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Professor Morris Brown

Morris

Professor of Endocrine Hypertension

Centre: Clinical Pharmacology and Precision Medicine

Email: morris.brown@qmul.ac.uk
Telephone: +44(0) 20 7882 3901

Profile

  • Qualified in Classics and Medicine from Cambridge in 1974.
  • Trained in Clinical Pharmacology at Royal Postgraduate Medical School, Hammersmith, MRC Senior Fellow 1982-1985.
  • Foundation Chair of Clinical Pharmacology, Cambridge, 1985-2016.
  • Director of Wellcome Trust Translational Medicine and Therapeutics training programme, 2008-2016.

Memberships and awards

Fellow of the Academy of Medical Sciences, the American Heart Association, the British Pharmacological Society.

  • 1985 Raymond Horton-Smith Prize (Cambridge MD Prize)
  • 2002 Lilly Prize, British Pharmacological Society
  • 2003 Hospital Doctor of the Year 2003
  • 2005 Walter Somerville Medal, British Cardiac Society
  • 2014 Pickering Lecturer, British Hypertension Society
  • 2016 Royal College of Physicians/Lancet Research Award (for ‘outstanding research contributing to excellent patient care’)

Research

Group members

  • Jackie Salsbury (Clinical trials co-ordinator)
  • Dr Elena Azizan (Royal Society Newton post-doc Fellow)
  • Dr Junhua Zhou (post-doc)
  • Dr Xilin Wu (NIHR Clinical PhD Fellow)
  • Dr Emily Goodchild (BTLC Clinical PhD fellow)
  • Sumedha Garg (visiting BHF PhD student)

Summary 

My research, laboratory and clinical, has sought to discover causes of hypertension, and to optimise its management either by achieving complete cure, e.g. by removal of a hormone-producing adrenal tumour (phaeochromocytoma, Conn's), or by finding the right drug for the right patient. In 1999, I proposed the AB/CD rule, relating choice of treatment to patient's age and plasma renin. As President of the British Hypertension Society 2005-7 I established a research network that won funding from the British Heart Foundation to conduct a series of clinical trials, the 'PATHWAY' programme establishing optimal treatment for different categories of Hypertension. These have been published in Lancet or American journals. My current research is mainly focussed on the adrenal gland, and the small aldosterone-producing adenomas which are a common cause of hypertension – unrecognised in 99% of cases. We discovered a sub-type of these with hallmark somatic mutations, often presenting with resistant hypertension. There diagnosis has been facilitated by development of a PET CT (using 11C-metomidate) that lights up even the tiniest (4-5 mm) nodules, often in patients whose conventional CT of the adrenals was normal. In an NIHR project, we are comparing our PET CT with the invasive test of adrenal vein sampling, for their accuracy in predicting cure of hypertension by adrenalectomy. In a BHF-funded project, we are evaluating a less invasive alternative to surgery, namely ultrasound guided endoscopic radiofrequency ablation of the adenoma.

Publications

  • Watson A, Syme H, Brown M (2024). Somatic GNAQ, CTNNB1, and CACNA1C Mutations in Cat Aldosterone-Secreting Tumors.. nameOfConference


    QMRO: qmroHref
  • Aminuddin A, Brown MJ, Azizan EA (publicationYear). Evaluating the role of aldosterone synthesis on adrenal cell fate. nameOfConference


    QMRO: qmroHref
  • Silins I, Moreno A, Wall A et al. (publicationYear). Radiation dosimetry of para-chloro-2-[18F]fluoroethyl-etomidate: a PET tracer for adrenocortical imaging. nameOfConference


    QMRO: qmroHref
  • Bohoran TA, Parke KS, Graham-Brown MPM et al. (publicationYear). Resource efficient aortic distensibility calculation by end to end spatiotemporal learning of aortic lumen from multicentre multivendor multidisease CMR images. nameOfConference


    QMRO: qmroHref
  • Lagou V, Jiang L, Ulrich A et al. (2023). GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification. nameOfConference


    QMRO: qmroHref
  • Azizan EAB, Drake WM, Brown MJ (2023). Primary aldosteronism: molecular medicine meets public health. nameOfConference


  • Wu X, Azizan EAB, Goodchild E et al. (2023). Somatic mutations of CADM1 in aldosterone-producing adenomas and gap junction-dependent regulation of aldosterone production. nameOfConference


  • Kida Y (2023). Baxdrostat for Treatment-Resistant Hypertension. nameOfConference


  • Wu X, Senanayake R, Goodchild E et al. (2023). [11C]metomidate PET-CT versus adrenal vein sampling for diagnosing surgically curable primary aldosteronism: a prospective, within-patient trial. nameOfConference


  • MacDonald TM, Mackenzie IS, Rogers A et al. (2023). S-28-1: CARDIOVASCULAR OUTCOMES IN ADULTS WITH HYPERTENSION WITH EVENING VERSUS MORNING DOSING OF USUAL ANTIHYPERTENSIVES IN THE UK. THE TIME STUDY. nameOfConference


  • Freeman MW, Halvorsen Y-D, Marshall W et al. (2023). Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension. nameOfConference


    QMRO: qmroHref
  • Mackenzie IS, Rogers A, Poulter NR et al. (2022). Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK (TIME study): a prospective, randomised, open-label, blinded-endpoint clinical trial. nameOfConference


  • Mackenzie IS, Hawkey CJ, Ford I et al. (2022). Allopurinol versus usual care in UK patients with ischaemic heart disease (ALL-HEART): a multicentre, prospective, randomised, open-label, blinded-endpoint trial. nameOfConference


  • Silins I, Sundin A, Lubberink M et al. (2023). First-in-human evaluation of [18F]CETO: a novel tracer for adrenocortical tumours. nameOfConference


    QMRO: qmroHref
  • Collaboration TBPLTT, Rahimi K, Bidel Z et al. (2021). Age-stratified and blood-pressure-stratified effects of blood-pressure-lowering pharmacotherapy for the prevention of cardiovascular disease and death: an individual participant-level data meta-analysis. nameOfConference


  • Brown MJ, Alazawi W, Kanoni S (2021). Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19. nameOfConference


    QMRO: qmroHref
  • Zhou J, Azizan EAB, Cabrera CP et al. (2021). Somatic mutations of GNA11 and GNAQ in CTNNB1-mutant aldosterone-producing adenomas presenting in puberty, pregnancy or menopause. nameOfConference


  • Sander K, Gendron T, Cybulska KA et al. (2021). Development of [18F]AldoView as the First Highly Selective Aldosterone Synthase PET Tracer for Imaging of Primary Hyperaldosteronism. nameOfConference


    QMRO: qmroHref
  • Kulkarni S, Dominiczak AF, Touyz RM et al. (2021). CONNed in Pregnancy. nameOfConference


    QMRO: qmroHref
  • Rahimi K, Bidel Z, Nazarzadeh M et al. (2021). Pharmacological blood pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data meta-analysis. nameOfConference


  • Copland E (2021). Antihypertensive treatment and risk of cancer: an individual participant data meta-analysis. nameOfConference


  • Azizan E, Brown M (2020). ACE2 role in SARS-CoV-2 infectivity and Covid-19 severity.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Guthrie G, Poulter N, Macdonald T et al. (2020). Chronotherapy in hypertension: the devil is in the details. nameOfConference


    QMRO: qmroHref
  • Causon RC, Murphy MB, Brown MJ (1982). Effect of hemolysis on radioenzymic assay of plasma catecholamines.. nameOfConference


    QMRO: qmroHref
  • Maniero C, Scudieri P, Shaikh LH et al. (2019). ANO4 (Anoctamin 4) Is a Novel Marker of Zona Glomerulosa That Regulates Stimulated Aldosterone Secretion. nameOfConference


    QMRO: qmroHref
  • Bentley AR, Sung YJ, Brown MR et al. (2019). Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. nameOfConference


  • Yehya A, Rajagopal V, Meduri C et al. (2019). Short-term results with transcatheter aortic valve replacement for treatment of left ventricular assist device patients with symptomatic aortic insufficiency. nameOfConference


    QMRO: qmroHref
  • O'Toole SM, Brown MJ, Drake WM (2019). Established endocrine practice. nameOfConference


    QMRO: qmroHref
  • Pinggera A, Negro G, Tuluc P et al. (2018). Gating defects of disease-causing de novo mutations in Cav1.3 Ca2+ channels. nameOfConference


    QMRO: qmroHref
  • Williams B, Brown MJ (2018). Investigation of primary aldosteronism in patients with resistant hypertension – Authors' reply. nameOfConference


    QMRO: qmroHref
  • Feitosa MF, Kraja AT, Chasman DI et al. (2018). Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.. nameOfConference


  • Williams B, MacDonald TM, Morant SV et al. (2018). Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies.. nameOfConference


  • BROWN MJ (2018). Investigation of the endocrine and haemodynamic changes in resistant hypertension, and its response to spironolactone or amiloride: the PATHWAY-2 mechanisms study. nameOfConference


  • MacDonald TM, Williams B, Webb DJ et al. (2017). Combination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double-Blind Randomized Controlled Trial.. nameOfConference


  • Liu DJ, Peloso GM, Yu H et al. (2017). Exome-wide association study of plasma lipids in >300,000 individuals. nameOfConference


  • Selvarajah V, Mäki-Petäjä KM, Pedro L et al. (2017). Novel Mechanism for Buffering Dietary Salt in Humans. nameOfConference


    QMRO: qmroHref
  • Wain LV, Vaez A, Jansen R et al. (2017). Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney. nameOfConference


  • Brown MJ (2017). Rapid Diagnosis of Primary Aldosteronism. nameOfConference


    QMRO: qmroHref
  • Tan GC, Negro G, Pinggera A et al. (2017). Aldosterone-Producing Adenomas. nameOfConference


    QMRO: qmroHref
  • Maniero C, Garg S, Zhao W et al. (2017). NEFM (Neurofilament Medium) Polypeptide, a Marker for Zona Glomerulosa Cells in Human Adrenal, Inhibits D1R (Dopamine D1 Receptor)–Mediated Secretion of Aldosterone. nameOfConference


    QMRO: qmroHref
  • Williams TA, Lenders JWM, Mulatero P et al. (2017). Outcomes after adrenalectomy for unilateral primary aldosteronism: an international consensus on outcome measures and analysis of remission rates in an international cohort. nameOfConference


    QMRO: qmroHref
  • Teo AED, Garg S, Johnson TI et al. (2017). Physiological and Pathological Roles in Human Adrenal of the Glomeruli-Defining Matrix Protein NPNT (Nephronectin).. nameOfConference


