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Professor Philip Eaton

Philip

Professor of Cardiovascular Biochemistry

Centre: Clinical Pharmacology and Precision Medicine

Email: p.eaton@qmul.ac.uk
Telephone: +44(0) 20 7882 6863

Profile

Philip Eaton gained a BSc in Biochemistry from Queen Mary College, University of London in 1989 before completing his PhD studies at the University of Sussex. After post-doctoral work at the Institute of Psychiatry, he joined the Department of Cardiovascular Research at the Rayne Institute, St Thomas’ Hospital in 1995. He remained there for nearly 24 years within the School of Cardiovascular Medicine & Sciences at King’s College London. In 2019, he moved to the William Harvey Research Institute, Queen Mary University of London where he heads a group studying the molecular basis of redox sensing and signalling in the cardiovascular system.

Research

Group members

Dr. Rebecca Charles (BHF Intermediate Fellow): Dr. Hyunju Cho; Dr. Mariana Fernandez-Caggiano; Dr. Lorena Fernandez-Mosquera; Dr. Asvi Francois; Dr. Alisa Kamynina; Dr. Gundeep Kaur; Dr. Oleksandra Prysyazhna; Dr. Daniel Simoes De Jesus; Dr. Christopher Switzer

Summary 

Oxidants, which can be produced in cells and tissues, have been causatively implicated in the pathogenesis of most major diseases. Whilst this paradigm is still prevalent, and oxidants may indeed play important roles in the disease etiology, it is now understood that they can also serve as regulatory entities that are important for the maintenance of homeostasis during health and disease. Oxidants can be sensed and transduced into a biological event via their reaction with select cysteine thiol side chains on some proteins. Such reactions can result in oxidative post-translational modifications of proteins that in some cases alter their function to enable adaptation and homeostasis. By identifying thiol-based redox sensor proteins susceptible to oxidant-dependent alterations in structure and function, it is hoped a better understanding of the biological significance of these modifications during cardiovascular health and disease can be gained. Indeed, in some cases we have developed new electrophilic drugs that modify precise redox regulated cysteines for therapeutic purposes to combat cardiovascular disease. 

Publications

  • Knight H, Abis G, Kaur M et al. (2023). Cyclin D-CDK4 Disulfide Bond Attenuates Pulmonary Vascular Cell Proliferation. nameOfConference


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  • Caggiano MF, Charles R, Prysyazhna O et al. (2023). UK-5099 does not inhibit the mitochondrial pyruvate carrier through irreversible adduction to cysteine 54 in MPC2. nameOfConference


  • Heusch G, Andreadou I, Bell R et al. (2023). Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection. nameOfConference


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  • Switzer CH, Kasamatsu S, Ihara H et al. (2023). SOD1 is an essential H2S detoxifying enzyme. nameOfConference


  • Kamynina A, Guttzeit S, Eaton P et al. (2022). Blood pressure lowering by nitroxyl donor CXL-1020 is mediated by oxidation of Protein Kinase G I. nameOfConference


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  • Varadarajan S, Abdelsaid K, Boatwright H et al. (2022). Abstract 9930: Exercise-Induced ATP7A, A Cu Transporter for SOD3, Restores Endothelial Dysfunction in Type2 Diabetes via Cysteine Oxidation of Protein Kinase G. nameOfConference


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  • Charles R, Fernandez-Caggiano M, Rudyk O et al. (2022). A novel inhibitor of soluble Epoxide Hydrolase that adducts C521 is cardioprotective. nameOfConference


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  • Francois AA, Yin X, Mayr M et al. (2022). Identification of Cardiac Proteins that Sense Oxidants by Intra-disulfide Formation. nameOfConference


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  • Baidanoff FM, Trebucq LL, Plano SA et al. (publicationYear). Cysteine Oxidation Promotes Dimerization/Oligomerization of Circadian Protein Period 2. nameOfConference


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  • Charles R, Eaton P (publicationYear). Redox Regulation of Soluble Epoxide Hydrolase—Implications for Cardiovascular Health and Disease. nameOfConference


