Skip to main content
The William Harvey Research Institute - Faculty of Medicine and Dentistry
  1. WHRI
  2. People
  3. Academic staff
  4. Items

Professor Rizgar Mageed

Rizgar

Professor of Experimental Immunology

Centre: Experimental Medicine and Rheumatology

Email: r.a.mageed@qmul.ac.uk
Telephone: +44(0) 20 7882 3989

Profile

ORCID iD: 0000-0003-1561-784X

Rizgar Mageed first qualified from the College of Pharmacy at Baghdad University in 1976. He was awarded his PhD at the Royal London Hospital Medical School, London University in 1985. He was appointed Research Fellow at the Department of Immunology University of Birmingham Medical School in 1984 where he worked until 1990 and then joined the Kennedy Institute of Rheumatology as a Senior Scientist. In 1996, Rizgar was appointed Senior Lecturer at Imperial College. In 2000, Rizgar was awarded Arthritis Research-UK Fellowship and appointed Senior Lecturer at the Centre for Rheumatology at University College London. Rizgar joined Queen Mary University of London in May 2003. In 2009 Rizgar become a fellow of the Royal College of Pathologists (FRCPath) and in 2014 was awarded his fellowship by the Royal College of Physicians (FRCP).

Research

Group members

  • Research fellows: Dr. T. E. Taher; Dr. J. Bystrom
  • PhD students: Miss N. Nordin; Mr. M. Albogami; Mr. H. Muhammad; Dr. G. Mittal

Bone and Joint Research Unit

Our studies are focused on defining the molecular basis of humoral autoimmunity in patients with rheumatic diseases. These studies explore how abnormalities in intracellular signaling pathways in lymphocytes promote hyperactivity and autoimmunity. Recent studies have identified defects in key intracellular pathways in B-lymphocytes in patients with systemic lupus erythematosus (SLE). These studies showed enhanced activation of signaling pathways linked with the B-cell receptor (BCR) and the PI-3 kinase. The effect of treating SLE patients with B-lymphocyte depleting antibodies on signaling defects is also being examined. Other studies examine how biological anti-TNF? therapies modulate the immune system in patients with rheumatoid arthritis (RA). These studies show that treatment with biological anti-TNF? agents influence humoral and cellular immunity and promote the expansion of T-helper 17 (TH17) lymphocytes. Excess activation of TH17 cells results in incomplete responsiveness of patients to anti-TNF? therapy. Most recent experiments aim to explore these discoveries to develop therapies that selectively target proteins and signaling pathways in lymphocytes from patients with autoimmune diseases. In this regard, we have developed and are assessing recombinant single chain variable regions (scFv) of antibodies and small molecular inhibitors to deliver inhibitors of defective signaling pathways.

B-lymphocytes in patients with SLE have reduced level of signalling molecules that help regulate cellular functions. (A) Confocal microscopy depicting reduced Lyn level and translocation to lipid raft signalling microdomains in SLE B-lymphocytes compared with a healthy individual. Translocation of Lyn (green) into lipid raft microdomains (red) is indicated by yellow patches from merging the green and red colours. The abnormality in Lyn expression is associated with increased CD45 translocation to lipid raft signalling microdomains (B). Other molecules that partake in regulating Lyn, such as Csk (C), and c-Cbl (D) are not affected. [Scale bar in red lines= 5µm). Quantification of signalling molecule translocation shows an inverse relationship between Lyn and CD45 (E and F).

Publications

  • Clanchy FI, Borghese F, Bystrom J et al. (2024). Inflammatory disease status and response to TNF blockade are associated with mechanisms of endotoxin tolerance. nameOfConference


  • Al-Bogami MM, Alkhorayef M, Sulieman A et al. (2024). The clinical assessment of changes in bone density in rheumatoid arthritis patients': Role of DEXA scan and bone turnover biomarkers. nameOfConference


  • Beesley C, Goldman N, Abraham D et al. (2024). OA26 Paired bulk and single cell analysis of transitional B cells in systemic sclerosis highlights defective peripheral tolerance. nameOfConference


  • Goldman NR, Tynan A, Beesley C et al. (2023). P153 Rituximab and tocilizumab and their effect on lung disease progression in scleroderma: a retrospective cohort study at a single centre. nameOfConference


  • Beesley C, Cole A, Goldman N et al. (2023). P157 Distinct differences in complement perturbation between scleroderma-related interstitial lung disease with and without emphysema. nameOfConference


    QMRO: qmroHref
  • Beesley CF, Goldman NR, Taher TE et al. (publicationYear). Dysregulated B cell function and disease pathogenesis in systemic sclerosis. nameOfConference


  • Al-Bogami MM, Akanle OA, Aldawood S et al. (2023). Comparison of bone mineral density changes between male and female osteoporosis patients using dual energy X-ray absorptiometry scan. nameOfConference


  • Bystrom J, Taher TE, Henson SM et al. (publicationYear). Metabolic requirements of Th17 cells and of B cells: Regulation and defects in health and in inflammatory diseases. nameOfConference


  • Clanchy FIL, Borghese F, Bystrom J et al. (2022). Disease status in human and experimental arthritis, and response to TNF blockade, is associated with MHC class II invariant chain (CD74) isoform expression. nameOfConference


  • Beesley C, Cole A, Goldman N et al. (2022). Distinct Differences in Complement Perturbation Between Scleroderma-related Interstitial Lung Disease with and Without Emphysema. nameOfConference