  • Ouyang J, Hardy R, Brown M et al. (2017). 11C-metomidate PET-CT scanning can identify aldosterone-producing adenomas after unsuccessful lateralisation with CT/MRI and adrenal venous sampling. nameOfConference


    QMRO: qmroHref
  • Warren HR, Evangelou E, Cabrera CP et al. (2017). Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.. nameOfConference


  • Brown MJ, Drake WM (2016). Primary aldosteronism as a public health issue – Authors' reply. nameOfConference


    QMRO: qmroHref
  • Bogman K, Schwab D, Delporte M-L et al. (2017). Preclinical and Early Clinical Profile of a Highly Selective and Potent Oral Inhibitor of Aldosterone Synthase (CYP11B2). nameOfConference


    QMRO: qmroHref
  • Zhou J, Lam B, Neogi SG et al. (2016). Transcriptome Pathway Analysis of Pathological and Physiological Aldosterone-Producing Human Tissues. nameOfConference


  • MUNROE PB (publicationYear). The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. nameOfConference


  • Brown MJ, Drake WM (2016). Splitting atoms: the Endocrine Society guideline for the management of primary aldosteronism. nameOfConference


    QMRO: qmroHref
  • Teo AED, Garg S, Shaikh LH et al. (2016). Effect of somatic CTNNB1 mutations on adrenocortical cell de-differentiation in adenoma presenting in early pregnancy or menopause. nameOfConference


    QMRO: qmroHref
  • Azizan EAB, Brown MJ (2016). Novel genetic determinants of adrenal aldosterone regulation. nameOfConference


    QMRO: qmroHref
  • Petruzzelli M, Taylor KP, Koo B et al. (2016). Telling Tails. nameOfConference


  • Xie CB, Haris Shaikh L, Garg S et al. (publicationYear). Regulation of aldosterone secretion by Cav1.3. nameOfConference


  • Murtha TD, Carling T, Scholl UI (2016). Pregnancy, Primary Aldosteronism, and Somatic CTNNB1 Mutations.. nameOfConference


    QMRO: qmroHref
  • Williams B, MacDonald TM, Morant SV et al. (2016). PATHWAY-2: spironolactone for resistant hypertension – Authors' reply. nameOfConference


    QMRO: qmroHref
  • Rorie DA, Rogers A, Mackenzie IS et al. (2016). Methods of a large prospective, randomised, open-label, blinded end-point study comparing morning versus evening dosing in hypertensive patients: the Treatment In Morning versus Evening (TIME) study. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Williams B, Morant SV et al. (2016). Effect of amiloride, or amiloride plus hydrochlorothiazide, versus hydrochlorothiazide on glucose tolerance and blood pressure (PATHWAY-3): a parallel-group, double-blind randomised phase 4 trial. nameOfConference


  • Teo AED, Garg S, Shaikh LH et al. (2015). Pregnancy, Primary Aldosteronism, and Adrenal CTNNB1 Mutations. nameOfConference


    QMRO: qmroHref
  • Williams B, MacDonald TM, Morant S et al. (2015). Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial. nameOfConference


  • Brown MJ, Williams B, MacDonald TM et al. (2015). Comparison of single and combination diuretics on glucose tolerance (PATHWAY-3): protocol for a randomised double-blind trial in patients with essential hypertension. nameOfConference


  • MacDonald TM, Williams B, Caulfield M et al. (2015). Monotherapy versus dual therapy for the initial treatment of hypertension (PATHWAY-1): a randomised double-blind controlled trial. nameOfConference


    QMRO: qmroHref
  • Williams B, MacDonald TM, Caulfield M et al. (2015). Prevention And Treatment of Hypertension With Algorithm-based therapy (PATHWAY) number 2: protocol for a randomised crossover trial to determine optimal treatment for drug-resistant hypertension. nameOfConference


    QMRO: qmroHref
  • Powlson AS, Gurnell M, Brown MJ (2015). Nuclear imaging in the diagnosis of primary aldosteronism. nameOfConference


    QMRO: qmroHref
  • Brown MJ (2015). Primary Aldosteronism: the spectre of cure. nameOfConference


    QMRO: qmroHref
  • Shaikh LH, Zhou J, Teo AED et al. (2015). LGR5 Activates Noncanonical Wnt Signaling and Inhibits Aldosterone Production in the Human Adrenal. nameOfConference


    QMRO: qmroHref
  • Zhou J, Shaikh LH, Neogi SG et al. (2015). DACH1, a Zona Glomerulosa Selective Gene in the Human Adrenal, Activates Transforming Growth Factor-&bgr; Signaling and Suppresses Aldosterone Secretion. nameOfConference


    QMRO: qmroHref
  • Jennings CG, MacDonald TM, Wei L et al. (2015). Does offering an incentive payment improve recruitment to clinical trials and increase the proportion of socially deprived and elderly participants?. nameOfConference


    QMRO: qmroHref
  • Ying A, Arima H, Czernichow S et al. (2015). Effects of blood pressure lowering on cardiovascular risk according to baseline body-mass index: a meta-analysis of randomised trials. nameOfConference


    QMRO: qmroHref
  • Brown MJ (2014). Clinical Value of Plasma Renin Estimation in the Management of Hypertension. nameOfConference


    QMRO: qmroHref
  • Collaboration TBPLTT (2014). Blood pressure-lowering treatment based on cardiovascular risk: a meta-analysis of individual patient data. nameOfConference


    QMRO: qmroHref
  • Ganesh SK, Chasman DI, Larson MG et al. (2014). Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations. nameOfConference


    QMRO: qmroHref
  • Arking DE, Pulit SL, Crotti L et al. (2014). Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. nameOfConference


  • Brown MJ (2014). Resistant hypertension: resistance to treatment or resistance to taking treatment?. nameOfConference


    QMRO: qmroHref
  • Auchus RJ, Brown M, Lenders JWM et al. (2014). Response to Implementation of Rapid Cortisol During Adrenal Vein Sampling. nameOfConference


    QMRO: qmroHref
  • Tragante V, Barnes MR, Ganesh SK et al. (2014). Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci. nameOfConference


  • Murthy M, Azizan EAB, Brown MJ et al. (2014). Erratum: Characterization of a novel somatic KCNJ5 mutation delI157 in an aldosterone-production adenoma (J Hypertens (2012) 30 (1827-1833)). nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Rossi GP, Auchus RJ, Brown M et al. (2014). An Expert Consensus Statement on Use of Adrenal Vein Sampling for the Subtyping of Primary Aldosteronism. nameOfConference


    QMRO: qmroHref
  • Brown MJ (2014). Ins and Outs of Aldosterone-Producing Adenomas of the Adrenal. nameOfConference


    QMRO: qmroHref
  • O'Seaghdha CM, Wu H, Yang Q et al. (2013). Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium Concentrations. nameOfConference


    QMRO: qmroHref
  • Azizan EAB, Poulsen H, Tuluc P et al. (2013). Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension. nameOfConference


    QMRO: qmroHref
  • van Meurs JBJ, Pare G, Schwartz SM et al. (2013). Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease 1 , 2 , 3 , 4 , 5. nameOfConference


    QMRO: qmroHref
  • Huertas-Vazquez A, Nelson CP, Guo X et al. (2013). Novel Loci Associated with Increased Risk of Sudden Cardiac Death in the Context of Coronary Artery Disease. nameOfConference


    QMRO: qmroHref
  • Bramham K, Nelson-Piercy C, Brown MJ et al. (2013). Postpartum management of hypertension. nameOfConference


    QMRO: qmroHref
  • Köttgen A, Albrecht E, Teumer A et al. (2013). Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. nameOfConference


    QMRO: qmroHref
  • Shaw KC, McEniery CM, Wilkinson IB et al. (2013). Unsafe health and safety: sphygmomanometer cuffs are not interchangeable. nameOfConference


    QMRO: qmroHref
  • Alvarez-Madrazo S, MacKenzie SM, Davies E et al. (2013). Common Polymorphisms in the CYP11B1 and CYP11B2 Genes. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Haydock S (2000). Pathoaetiology, Epidemiology and Diagnosis of Hypertension. nameOfConference


    QMRO: qmroHref
  • Brown MJ (2008). Therapeutic Potential of Vaccines in the Management of Hypertension. nameOfConference


    QMRO: qmroHref
  • Murthy M, Azizan EAB, Brown MJ et al. (2012). Characterization of a novel somatic KCNJ5 mutation delI157 in an aldosterone-producing adenoma. nameOfConference


    QMRO: qmroHref
  • Cooper JD, Simmonds MJ, Walker NM et al. (2012). Seven newly identified loci for autoimmune thyroid disease. nameOfConference


    QMRO: qmroHref
  • Brown M (2012). Classification and naming of drugs. nameOfConference


    QMRO: qmroHref
  • Bennett PN, Brown MJ, Sharma P (2012). Clinical Pharmacology: Eleventh Edition. nameOfConference

    DOI: doi

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  • Bennett PN, Brown MJ, Sharma P (2012). Preface. nameOfConference


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  • Perucca E, Richens A (1980). Water intoxication produced by carbamazepine and its reversal by phenytoin [proceedings]. nameOfConference


    QMRO: qmroHref
  • Kaumann AJ, Sanders L, Brown AM et al. (1990). A 5‐hydroxytryptamine receptor in human atrium. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Harland D (1986). B‐HT 958 lowers blood pressure and heart rate in the rat through stimulation of dopamine receptors. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Harland D (1984). Evidence for a peripheral component in the sympatholytic effect of clonidine in rats. nameOfConference


    QMRO: qmroHref
  • Barnes PJ, Brown MJ, Dollery CT et al. (1986). Histamine is released from skin by substance P but does not act as the final vasodilator in the axon reflex. nameOfConference


    QMRO: qmroHref
  • Price JS, Kenny AJ, Huskisson NS et al. (1991). Neuropeptide Y (NPY) metabolism by endopeptidase‐2 hinders characterization of NPY receptors in rat kidney. nameOfConference


    QMRO: qmroHref
  • Ferro A, Kaumann AJ, Brown MJ (1993). β1‐ and β2‐adrenoceptor‐mediated relaxation in human internal mammary artery and saphenous vein: unchanged β‐ and α‐adrenoceptor responsiveness after chronic β1‐adrenoceptor blockade. nameOfConference


    QMRO: qmroHref
  • Okada Y, Sim X, Go MJ et al. (2012). Meta-analysis identifies multiple loci associated with kidney function–related traits in east Asian populations. nameOfConference


    QMRO: qmroHref
  • Lanktree MB, Guo Y, Murtaza M et al. (2012). Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. nameOfConference