  • Switzer CH, Cho H-J, Eykyn TR et al. (2022). NOS2 and S-nitrosothiol signaling induces DNA hypomethylation and LINE-1 retrotransposon expression.. nameOfConference


  • Switzer CH, Cho H-J, Eykyn TR et al. (2022). NOS2 and S-nitrosothiol signaling induces DNA hypomethylation and LINE-1 retrotransposon expression. nameOfConference


  • Kamynina A, Guttzeit S, Eaton P et al. (2022). Nitroxyl Donor CXL-1020 Lowers Blood Pressure by Targeting C195 in Cyclic Guanosine-3’,5’-Monophosphate-Dependent Protein Kinase I. nameOfConference


  • Nishiyama K, Nishimura A, Shimoda K et al. (2022). Redox-dependent internalization ofthe purinergic P2Y6 receptor limits colitis progression. nameOfConference


  • Varadarajan S, Abdelsaid K, Boatwright H et al. (2022). Exercise-Induced ATP7A, A Cu Transporter for SOD3, Restores Endothelial Dysfunction in Type2 Diabetes via Cysteine Oxidation of Protein Kinase G. nameOfConference

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  • Queiroz RF, Stanley CP, Wolhuter K et al. (publicationYear). Hydrogen peroxide signaling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation. nameOfConference


  • Switzer CH, Guttzeit S, Eykyn TR et al. (2021). Cysteine trisulfide oxidizes protein thiols and induces electrophilic stress in human cells. nameOfConference


  • Islam MMT, Tarnowski D, Zhang M et al. (2021). Enhanced Heart Failure in Redox‐Dead Cys17Ser PKARIα Knock‐In Mice. nameOfConference


  • Charles RL, Abis G, Fernandez BF et al. (2021). A thiol redox sensor in soluble epoxide hydrolase enables oxidative activation by intra-protein disulfide bond formation. nameOfConference


  • Fernandez-Caggiano M, Eaton P (2021). Heart failure—emerging roles for the mitochondrial pyruvate carrier. nameOfConference


  • Simon JN, VRELLAKU B, Monterisi S et al. (2020). Abstract 14219: Oxidation of PKA-RIα Protects Against Ischemia-reperfusion Injury by Inhibiting Lysosomal-triggered Calcium Release. nameOfConference


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  • Simon JN, Vrellaku B, Monterisi S et al. (2021). Oxidation of Protein Kinase A Regulatory Subunit PKARIα Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Lysosomal-Triggered Calcium Release. nameOfConference


  • Fernandez-Caggiano M, Kamynina A, Francois AA et al. (2020). Mitochondrial pyruvate carrier abundance mediates pathological cardiac hypertrophy. nameOfConference


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  • Trum M, Islam MMT, Lebek S et al. (2020). Inhibition of cardiac potassium currents by oxidation-activated protein kinase A contributes to early afterdepolarizations in the heart. nameOfConference


  • Simon JN, Vrellaku B, Monterisi S et al. (2020). B Oxidized PKARIα protects against ischemia-reperfusion injury by inhibiting lysosomal-triggered calcium release. nameOfConference


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  • Wack G, Eaton P, Schmidtko A et al. (2020). Redox regulation of soluble epoxide hydrolase does not affect pain behavior in mice. nameOfConference


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  • Cho H-J, Switzer CH, Kamynina A et al. (2020). Complex interrelationships between nitro-alkene-dependent inhibition of soluble epoxide hydrolase, inflammation and tumor growth. nameOfConference


  • Csato V, Kadir SZSA, Khavandi K et al. (2019). “A Step and a Ceiling”: mechanical properties of Ca2+ spark vasoregulation in resistance arteries by pressure‐induced oxidative activation of PKG. nameOfConference


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  • Prysyazhna O, Wolhuter K, Switzer C et al. (2019). Response by Prysyazhna et al to Letter Regarding Article, “Blood Pressure–Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase”. nameOfConference


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  • Feelisch M, Akaike T, Griffiths K et al. (2020). Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides, and oxidation of protein kinase G1α redox signalling. nameOfConference


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  • Rudyk O, Rowan A, Prysyazhna O et al. (2019). Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension. nameOfConference