    DOI: doi

  • Goldman N, Tynan A, Shah S et al. (2022). Rituximab and Tocilizumab and Their Effect on Lung Disease Progression in Scleroderma. a Retrospective Cohort Study at a Single Centre. nameOfConference

    DOI: doi

  • Al-Bogami M, Bystrom J, Clanchy F et al. (2021). TNFα inhibitors reduce bone loss in rheumatoid arthritis independent of clinical response by reducing osteoclast precursors and IL-20. nameOfConference


  • Clanchy FIL, Borghese F, Bystrom J et al. (2021). TLR expression profiles are a function of disease status in rheumatoid arthritis and experimental arthritis. nameOfConference


  • Taher TE, Bystrom J, Mignen O et al. (2020). CD5 and B lymphocyte responses: multifaceted effects through multitudes of pathways and channels. nameOfConference


  • Bystrom J, Taher TE, Mageed RA (2020). Metabolic Pathways Underpinning Lymphocyte Differentiation and Responses in Health and Disease. nameOfConference


  • Bystrom J, Clanchy FIL, Taher TE et al. (2019). Functional and phenotypic heterogeneity of Th17 cells in health and disease. nameOfConference


  • Taher TE, Ong VH, Bystrom J et al. (2017). Defective regulation of autoreactive IL-6-producing transitional B lymphocytes is associated with disease in patients with systemic sclerosis.. nameOfConference


  • Taher TE, Bystrom J, Ong VH et al. (2017). Intracellular B Lymphocyte Signalling and the Regulation of Humoral Immunity and Autoimmunity.. nameOfConference


  • Bystrom J, Clanchy FI, Taher TE et al. (2017). Response to Treatment with TNFα Inhibitors in Rheumatoid Arthritis Is Associated with High Levels of GM-CSF and GM-CSF+ T Lymphocytes.. nameOfConference


  • Clanchy FI, Williams RO, Mageed RA (publicationYear). Lymphocytes: Precursor Frequencies. nameOfConference


    QMRO: qmroHref
  • Bystrom J, Clanchy FI, Taher TE et al. (2018). TNFα in the regulation of Treg and Th17 cells in rheumatoid arthritis and other autoimmune inflammatory diseases. nameOfConference


  • Garaud S, Taher TE, Debant M et al. (2018). CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes. nameOfConference


  • Al-Bogami MM, Alkhorayef MA, Bystrom J et al. (2015). Favorable therapeutic response of osteoporosis patients to treatment with intravenous zoledronate compared with oral alendronate. nameOfConference


  • Simon Q, Pers J-O, Cornec D et al. (publicationYear). In-depth characterization of CD24highCD38high transitional human B cells reveals different regulatory profiles. nameOfConference


  • Simon Q, Pers J-O, Cornec D et al. (2015). AB0032 In-Depth Characterization of Cd24Highcd38High Transitional Human B Cells Reveals Different Regulatory Profiles and Are Abnormally Distributed in Autoimmune Diseases. nameOfConference


  • Bystrom J, Taher TE, Muhyaddin MS et al. (2015). Harnessing the Therapeutic Potential of Th17 Cells. nameOfConference


  • Hillion S, Simon Q, Cornec D et al. (2015). A1.21 In-depth characterisation of CD24highCD38high transitional human B cells reveals different regulatory profiles. nameOfConference


    QMRO: qmroHref
  • Simon Q, Cornec D, Mageed R et al. (2015). In-Depth Characterization of CD24highCD38high Transitional Human B Cells Reveals Different Regulatory Profiles and are Abnormally Distributed in Sjogren's Syndrome. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Bystrom J, Taher T, Al-Bogami M et al. (2014). THU0500 Cytokine Production Identifies A Subset of Rheumatoid Arthritis Patients T Lymphocytes That is Associated with Responsiveness to Biologic Anti-TNF-Alpha Agents. nameOfConference


  • Albogami MM, Jawad AS, Mageed RA (2014). Bone loss in osteoporosis and arthritis. Pathogenesis and therapeutic strategies.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Albogami MM, Jawad AS, Mageed RA (2014). Bone loss in osteoporosis and arthritis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Muhammad H, Taher T, Mullen L et al. (2014). Development of a novel approach for targeted delivery of siRNA to B lymphocytes with a potential application in cancer. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Taher TE, Muhammad HA, Rahim A et al. (2013). Aberrant B-lymphocyte responses in lupus: inherent or induced and potential therapeutic targets.. nameOfConference


  • Taher TE, Muhammad HA, Bariller E et al. (2013). B-lymphocyte signalling abnormalities and lupus immunopathology.. nameOfConference


  • Bystrom J, Al-Adhoubi N, Al-Bogami M et al. (2013). Th17 lymphocytes in respiratory syncytial virus infection.. nameOfConference


  • Nordin NI, Gibbons S, Perrett D et al. (2013). Immunomodulatory Effects of Roscoe var. (Halia Bara) ON Inflammatory Responses Relevant to Psoriasis. nameOfConference