    QMRO: qmroHref
  • Stears AJ, Woods SH, Watts MM et al. (2012). A Double-Blind, Placebo-Controlled, Crossover Trial Comparing the Effects of Amiloride and Hydrochlorothiazide on Glucose Tolerance in Patients With Essential Hypertension. nameOfConference


    QMRO: qmroHref
  • Azizan EAB, Lam BYH, Newhouse SJ et al. (2012). Microarray, qPCR, and KCNJ5 Sequencing of Aldosterone-Producing Adenomas Reveal Differences in Genotype and Phenotype between Zona Glomerulosa- and Zona Fasciculata-Like Tumors. nameOfConference


    QMRO: qmroHref
  • Brown MJ (2012). Author’s reply to Rogers. nameOfConference


    QMRO: qmroHref
  • Azizan EAB, Murthy M, Stowasser M et al. (2012). Somatic Mutations Affecting the Selectivity Filter of KCNJ5 Are Frequent in 2 Large Unselected Collections of Adrenal Aldosteronomas. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Cruickshank JK, MacDonald TM (2012). Navigating the shoals in hypertension: discovery and guidance. nameOfConference


    QMRO: qmroHref
  • Burton TJ, Mackenzie IS, Balan K et al. (2012). Evaluation of the Sensitivity and Specificity of 11C-Metomidate Positron Emission Tomography (PET)-CT for Lateralizing Aldosterone Secretion by Conn's Adenomas. nameOfConference


    QMRO: qmroHref
  • Johnson T, Gaunt TR, Newhouse SJ et al. (2011). Blood Pressure Loci Identified with a Gene-Centric Array. nameOfConference


    QMRO: qmroHref
  • Chambers JC, Zhang W, Sehmi J et al. (2011). Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. nameOfConference


    QMRO: qmroHref
  • (2011). Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. nameOfConference


  • Brown MJ (2011). The choice of diuretic in hypertension: saving the baby from the bathwater. nameOfConference


    QMRO: qmroHref
  • Burton TJ, Salsbury J, Hood S et al. (2011). Conn's syndrome unmasked by thiazide-induced hypokalaemia. nameOfConference


    QMRO: qmroHref
  • Brown MJ (2011). Personalised medicine for hypertension. nameOfConference


    QMRO: qmroHref
  • Brown MJ, McInnes GI, MacDonald TM et al. (2011). Initial combination therapy for treatment of hypertension – Authors' reply. nameOfConference


    QMRO: qmroHref
  • Schunkert H, König IR, Kathiresan S et al. (2011). Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. nameOfConference


    QMRO: qmroHref
  • Wensley F, Gao P, Burgess S et al. (2011). Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data. nameOfConference


    QMRO: qmroHref
  • Burton TJ, Azizan EAB, Brown MJ (2011). Investigating the function of an aldosterone response pathway in primary human adrenocortical cells obtained from Conn's and phaeochromocytoma patients. nameOfConference


    QMRO: qmroHref
  • Brown MJ, McInnes GT, Papst CC et al. (2011). Aliskiren and the calcium channel blocker amlodipine combination as an initial treatment strategy for hypertension control (ACCELERATE): a randomised, parallel-group trial. nameOfConference


    QMRO: qmroHref
  • Lanktree MB, Guo Y, Murtaza M et al. (2011). Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. nameOfConference


    QMRO: qmroHref
  • Padmanabhan S, Melander O, Johnson T et al. (publicationYear). Genome-Wide Association Study of Blood Pressure Extremes Identifies Variant near UMOD Associated with Hypertension. nameOfConference


  • Speliotes EK, Willer CJ, Berndt SI et al. (2010). Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. nameOfConference


    QMRO: qmroHref
  • Brown MJ (2010). Heterogeneity of Blood Pressure Response to Therapy. nameOfConference


    QMRO: qmroHref
  • Brown M (2010). Biological clocks advance. nameOfConference

    DOI: doi

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  • Vergeer M, Boekholdt SM, Sandhu MS et al. (2010). Genetic Variation at the Phospholipid Transfer Protein Locus Affects Its Activity and High-Density Lipoprotein Size and Is a Novel Marker of Cardiovascular Disease Susceptibility. nameOfConference


    QMRO: qmroHref
  • Burgess S, Thompson SG, Burgess S et al. (2010). Bayesian methods for meta‐analysis of causal relationships estimated using genetic instrumental variables. nameOfConference


    QMRO: qmroHref
  • Chambers JC, Zhang W, Lord GM et al. (2010). Genetic loci influencing kidney function and chronic kidney disease. nameOfConference


    QMRO: qmroHref
  • Cheriyan J, O'Shaughnessy KM, Brown MJ (publicationYear). Primary prevention of CVD: treating hypertension.. nameOfConference

    DOI: doi

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  • Brown MJ (2009). Impact of EU directive 2001/20/EC on investigator-led clinical trials in the UK. nameOfConference

    DOI: doi

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  • Brown MJ, Grossman AB, Bornstein SR (2009). Pheochromocytoma. nameOfConference


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  • Brown M (2009). Circles of Hell: researchers' nightmare or laps of the regulatory pentathlon?. nameOfConference


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  • Burton TJ, Cope G, Wang J et al. (2009). Corrigendum to: “Expression of the epithelial Na+ channel and other components of an aldosterone response pathway in human adrenocortical cells” [European Journal of Pharmacology 613 (2009) 176–181]. nameOfConference


    QMRO: qmroHref
  • Brown MJ (2009). Success and failure of vaccines against renin–angiotensin system components. nameOfConference


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  • Nolte IM, Wallace C, Newhouse SJ et al. (publicationYear). Common Genetic Variation Near the Phospholamban Gene Is Associated with Cardiac Repolarisation: Meta-Analysis of Three Genome-Wide Association Studies. nameOfConference


    QMRO: qmroHref
  • Mancia G, Ruilope L, Palmer C et al. (2004). Effects of nifedipine GITS and diuretics in isolated systolic hypertension - a subanalysis of the INSIGHT study. nameOfConference


    QMRO: qmroHref
  • Sõber S, Org E, Kepp K et al. (publicationYear). Targeting 160 Candidate Genes for Blood Pressure Regulation with a Genome-Wide Genotyping Array. nameOfConference


  • Kolz M, Johnson T, Sanna S et al. (2009). Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations. nameOfConference


  • Mackenzie IS, McEniery CM, Dhakam Z et al. (2009). Comparison of the Effects of Antihypertensive Agents on Central Blood Pressure and Arterial Stiffness in Isolated Systolic Hypertension. nameOfConference


    QMRO: qmroHref
  • Newton-Cheh C, Johnson T, Gateva V et al. (2009). Genome-wide association study identifies eight loci associated with blood pressure. nameOfConference


    QMRO: qmroHref
  • Brown MJ (2009). The impact of clinical trials legislation on clinical pharmacology: problems and solutions. nameOfConference


    QMRO: qmroHref
  • Burton TJ, Cope G, Wang J et al. (2009). Expression of the epithelial Na+ channel and other components of an aldosterone response pathway in human adrenocortical cells. nameOfConference


    QMRO: qmroHref
  • Newhouse S, Farrall M, Wallace C et al. (2009). Polymorphisms in the WNK1 Gene Are Associated with Blood Pressure Variation and Urinary Potassium Excretion. nameOfConference


  • Brown MJ (1988). Adrenaline and Alpha2‐Adrenoceptors in Hypertension. nameOfConference


    QMRO: qmroHref
  • Org E, Eyheramendy S, Juhanson P et al. (2009). Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations. nameOfConference


    QMRO: qmroHref
  • Group HPSC (2009). Statin Cost-Effectiveness in the United States for People at Different Vascular Risk Levels. nameOfConference


    QMRO: qmroHref
  • Stark JCC, Haydock SF, Foo R et al. (2004). Effect of overexpressed adenylyl cyclase VI on β1‐ and β2‐adrenoceptor responses in adult rat ventricular myocytes. nameOfConference


    QMRO: qmroHref
  • Mackenzie IS, Brown MJ (2009). Molecular and clinical investigations in patients with low-renin hypertension. nameOfConference


    QMRO: qmroHref
  • Sandilands AJ, O'Shaughnessy KM, Brown MJ (2003). Greater inotropic and cyclic AMP responses evoked by noradrenaline through Arg389 β1‐adrenoceptors versus Gly389 β1‐adrenoceptors in isolated human atrial myocardium. nameOfConference


    QMRO: qmroHref
  • Lewis CJ, Gong H, Brown MJ et al. (2004). Overexpression of β1‐adrenoceptors in adult rat ventricular myocytes enhances CGP 12177A cardiostimulation: implications for ‘putative’β4‐adrenoceptor pharmacology. nameOfConference


    QMRO: qmroHref
  • Wang T, Plumpton C, Brown MJ (1999). Selective β1‐adrenoceptor blockade enhances the activity of the stimulatory G‐protein in human atrial myocardium. nameOfConference


    QMRO: qmroHref
  • (2009). Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. nameOfConference


    QMRO: qmroHref
  • Stewart P, Stears A, Tomlinson JW et al. (2008). Regulation - The real threat to clinical research. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Stewart PM, Stears A, Tomlinson JW et al. (2008). Regulation—the real threat to clinical research. nameOfConference


    QMRO: qmroHref
  • Caulfield MJ, Munroe PB, O'Neill D et al. (2008). SLC2A9 Is a High-Capacity Urate Transporter in Humans. nameOfConference


  • Brown MJ (2008). Aliskiren. nameOfConference


    QMRO: qmroHref
  • Delles C, Padmanabhan S, Lee WK et al. (2008). Glutathione S-transferase variants and hypertension. nameOfConference


    QMRO: qmroHref
  • Turnbull F, Woodward M, Neal B et al. (2008). Do men and women respond differently to blood pressure-lowering treatment? Results of prospectively designed overviews of randomized trials. nameOfConference


    QMRO: qmroHref
  • Loos RJF, Lindgren CM, Li S et al. (2008). Common variants near MC4R are associated with fat mass, weight and risk of obesity. nameOfConference


    QMRO: qmroHref
  • Struthers AD, Burrin JM, Brown MJ (1986). Exercise-Induced Increases in Plasma Catecholamines and Growth Hormone Are Augmented by Selective α2-Adrenoceptor Blockade in Man. nameOfConference


    QMRO: qmroHref
  • BROWN MJ (1984). Simultaneous assay of noradrenaline and its deaminated metabolite, dihydroxyphenylglycol, in plasma: a simplified approach to the exclusion of phaeochromocytoma in patients with borderline elevation of plasma noradrenaline concentration. nameOfConference


    QMRO: qmroHref
  • STRUTHERS AD, BROWN DC, BROWN MJ et al. (1985). SELECTIVE α2 RECEPTOR BLOCKADE FACILITATES THE INSULIN RESPONSE TO ADRENALINE BUT NOT TO GLUCOSE IN MAN. nameOfConference


