Dr Suzanne Eldridge

Profile

Dr Suzanne Eldridge is a molecular biologist with a background in engineering whose main research interest is in the regeneration of musculoskeletal tissues. During her PhD she discovered the role of Agrin in cartilage homeostasis. Her predominant aim is to develop new therapeutic technologies which will either prevent cartilage breakdown or enhance cartilage repair, for use in disease (such as osteoarthritis) and following cartilage trauma.

Research

Group members

Aida Barawi (PhD student); Manasi Sayilakshmy (Technician); Zara Khan (PhD student)

Summary

Dr Eldridge is a molecular biologist with a background in engineering whose main research interest is in the regeneration of musculoskeletal tissues. During her PhD she discovered the role of Agrin in cartilage homeostasis. Her predominant aim is to develop new therapeutic technologies which will either prevent cartilage breakdown or enhance cartilage repair, for use in disease (such as osteoarthritis) and following cartilage trauma.

Opportunities in the group

Dr Eldridge has a range of projects available to students including:

• Short/long term undergraduate projects (either as part of a degree programme or independently)
• MSc projects
• PhD studentships (funded when possible) 

Please email Dr Eldridge at s.e.eldridge@qmul.ac.uk for more information.

Publications

• Caxaria S, Kouvatsos N, Eldridge SE et al. (2022). Disease modification and symptom relief in osteoarthritis using a mutated GCP-2/CXCL6 chemokine. nameOfConference

  
  

  DOI: 10.15252/emmm.202216218

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/82578
• Thorup A-S, Dell’Accio F, Eldridge SE (2023). A Mouse Model of Acute Cartilage Injury and Repair. nameOfConference

  
  

  DOI: 10.1007/978-1-0716-2839-3_24

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/82668
• Eldridge S, Barawi A, Thorup AS et al. (2022). AB0156 INTRA-ARTICULAR AGRIN PROVIDES DIRECT PAIN RELIEF IN OSTEOARTHRITIS AND CARTILAGE DEFECTS. nameOfConference

  
  

  DOI: 10.1136/annrheumdis-2022-eular.3483

  
  

  QMRO: qmroHref
• Thorup A-S, Wilson J, Strachan D et al. (2022). BLOCKING ROR2 IMPROVES CARTILAGE INTEGRITY AND PROVIDES PAIN RELIEF IN OSTEOARTHRITIS, IN PART BY MODULATING YAP SIGNALLING. nameOfConference

  
  

  DOI: 10.1016/j.joca.2022.02.201

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/95161
• THORUP A, Caxaria S, Dell'Accio F et al. (2022). In vivo potency assay for the screening of bioactive molecules on cartilage formation. nameOfConference

  
  

  DOI: 10.1038/s41684-022-00943-y

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/76951
• Eldridge S, Barawi A, Wang H et al. (2021). AB0039 AGRIN REPAIRS BONE AND CARTILAGE IN VIVO. nameOfConference

  
  

  DOI: 10.1136/annrheumdis-2021-eular.2584

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/73100
• Thorup AS, Strachan D, Caxaria S et al. (2021). OP0200 BLOCKING ROR2 IMPROVES CARTILAGE INTEGRITY AND PROVIDES PAIN RELIEF IN OSTEOARTHRITIS. nameOfConference

  
  

  DOI: 10.1136/annrheumdis-2021-eular.2358

  
  

  QMRO: qmroHref
• Thomas B, Eldridge S, Nosrati B et al. (2021). WNT3A-loaded exosomes enable cartilage repair. nameOfConference

  
  

  DOI: 10.1002/jev2.12088

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/68377
• Nalesso G, Thorup A-S, Eldridge SE et al. (publicationYear). Calcium calmodulin kinase II activity is required for cartilage homeostasis in osteoarthritis. nameOfConference

  
  

  DOI: 10.1038/s41598-021-82067-w

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/70801
• Thorup A-S, Strachan D, Caxaria S et al. (2020). ROR2 blockade as a therapy for osteoarthritis. nameOfConference

  
  

  DOI: 10.1126/scitranslmed.aax3063

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/67172
• Eldridge SE, Barawi A, Wang H et al. (2020). Agrin induces long term osteochondral regeneration by supporting repair morphogenesis. nameOfConference

