Professor Alberto Mantovani Chair of Inflammation and Therapeutic InnovationCentre: Experimental Medicine and RheumatologyEmail: a.mantovani@qmul.ac.ukProfileResearchPublicationsNewsProfileORCID iD: 0000-0001-5578-236XAlberto Mantovani, MD, is Emeritus Professor of Pathology at the Humanitas University in Milan, Scientific Director of the Istituto Clinico Humanitas and Chair of Inflammation and Therapeutic Innovation, William Harvey Research Institute, Queen Mary University, London, UK. His attention has been focused on molecular mechanisms of innate immunity and inflammation and on the role in the tumor microenvironment and cancer progression of tumor-associated macrophages (TAM). He has contributed to the advancement of knowledge in the field of Immunology formulating new paradigms and identifying new molecules and functions. More recently he focused on COVID-19, contributing to the identification of genetic associations and of a novel severity biomarker. For his research activity, he has received several national and international awards, such as the Triennial OECI Award from the Organization of the European Cancer Institutes, the Robert Koch Award for his contribution to tumor immunology and immunotherapy, the American-Italian Cancer Foundation (AICF) Prize for Excellence in Medicine, the American Association for Cancer Research International Pezcoller Award for Extraordinary Achievement in Cancer Research and, most recently, the CIMT Lifetime Achievement Award. The broad impact of his contributions is testified by citations. As of May 2021, he has over 137,000 citations and an H-index of 173 (Scopus). Selected major honors National or International awarded in Italy 1998: Biotec Award 2004: Guido Venosta Award for Cancer Research by the President of the Republic of Italy 2005: Premio Ippocrate per la Ricerca Biomedica 2006: “Onorificenza al Merito della Repubblica Italiana” (Commendatore, knightwood equivalent) for scientific contribution by the President of the Republic of Italy 2007: Galileo Galilei Prize for Research in Biomedical Sciences (International Jury) 2012: Premio Nazionale "L'Altra Italia ... Vite da Premio" 2014: Premio Rosa Camuna 2014, Regione Lombardia 2015: Ferrari-Soave International Prize, Accademia delle Scienze, Torino. 2016: NIBIT Award, Siena 2016: Premio Roma allo Sviluppo del Paese. 2016: International Feltrinelli Prize from the Accademia dei Lincei. 2017: Premio Scanno, Fondazione Tanturri, Scanno, Italy. 2018: Medaglia d’Oro di Benemerenza Civica, Milan Municipality (Ambrogino d’Oro). International 2000: Marie T. Bonazinga Award, Society for Leukocyte Biology, Boston, USA 2006: European Federation of Immunological Societies – Schering Plough, 1st European Immunology Prize, Paris, France 2009: William Harvey Award, Oustanding Scientist 2009, London, UK. 2015: European Society for Clinical Investigation Albert Struyvenberg Medal 2015: The Milstein Award for Excellence in Interferon and Cytokine Research, International Cytokine & Interferon Society. 2016: OECI (Organization of European Cancer Institutes) Prize for contribution to Cancer Immunology and Immunotherapy. OECI awards the OECI Prize every three years. 2016: Robert Koch Award, Robert Koch Stiftung, Germany 2017: Journal of Autoimmunity dedicated Issue to Alberto Mantovani 2018: American-Italian Cancer Foundation (AICF, New York) Prize for Excellence in Medicine. 2019: American Association for Cancer Research International Pezcoller Award for Extraordinary Achievement in Cancer Research. 2019: ITOC6 – 6th Immunotherapy of Cancer Conference Lifetime Achievement Award Selected memberships, boards and academies 1995-1998: President, Italian Federation of Immunological Societies 1998-2001: President, Italian Society of Immunology 2000 to date: European Molecular Biology Organization (EMBO) Member 2002: Member, The Henry Kunkel Society 2005-2010: Board Member of the Global Alliance for Vaccines and Immunization (GAVI Alliance) 2008: Member, Faculty of 1000 Biology 2009-2010: President, International Cytokine Society 2011-2013: Board Member, International Union of Immunological Societies (IUIS) 2013-2016: Vice-President/President Elect, International