Dr Ingrid Dumitriu (University of Birmingham)

Interrogating inflammatory pathways in patients with cardiovascular disease to identify novel targets for personalised interventions

 

5th September

Professor Jared Rutter (HHMI, University of Utah School of Medicine)

Metabolism, cellular decisions and the language that unites them

 

19th September

Ancheng Zheng (QMUL)

NRF3-mediated mitochondrial superoxide promotes cardiomyocyte apoptosis and impairs cardiac functions by suppressing pitx2

 

3rd October

Associate Professor Pieter-Jan Guns (University of Antwerp)

Physical exercise during experimental myocarditis in mice, raising a red flag?

 

17th October

Professor Allan Lawrie (Imperial College London)

Unraveling layers of heterogeneity to reclassify pulmonary hypertension

 

14th November

Heartfelt Stories: why public engagement and involvement matters