  
  

  DOI: 10.1126/scitranslmed.aax9086

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/67045
• Thorup A, Dell'Accio F, Eldridge SE (2021). Lessons from joint development for cartilage repair in the clinic. nameOfConference

  
  

  DOI: 10.1002/dvdy.228

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/66354
• Pengas I, Eldridge S, Assiotis A et al. (2018). MMP‐3 in the peripheral serum as a biomarker of knee osteoarthritis, 40 years after open total knee meniscectomy. nameOfConference

  
  

  DOI: 10.1186/s40634-018-0132-x

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/66334
• Thorup A-S, Eldridge SE, Caxaria S et al. (2017). A Potency Assay for Assessing the Chondrogenic Efficiency of Bioactive Molecules in Human Cartilage in vivo. nameOfConference

  
  

  DOI: 10.1016/j.joca.2017.02.462

  
  

  QMRO: qmroHref
• Eldridge SE, Thomas BL, Shanmuganathan K et al. (2017). Agrin inhibits canonical WNT signalling through LRP4. nameOfConference

  
  

  DOI: 10.1016/j.joca.2017.02.281

  
  

  QMRO: qmroHref
• Thomas BL, Nalesso G, Eldridge SE et al. (2017). WNT16 is up-regulated in the joint following inflammation. nameOfConference

  
  

  DOI: 10.1016/j.joca.2017.02.264

  
  

  QMRO: qmroHref
• nalesso, thomas, sherwood JC et al. (publicationYear). WNT16 antagonises excessive canonical WNT activation and protects cartilage in osteoarthritis. nameOfConference

  
  

  DOI: 10.1136/annrheumdis-2015-208577

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/12224
• Eldridge SE, Petrycki E, Pitzalis C et al. (2016). MMP3 cleaves agrin in cartilage and reduces its chondrogenic potency. nameOfConference

  
  

  DOI: 10.1016/j.joca.2016.01.676

  
  

  QMRO: qmroHref
• Nalesso G, Wagner K, Bertrand J et al. (2016). Pharmacological Blockade of CAMKII is Detrimental for Osteoarthritis Progression. 2016 OARSI World Congress on Osteoarthritis

  
  

  DOI: 10.1016/j.joca.2016.01.292

  
  

  QMRO: qmroHref
• Eldridge S, Nalesso G, Ismail H et al. (2016). Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo. nameOfConference

  
  

  DOI: 10.1136/annrheumdis-2015-207316

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/18402
• Sherwood JC, Bertrand J, Eldridge SE et al. (2014). Cellular and molecular mechanisms of cartilage damage and repair. nameOfConference

  
  

  DOI: 10.1016/j.drudis.2014.05.014

  
  

  QMRO: qmroHref
• Eldridge S, Vicente-Greco K, Nalesso G et al. (2014). Agrin expression is downregulated in OA and is required for chondrocyte differentiation. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Eldridge S, Vicent-Greco K, Nalesso G et al. (2013). Agrin expression is downregulated in OA and is required for chondrocyte differentiation. nameOfConference

  
  

  DOI: 10.1016/j.joca.2013.02.238

  
  

  QMRO: qmroHref
• Nalesso G, Thomas BL, Eldridge SE et al. (2013). Wnt5a/CaMKII pathway is activated in osteoarthritis and promotes loss of chondrocyte phenotype. nameOfConference

  
  

  DOI: 10.1016/j.joca.2013.02.466

  
  

  QMRO: qmroHref

News

• Doubling down on osteoarthritis (Nature), October 2020
• New molecule repairs cartilage and relieves symptoms of osteoarthritis (Queen Mary University of London), September 2020
• BBC Radio 5 Live interview (14:38), (BBC) September 2020
• Agrin induces long-term osteochondral regeneration by supporting repair morphogenesis (Science Translational Medicine), September 2020
• ROR2 blockade as a therapy for osteoarthritis (Science Translational Medicine), September 2020
• Preventing the pain of osteoarthritis - do molecules and proteins hold the answers? (Centre for Sport, Exercise & Osteoarthritis Research / Versus Arthritis), August 2017