    QMRO: qmroHref
  • Richards JB, Valdes AM, Gardner JP et al. (2008). Homocysteine levels and leukocyte telomere length. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Hood SJ, Ashby MJ et al. (2008). Response to Letter Regarding Article, “The Spironolactone, Amiloride, Losartan, and Thiazide (SALT) Double-Blind Crossover Trial in Patients With Low-Renin Hypertension and Elevated Aldosterone-Renin Ratio”. nameOfConference


    QMRO: qmroHref
  • Brown M (2008). 'Wondrous true, lest I be misTooke'. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Dhakam Z, Yasmin, McEniery CM et al. (2008). A comparison of atenolol and nebivolol in isolated systolic hypertension. nameOfConference


    QMRO: qmroHref
  • Price L, Kassianos G, Brown MJ et al. (2008). Aliskiren - The first of a new class of antihypertensive. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Wallace C, Newhouse SJ, Braund P et al. (2008). Genome-wide Association Study Identifies Genes for Biomarkers of Cardiovascular Disease: Serum Urate and Dyslipidemia. nameOfConference


    QMRO: qmroHref
  • Myint KS, Watts M, Appleton DS et al. (2008). Primary hyperaldosteronism due to adrenal microadenoma: a curable cause of refractory hypertension. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Toal CB (2008). Formulation of long‐acting nifedipine tablets influences the heart rate and sympathetic nervous system response in hypertensive patients. nameOfConference


    QMRO: qmroHref
  • Mir FA, Brown MJ, Appleton DS (2007). Erratum: Lessons in the diagnosis and management of Conn's syndrome (Clinical Medicine, Journal of the Royal College of Physicians of London (2007) 7, (530-532)). nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Mackenzie IS, Brown MJ (2007). Pseudopheochromocytoma. nameOfConference


    QMRO: qmroHref
  • Mir F, Brown M, Appleton D (2007). Lesson of the month. nameOfConference


    QMRO: qmroHref
  • Mackenzie IS, Gurnell M, Balan KK et al. (2007). The use of 18-fluoro-dihydroxyphenylalanine and 18-fluorodeoxyglucose positron emission tomography scanning in the assessment of metaiodobenzylguanidine-negative phaeochromocytoma. nameOfConference


    QMRO: qmroHref
  • Bates PR, Carson MN, Trainer PJ et al. (2008). Wide variation in surgical outcomes for acromegaly in the UK. nameOfConference


    QMRO: qmroHref
  • MUNROE PB, Caulfield MJ, Wallace C et al. (2007). Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension. nameOfConference


    QMRO: qmroHref
  • Freel EM, Ingram M, Friel EC et al. (2007). Phenotypic consequences of variation across the aldosterone synthase and 11‐beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study. nameOfConference


    QMRO: qmroHref
  • Brady AJB, Mackenzie IS, Ritchie S et al. (2007). Grand Rounds at the British Hypertension Society: renal artery stenosis. nameOfConference


    QMRO: qmroHref
  • Hood SJ, Taylor KP, Ashby MJ et al. (2007). The Spironolactone, Amiloride, Losartan, and Thiazide (SALT) Double-Blind Crossover Trial in Patients With Low-Renin Hypertension and Elevated Aldosterone-Renin Ratio. nameOfConference


    QMRO: qmroHref
  • Siva A, De Lange M, Clayton D et al. (2007). The heritability of plasma homocysteine, and the influence of genetic variation in the homocysteine methylation pathway. nameOfConference


    QMRO: qmroHref
  • WALLACE C, Wellcome Trust CCC (2007). Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. nameOfConference


    QMRO: qmroHref
  • Brown MJ (2007). Renin: friend or foe?. nameOfConference


    QMRO: qmroHref
  • Turnbull F, Neal B, Pfeffer M et al. (2007). Blood pressure-dependent and independent effects of agents that inhibit the renin–angiotensin system. nameOfConference


    QMRO: qmroHref
  • Brown M, Boon N, Brooks N et al. (2007). Medical training in the UK: sleepwalking to disaster. nameOfConference


    QMRO: qmroHref
  • Brown MJ (2007). Raging against MTAS [1]. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Brown MJ (2007). Raging against MTAS (UK Medical Training Application Service). nameOfConference


    QMRO: qmroHref
  • Brown M, Boon N, Brooks N et al. (2007). Modernising Medical Careers, Medical Training Application Service, and the Postgraduate Medical Education and Training Board: time for the emperors to don their clothes. nameOfConference


    QMRO: qmroHref
  • Burton T, O'Shaughnessy K, Brown M (2007). The Epithelial Na+ Channel as a Determinant of Blood Pressure. nameOfConference


    QMRO: qmroHref
  • Barr M, MacKenzie SM, Friel EC et al. (2007). Polymorphic Variation in the 11β-Hydroxylase Gene Associates With Reduced 11-Hydroxylase Efficiency. nameOfConference


    QMRO: qmroHref
  • BROWN MJ, MACKENZIE IS, ASHBY MJ et al. (2006). AT2 Receptor Stimulation May Halt Progression of Pheochromocytoma. nameOfConference


    QMRO: qmroHref
  • Foo RSY, Siow RCM, Brown MJ et al. (2006). Heme oxygenase‐1 gene transfer inhibits angiotensin II‐mediated rat cardiac myocyte apoptosis but not hypertrophy. nameOfConference


    QMRO: qmroHref
  • Munroe PB, CAULFIELD MJ, Newhouse SJ et al. (2006). Increased support for linkage of a novel locus on chromosome 5q13 for essential hypertension in the British Genetics of Hypertension Study. nameOfConference


    QMRO: qmroHref
  • Munroe PB, CAULFIELD MJ, Wallace C et al. (2006). Linkage Analysis Using Co-Phenotypes in the BRIGHT Study Reveals Novel Potential Susceptibility Loci for Hypertension. nameOfConference


    QMRO: qmroHref
  • Brown MJ (2006). Direct renin inhibition — a new way of targeting the renin system. nameOfConference


    QMRO: qmroHref
  • IND PW, BARNES PJ, BROWN MJ et al. (1983). Measurement of plasma histamine in asthma. nameOfConference


    QMRO: qmroHref
  • RAMPTON DS, BROWN MJ, CAUSON R et al. (1982). The effect of disodium cromoglycate on rectal mucosal histamine release, eosinophil exudation and disease activity in active ulcerative colitis. nameOfConference


    QMRO: qmroHref
  • Brown MJ (2006). Hypertension and ethnic group. nameOfConference


    QMRO: qmroHref
  • Mackenzie IS, Ashby MJ, Donovan T et al. (2006). Bilateral adrenal masses: phaeochromocytoma or melanoma?. nameOfConference


    QMRO: qmroHref
  • Padmanabhan S, Wallace C, Munroe PB et al. (2006). Chromosome 2p shows significant linkage to antihypertensive response in the British Genetics of Hypertension Study.. nameOfConference


    QMRO: qmroHref
  • Munroe PB, CAULFIELD MJ, Wallace C et al. (2006). Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension. nameOfConference


    QMRO: qmroHref
  • Dhakam Z, McEniery CM, Yasmin et al. (2006). Atenolol and Eprosartan: Differential Effects on Central Blood Pressure and Aortic Pulse Wave Velocity. nameOfConference


    QMRO: qmroHref
  • Sharma P, Middelberg RP, Andrew T et al. (2006). Heritability of left ventricular mass in a large cohort of twins. nameOfConference


    QMRO: qmroHref
  • Sandilands AJ, Parameshwar J, Large S et al. (2005). Confirmation of a role for the 389R>G β-1 adrenoceptor polymorphism on exercise capacity in heart failure. nameOfConference


    QMRO: qmroHref
  • Mackenzie IS, Maki-Petaja KM, McEniery CM et al. (2005). Aldehyde Dehydrogenase 2 Plays a Role in the Bioactivation of Nitroglycerin in Humans. nameOfConference


    QMRO: qmroHref
  • MUNROE PB, Caulfield M, Dobson R et al. (2005). Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study. nameOfConference


    QMRO: qmroHref
  • McEniery CM, Yasmin, Wallace S et al. (2005). Increased Stroke Volume and Aortic Stiffness Contribute to Isolated Systolic Hypertension in Young Adults. nameOfConference


    QMRO: qmroHref
  • Neal DAJ, Brown MJ, Wilkinson IB et al. (2005). Mechanisms of Hypertension After Liver Transplantation. nameOfConference


    QMRO: qmroHref
  • Standridge JB, Sealey JE, Laragh JH et al. (2005). A free-ranging roundtable discussion on hypertension. nameOfConference


    QMRO: qmroHref
  • Hood S, Cannon J, Foo R et al. (2005). Prevalence of primary hyperaldosteronism assessed by aldosterone/renin ratio and spironolactone testing. nameOfConference


    QMRO: qmroHref
  • de Leeuw PW, Ruilope LM, Palmer CR et al. (2004). Clinical Significance of Renal Function in Hypertensive Patients at High Risk: Results From the INSIGHT Trial. nameOfConference


    QMRO: qmroHref
  • Healy D, Paykel ES, White W et al. (1992). Plasma noradrenaline, adrenaline and DHPG responses to clonidine in control and depressed subjects. nameOfConference


    QMRO: qmroHref
  • Wang T, Brown MJ (2004). Differential expression of adenylyl cyclase subtypes in human cardiovascular system. nameOfConference


    QMRO: qmroHref
  • BROWN MJ, COLTART J, GUNEWARDENA K et al. (2004). Randomized double-blind placebo-controlled study of an angiotensin immunotherapeutic vaccine (PMD3117) in hypertensive subjects. nameOfConference


    QMRO: qmroHref
  • Sandilands A, Yeo G, Brown MJ et al. (2004). Functional responses of human β1 adrenoceptors with defined haplotypes for the common 389R>G and 49S>G polymorphisms. nameOfConference


    QMRO: qmroHref
  • Halliday A, Mansfield A, Marro J et al. (2004). Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: randomised controlled trial. nameOfConference


    QMRO: qmroHref
  • Yasmin, Falzone R, Brown MJ (2004). Determinants of arterial stiffness in offspring of families with essential hypertension*. nameOfConference


    QMRO: qmroHref
  • Williams B, Poulter NR, Brown MJ et al. (2004). British Hypertension Society guidelines for hypertension management 2004 (BHS-IV): summary. nameOfConference


    QMRO: qmroHref
  • Neal DAJ, Brown MJ, Wilkinson IB et al. (2004). Hemodynamic effects of amlodipine, bisoprolol, and lisinopril in hypertensive patients after liver transplantation1. nameOfConference