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  • Prysyazhna O, Wolhuter K, Switzer C et al. (2019). Blood Pressure-Lowering by the Antioxidant Resveratrol is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase. nameOfConference


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  • Abis G, Charles RL, Kopec J et al. (publicationYear). 15-deoxy-Δ12,14-Prostaglandin J2 inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism. nameOfConference


  • Dunham-Snary KJ, Wu D, Potus F et al. (2019). Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction. nameOfConference


  • Stanley CP, Maghzal GJ, Ayer A et al. (2019). Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation. nameOfConference


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  • Duraffourd C, Huckstepp RTR, Braren I et al. (2019). PKG1α oxidation negatively regulates food seeking behaviour and reward. nameOfConference


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  • Smith J, Schroder E, Prysyazhna O et al. (2018). 61 Sulforaphane-mediated inhibition of SHP2 as a potential pharmacotherapy for Noonan syndrome. nameOfConference


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  • Cuello F, Eaton P (2019). Cysteine-Based Redox Sensing and Its Role in Signaling by Cyclic Nucleotide-Dependent Kinases in the Cardiovascular System. nameOfConference


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  • Abis G, Charles RL, Eaton P et al. (2019). Expression, purification, and characterisation of human soluble Epoxide Hydrolase (hsEH) and of its functional C-terminal domain. nameOfConference


  • Cuello F, Wittig I, Lorenz K et al. (2018). Oxidation of cardiac myofilament proteins: Priming for dysfunction?. nameOfConference


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  • De Nicola GF, Bassi R, Nichols C et al. (2018). The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules. nameOfConference


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  • Wolhuter K, Whitwell HJ, Switzer CH et al. (2018). Evidence against Stable Protein S-Nitrosylation as a Widespread Mechanism of Post-translational Regulation. nameOfConference


  • Kapil V (2017). Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017.. nameOfConference


  • Donzelli S, Goetz M, Schmidt K et al. (publicationYear). Oxidant sensor in the cGMP-binding pocket of PKGIα regulates nitroxyl-mediated kinase activity. nameOfConference


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  • Bassi R, Burgoyne JR, DeNicola GF et al. (2017). Redox-dependent dimerization of p38α mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3. nameOfConference


  • Burgoyne JR, Prysyazhna O, Richards DA et al. (2017). Proof of Principle for a Novel Class of Antihypertensives That Target the Oxidative Activation of PKG I&agr; (Protein Kinase G I&agr;). nameOfConference


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  • Rudyk O, Eaton P (2017). Examining a role for PKG Iα oxidation in the pathogenesis of cardiovascular dysfunction during diet-induced obesity. nameOfConference


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  • Sag CM, Schnelle M, Zhang J et al. (2017). Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell NAPDH Oxidase 2 on Blood Pressure. nameOfConference


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  • Wolhuter K, Eaton P (2017). How widespread is stable protein S-nitrosylation as an end-effector of protein regulation?. nameOfConference


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  • Valek L, Häussler A, Dröse S et al. (2017). Redox-guided axonal regrowth requires cyclic GMP dependent protein kinase 1: Implication for neuropathic pain. nameOfConference


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  • Prysyazhna O, Scotcher J, Boguslavskyi A et al. (2016). 348 Redox Control of Protein Kinase G Iα Fine-Tunes the Frank-Starling Law of the Heart in Vivo by Regulating Diastolic Relaxation. nameOfConference


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  • Scotcher J, Prysyazhna O, Boguslavskyi A et al. (2016). Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response.. nameOfConference


  • Khavandi K, Baylie RA, Sugden SA et al. (2016). Pressure-induced oxidative activation of PKG enables vasoregulation by Ca2+ sparks and BK channels. nameOfConference


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  • Prysyazhna O, Burgoyne JR, Scotcher J et al. (2016). Phosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G Iα Oxidation.. nameOfConference


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  • Fernandez-Caggiano M, Schröder E, Cho H-J et al. (2016). Oxidant-induced Interprotein Disulfide Formation in Cardiac Protein DJ-1 Occurs via an Interaction with Peroxiredoxin 2*. nameOfConference


