Skip to main content
The William Harvey Research Institute - Faculty of Medicine and Dentistry

Dr Marika Charalambous

Marika

Senior Lecturer in Endocrinology and MRC New Investigator

Email: m.charalambous@qmul.ac.uk
Telephone: +44(0) 20 7882 6292

Profile

I studied Natural Sciences in Cambridge, and then completed a PhD at the University of Bath on the transcriptional control of the imprinted insulin-like growth factor 2 (Igf2) gene. My research career has focused primarily on the relationship between epigenetic gene dosage control and developmental physiology. Much of my work has utilised imprinted genes in the mouse as experimental models, since the epigenetic modulation of these exquisitely dosage-sensitive genes has important consequences for prenatal growth and development in mouse and man. Some examples of my work include the demonstration that loss of imprinting on mouse chromosome 12 causes failure of timely development of brown adipose tissue, resulting in animals that are unable to survive the transition to independent postnatal life. I previously described a mouse model with defects in placental development and growth as a result of the loss of function of the imprinted Grb10 gene. In addition I undertook a training postdoctoral position in metabolic medicine in order to link my interest in prenatal growth and development with lifelong outcomes on metabolic health. I was appointed to an Early Careers Fellowship at the Centre for Endocrinology in early 2013, and became a Senior Lecturer in 2015.

Memberships and awards

Committee member of the Genetics Society since April 2015.

Back to top