    QMRO: qmroHref
  • Williams B, Poulter NR, Brown MJ et al. (2004). Guidelines for management of hypertension: report of the fourth working party of the British Hypertension Society, 2004—BHS IV. nameOfConference


    QMRO: qmroHref
  • Turnbull F (2003). Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials. nameOfConference


    QMRO: qmroHref
  • HARACH HR, WHEATLEY T, SMELLIE WAB et al. (1996). Phaeochromocytoma of the organ of Zuckerkandl invading inferior vena cava. nameOfConference


    QMRO: qmroHref
  • WANG T, KAUMANN AJ, BROWN MJ (1996). (−)‐Timolol is a more potent antagonist of the positive inotropic effects of (−)‐adrenaline than of those of (−)‐noradrenaline in human atrium. nameOfConference


    QMRO: qmroHref
  • BROWN MJ (1996). The causes of essential hypertension. nameOfConference


    QMRO: qmroHref
  • Brown MJ (2003). Review: Implications from hypertension outcome trials for the management of patients with hypertension and diabetes. nameOfConference


    QMRO: qmroHref
  • Brown MJ (2003). A RATIONAL BASIS FOR SELECTION AMONG DRUGS OF THE SAME CLASS. nameOfConference


    QMRO: qmroHref
  • Connell J, Munroe P, CAULFIELD MJ et al. (2003). Genome-wide mapping of human loci for essential hypertension. nameOfConference


    QMRO: qmroHref
  • Palmer CR, Brown MJ, Mancia G et al. (2003). Long-term Cardiovascular Consequences of Diuretics vs Calcium Channel Blockers vs Angiotensin-Converting Enzyme Inhibitors. nameOfConference


    QMRO: qmroHref
  • Mancia G, Brown M, Castaigne A et al. (2003). Outcomes With Nifedipine GITS or Co-Amilozide in Hypertensive Diabetics and Nondiabetics in Intervention as a Goal in Hypertension (INSIGHT). nameOfConference


    QMRO: qmroHref
  • Brown MJ, Cruickshank JK, Dominiczak AF et al. (2003). Better blood pressure control: how to combine drugs. nameOfConference


    QMRO: qmroHref
  • Robins SJ, Despres J-P (2002). MRC/BHF Heart Protection Study. nameOfConference


    QMRO: qmroHref
  • DEARY AJ, SCHUMANN AL, MURFET H et al. (2002). Influence of drugs and gender on the arterial pulse wave and natriuretic peptide secretion in untreated patients with essential hypertension. nameOfConference


    QMRO: qmroHref
  • Mackenzie IS, Brown MJ (2002). Genetic profiling versus drug rotation in the optimisation of antihypertensive treatment. nameOfConference


    QMRO: qmroHref
  • Sadhra S, Jackson CA, Ryder T et al. (2002). Noise Exposure and Hearing Loss among Student Employees Working in University Entertainment Venues. nameOfConference


    QMRO: qmroHref
  • Mancia G, Ruilope LM, Brown MJ et al. (2002). The effect of nifedipine GITS on outcomes in patients with previous myocardial infarction: A subgroup analysis of the INSIGHT study. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Poole-Wilson PA, Lubsen J (2002). Losartan for cardiovascular disease in patients with and without diabetes in the LIFE study. nameOfConference


    QMRO: qmroHref
  • Deary AJ, Schumann AL, Murfet H et al. (2002). Double-blind, placebo-controlled crossover comparison of five classes of antihypertensive drugs. nameOfConference


    QMRO: qmroHref
  • Brown M (2001). Calcium channel blocker versus diuretics for high-risk hypertension. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Foo R, O'Shaughnessy KM, Brown MJ (2001). Hyperaldosteronism: recent concepts, diagnosis, and management. nameOfConference


    QMRO: qmroHref
  • Tao W, BROWN MJ (2001). Influence of β1-adrenoceptor blockade on the gene expression of adenylate cyclase subtypes and β-adrenoceptor kinase in human atrium. nameOfConference


    QMRO: qmroHref
  • Sharma P, Wang T, Brown MJ et al. (2001). Fits and strokes. nameOfConference


    QMRO: qmroHref
  • Brown MJ (2001). Matching the right drug to the right patient in essential hypertension. nameOfConference


    QMRO: qmroHref
  • Lowe MD, Rowland E, Brown MJ et al. (2001). β2 Adrenergic receptors mediate important electrophysiological effects in human ventricular myocardium. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Palmer CR, Castaigne A et al. (2001). Principal results from the international nifedipine GITS study: Intervention as a goal in hypertension treatment (INSIGHT). nameOfConference


    QMRO: qmroHref
  • Brown MJ (2001). Blood-pressure-lowering treatment. nameOfConference


    QMRO: qmroHref
  • Sharma P, Brown MJ (2001). Neurovascular lessons from a pair of identical twins with cerebral aneurysms. nameOfConference


    QMRO: qmroHref
  • Kloner RA, Brown M, Prisant LM et al. (2001). Effect of sildenafil in patients with erectile dysfunction taking antihypertensive therapy. nameOfConference


    QMRO: qmroHref
  • Mulrow CD (2001). Long acting nifedipine was as effective as hydrochlorothiazide plus amiloride for reducing mortality and morbidity in hypertension. nameOfConference


    QMRO: qmroHref
  • Zusman RM, Prisant LM, Brown MJ (2000). Effect of sildenafil citrate on blood pressure and heart rate in men with erectile dysfunction taking concomitant antihypertensive medication. nameOfConference


    QMRO: qmroHref
  • Neal B, MacMahon S, Chapman N (2000). Effects of ACE inhibitors, calcium antagonists, and other blood-pressure-lowering drugs: results of prospectively designed overviews of randomised trials. nameOfConference


    QMRO: qmroHref
  • García-López FJ, de Álvaro F (2000). INSIGHT and NORDIL. nameOfConference


    QMRO: qmroHref
  • Wang T, Sharma SD, Fox N et al. (2000). Description of a simple test for CADASIL disease and determination of mutation frequencies in sporadic ischaemic stroke and dementia patients. nameOfConference


    QMRO: qmroHref
  • O'SHAUGHNESSY KM, FU B, DICKERSON C et al. (2000). The gain-of-function G389R variant of the β1-adrenoceptor does not influence blood pressure or heart rate response to β-blockade in hypertensive subjects. nameOfConference


    QMRO: qmroHref
  • Brown MJ (2000). Error: Morbidity and mortality in patients randomised to double-blind treatment with long-acting calcium-channel blocker or diuretic in the International Nifedipine GITS Study: Intervention as a Goal in Hypertension Treatment (INSIGHT) (The Lancet (July 29) (366)). nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Brown MJ, Palmer CR, Castaigne A et al. (2000). Morbidity and mortality in patients randomised to double-blind treatment with a long-acting calcium-channel blocker or diuretic in the International Nifedipine GITS study: Intervention as a Goal in Hypertension Treatment (INSIGHT). nameOfConference


    QMRO: qmroHref
  • Sharma P, Fatibene J, Ferraro F et al. (2000). A Genome-Wide Search For Susceptibility Loci to Human Essential Hypertension. nameOfConference


    QMRO: qmroHref
  • Jia H, Sharma P, Hopper R et al. (2000). β2-Adrenoceptor gene polymorphisms and blood pressure variations in East Anglian Caucasians. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Castaigne A, de Leeuw PW et al. (2000). Influence of Diabetes and Type of Hypertension on Response to Antihypertensive Treatment. nameOfConference


    QMRO: qmroHref
  • Lowe MD, Rowland E, Brown MJ et al. (2000). β2-Adrenergic receptors mediate important electrophysiological effects in human ventricular myocardium. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Wang JG, Gasowski J, Fagard R et al. (2000). What does STOP-2 tell us about management of hypertension?. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Sharma P, Stevens PA (2000). Association Between Diastolic Blood Pressure and Variants of the Endothelin-1 and Endothelin-2 Genes. nameOfConference


    QMRO: qmroHref
  • Hingorani AD, Liang CF, Fatibene J et al. (1999). A Common Variant of the Endothelial Nitric Oxide Synthase (Glu298→Asp) Is a Major Risk Factor for Coronary Artery Disease in the UK. nameOfConference


    QMRO: qmroHref
  • Yasmin, Brown MJ (1999). Similarities and differences between augmentation index and pulse wave velocity in the assessment of arterial stiffness. nameOfConference


    QMRO: qmroHref
  • Hockly E, Brown MJ (1999). Homocysteine, vitamins and sex. nameOfConference


    QMRO: qmroHref
  • Sharma P, Hingorani A, Jia H et al. (1999). Quantitative association between a newly identified molecular variant in the endothelin-2 gene and human essential hypertension. nameOfConference


    QMRO: qmroHref
  • Brown M (1999). Do vitamin E and fish oil protect against ischaemic heart disease?. nameOfConference


    QMRO: qmroHref
  • Jia H, Hingorani AD, Sharma P et al. (1999). Association of the Gsα Gene With Essential Hypertension and Response to β-Blockade. nameOfConference


    QMRO: qmroHref
  • Dickerson JC, Hingorani AD, Ashby MJ et al. (1999). Optimisation of antihypertensive treatment by crossover rotation of four major classes. nameOfConference


    QMRO: qmroHref
  • Brown J, Brown M (1999). CAPPP trial. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Hopper RV (1999). Calcium-channel blockade can mask the diagnosis of Conn's syndrome. nameOfConference


    QMRO: qmroHref
  • Wang T, Brown MJ (1999). mRNA Quantification by Real Time TaqMan Polymerase Chain Reaction: Validation and Comparison with RNase Protection. nameOfConference


    QMRO: qmroHref
  • Mitchinson MJ, Stephens NG, Parsons A et al. (1999). Mortality in the CHAOS trial. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Castaigne A, de Leeuw PW et al. (1998). Study population and treatment titration in the International Nifedipine GITS Study: Intervention as a Goal in Hypertension Treatment (INSIGHT).. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Brown MJ (1998). Irbesartan treatment in hypertension.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Sharma P, Hingorani A, Jia H et al. (1998). Positive Association of Tyrosine Hydroxylase Microsatellite Marker to Essential Hypertension. nameOfConference


    QMRO: qmroHref
  • Yasmin, Mascie‐Taylor C, Brown M et al. (1998). THE EFFECT OF DIETARY INTERVENTION ON CHANGES IN TOTAL CHOLESTEROL, BLOOD PRESSURE AND WEIGHT IN A CAMBRIDGE STUDY. nameOfConference


    QMRO: qmroHref
  • Brown MJ (1998). Who Manages Hypertensive Patients?*. nameOfConference