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  • Stathopoulou K, Wittig I, Heidler J et al. (2016). S‐glutathiolation impairs phosphoregulation and function of cardiac myosin‐binding protein C in human heart failure. nameOfConference


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  • Akashi S, Ahmed KA, Sawa T et al. (2016). Persistent Activation of cGMP-Dependent Protein Kinase by a Nitrated Cyclic Nucleotide via Site Specific Protein S‑Guanylation. nameOfConference


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  • Kohl T, Weninger G, Zalk R et al. (2015). Intensity matters: Ryanodine receptor regulation during exercise. nameOfConference


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  • Mistry RK, Murray TVA, Prysyazhna O et al. (2016). Transcriptional Regulation of Cystathionine-γ-Lyase in Endothelial Cells by NADPH Oxidase 4-Dependent Signaling*. nameOfConference


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  • Fernández-Caggiano M, Prysyazhna O, Barallobre-Barreiro J et al. (2016). Analysis of Mitochondrial Proteins in the Surviving Myocardium after Ischemia Identifies Mitochondrial Pyruvate Carrier Expression as Possible Mediator of Tissue Viability*. nameOfConference


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  • Rudyk O, Prysyazhna O, Zhao L et al. (2015). Evaluating a possible role for PKG1α redox state in chronic hypoxia-induced pulmonary hypertension. nameOfConference


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  • Prysyazhna O, Burgoyne JR, Eaton P (2015). Tadalafil protects from doxorubicin-induced heart failure by attenuating PKG Iα disulfide dimerisation. nameOfConference


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  • Burgoyne JR, Rudyk O, Cho H-J et al. (publicationYear). Deficient angiogenesis in redox-dead Cys17Ser PKARIα knock-in mice. nameOfConference


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  • Prysyazhna O, Eaton P (publicationYear). Redox regulation of cGMP-dependent protein kinase Iα in the cardiovascular system. nameOfConference


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  • Cameron JM, Gabrielsen M, Chim YH et al. (2015). Polarized Cell Motility Induces Hydrogen Peroxide to Inhibit Cofilin via Cysteine Oxidation. nameOfConference


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  • Nakamura T, Ranek MJ, Lee DI et al. (2015). Prevention of PKG1α oxidation augments cardioprotection in the stressed heart. nameOfConference


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  • Eaton P (2015). OP7 Thiol redox sensing and signalling and the control of blood pressure. nameOfConference


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  • Sawa T, Ahmed A, Ono K et al. (2014). P179 Persistent activation of protein kinase G by a nitrated cyclic nucleotide via site specific S-guanylation and its implication for vascular hyporeactivity in endotoxin shock. nameOfConference


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  • Stubbert D, Prysyazhna O, Rudyk O et al. (2014). Protein Kinase G I&agr; Oxidation Paradoxically Underlies Blood Pressure Lowering by the Reductant Hydrogen Sulfide. nameOfConference


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  • Rudyk O, Eaton P (2014). Biochemical methods for monitoring protein thiol redox states in biological systems. nameOfConference


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  • Charles RL, Rudyk O, Prysyazhna O et al. (2014). Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase. nameOfConference


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  • Eaton P, Shah AM (2014). Preface for redox signalling in the cardiovascular system. nameOfConference


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  • Lorenz JE, Kallenborn-Gerhardt W, Lu R et al. (2014). Oxidant-Induced Activation of cGMP-Dependent Protein Kinase Iα Mediates Neuropathic Pain After Peripheral Nerve Injury. nameOfConference


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  • Bassi R, Rudyk O, Burgoyne J et al. (2014). 3 Can Redox-Sensitive Cysteines in P38A-MAPK Modulate Activation During Stress?. nameOfConference


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  • Islam T, Dantz C, Daniel H et al. (2014). Disruption of oxidative PKA activation contributes to ventricular remodeling upon increased afterload. nameOfConference

    DOI: doi

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  • Hohl M, Ardehali H, Azuaje FJ et al. (2014). Meeting highlights from the 2013 European Society of Cardiology Heart Failure Association Winter Meeting on Translational Heart Failure Research. nameOfConference