    QMRO: qmroHref
  • Muhammad H, Taher T, Mullen L et al. (2013). Generation of a secreted scFv for specific delivery of siRNA to B-lymphocytes. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Al-Bogami MM, Alkhorayef MA, Akanle OA et al. (2013). The effects of smoking on response of osteoporosis treatment using dual energy X-ray absorptiometry scans, invited. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Alzabin S, Abraham SM, Taher TE et al. (2012). Incomplete response of inflammatory arthritis to TNFα blockade is associated with the Th17 pathway.. nameOfConference


    QMRO: qmroHref
  • Thabet Y, Cañas F, Ghedira I et al. (2012). Altered patterns of epigenetic changes in systemic lupus erythematosus and auto-antibody production: is there a link?. nameOfConference


    QMRO: qmroHref
  • Mageed RA, Garaud S, Taher TE et al. (2012). CD5 expression promotes multiple intracellular signaling pathways in B lymphocyte.. nameOfConference


    QMRO: qmroHref
  • Chernajovsky Y, Annenkov A, Herman C et al. (1998). Gene Therapy for Rheumatoid Arthritis. nameOfConference


    QMRO: qmroHref
  • Campbell R, Hofmann D, Hatch S et al. (2012). Muscle disorders111. The impact of fatigue in patients with idiopathic inflammatory myopathy: a mixed method study. nameOfConference


    QMRO: qmroHref
  • Alzabin S, Abraham SM, Taher TE et al. (2012). Incomplete response of inflammatory arthritis to TNFα blockade is associated with the Th17 pathway. nameOfConference


    QMRO: qmroHref
  • Nordin NI, D'acquisto F, Gibbons S et al. (2011). Potent anti-inflammatory compounds identified in Zingiber officinale Roscoe var. rubrum Theilade: Mechanisms of action in psoriasis. nameOfConference


    QMRO: qmroHref
  • Garaud S, Morva A, Lemoine S et al. (2011). CD5 promotes IL-10 production in chronic lymphocytic leukemia B cells through STAT3 and NFAT2 activation.. nameOfConference


    QMRO: qmroHref
  • Mittal GA, Mageed RA, Chernajovsky Y (2011). HUMAN (H161R) IL-17F MUTANT IS A DUAL ANTAGONIST OF IL-17A AND IL-17F. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Nesbitt A, Fossati G, Whittall CE et al. (2011). Cytokines and inflammatory mediators. nameOfConference


    QMRO: qmroHref
  • Nordin NI, D'Acquisto F, Gibbons S et al. (2010). Immune-modulatory effects of compounds isolated from Zingiber officinale Roscoe (var. rubrum Theilade) on immune mechanisms associated with psoriasis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • HARMER IJ, MAGEED RA, KAMINSKI A et al. (1996). Chimaeric monoclonal antibodies encoded by the human VH26 gene from naïve transgenic mice display a wide range of antigen‐binding specificities. nameOfConference


    QMRO: qmroHref
  • Séïté J-F, Cornec D, Renaudineau Y et al. (2010). IVIg modulates BCR signaling through CD22 and promotes apoptosis in mature human B lymphocytes.. nameOfConference


    QMRO: qmroHref
  • Taher TE, Parikh K, Flores-Borja F et al. (2010). Protein phosphorylation and kinome profiling reveal altered regulation of multiple signaling pathways in B lymphocytes from patients with systemic lupus erythematosus.. nameOfConference


  • Mageed RA, Taher TE, Jawad AS (2010). Disease mechanisms, genetic susceptibility and therapeutic approaches in lupus disease. nameOfConference


    QMRO: qmroHref
  • Garaud S, Le Dantec C, de Mendoza AR et al. (2009). IL-10 production by B cells expressing CD5 with the alternative exon 1B.. nameOfConference


    QMRO: qmroHref
  • Church MK, Mageed RAK, Holgate ST (1983). Human Tonsillar Mast Cells. nameOfConference


    QMRO: qmroHref
  • Alard J-E, Dueymes M, Mageed RA et al. (2009). Mitochondrial heat shock protein (HSP) 70 synergizes with HSP60 in transducing endothelial cell apoptosis induced by anti-HSP60 autoantibody.. nameOfConference


    QMRO: qmroHref
  • Mageed RA, Carson DA, Jefferis R (1988). Analysis of Rheumatoid Factor Autoantibodies in Patients with Essential Mixed Cryoglobulinaemia and Rheumatoid Arthritis. nameOfConference


    QMRO: qmroHref
  • Hajeer AH, Lazarus M, Turner D et al. (1998). IL-10 Gene Promoter Polymorphisms in Rheumatoid Arthritis: SHORT REPORT. nameOfConference


    QMRO: qmroHref
  • Jefferis R, Mageed RA (1988). The Epitope Specificity and Idiotypy of Monoclonal Rheumatoid Factors. nameOfConference


    QMRO: qmroHref
  • Youinou P, Taher TE, Pers J-O et al. (2009). B lymphocyte cytokines and rheumatic autoimmune disease.. nameOfConference


    QMRO: qmroHref
  • Garaud S, Le Dantec C, Jousse-Joulin S et al. (2009). IL-6 modulates CD5 expression in B cells from patients with lupus by regulating DNA methylation.. nameOfConference


    QMRO: qmroHref
  • Rochas C, Hillion S, Saraux A et al. (2009). Transmembrane BAFF from rheumatoid synoviocytes requires interleukin-6 to induce the expression of recombination-activating gene in B lymphocytes.. nameOfConference