Union of Immunological Societies (IUIS) 2016: Member, Accademia dei Lincei, Rome, Italy 2016: Member, Robert Koch Stiftung, Berlin 2016-2019: President, International Union of Immunological Societies (IUIS) 2017: Member, Academia Europaea 2017: Honorary Member, Scandinavian Society of Immunology ResearchTumor-associated macrophages (TAM)Demonstration in the late ‘70s of the protumor function of tumor-associated macrophages (TAM, an acronym now generally used and coined by him in the ‘70s) linking inflammation and cancer (reviewed in Balkwill and Mantovani, Lancet, 2001). TAM as an M2-like population (Bottazzi et al, Science 1983; Mantovani et al., Nature 2008; Balkwill et al., Cancer Cell 2005). Promotion of tumor progression by IL-1 (Cancer Res. 1990; 1993). First linking of a genetic event (RET/PTC rearrangement) causing cancer in humans to the construction of an inflammatory microenvironment (Borrello et al., PNAS 2005). Proof of principle that targeting tumor promoting macrophages has therapeutic value in humans (Germano et al, Cancer Cell 2013). Demonstration that PTX3 is an extrinsic oncosuppressor regulating Complement and macrophage-driven tumor promoting inflammation (Bonavita et al Cell 2015). Discovery of a novel pathway of anti-tumor immunity involving neutrophils, macrophages and unconventional, double negative T cells (Ponzetta et al, Cell 2019). Alberto Mantovani is recognized among his peers as a forerunner in the ‘70s and a “founding father” of the renaissance of the inflammation-cancer connection. For IL-1R8, see below, IL-1. ChemokinesDescription and role in TAM recruitment of a unique monocyte attractant, Monocyte Chemotactic Protein-1 (CCL2), as tumor-derived chemotactic factor (Bottazzi et al, Science 1983). Characterization of chemokines and role in pathophysiology, including dendritic cell and polarized T cell migration. Induction of chemokine production by IL-6 in endothelial cells via trans-signaling, a key component of chronic inflammation and cancer (Romano et al, Immunity 1997). Characterization of D6 as a decoy receptor for inflammatory CC chemokines (Mantovani et al, Nature Rev. Immunol 2006). Role of chemokines in carcinogenesis (for a recent contribution Bonavita et al Cell 2015). IL-1/Toll-like receptors (TLR)Endothelial cell activation by IL-1 and cytokines (Rossi et al., Science 1985; Bussolino et al, Nature 1989; Romano et al, Immunity 1997). Identification of the type II receptor as a decoy receptor, a novel concept in biology (Colotta et al, Science 1993); the discovery of a decoy receptor represented a paradigm shift after the original definition of the concept of “receptor” by Langley in the 1930’; decoy receptors are now recognized as a general, evolutionary conserved strategy to tune cytokines, chemokines and growth factors. Cloning of an intracellular isoform of the IL-1 receptor antagonist (Muzio et al., J. Exp. Med. 1995). First demonstration of MyD88 as the adaptor of mammalian Toll-Like Receptors (TLR) and identification of downstream transducers (Muzio et al., J. Exp. Med. 1998). Cloning and characterization of TIR8/SIGIRR (IL-1R8), a negative regulator of IL-1 receptor and TLR signalling (Garlanda et al, Immunity 2013; 2019). Role in carcinogenesis. In NK cells IL-1R8 serves as a checkpoint: its blocking unleashes resistance to carcinogenesis and metastasis at selected anatomical sites (Molgora et al, Nature 2017). Humoral innate immunityCloning (cDNA and genomic, mouse and human), structural and functional characterization of the first long pentraxin PTX3 as an IL-1 inducible gene (Garlanda et al, Nature 2002; Jeannin et al, Immunity 2005; Jaillon et al. J. Exp Med 2007 ; Deban et al, Nature Immunol. 