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  • Burgoyne JR, Rudyk O, Prysyazhna O et al. (2013). PSS132 Oxidation of Camp Dependent Protein Kinase Regulatory RIα Mediates Angiogenesis. nameOfConference


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  • Charles RL, Rudyk O, Prysyazhna O et al. (2013). PSS135 Loss of Redox Regulation in Cys521Ser Soluble Epoxide Hydrolase Knock-In Mice Results in Hypertension and Hypertrophy. nameOfConference


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  • Prysyazhna O, Burgoyne JR, Eaton PP (2013). PSS167 Cys42Ser PKG Iα Mutant Mice Are Protected from Doxorubicin-Induced Cardiomyopathy. nameOfConference


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  • Rudyk O, Prysyazhna O, Eaton P (2013). PSS171 Redox-Dead Protein Kinase a RIα knock-in Mouse Is Not Hypertensive But Has Increased Vascular Reactivity to Oxidants. nameOfConference


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  • Stubbert D, Prysyazhna O, Rudyk O et al. (2013). PSS176 The Blood Pressure-Lowering Action of the Reductant Hydrogen Sulfide Is Paradoxically Mediated by the Oxidative Activation of Protein Kinase G Iα. nameOfConference


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  • Rudyk O, Phinikaridou A, Prysyazhna O et al. (2013). Protein kinase G oxidation contribute to hypotension and organ injury during sepsis. nameOfConference


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  • Burgoyne JR, Oviosu O, Eaton P (2013). The PEG-switch assay: A fast semi-quantitative method to determine protein reversible cysteine oxidation. nameOfConference


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  • Rudyk O, Phinikaridou A, Prysyazhna O et al. (2013). Protein kinase G oxidation is a major cause of injury during sepsis. nameOfConference


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  • Burgoyne JR, Eaton P (2013). Approaches for Monitoring PKG1α Oxidative Activation. nameOfConference


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  • Charles R, Jayawardhana T, Eaton P (2014). Gel-based methods in redox proteomics. nameOfConference


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  • Burgoyne JR, Din HM, Eaton P et al. (2013). Response to Detailed Aspects of Redox Signaling in Cardiac Physiology and Pathology. nameOfConference


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  • Burgoyne JR, Eaton P (2013). Chapter Seven Detecting Disulfide-Bound Complexes and the Oxidative Regulation of Cyclic Nucleotide-Dependent Protein Kinases by H2O2. nameOfConference


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  • Fernandez-Caggiano M, Schroder E, Burgoyne J et al. (2012). Characterization of Redox Changes in Cardiac DJ-1 during Oxidant Stress. nameOfConference


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  • Schroder E, Prysyazhna O, Charles R et al. (2012). Detection of Systemic Modification of Proteins in Mice by Sulforaphane after Oral Consumption. nameOfConference


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  • Prysyazhna O, Cuello F, Eaton P (2012). Impaired Diastolic Relaxation in Cys42Ser PKGIalpha Mutant Mice. nameOfConference


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  • Burgoyne JR, Rudyk O, Eaton P (2012). Protein Kinase a Regulatory RI Oxidation Mediates Angiogenesis. nameOfConference


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  • Burgoyne JR, Prysyazhna O, Rudyk O et al. (2012). cGMP Impedes Disulfide Activation of Protein Kinase G: Implications in Blood Pressure Regulation. nameOfConference


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  • Burgoyne JR, Mongue-Din H, Eaton P et al. (2012). Redox Signaling in Cardiac Physiology and Pathology. nameOfConference


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  • Burgoyne JR, Prysyazhna O, Rudyk O et al. (2012). cGMP-Dependent Activation of Protein Kinase G Precludes Disulfide Activation. nameOfConference


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  • Burgoyne JR, Oka S-I, Ale-Agha N et al. (2013). Hydrogen Peroxide Sensing and Signaling by Protein Kinases in the Cardiovascular System. nameOfConference


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  • Burgoyne⁎ JR, Rudyk O, Eaton P (2012). A potential role for PKA oxidation in growth factor mediated angiogenesis. nameOfConference


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  • Fernandez-Caggiano⁎ M, Schroder E, Eaton P (2012). Dynamic and Complex Redox-Dependent Modifications of DJ-1 in Cardiac Cells and Tissue During Oxidative Stress. nameOfConference