    QMRO: qmroHref
  • Mageed RA, Mletzko S, Varin M et al. (2009). ALTERED MEMBRANE CD45 ISOFORM EXPRESSION AND INTRACELLULAR SIGNALLING DEFECTS IN B CELLS FROM PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS(SLE). nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Jawad AS, Taher TE, Rahim A et al. (2009). SELECTIVE TARGETING OF THE CANONICAL OR ALTERNATIVE NF-kappa B PATHWAY REVEALS NEW INSIGHTS INTO MECHANISMS OF B-LYMPHOCYTE SURVIVAL AND SELECTION. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Habib HM, Taher TE, Isenberg DA et al. (2009). Enhanced propensity of T lymphocytes in patients with systemic lupus erythematosus to apoptosis in the presence of tumour necrosis factor alpha.. nameOfConference


    QMRO: qmroHref
  • Mletzko S, Varin MM, Duchene J et al. (2008). Altered membrane expression levels of distinct CD45RB isoforms are associated with B cell hyperactivity in systemic lupus erythematosus (SLE). nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Youinou P, Taher T, Mankai A et al. (2008). Anti-CD20 in Targeting B Lymphocytes for the Treatment of Autoimmune Diseases: Clinical Benefits and Insights into the Role of B Lymphocytes in Pathophysiology. nameOfConference


    QMRO: qmroHref
  • Mageed R (2008). New Strategies and Biological Agents in the Treatment of Autoimmune Inflammatory Diseases. Progress and Challenges. nameOfConference


    QMRO: qmroHref
  • Taher TE, Tulone C, Fatah R et al. (2008). Repopulation of B-lymphocytes with restricted gene expression using haematopoietic stem cells engineered with lentiviral vectors.. nameOfConference


    QMRO: qmroHref
  • Brown CMS, Plater-Zyberk C, Mageed RA et al. (2008). Analysis of immunoglobulins secreted by hybridomas derived from rheumatoid synovia. nameOfConference


    QMRO: qmroHref
  • Deacon EM, Matthews JB, Potts AJC et al. (2008). Expression of rheumatoid factor associated cross-reactive idiotopes by glandular B cells in Sjögren's syndrome. nameOfConference


    QMRO: qmroHref
  • SCOTT BB, SADIGH S, STOW M et al. (2008). Molecular mechanisms resulting in pathogenic anti-mouse erythrocyte antibodies in New Zealand black mice. nameOfConference


    QMRO: qmroHref
  • Shokri F, Mageed RAK, Kitas GD et al. (2008). Quantification of cross-reactive idiotype-positive rheumatoid factor produced in autoimmune rheumatic diseases. An indicator of clonality and B cell proliferative mechanisms. nameOfConference


    QMRO: qmroHref
  • MACKENZIE LE, MAGEED RA, YOUINOU PY et al. (2008). Repertoire of CDS+ and CD5− cord blood B cells: specificity and expression of VH I and VH III associated idiotopes. nameOfConference


    QMRO: qmroHref
  • Jawad AS, Mangat P, Perry D et al. (2008). Anti-TNF alpha-based therapy in rheumatoid arthritis (RA): Mechanisms of action and possible causes of non-responsiveness. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • YOUINOU P, MACKENZIE LE, LAMOUR A et al. (1993). Human CD5‐positive B Cells in lymphoid malignancy and connective tissue diseases. nameOfConference


    QMRO: qmroHref
  • Zouali M, Mageed RA (2008). Cellular interactions and signalling defects in lupus(1). nameOfConference


    QMRO: qmroHref
  • Flores-Borja F, Kabouridis PS, Jury EC et al. (2007). Altered lipid raft-associated proximal signaling and translocation of CD45 tyrosine phosphatase in B lymphocytes from patients with systemic lupus erythematosus.. nameOfConference


  • VENCOVSKÝ J, MAINI RN, OLLIER WE et al. (1997). Immunoglobulin Variable Region (IgV) Gene Expression in Rheumatoid Factors from Monozygotic Twins with Rheumatoid Arthritis. nameOfConference


    QMRO: qmroHref
  • MAGEED RA, BØRRETZEN M, MOYES SP et al. (1997). Rheumatoid Factor Autoantibodies in Health and Diseasea. nameOfConference


    QMRO: qmroHref
  • MAGEED RA, MOYES SP, VENCOVSKÝ J et al. (1997). Somatic Mutation and CDR3 Length of Immunoglobulin Lambda Variable Region Genes in the Synovium of Patients with Rheumatoid Arthritis. nameOfConference


    QMRO: qmroHref
  • LYDYARD PM, MacKENZIE LE, YOUINOU PY et al. (1992). Specificity and Idiotope Expression of IgM Produced by CD5+ and CD5− Cord Blood B‐Cell Clonesa. nameOfConference


    QMRO: qmroHref
  • Moazzeni M, Mosayyebi G, Stevenson FK et al. (1994). Biased utilization of immunoglobulin variable region heavy‐ and light‐chain genes by the malignant CD5‐ B lymphocytes from patients with Burkitt's lymphoma. nameOfConference


    QMRO: qmroHref
  • SCOTT BB, SADIGH S, ANDREW EM et al. (1994). Affinity Maturation and Isotype Switch in Clonally Related Anti‐Erythrocyte Autoantibodies. nameOfConference