    QMRO: qmroHref
  • Sharma P, Lu F, Rut A et al. (1998). Structure of Human Endothelin-2 Gene and Demonstration of Common Expression in Human Right Atrial Tissue. nameOfConference


    QMRO: qmroHref
  • (1998). Protocol for prospective collaborative overviews of major randomized trials of blood-pressure-lowering treatments. World Health Organization-International Society of Hypertension Blood Pressure Lowering Treatment Trialists' Collaboration.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Sharma P, Pathan S, Fatibene J et al. (1997). 1.1 Genome wide search for susceptibility loci in essential hypertension. nameOfConference


    QMRO: qmroHref
  • Dickerson JEC, Hingorani AD, Brown MJ (1997). 2.3 Sequential monotherapy as a method of optimal treatment selection for young patients with hypertension. nameOfConference


    QMRO: qmroHref
  • Brown M, Castaigne A (1997). INSIGHT - the baseline characteristics of randomised patients. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Brown MJ, Castaigne A, De Leeuw PW et al. (1997). INSIGHT - study rationale and design. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Ferro A, Hall JA, Dickerson JE et al. (1997). A prospective study of the effects of prolonged timolol therapy on alpha- and beta-adrenoceptor and angiotensin II receptor mediated responses in normal subjects.. nameOfConference


    QMRO: qmroHref
  • Sharma P, Smith I, Maguire G et al. (1997). Clinical value of ACE genotyping in diagnosis of sarcoidosis. nameOfConference


    QMRO: qmroHref
  • Medina RA, Cardona-Sanclemente LE, Born GVR et al. (1997). Effect of deoxycorticosterone acetate on blood pressure in relation to accumulation of low-density lipoprotein and fibrinogen by aorta and other tissues of normotensive Wistar rats. nameOfConference


    QMRO: qmroHref
  • Brown MJ (1997). Science, medicine, and the future : Hypertension. nameOfConference


    QMRO: qmroHref
  • Sharma P, Pathan S, Fatibene J et al. (1997). Annual Scientific Meeting of the British Hypertension Society. Wills Hall, University of Bristol, 15-17 September 1997. Genome wide search for susceptibility loci in essential hypertension: Early results. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Longmore J, Hargreaves RJ, Boulanger CM et al. (1997). Comparison of the vasoconstrictor properties of the 5-HT1D-receptor agonists rizatriptan (MK-462) and sumatriptan in human isolated coronary artery: outcome of two independent studies using different experimental protocols.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Medina R, E. C-SL, Born GVR et al. (1997). Effect of Captopril and Losartan on Blood Pressure and Accumulation of LDL and Fibrinogen by Aortic Wall and Other Tissues in Normotensive and Hypertensive Rats. nameOfConference


    QMRO: qmroHref
  • Jia H, Lloyd D, Trutwein D et al. (1996). Levels of GTPγS-stimulated adenylyl cyclase activity in human lymphocytes: Effects of Gsα genotype. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Hingorani AD, Sharma P, Jia H et al. (1996). Blood pressure and the M235T polymorphism of the angiotensinogen gene.. nameOfConference


    QMRO: qmroHref
  • Oliver S (1996). Calcium-channel blockers and cancer. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Castaigne A, Ruilope LM et al. (1996). INSIGHT: international nifedipine GITS study intervention as a goal in hypertension treatment.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Hingorani AD, Brown MJ (1996). Identifying the genes for human hypertension.. nameOfConference


    QMRO: qmroHref
  • Stephens NG, Parsons A, Brown MJ et al. (1996). Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). nameOfConference


    QMRO: qmroHref
  • (1996). ERRATUM. nameOfConference


    QMRO: qmroHref
  • Brown MJ (1995). Stress, Catecholamines, and Cardiovascular Disease. nameOfConference


    QMRO: qmroHref
  • Fernandez-Durango R, Nunez DJR, Brown MJ (1995). Messenger RNAs encoding the natriuretic peptides and their receptors are expressed in the eye. nameOfConference


    QMRO: qmroHref
  • Hingorani AD, Stevens PA, Brown MJ et al. (1995). Renin-angiotensin system gene polymorphisms influence blood pressure and the response to angiotensin converting enzyme inhibition. nameOfConference


    QMRO: qmroHref
  • Monteith MS, Wang T, Brown MJ (1995). Differences in transcription and translation of long and short Gs alpha, the stimulatory G-protein, in human atrium.. nameOfConference


    QMRO: qmroHref
  • Dickerson JE, Garratt CJ, Brown MJ (1995). Management of hypertension in general practice: agreements with and variations from the British Hypertension Society guidelines.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Brown MJ (1995). To (β) block or better block?. nameOfConference


    QMRO: qmroHref
  • Messerli F, Macdonald G, Brown MJ et al. (1995). Are calcium antagonists safe?. nameOfConference


    QMRO: qmroHref
  • Hingorani AD, Brown MJ (1995). A Simple Molecular Assay for the C1166 Variant of the Angiotensin II Type 1 Receptor Gene. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Dickerson JEC (1995). Alpha-blockade and calcium antagonism: an effective and well-tolerated combination for the treatment of resistant hypertension. nameOfConference


    QMRO: qmroHref
  • Jia H, Monteith S, Brown MJ (1995). Expression of the alpha- and beta-subunits of the stimulatory and inhibitory G-proteins in beta 1-adrenoceptor-blocked and non-beta-adrenoceptor-blocked human atrium.. nameOfConference


    QMRO: qmroHref
  • Dickerson JEC, Brown MJ (1995). Influence of age on general practitioners' definition and treatment of hypertension. nameOfConference


    QMRO: qmroHref
  • Stevens PA, Brown MJ (1995). Genetic Variability of the ET-1 and the ETA Receptor Genes in Essential Hypertension. nameOfConference


    QMRO: qmroHref
  • Ferro A, Kaumann AJ, Brown MJ (1995). β-Adrenoceptor Subtypes in Human Coronary Artery. nameOfConference


    QMRO: qmroHref
  • Karet FE, Dickerson JEC, Brown J et al. (1994). Bovril and moclobemide: a novel therapeutic strategy for central autonomic failure. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Clayton D (1994). Linkage of the Angiotensinogen Gene to Essential Hypertension. nameOfConference


    QMRO: qmroHref
  • Cheung BMY, Dickerson JEC, Ashby MJ et al. (1994). Effects of physiological increments in human alpha-atrial natriuretic peptide and human brain natriuretic peptide in normal male subjects.. nameOfConference


    QMRO: qmroHref
  • Karet FE, Brown MJ (1994). Phaeochromocytoma: diagnosis and management. nameOfConference


    QMRO: qmroHref
  • Cheung BM, Brown MJ (1994). Plasma brain natriuretic peptide and C-type natriuretic peptide in essential hypertension. nameOfConference


    QMRO: qmroHref
  • Sun B, Plumpton C, Sinclair JH et al. (1994). In vitro expression of calcitonin gene-related peptide in human endothelial cells transfected with plasmid and retroviral vectors. nameOfConference


    QMRO: qmroHref
  • Tsakayannis D, Li W, Razvi S et al. (1994). Sucralfate and chronic venous stasis ulcers. nameOfConference


    QMRO: qmroHref
  • Brown MJ (1993). Angiotensin receptor blockers in essential hypertension. nameOfConference


    QMRO: qmroHref
  • Kerstens PSM, Stolk J, Hilbrands L et al. (1993). 5-nucleotidase and azathioprine-related bone-marrow toxicity. nameOfConference


    QMRO: qmroHref
  • Philpott N, Marsh JCW, Gordon-Smith EC et al. (1993). Aplastic anaemia and remoxipride. nameOfConference


    QMRO: qmroHref
  • Cheung BMY, Brown MJ (1993). "New" natriuretic peptides and blood pressure. nameOfConference


    QMRO: qmroHref
  • Ferro A, Plumpton C, Brown MJ (1993). Is receptor cross-regulation in human heart caused by alterations in cardiac guanine nucleotide-binding proteins?. nameOfConference


    QMRO: qmroHref
  • Brown MJ (1993). What do beta-blockers really do? A view from both sides of the receptor. Based on the Oliver Sharpey Lecture 1992.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Brown MJ (1993). Causes of essential hypertension: can it be cured?. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Hall JA, Ferro A, Dickerson JE et al. (1993). Beta adrenoreceptor subtype cross regulation in the human heart.. nameOfConference


    QMRO: qmroHref
  • Sun B, Plumpton C, Sinclair JH et al. (1993). Comparison of plasmid- and retrovirus-mediated gene expression in cultured human endothelial cells. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Sun B, Davenport AP, Brown MJ (1993). Quantitative autoradiography reveals higher densities of specific calcitonin-gene-related peptide receptors in small intramyocardial compared with large epicardial coronary arteries.. nameOfConference


    QMRO: qmroHref
  • Ferro A, Hall JA, Brown MJ (1993). β1-adrenoceptor blocker-induced β2-adrenoceptor sensitisation is prevented by β2-adrenoceptor blockade. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Brown MJ, Hughes M, White R et al. (1992). 6 Blood pressure, cholesterol and height. The birth weight hypothesis revisited in 15696 adults. nameOfConference


    QMRO: qmroHref
  • Nunez DJ, Dickson MC, Brown MJ (1992). Natriuretic peptide receptor mRNAs in the rat and human heart.. nameOfConference


    QMRO: qmroHref
  • Cameron IT, Davenport AP, van Papendorp C et al. (1992). Endothelin-like immunoreactivity in human endometrium. nameOfConference


    QMRO: qmroHref
  • Nunez DJ, Vassilikioti S, Brown MJ (1992). The human atrial natriuretic factor (ANF) 'C' receptor is encoded by two messenger RNAs. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • van Papendorp CL, Cameron IT, Davenport AP et al. (1991). Localization and endogenous concentration of endothelin-like immunoreactivity in human placenta. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Dickerson JE (1991). Synergism between alpha 1-blockade and angiotensin converting enzyme inhibition in essential hypertension.. nameOfConference


    QMRO: qmroHref
  • Hall JA, Petch MC, Brown MJ (1991). In vivo demonstration of cardiac beta 2-adrenoreceptor sensitization by beta 1-antagonist treatment.. nameOfConference


    QMRO: qmroHref
  • Kaumann AJ, Sanders L, Brown AM et al. (1991). A 5-HT4-like receptor in human right atrium. nameOfConference


    QMRO: qmroHref
  • Shawket SA, Brown MJ (1991). Pathogenetic and therapeutic implications of calcitonin-gene-related peptide in the cardiovascular system. nameOfConference