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  • Burgoyne⁎ JR, Prysyazhna O, Eaton P (2012). Dynamic interplay between classical and oxidative activation of PKG1α - implications for blood pressure control. nameOfConference


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  • Rudyk⁎ O, Prysyazhna O, Eaton P (2012). Nitroglycerin fails to lower blood pressure in redox-dead Cys42Ser PKG1α knock-in mouse. nameOfConference


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  • Zhang M, Takimoto E, Lee D-I et al. (2012). Pathological Cardiac Hypertrophy Alters Intracellular Targeting of Phosphodiesterase Type 5 From Nitric Oxide Synthase-3 to Natriuretic Peptide Signaling. nameOfConference


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  • Rudyk O, Prysyazhna O, Burgoyne JR et al. (2012). Loss of nitroglycerin-induced blood pressure lowering in redox-dead Cys42Ser PKG1α knock-in mouse. nameOfConference


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  • Rudyk O, Prysyazhna O, Burgoyne JR et al. (2012). Nitroglycerin Fails to Lower Blood Pressure in Redox-Dead Cys42Ser PKG1&agr; Knock-In Mouse. nameOfConference


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  • Prysyazhna O, Rudyk O, Eaton P (2012). Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension. nameOfConference


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  • Prysyazhna O, Rudyk O, Eaton P (2012). ATTENUATED EDHF-RESPONSE UNDERLIES HYPERTENSION IN REDOX-DEAD CYS42SER PKGIα KNOCK-IN MOUSE. nameOfConference

    DOI: doi

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  • Prysyazhna O, Rudyk O, Eaton P (2011). Cys42Ser Substitution in Murine Protein Kinase G1alpha Eliminates Oxidant Sensing To Cause Hypertension. nameOfConference


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  • Rudyk O, Prysyazhna O, Burgoyne J et al. (2011). Oxidation-Induced Activation of PKG 1alpha Contributes To Nitroglycerin-Induced Vasorelaxation. nameOfConference


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  • Burgoyne JR, Eaton P (2011). Contemporary techniques for detecting and identifying proteins susceptible to reversible thiol oxidation. nameOfConference


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  • Shao D, Oka S-I, Brady CD et al. (2012). Redox modification of cell signaling in the cardiovascular system. nameOfConference


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  • Prysyazhna O, Rudyk O, Eaton P (2011). High blood pressure and lost EDHF response in redox dead Cys42Ser PKGIα knock-in mouse. nameOfConference


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  • Akaike T, van der Vliet A, Eaton P (2011). Frontiers in nitric oxide and redox signaling. nameOfConference


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  • Ray R, Murdoch CE, Wang M et al. (2011). Endothelial Nox4 NADPH Oxidase Enhances Vasodilatation and Reduces Blood Pressure In Vivo. nameOfConference


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  • Charles RL, Burgoyne JR, Mayr M et al. (2011). Redox Regulation of Soluble Epoxide Hydrolase by 15-Deoxy-&Dgr;-Prostaglandin J2 Controls Coronary Hypoxic Vasodilation. nameOfConference


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  • Burgoyne JR, Rudyk O, Mayr M et al. (2011). Nitrosative protein oxidation is modulated during early endotoxemia. nameOfConference


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  • Maller C, Schröder E, Eaton P (2011). Glyceraldehyde 3-Phosphate Dehydrogenase is Unlikely to Mediate Hydrogen Peroxide Signaling: Studies with a Novel Anti-Dimedone Sulfenic Acid Antibody. nameOfConference


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  • Madhani M, Hall AR, Cuello F et al. (2010). Phospholemman Ser69 phosphorylation contributes to sildenafil-induced cardioprotection against reperfusion injury. nameOfConference


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  • Burgoyne JR, Eaton P (2010). Oxidant Sensing by Protein Kinases A and G Enables Integration of Cell Redox State with Phosphoregulation. nameOfConference


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  • Burgoyne JR, Eaton P (2010). Chapter 15 A Rapid Approach for the Detection, Quantification, and Discovery of Novel Sulfenic Acid or S-Nitrosothiol Modified Proteins Using a Biotin-Switch Method. nameOfConference