    QMRO: qmroHref
  • ABDERRAZIK M, MOYNIER M, JEFFFRIS R et al. (1992). Analysis of Monoclonal Rheumatoid Factors obtained from the B‐Cell Repertoire in Rheumatoid Arthritis. nameOfConference


    QMRO: qmroHref
  • MACKENZIE LE, YOUINOU PY, HICKS R et al. (1991). Auto‐ and Polyreactivity of IgM from CD5+ and CD5− Cord Blood B Cells. nameOfConference


    QMRO: qmroHref
  • MAGEED RA, CARSON DA, JEFFERIS R (1988). Immunogenic and Antigenic Epitopes of Immunoglobulins. nameOfConference


    QMRO: qmroHref
  • MAGEED RA, KIRWAN JR, HOLBOROW EJ (1991). Localization of Circulating Immune Complexes from Patients with Rheumatoid Arthritis in Murine Spleen Germinal Centres. nameOfConference


    QMRO: qmroHref
  • SHOKRI F, MAGEED RA, RICHARDSON P et al. (1993). Modulation and High Frequency Expression of Autoantibody‐Associated Cross‐Reactive Idiotypes linked to the VhI Subgroup in CD5‐Expressing B Lymphocytes from Patients with Chronic Lymphocytic Leukaemia (B‐CLL). nameOfConference


    QMRO: qmroHref
  • VENCOVSKY J, MAGEED RA, OLLIER WE et al. (1995). Monozygotic Rheumatoid Arthritis Twin Pairs Express Similar Levels of Conserved Immunoglobulin V Gene in Polyclonal Rheumatoid Factors Irrespective of Disease Status. nameOfConference


    QMRO: qmroHref
  • LYDYARD PM, QUARTEY‐PAPAFIO RP, BRÖKER BM et al. (1990). The Antibody Repertoire of Early Human B Cells. nameOfConference


    QMRO: qmroHref
  • DEANE M, MACKENZIE LE, STEVENSON FK et al. (1993). The Genetic Basis of Human Vh4 Gene Family‐Associated Cross‐Reactive Idiotype Expression in CD5+ and CD5‐ Cord Blood B‐Lymphocyte Clones. nameOfConference


    QMRO: qmroHref
  • SULEYMAN S, THOMPSON KM, FØRRE Ø et al. (1994). Three New Cross‐Reacting Idiotopes as Markers for the Products of Two Distinct Human VH3 Genes Expressed in the Early Repertoire. nameOfConference


    QMRO: qmroHref
  • Flores-Borja F, Kabouridis PS, Jury EC et al. (2006). Lyn dericiency in B cells from patients with systemic lupus erythematosus: comment on the article by Flores-Borja et al - Reply. nameOfConference


    QMRO: qmroHref
  • Shokri F, Mageed RA, Maziak BR et al. (1993). Lymphoproliferation in primary sjögren's syndrome. evidence of selective expansion of a b cell subset characterized by the expression of cross‐reactive idiotypes. nameOfConference


    QMRO: qmroHref
  • Flores-Borja F, Kabouridis PS, Jury EC et al. (2005). Decreased Lyn expression and translocation to lipid raft signaling domains in B lymphocytes from patients with systemic lupus erythematosus.. nameOfConference


  • Thompson KM, Randen I, Natvig JB et al. (1990). Human monoclonal rheumatoid factors derived from the polyclonal repertoire of rheumatoid synovial tissue: Incidence of cross‐reactive idiotopes and expression of VH and Vϰ subgroups. nameOfConference


    QMRO: qmroHref
  • Renaudineau Y, Hillion S, Saraux A et al. (2005). An alternative exon 1 of the CD5 gene regulates CD5 expression in human B lymphocytes. nameOfConference


    QMRO: qmroHref
  • Flores-Borja F, Kabouridis PS, Jury E et al. (2005). Translocation of CD45 to lipid raft signalling domains and abnormal relocation during B-lymphocyte activation in SLE. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Jury EC, Kabouridis PS, Flores-Borja F et al. (2004). ALTERED LIPID RAFT EXPRESSION AND ASSOCIATED SIGNALLING IN T LYMPHOCYTES FROM PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS (SLE). nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Flores-Borja F, Kabouridis PS, Jury E et al. (2004). ATYPICAL CO-LOCALISATION OF CD45 AND LYN TO LIPID RAFT SIGNALLING DOMAINS CORRELATES WITH B-LYMPHOCYTE HYPER RESPONSIVENESS IN PATIENTS WITH LUPUS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Kabouridis PS, MAGEED R, Flores-Borja F et al. (2004). Altered lipid raft-associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus. nameOfConference


    QMRO: qmroHref
  • Jury EC, Kabouridis PS, Flores-Borja F et al. (2004). Altered lipid raft-associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus.. nameOfConference


    QMRO: qmroHref
  • Mackworth-Young CG, Harmer IJ, Mageed RA (2003). The role of antigen in the selection of the human V3-23 immunoglobulin heavy chain variable region gene.. nameOfConference


    QMRO: qmroHref
  • Moyes SP, Brown CM, Scott BB et al. (2003). Analysis of Vκ genes in rheumatoid arthritis (RA) synovial B lymphocytes provides evidence for both polyclonal activation and antigen-driven selection. nameOfConference


    QMRO: qmroHref
  • Oliveira GGD, Izui S, Ravirajan CT et al. (2003). Diverse antigen specificity of erythrocyte-reactive monoclonal autoantibodies from NZB mice. nameOfConference