    QMRO: qmroHref
  • Nunez DJR, Taylor EA, Oh VMS et al. (1991). Endothelin-1 mRNA expression in the rat kidney. nameOfConference


    QMRO: qmroHref
  • Davenport AP, Cameron IT, Smith SK et al. (1991). Binding sites for iodinated endothelin-1, endothelin-2 and endothelin-3 demonstrated on human uterine glandular epithelial cells by quantitative high-resolution autoradiography. nameOfConference


    QMRO: qmroHref
  • Cameron IT, Davenport AP, Brown MJ et al. (1991). Endothelin-1 stimulates prostaglandin F2α release from human endometrium. nameOfConference


    QMRO: qmroHref
  • Davenport AP, Morton AJ, Brown MJ (1991). Localization of Endothelin-1 (ET-1), ET-2, and ET-3, Mouse VIC, and Sarafotoxin S6b Binding Sites in Mammalian Heart and Kidney. nameOfConference


    QMRO: qmroHref
  • Nunez DJ, Davenport AP, Brown MJ (1991). Molecular aspects of atrial natriuretic factor physiology.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Tan KKC, Brown MJ (1991). Selected side effects: 3. Angiotensin-converting enzyme inhibitors and cough. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Nunez DJR, Davenport AP, Brown MJ (1990). Atrial natriuretic factor mRNA and binding sites in the adrenal gland. nameOfConference


    QMRO: qmroHref
  • Brown MJ (1990). Efficacy and tolerance of doxazosin: a review.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Taylor EA, Oh VMS, Nunez DJ et al. (1990). Expression of endothelin-1 messenger RNA in kidneys of hypertensive and normotensive rats. nameOfConference


    QMRO: qmroHref
  • Davenport AP, Nunez DJ, Brown MJ (1990). Localisation off binding sites for iodinated endothelin and saraffotoxin peptides in mammalian tissues using quantitative receptor autoradiography. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Sanders L (1990). Effects of dilevalol on human atrial muscle.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Hall JA, Kaumann AJ, Brown MJ (1990). Selective beta 1-adrenoceptor blockade enhances positive inotropic responses to endogenous catecholamines mediated through beta 2-adrenoceptors in human atrial myocardium.. nameOfConference


    QMRO: qmroHref
  • Nunez DJ, Brown MJ, Davenport AP et al. (1990). Endothelin-1 mRNA is widely expressed in porcine and human tissues.. nameOfConference


    QMRO: qmroHref
  • Davenport AP, Ashby MJ, Easton P et al. (1990). A sensitive radioimmunoassay measuring endothelin-like immunoreactivity in human plasma: comparison of levels in patients with essential hypertension and normotensive control subjects.. nameOfConference


    QMRO: qmroHref
  • Price JS, Brown MJ (1990). 125I-neuropeptide Y binding activity of pig spleen cell membranes: Effect of solubilisation. nameOfConference


    QMRO: qmroHref
  • Shawket S, Dickerson JEC, Hazleman B et al. (1990). Double-blind comparison of CGRP and prostacyclin in primary Raynaud's phenomenon: Prolonged hand rewarming after CGRP. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Shawket S, Hazleman B, Dickerson C et al. (1989). SELECTIVE SUPRASENSITIVITY TO CALCITONIN-GENE-RELATED PEPTIDE IN THE HANDS IN RAYNAUD'S PHENOMENON. nameOfConference


    QMRO: qmroHref
  • Nunez DJ, Davenport AP, Emson PC et al. (1989). A quantitative ‘in-situ’ hybridization method using computer-assisted image analysis. Validation and measurement of atrial-natriuretic-factor mRNA in the rat heart. nameOfConference


    QMRO: qmroHref
  • Hall JA, Petch MC, Brown MJ (1989). Intracoronary injections of salbutamol demonstrate the presence of functional beta 2-adrenoceptors in the human heart.. nameOfConference


    QMRO: qmroHref
  • Brown MJ (1989). Investigation of alpha2-adrenoceptors in humans. nameOfConference


    QMRO: qmroHref
  • Davenport AP, Nunez DJ, Brown MJ (1989). Binding sites for 125I-labelled endothelin-1 in the kidneys: differential distribution in rat, pig and man demonstrated by using quantitative autoradiography.. nameOfConference


    QMRO: qmroHref
  • Kaumann AJ, Hall JA, Murray KJ et al. (1989). A comparison of the effects of adrenaline and noradrenaline on human heart: the role of β1- and β2-adrenoceptors in the stimulation of adenylate cyclase and contractile force. nameOfConference


    QMRO: qmroHref
  • Davenport AP, Nunez DJ, Hall JA et al. (1989). Autoradiographical Localization of Binding Sites for Porcine [125I]Endothelin-1 in Humans, Pigs, and Rats. nameOfConference


    QMRO: qmroHref
  • Barker PM, Brown MJ, Ramsden CA et al. (1988). The effect of thyroidectomy in the fetal sheep on lung liquid reabsorption induced by adrenaline or cyclic AMP.. nameOfConference


    QMRO: qmroHref
  • Brown MJ (1988). Sites of action of alpha2 agonists and antagonists. nameOfConference


    QMRO: qmroHref
  • Causon R, Davies D, Brown M (1987). Bio-medical applications of high performance liquid chromatography (HPLC) with amperometric detection. nameOfConference


    QMRO: qmroHref
  • Cockcroft JR, Ritter JM, Allison DJ et al. (1987). Location of extra-adrenal catecholamine secreting tumours by selective venous sampling and nuclear magnetic resonance scanning. nameOfConference


    QMRO: qmroHref
  • ALLEN JM, YEATS JC, CAUSON R et al. (1987). Neuropeptide Y and Its Flanking Peptide in Human Endocrine Tumors and Plasma. nameOfConference


    QMRO: qmroHref
  • Glazier JJ, Chierchia S, Brown MJ et al. (1986). Importance of generalized defective perception of painful stimuli as a cause of silent myocardial ischemia in chronic stable angina pectoris. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Brown J (1986). DOES ANGIOTENSIN-II PROTECT AGAINST STROKES?. nameOfConference


    QMRO: qmroHref
  • Corr L, Grounds RM, Brown MJ et al. (1986). Plasma catecholamine changes during cardiopulmonary bypass: a randomised double blind comparison of trimetaphan camsylate and sodium nitroprusside.. nameOfConference


    QMRO: qmroHref
  • Dunn GD, Sapsford RN, Hemingway A et al. (1986). FUNCTIONING MIDDLE MEDIASTINAL PARAGANGLIOMA (PHAEOCHROMOCYTOMA) ASSOCIATED WITH INTERCAROTID PARAGANGLIOMAS. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Causon RC, Brennan P et al. (1985). Adrenaline and noradrenaline excretion in placebo treated patients in the Medical Research Council Hypertension Trial and in matched normotensive controls.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Ind PW, Barnes PJ, Brown MJ et al. (1985). Plasma histamine concentration during propranolol induced bronchoconstriction.. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Causon RC, Barnes VF et al. (1985). Urinary catecholamines in essential hypertension: results of 24-hour urine catecholamine analyses from patients in the Medical Research Council trial for mild hypertension and from matched controls.. nameOfConference


    QMRO: qmroHref
  • Brown MJ (1985). Hypokalemia from beta2-receptor stimulation by circulating epinephrine. nameOfConference


    QMRO: qmroHref
  • Ind PW, Causon RC, Brown MJ et al. (1985). Circulating catecholamines in acute asthma.. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Struthers AD, di Silvio L (1985). Peripheral α2 Adrenoceptor Stimulation Contributes to the Sympatholytic Effect of Guanfacine in Humans. nameOfConference


    QMRO: qmroHref
  • Causon RC, Brown MJ, Davies DS (1985). Reversed-phase high-performance liquid chromatography and amperometric detection of 3-O-methyl isoprenaline sulphate: application to studies on the presystemic metabolism of d-isoprenaline in man. nameOfConference


    QMRO: qmroHref
  • Spencer JA, Brown MJ (1985). Treatment with nifedipine for malignant hypertension inducing acute reversible renal impairment. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Murphy MB, Brown MJ, Scriven AJI et al. (1984). Nifedipine and alpha adrenoceptor antagonism. nameOfConference


    QMRO: qmroHref
  • Causon RC, Brown MJ (1984). High-performance liquid chromatography with amperometric determination of plasma tyramine. nameOfConference


    QMRO: qmroHref
  • Conway EL, Brown MJ, Dollery CT (1984). Studies on the pharmacology of central opioid-induced increases in plasma catecholamines in conscious rats. nameOfConference


    QMRO: qmroHref
  • Scriven AJI, Brown MJ, Murphy MB et al. (1984). Changes in Blood Pressure and Plasma Catecholamines Caused by Tyramine and Cold Exposure. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Harland D, Murphy MB et al. (1984). Effect of centrally acting alpha-adrenergic agonists on sympathetic nervous system function in humans.. nameOfConference


    QMRO: qmroHref
  • Conway EL, Brown MJ, Dollery CT (1984). No evidence for involvement of endogenous opioid peptides in effects of clonidine on blood pressure, heart rate and plasma norepinephrine in anesthetized rats.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • (1984). Hypokalemia from Beta2-Receptor Stimulation by Epinephrine. nameOfConference


    QMRO: qmroHref
  • Lee TH, Nagakura T, Cromwell O et al. (1984). Neutrophil Chemotactic Activity and Histamine in Atopic and Nonatopic Subjects after Exercise-induced Asthma1–3. nameOfConference


    QMRO: qmroHref
  • Causon RC, Desjardins R, Brown MJ et al. (1984). Determination of d-isoproterenol sulphate by high-performance liquid chromatography with amperometric detection. nameOfConference


    QMRO: qmroHref
  • Causon RC, Brown MJ (1984). Measurement of tyramine in human plasma, utilising ion-pair extraction and high-performance liquid chromatography with amperometric detection. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Brown DC, Murphy MB (1983). Hypokalemia from Beta2-Receptor Stimulation by Circulating Epinephrine. nameOfConference


    QMRO: qmroHref
  • Dollery CT, Brown MJ, Davies DS et al. (1983). Oral absorption and concentration‐effect relationship of tyramine with and without cimoxatone, a type‐A specific inhibitor of monoamine oxidase. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Olver RE, Ramsden CA et al. (1983). Effects of adrenaline and of spontaneous labour on the secretion and absorption of lung liquid in the fetal lamb.. nameOfConference


    QMRO: qmroHref
  • Conway EL, Brown MJ, Dollery CT (1983). Plasma catecholamine and cardiovascular responses to morphine and D-ala2-d-leu5-enkephalin in conscious rats.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Adrian TE, Terenghi G, Brown MJ et al. (1983). NEUROPEPTIDE Y IN PHAEOCHROMOCYTOMAS AND GANGLIONEUROBLASTOMAS. nameOfConference