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  • Burgoyne JR, Eaton P (2009). Transnitrosylating Nitric Oxide Species Directly Activate Type I Protein Kinase A, Providing a Novel Adenylate Cyclase-independent Cross-talk to β-Adrenergic-like Signaling*. nameOfConference


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  • Schröder E, Eaton P (2009). Hydrogen Peroxide and Cysteine Protein Signaling Pathways. nameOfConference


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  • Burgoyne JR, Eaton P (2009). Beating the silent killer: A new way to relax. nameOfConference

    DOI: doi

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  • Eaton P, Clements‐Jewery H (2008). Peroxynitrite: in vivo cardioprotectant or arrhythmogen?. nameOfConference


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  • Charles RL, Eaton P (2008). Redox signalling in cardiovascular disease. nameOfConference


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  • Schröder E, Brennan JP, Eaton P (2008). Cardiac peroxiredoxins undergo complex modifications during cardiac oxidant stress. nameOfConference


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  • Schröder E, Eaton P (2008). Hydrogen peroxide as an endogenous mediator and exogenous tool in cardiovascular research: issues and considerations. nameOfConference


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  • Bell JR, Kennington E, Fuller W et al. (2008). Characterization of the phospholemman knockout mouse heart: depressed left ventricular function with increased Na-K-ATPase activity. nameOfConference


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  • Bell JR, Eaton P, Shattock MJ (publicationYear). ROLE OF p38-MITOGEN-ACTIVATED PROTEIN KINASE IN ISCHAEMIC PRECONDITIONING IN RAT HEART. nameOfConference


    QMRO: qmroHref
  • Burgoyne JR, Madhani M, Cuello F et al. (2007). Cysteine Redox Sensor in PKGIa Enables Oxidant-Induced Activation. nameOfConference


    QMRO: qmroHref
  • Charles RL, Schröder E, May G et al. (2007). Protein Sulfenation as a Redox Sensor Proteomics Studies Using a Novel Biotinylated Dimedone Analogue*. nameOfConference


    QMRO: qmroHref
  • Brennan JP, Eaton P (2006). Oxidized Proteins in Cardiac Ischemia and Reperfusion. nameOfConference


    QMRO: qmroHref
  • Brennan JP, Bardswell SC, Burgoyne JR et al. (2006). Oxidant-induced Activation of Type I Protein Kinase A Is Mediated by RI Subunit Interprotein Disulfide Bond Formation*. nameOfConference


    QMRO: qmroHref
  • Eaton P (2006). Protein thiol oxidation in health and disease: Techniques for measuring disulfides and related modifications in complex protein mixtures. nameOfConference


    QMRO: qmroHref
  • EATON P, SHATTOCK MJ (2002). Purification of Proteins Susceptible to Oxidation at Cysteine Residues: Identification of Malate Dehydrogenase as a Target for S‐Glutathiolation. nameOfConference


    QMRO: qmroHref
  • Brennan JP, Bardswell SC, Burgoyne JR et al. (2006). Direct activation of type I protein kinase a (PKA) by oxidants independently of cAMP is mediated by RI subunit interprotein disulphide bond formation. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Brennan JP, Miller JIA, Fuller W et al. (2006). The Utility of N,N-Biotinyl Glutathione Disulfide in the Study of Protein S-Glutathiolation*. nameOfConference


    QMRO: qmroHref
  • Eaton P, Bell RM, Cave AC et al. (2005). Ischemic Preconditioning: A Potential Role for Protein S-Thiolation?. nameOfConference


    QMRO: qmroHref
  • Eaton P, Shattock MJ (2005). Protein S-Thiolation: Emphasis on Cell Signaling and Gene Expression. nameOfConference


    QMRO: qmroHref
  • Silverman BDZ, Fuller W, Eaton P et al. (2005). Serine 68 phosphorylation of phospholemman: acute isoform-specific activation of cardiac Na/K ATPase. nameOfConference