    QMRO: qmroHref
  • Jury EC, Kabouridis PS, Flores-Borja F et al. (2003). Abnormal co-localisation of CD45 and lipid rafts is associated with reduced LCK expression in T cells from patients with SLE.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Mageed RA, Prud'homme GJ (2003). Immunopathology and the gene therapy of lupus. nameOfConference


    QMRO: qmroHref
  • Jury EC, Kabouridis PS, Abba A et al. (2003). Increased ubiquitination and reduced expression of LCK in T lymphocytes from patients with systemic lupus erythematosus. nameOfConference


    QMRO: qmroHref
  • Flores-Borja F, Kabouridis PS, Jury E et al. (2003). ANALYSIS OF LIPID RAFT-ASSOCIATED SIGNALLING MOLECULES IN B CELLS FROM NORMAL AND PATIENTS WITH SLE. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Jury EC, Kabouridis PS, Flores-Borja F et al. (2003). CD45 IS ABNORMALLY ASSOCIATED WITH LIPID RAFTS IN T LYMPHOCYTES FROM PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS (SLE). nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Williams RO, Ahmed S, Isenberg DA et al. (2003). DEFICIENCY IN A-KINASE ANCHOR PROTEIN EXPRESSION IN PERIPHERAL BLOOD LEUKOCYTES FROM PATIENTS WITH SLE. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Potter, Li, Mageed et al. (1999). Molecular Characterization of the VH1‐Specific Variable Region Determinants Recognized by Anti‐Idiotypic Monoclonal Antibodies G6 and G8. nameOfConference


    QMRO: qmroHref
  • Melero, Aguilera, Mageed et al. (1998). The Frequent Expansion of a Subpopulation of B Cells that Express RF‐Associated Cross‐Reactive Idiotypes: Evidence from Analysis of a Panel of Autoreactive Monoclonal Antibodies. nameOfConference


    QMRO: qmroHref
  • MAGEED R, Lydyard PM, Youinou P (2002). B cells underpin lupus immunopathology.. nameOfConference


    QMRO: qmroHref
  • Mageed RA, Zack DJ (2002). Cross-reactivity and pathogenicity of anti-DNA autoantibodies in systemic lupus erythematosus. nameOfConference


    QMRO: qmroHref
  • MAGEED R, Zack DJ (2002). Cross-reactivity and pathogenicity of anti-DNA autoantibodies in systemic lupus erythematosus.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • MAGEED R, Ruzickova S, Zd'arsky E et al. (2002). Polymorphism in the immunoglobulin VH gene V1-69 affects susceptibility to rheumatoid arthritis in subjects lacking the HLA-DRB1 shared epitope.. nameOfConference


    QMRO: qmroHref
  • Mageed RA, Isenberg DA (2002). Tumour necrosis factor alpha in systemic lupus erythematosus and anti-DNA autoantibody production. nameOfConference


    QMRO: qmroHref
  • Moyes SP, Maini RN, Mageed RA (2001). Differential use of immunoglobulin light chain genes and B lymphocyte expansion at sites of disease in rheumatoid arthritis (RA) compared with circulating B lymphocytes. nameOfConference


    QMRO: qmroHref
  • Suleyman S, Thompson KM, Mageed RA et al. (2000). Molecular Analysis of Human Immunoglobulin Heavy Chain Variable Region Associated Determinants Recognized by Anti‐VH3 Antibodies 7B4, B6 and D12. nameOfConference


    QMRO: qmroHref
  • Williams, Moyes, Mageed (1999). Rheumatoid factor isotype switch and somatic mutation variants within rheumatoid arthritis synovium. nameOfConference


    QMRO: qmroHref
  • MAGEED R, Jarosova K, Ozen S et al. (2001). Higher Frequency of Allele 2 of the Interleukin-1 Receptor Antagonist Gene in Patients With Juvenile Idiopathic Arthritis. nameOfConference


    QMRO: qmroHref
  • MAGEED R, Mackworth-Young CG, Maziak BB et al. (2001). Rearrangement of the human heavy chain variable region gene V3-23 in transgenic mice generates antibodies reactive with a range of antigens on the basis of VHCDR3 and residues intrinsic to the heavy chain variable region.. nameOfConference


    QMRO: qmroHref
  • MAGEED R, Renaudineau Y, Pers JO et al. (2001). Recent progress in the understanding of B-cell functions in autoimmunity.. nameOfConference


    QMRO: qmroHref
  • MAGEED R, Mackworth-Young CG, Mason AN (2001). The effects of a human IgM monoclonal anticardiolipin antibody on pregnancy in a transgenic mouse model.. nameOfConference


    QMRO: qmroHref
  • Lettesjö H, Burd GP, Mageed RA (2000). CD4+ T Lymphocytes with Constitutive CD40 Ligand in Preautoimmune (NZB × NZW)F1 Lupus-Prone Mice: Phenotype and Possible Role in Autoreactivity. nameOfConference


    QMRO: qmroHref
  • Gharagozloo S, Sharifian RA, Mageed RA et al. (2000). Analysis of the expressed immunoglobulin variable region heavy chain gene products in paraproteins from Iranian patients with multiple myeloma. nameOfConference


    QMRO: qmroHref
  • Chernajovsky Y, Dreja H, Daly G et al. (2000). Immuno- and genetic therapy in autoimmune diseases. nameOfConference