    QMRO: qmroHref
  • Brown MJ (1983). Catecholamine measurements in clinical medicine. nameOfConference


    QMRO: qmroHref
  • Scriven AJI, Dollery CT, Murphy MB et al. (1983). Blood pressure and plasma norepinephrine concentrations after endogenous norepinephrine release by tyramine. nameOfConference


    QMRO: qmroHref
  • Causon RC, Brown MJ, Boulous PM et al. (1983). Analytical differences in measurement of plasma catecholamines.. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Brown DC, Murphy MB (1983). Adrenaline associated hypokalaemia and tachycardia are selectively antagonised by low dose beta2-receptor blockade in man. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Ind PW, Miyatake A, Brown MJ et al. (1983). Do human mast cells possess functional beta adrenoceptors in vivo?. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Causon RC, Brown MJ, Leenders KL et al. (1983). High-performance liquid chromatography with amperometric detection of plasma L-3,4-dihydroxyphenylalanine in parkinsonian patients. nameOfConference


    QMRO: qmroHref
  • Lee TH, Nagy L, Brown MJ et al. (1983). Mechanism of antigen-induced late asthmatic reactions.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Brown MJ (1983). Simultaneous assay of noradrenaline and its deaminated metabolite in plasma: Application to diagnosis of phaeochromocytoma. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Murphy MB, Brown MJ, Causon RC et al. (1983). The effects of pentolinium on sympathetic activity in hypertensives and normotensive controls.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Causon RC, Brown MJ (1982). Catecholamine Measurements in Phaeochromocytoma: A Review. nameOfConference


    QMRO: qmroHref
  • Murphy MB, Scriven AJ, Brown MJ et al. (1982). The effects of nifedipine and hydralazine induced hypotension on sympathetic activity. nameOfConference


    QMRO: qmroHref
  • Lee TH, Brown MJ, Nagy L et al. (1982). Exercise-induced release of histamine and neutrophil chemotactic factor in atopic asthmatics. nameOfConference


    QMRO: qmroHref
  • Watkins J, Dargie HJ, Brown MJ et al. (1982). Effects of histamine type 2 receptor stimulation on myocardial function in normal subjects.. nameOfConference


    QMRO: qmroHref
  • Barnes PJ, Ind PW, Brown MJ (1982). Plasma Histamine and Catecholamines in Stable Asthmatic Subjects. nameOfConference


    QMRO: qmroHref
  • Walters DV, Ramsden CA, Brown MJ et al. (1982). Fetal Lung Liquid Absorption during Epinephrine Infusion and Spontaneous Labor in the Lamb. nameOfConference


    QMRO: qmroHref
  • Ind PW, Brown MJ, Lhoste FJM et al. (1982). Concentration effect relationships of infused histamine in normal volunteers. nameOfConference


    QMRO: qmroHref
  • Brown MJ, MacQuin I, Murphy MB et al. (1982). Sustained Increase in Sympathetic Activity Due to Neuronal Uptake of Adrenaline: Mechanism for Stress-Induced Hypertension and Arrhythmias?. nameOfConference


    QMRO: qmroHref
  • Rampton DS, Brown MJ, Sahib M (1982). The Effect of Disodium Cromoglycate on Rectal Mucosal Histamine Release and Eosinophil Exudation in Active Ulcerative Colitis. nameOfConference


    QMRO: qmroHref
  • (1982). Clonidine-Suppression Test for Diagnosis of Pheochromocytoma. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Ind PW, Causon R et al. (1982). A novel double-isotope technique for the enzymatic assay of plasma histamine: application to estimation of mast cell activation assessed by antigen challenge in asthmatics. nameOfConference


    QMRO: qmroHref
  • Warren JB, Keynes RJ, Brown MJ et al. (1982). Blunted sympathoadrenal response to exercise in asthmatic subjects. nameOfConference


    QMRO: qmroHref
  • Ind PW, Brown MJ, Barnes PJ et al. (1982). Effect of propranolol on mediator release in asthmatics. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Brown MJ, Lhoste FJM, Zamboulis C et al. (1982). Estimation of sympathetic activity in essential hypertension. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Macquin I (1981). IS ADRENALINE THE CAUSE OF ESSENTIAL HYPERTENSION?. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Jenner DA (1981). Novel Double-Isotope Technique for Enzymatic Assay of Catecholamines, Permitting High Precision, Sensitivity and Plasma Sample Capacity. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Jenner DA, Allison DJ et al. (1981). Variations in Individual Organ Release of Noradrenaline Measured by An Improved Radioenzymatic Technique; Limitations of Peripheral Venous Measurements in the Assessment of Sympathetic Nervous Activity. nameOfConference


    QMRO: qmroHref
  • Barnes PJ, Wilson NM, Brown MJ (1981). A calcium antagonist, nifedipine, modifies exercise-induced asthma.. nameOfConference


    QMRO: qmroHref
  • Jenner DA, Brown MJ, Lhoste FJM (1981). Determination of α-methyldopa, α-methylnoradrenaline, noradrenaline and adrenaline in plasma using high-performance liquid chromatography with electrochemical detection. nameOfConference


    QMRO: qmroHref
  • Barnes PJ, Brown MJ (1981). Venous Plasma Histamine in Exercise- and Hyperventilation Induced Asthma in Man. nameOfConference


    QMRO: qmroHref
  • Barnes PJ, Brown MJ, Silverman M et al. (1981). Circulating catecholamines in exercise and hyperventilation induced asthma.. nameOfConference


    QMRO: qmroHref
  • Brown M, Causon R, Holly JMP et al. (1981). "Na" OR "NA" IN HYPERTENSION?. nameOfConference


    QMRO: qmroHref
  • Amorim DS, Heer K, Jenner D et al. (1981). IS THERE AUTONOMIC IMPAIRMENT IN CONGESTIVE (DILATED) CARDIOMYOPATHY?. nameOfConference


    QMRO: qmroHref
  • Weinkove C, Brown M (1981). SENSITIVITY AND ACCURACY OF PHAEOCHROMOCYTOMA DIAGNOSIS. nameOfConference


    QMRO: qmroHref
  • Stevenson JC, Hillyard CJ, Spanos E et al. (1981). Sipple syndrome: marked variability of the disease within a family and implications for management. nameOfConference


    QMRO: qmroHref
  • Barnes PJ, Wilson NM, Brown MJ et al. (1981). Calcium antagonist nifedipine modifies exercise-induced asthma. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Brown MJ, Jenner DA, Allison DJ et al. (1981). INCREASED SENSITIVITY AND ACCURACY OF PHAEOCHROMOCYTOMA DIAGNOSIS ACHIEVED BY USE OF PLASMA-ADRENALINE ESTIMATIONS AND A PENTOLINIUM-SUPPRESSION TEST. nameOfConference


    QMRO: qmroHref
  • Lhoste F, Brown M, Jenner D et al. (1981). Methyldopa, methylnoradrenaline and noradrenaline in hypertension. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Jenner DA, Brown MJ (1981). Simultaneous determination of endogenous catecholamines, α-methyldopa and α-methylnoradrenaline in plasma, using HPLC with electrochemical detection. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • FitzGerald GA, Barnes P, Brown MJ et al. (1980). The circadian variability of circulating adrenaline and bronchomotor reactivity in asthma. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Fairfax AJ (1980). Nocturnal Asthma and Circulating Epinephrine, Histamine, and Cortisol. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Ind PW, Barnes PJ et al. (1980). A sensitive and specific radiometric method for the measurement of plasma histamine in normal individuals. nameOfConference


    QMRO: qmroHref
  • Watkins J, FitzGerald G, Zamboulis C et al. (1980). Absence of opiate and histamine H2 receptor–mediated effects of Clonidine. nameOfConference


    QMRO: qmroHref
  • Karliner JS, Barnes P, Brown M et al. (1980). Chronic heart failure in the guinea pig increases cardiac α1- and β-adrenoceptors. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Ind PW, Jenner DA (1980). Platelet Histamine. nameOfConference


    QMRO: qmroHref
  • Barnes P, FitzGerald G, Brown M et al. (1980). Nocturnal Asthma and Changes in Circulating Epinephrine, Histamine, and Cortisol. nameOfConference


    QMRO: qmroHref
  • Rossor MN, Watkins J, Brown MJ et al. (1980). Plasma levodopa, dopamine and therapeutic response following levodopa therapy of Parkinsonian patients. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Lewis PJ, Dollery CT (1980). DIAGNOSIS OF SMALL PHÆOCHROMOCYTOMAS. nameOfConference


    QMRO: qmroHref
  • Brown MJ (1980). PLASMA CATECHOLAMINE ASSAYS. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Barnes PJ, Lhoste F (1980). Use of a new radioenzymatic assay for plasma histamine to detect abnormal release in asthmatics. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Petty MA, Chalmers JP, Brown M et al. (1979). Effect of Baroreceptor Deafferentation on Central Catecholamines in the Rat. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Davies DS, Dollery CT (1979). Quantitative analysis of noradrenaline clearance [proceedings].. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Brown MJ, Dollery CT, Reid JL et al. (1979). Plasma catecholamines and the acute effects of oral L-dopa in Parkinsonian patients [proceedings].. nameOfConference


    QMRO: qmroHref
  • Brown M, Chalmers JP, Petty MA et al. (1979). The involvement of catecholamines in the central connexions of arterial baroreceptor reflexes in the rat [proceedings].. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Rossor M, Watkins J, Brown MJ (1979). Plasma catecholamines and the acute effects of oral L-dopa by Parkinsonian patients. nameOfConference

    DOI: doi

    QMRO: qmroHref

Sponsors

Collaborators

Internal

External

  • Ms Laila Parvanta (Barts)
  • Prof Annette Dolphin (UCL)
  • Prof Stephen Pereira (UCL)
  • Prof Erik Arstad (UCL)
  • Dr Mark Gurnell (Cambridge)
  • Dr HK Cheow (Cambridge)

BHF PATHWAY Investigators

  • Prof Bryan Williams (UCL)
  • Prof Tom Macdonald (Dundee)
  • Prof Kennedy Cruickshank (KCL)
  • Prof Philip Chowienczyk (KCL)
  • Dr Steve Morant (Dundee)
  • Prof Joerg Striessnig (Innsbruck)
  • Prof Felix Beuschlein (Munich)
  • Prof Akihiko Ito (Kindai, Japan)
  • Dr Celso Gomez Sanchez (Mississippi)

News

Teaching

  • PhD supervision
  • Lectures to MRes courses
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