    QMRO: qmroHref
  • Saurin AT, Neubert H, Brennan JP et al. (2004). Widespread sulfenic acid formation in tissues in response to hydrogen peroxide. nameOfConference


    QMRO: qmroHref
  • Brennan JP, Wait R, Begum S et al. (2004). Detection and Mapping of Widespread Intermolecular Protein Disulfide Formation during Cardiac Oxidative Stress Using Proteomics with Diagonal Electrophoresis*. nameOfConference


    QMRO: qmroHref
  • Fuller W, Eaton P, Bell JR et al. (2004). Ischemia‐induced phosphorylation of phospholemman directly activates rat cardiac Na/K ATPase. nameOfConference


    QMRO: qmroHref
  • THOMAS JD, EATON P (1996). Accumulation of free amino acids and humic substances in a freshwater modular system and their ecological significance. nameOfConference


    QMRO: qmroHref
  • Fuller W, Parmar V, Eaton P et al. (2003). Cardiac ischemia causes inhibition of the Na/K ATPase by a labile cytosolic compound whose production is linked to oxidant stress. nameOfConference


    QMRO: qmroHref
  • LEUNG K, Shattock MJ, Pratt JR et al. (2003). Reversible cysteine-targeted oxidation of proteins during renal oxidative stress. nameOfConference


    QMRO: qmroHref
  • Eaton P, Wright N, Hearse DJ et al. (2002). Glyceraldehyde Phosphate Dehydrogenase Oxidation During Cardiac Ischemia and Reperfusion. nameOfConference


    QMRO: qmroHref
  • Eaton P, Fuller W, Shattock MJ (2002). S-Thiolation of HSP27 Regulates Its Multimeric Aggregate Size Independently of Phosphorylation*. nameOfConference


    QMRO: qmroHref
  • Eaton P, Byers HL, Leeds N et al. (2002). Detection, Quantitation, Purification, and Identification of Cardiac Proteins S-Thiolated during Ischemia and Reperfusion*. nameOfConference


    QMRO: qmroHref
  • Eaton P, Fuller W, Bell JR et al. (2001). α B Crystallin Translocation and Phosphorylation: Signal Transduction Pathways and Preconditioning in the Isolated Rat Heart. nameOfConference


    QMRO: qmroHref
  • Eaton P, Hearse DJ, Shattock MJ (2001). Lipid hydroperoxide modification of proteins during myocardial ischaemia. nameOfConference


    QMRO: qmroHref
  • Fuller W, Eaton P, Medina RA et al. (2001). Differential Centrifugation Separates Cardiac Sarcolemmal and Endosomal Membranes from Langendorff-Perfused Rat Hearts. nameOfConference


    QMRO: qmroHref
  • Eaton P, Awad WI, Miller JI et al. (2000). Ischemic Preconditioning: a Potential Role for Constitutive Low Molecular Weight Stress Protein Translocation and Phosphorylation?. nameOfConference


    QMRO: qmroHref
  • Eaton P, Thomas JD (1999). The accumulation and metabolism of amino acids by Biomphalaria glabrata, a freshwater pulmonate snail. nameOfConference


    QMRO: qmroHref
  • Eaton P, Li J-M, Hearse DJ et al. (1999). Formation of 4-hydroxy-2-nonenal-modified proteins in ischemic rat heart. nameOfConference


    QMRO: qmroHref
  • Thomas JD, Eaton P (1998). The Origins, Fate, and Ecological Significance of Free Amino Compounds Released by Freshwater Pulmonate Snails. nameOfConference


    QMRO: qmroHref
  • Thomas JD, Eaton P (1996). The accumulation of amino-acids and humic substances in media conditioned by axenic and non-axenic duckweed (Lemna minor L.) and their possible ecological significance. nameOfConference


    QMRO: qmroHref
  • Thomas JD, Eaton P (1996). The spatio-temporal patterns and ecological significance of free amino acids and humic substances in contrasting oligotrophic and eutrophic freshwater ecosystems. nameOfConference


    QMRO: qmroHref
  • Thomas JD, Eaton P (1993). Amino acid medleys of snail origin as possible sources of information for conspecifics, schistosome miracidia and predators. nameOfConference


    QMRO: qmroHref

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