    QMRO: qmroHref
  • Axford JS, Rees DH, Mageed RA et al. (1999). Increased IgA rheumatoid factor and VH1 associated cross reactive idiotype expression in patients with Lyme arthritis and neuroborreliosis. nameOfConference


    QMRO: qmroHref
  • Mason AN, Harmer IJ, Mageed RA et al. (1999). The BH1 idiotype defines a population of anticardiolipin antibodies closely associated with the antiphospholipid syndrome. nameOfConference


    QMRO: qmroHref
  • Potter KN, Li Y, Mageed RA et al. (1998). Anti-idiotypic antibody D12 and superantigen spa both interact with human VH3-encoded antibodies on the external face of the heavy chain involving FR1, CDR2 and FR3. nameOfConference


    QMRO: qmroHref
  • Annenkov AE, Moyes SP, Eshhar Z et al. (1998). Loss of original antigenic specificity in T cell hybridomas transduced with a chimeric receptor containing single-chain Fv of an anti-collagen antibody and Fc epsilonRI-signaling gamma subunit.. nameOfConference


    QMRO: qmroHref
  • Mageed R, Adams G, Woodrow D et al. (1998). Prevention of collagen-induced arthritis by gene delivery of soluble p75 tumour necrosis factor receptor. nameOfConference


    QMRO: qmroHref
  • Abadi J, Friedman J, Mageed RA et al. (1998). Human Antibodies Elicited by a Pneumococcal Vaccine Express Idiotypic Determinants Indicative of Vh3 Gene Segment Usage. nameOfConference


    QMRO: qmroHref
  • Gharagozloo S, Mageed RA, Stevenson FK et al. (1997). Analysis of immunoglobulin variable region heavy (VH) and light (VL) chain gene products in paraproteins isolated from Iranian patients with multiple myeloma. nameOfConference


    QMRO: qmroHref
  • Mageed RA, Moyes SP, Thompson KM et al. (1997). Molecular and Cellular Aspects of Human Rheumatoid Factor Production and Idiotypes. nameOfConference


    QMRO: qmroHref
  • Mageed RA (1996). The RF antigen. nameOfConference


    QMRO: qmroHref
  • MacGregor AJ, Ollier WE, Venkovsky J et al. (1995). Rheumatoid factor isotypes in monozygotic and dizygotic twins discordant for rheumatoid arthritis.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • MACGREGOR AJ, BAMBER S, CARTHY D et al. (1995). HETEROGENEITY OF DISEASE PHENOTYPE IN MONOZYGOTIC TWINS CONCORDANT FOR RHEUMATOID ARTHRITIS. nameOfConference


    QMRO: qmroHref
  • Brown CM, Fitzgerald KJ, Moyes SP et al. (1995). Sequence analysis of immunoglobulin heavy-chain variable region genes from the synovium of a rheumatoid arthritis patient shows little evidence of mutation but diverse CDR3.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Sadigh S, Scott BB, Mageed RA et al. (1994). Identification of hybridomas derived from mouse CD5+ B lymphocytes by fluorescent staining for cytoplasmic CD5 expression.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • MAGEED RA, VENCOVSKY J, MAINI RN (1994). RHEUMATOID FACTORS AND GERMLINE GENES IN RHEUMATOID ARTHRITIS: EVIDENCE OF AN INTRINSIC B-LYMPHOCYTE DEFECT?. nameOfConference


    QMRO: qmroHref
  • MAGEED R (1994). The RF antigen. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • SHOKRI F, MAGEED RA, JEFFERIS R (1993). A QUANTITATIVE ELISA FOR MEASUREMENT OF RHEUMATOID FACTOR ASSOCIATED CROSS-REACTIVE IDIOTYPES IN SERUM FROM PATIENTS WITH RHEUMATIC DISEASES. nameOfConference


    QMRO: qmroHref
  • Lydyard PM, Lamour A, MacKenzie LE et al. (1993). CD5+ B cells and the immune system. nameOfConference


    QMRO: qmroHref
  • Scott BB, Sadigh S, Stow M et al. (1993). Anti-mouse red blood cell monoclonal antibodies use functionally rearranged genes from the VH J558 family and are derived from the CD5- B-lymphocyte subpopulation.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Shokri F, Mageed RA, Richardson P et al. (1993). Immunophenotypic and idiotypic characterisation of the leukaemic B-cells from patients with prolymphocytic leukaemia: Evidence for a selective expression of immunoglobulin variable region (IGV) gene products. nameOfConference


    QMRO: qmroHref
  • Newkirk MM, Rauch J, Mageed RAK et al. (1993). Restricted immunoglobulin variable region gene usage by hybridoma rheumatoid factors from patients with systemic lupus erythematosus and rheumatoid arthritis. nameOfConference


    QMRO: qmroHref
  • Mierau R, Gause A, Küppers R et al. (1992). A human monoclonal IgA rheumatoid factor using the VkIV light chain gene. nameOfConference


    QMRO: qmroHref
  • Macgregor AJ, Carthy D, Mageed R et al. (1991). Lack of concordance for rheumatoid factor positivity ue. In a nationwide study of twins with rheumatoid arthritis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Mageed RA, MacKenzie LE, Stevenson FK et al. (1991). Selective expression of a VHIV subfamily of immunoglobulin genes in human CD5+ B lymphocytes from cord blood.. nameOfConference


  • Mageed RA, Kirwan JR, Thompson PW et al. (1991). Characterisation of the size and composition of circulating immune complexes in patients with rheumatoid arthritis.. nameOfConference


    QMRO: qmroHref
  • Silman AJ, Ollier B, Mageed RA (1991). Rheumatoid factor detection in the unaffected first degree relatives in families with multicase rheumatoid arthritis.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Shokri F, Mageed RA, Maziak BR et al. (1991). Expression of VHIII-associated cross-reactive idiotype on human B lymphocytes. Association with staphylococcal protein A binding and Staphylococcus aureus Cowan I stimulation.. nameOfConference


    QMRO: qmroHref
  • Mageed RAK, Goodall DM, Jefferis R (1990). A highly conserved conformational idiotope on human IgM rheumatoid factor paraproteins of the Wa cross-reactive idiotype family defined by a monoclonal antibody. nameOfConference


    QMRO: qmroHref
  • Shokri F, Mageed RA, Tunn E et al. (1990). Qualitative and quantitative expression of VHI associated cross reactive idiotopes within IgM rheumatoid factor from patients with early synovitis.. nameOfConference


    QMRO: qmroHref
  • Kondratowicz GM, Symmons DP, Bacon PA et al. (1990). Rheumatoid lymphadenopathy: a morphological and immunohistochemical study.. nameOfConference


    QMRO: qmroHref
  • Natvig JB, Randen I, Thompson K et al. (1990). Probing of the rheumatoid factor (RF) V gene repertoire in rheumatoid arthritis (RA) by hybridoma clones.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Crowley JJ, Mageed RA, Silverman GJ et al. (1990). The incidence of a new human cross-reactive idiotype linked to subgroup VHIII heavy chains. nameOfConference


    QMRO: qmroHref
  • SHOKRI F, MAGEED RA, JEFFERIS R et al. (1989). Monoclonal Anti-cross-reactive Idlotype Antibodies as Possible Probes for Lymphoprollferatlon in Primary Sjögren's Syndrome. nameOfConference


    QMRO: qmroHref
  • Venables PJW, Baboonian C, Horsfall AC et al. (1989). The response to Epstein-Barr virus infection in Sjögren's syndrome. nameOfConference


    QMRO: qmroHref
  • MAGEED R, Venables PJ, Baboonian C et al. (1989). The response of Epstein-Barr virus infection in Sjogren's syndrome.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Jefferis R, Mageed RA (1989). The specificity and reactivity of rheumatoid factors with human IgG.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Silverman GJ, Goldfien RD, Chen P et al. (1988). Idiotypic and subgroup analysis of human monoclonal rheumatoid factors. Implications for structural and genetic basis of autoantibodies in humans.. nameOfConference


    QMRO: qmroHref
  • Crowley JJ, Goldfien RD, Schrohenloher RE et al. (1988). Incidence of three cross-reactive idiotypes on human rheumatoid factor paraproteins.. nameOfConference


    QMRO: qmroHref
  • Jones VE, Puttick AH, Williamson EA et al. (1988). A new assay uses monoclonal anti-Rh(D) antibodies to determine rheumatoid factor specificity: reactivity to a monoclonal antibody of the Gm allotype G3m(21) is more frequent in rheumatoid patients negative for G3m(21). nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Jose SA, Griffiths H, Lunec J et al. (1987). Immunogenic and antigenic epitopes of immunoglobulin—XX. Denaturation of human IgG3 by free radicals. nameOfConference


    QMRO: qmroHref
  • Newkirk MM, Mageed RA, Jefferis R et al. (1987). Complete amino acid sequences of variable regions of two human IgM rheumatoid factors, BOR and KAS of the Wa idiotypic family, reveal restricted use of heavy and light chain variable and joining region gene segments.. nameOfConference


  • Mageed RA, Jefferis R (1987). Molecular specificity and idiotypy of human rheumatoid factors.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Mageed RA, Walker MR, Jefferis R (1986). Restricted light chain subgroup expression on human rheumatoid factor paraproteins determined by monoclonal antibodies.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Kirk AP, O'Hara BP, Mageed RA et al. (1986). Pepsinogen--an immunoglobulin binding artefact in 'collagen' preparations.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Mageed RA, Dearlove M, Goodall DM et al. (1986). Immunogenic and antigenic epitopes of immunoglobulins XVII-monoclonal antibodies reactive with common and restricted idiotopes to the heavy chain of human rheumatoid factors. nameOfConference


    QMRO: qmroHref
  • Bourne JT, Kumar P, Huskisson EC et al. (1985). Arthritis and coeliac disease.. nameOfConference


    QMRO: qmroHref

Sponsors

 

Collaborators

Internal

  • A. S. Jawad (Rheumatology)
  • David Perrett (WHRI)
  • P. Wang (Blizard Institute)

External

  • D. Isenberg (UCL)
  • R. Jefferis (Birmingham)
  • P. Taylor (Oxford)
  • R. O. Williams (Oxford)
  • S. Gibbons (UCL)
  • P. Youinou (Brest, France)
  • Y. Renaudineau (Brest, France)
  • K. Thompson (Oslo, Norway)
  • N. Chiorazzi (New York, USA)
  • D. Capra (Oklahoma, USA)
Back to top