2010; Jaillon et al. Immunity 2014; Bonavita et al. Cell 2015); structural immunobiology; role as a paradigm for humoral innate immunity; role as an extrinsic oncosuppresor in murine and human tumors regulating Complement and macrophage driven tumor promoting inflammation (Bonavita et al. Cell 2015); diagnostic and therapeutic translation (Cunha et al New England J. Med. 2014; ongoing). Thus, a regulator of macrophage-driven tumor promoting inflammation is a bona fide cancer gene, silenced in selected human tumors such as colorectal cancer, a finding now independently confirmed in large patients cohorts. PTX3 emerged as a strong prognostic biomarker in COVID-19 (Nature Immunology 2021).Publications Marcoccia D, Smeriglio A, Mantovani A et al. (2022). Intracellular distribution of vinclozolin and its metabolites differently affects 5α-dihydrotestosterone (DHT)-induced PSA secretion in LNCaP cells. nameOfConference DOI: 10.1016/j.reprotox.2022.05.006 QMRO: qmroHref Pipoyan D, Hovhannisyan A, Beglaryan M et al. (2022). Risk assessment of potentially toxic trace elements via consumption of dairy products sold in the city of Yerevan, Armenia. nameOfConference DOI: 10.1016/j.fct.2022.112922 QMRO: qmroHref Oliveira H, Blocquel C, Santos M et al. (2021). Semi-industrial development of nutritious and healthy seafood dishes from sustainable species. nameOfConference DOI: 10.1016/j.fct.2021.112431 QMRO: qmroHref Ferraris F, Iacoponi F, Raggi A et al. (2021). Essential and toxic elements in sustainable and underutilized seafood species and derived semi-industrial ready-to-eat products. nameOfConference DOI: 10.1016/j.fct.2021.112331 QMRO: qmroHref Ashot DP, Sergey AH, Radik MB et al. (2020). Risk assessment of dietary exposure to potentially toxic trace elements in emerging countries: A pilot study on intake via flour-based products in Yerevan, Armenia. nameOfConference DOI: 10.1016/j.fct.2020.111768 QMRO: qmroHref Pipoyan D, Stepanyan S, Beglaryan M et al. (2020). Health risk assessment of toxicologically relevant residues in emerging countries: A pilot study on Malachite Green residues in farmed freshwater fish of Armenia. nameOfConference DOI: 10.1016/j.fct.2020.111526 QMRO: qmroHref Asselta R, Paraboschi EM, Mantovani A et al. (publicationYear). ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy. nameOfConference DOI: 10.1101/2020.03.30.20047878 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/63665 Mattiola I, Tomay F, De Pizzol M et al. (2019). The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis. nameOfConference DOI: 10.1038/s41590-019-0417-y QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/58603 Ponzetta A, Carriero R, Carnevale S et al. (2019). Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors. nameOfConference DOI: 10.1016/j.cell.2019.05.047 QMRO: qmroHref Riva F, Ponzoni M, Supino D et al. (2019). IL1R8 deficiency drives autoimmunity-associated lymphoma development. nameOfConference DOI: 10.1158/2326-6066.CIR-18-0698 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/61298 Feed EPOAAPOSUIA, Bampidis V, Azimonti G et al. (publicationYear). Safety and efficacy of l‐lysine monohydrochloride and l‐lysine sulfate produced using Corynebacterium glutamicum CCTCC M 2015595 for all animal species. nameOfConference DOI: 10.2903/j.efsa.2019.5643 QMRO: qmroHref Feed EPOAAPOSUIA, Bampidis V, Azimonti G et al. (publicationYear). Safety and efficacy of l‐tryptophan produced with Escherichia coli CGMCC 11674 for all animal species. nameOfConference DOI: 10.2903/j.efsa.2019.5642 QMRO: qmroHref Feed EPOAAPOSUIA, Bampidis V, Azimonti G et al. (publicationYear). Efficacy of methyl ester of conjugated linoleic acid (t10,c12 isomer) for sows and cows for reproduction. nameOfConference DOI: 10.2903/j.efsa.2019.5614 QMRO: qmroHref Feed EPOAAPOSUIA, Bampidis V, Azimonti G et al. (publicationYear). Safety and efficacy of l‐valine produced using Corynebacterium glutamicum CGMCC 11675 for all animal species. nameOfConference DOI: 10.2903/j.efsa.2019.5611 QMRO: qmroHref Feed EPOAAPOSUIA, Bampidis V, Azimonti G et al. (publicationYear). Safety and efficacy of l‐threonine produced by fermentation with Corynebacterium glutamicum ■■■■■ for all animal species. nameOfConference DOI: 10.2903/j.efsa.2019.5603 QMRO: qmroHref Feed EPOAAPOSUIA, Bampidis V, Azimonti G et al. (publicationYear). Safety and efficacy of vitamin B2 (riboflavin 5′‐phosphate ester monosodium salt) for all animal species when used in water for drinking. nameOfConference DOI: 10.2903/j.efsa.2018.5531 QMRO: qmroHref Feed EPOAAPOSUIA, Bampidis V, Azimonti G et al. (publicationYear). Safety and efficacy of l‐threonine produced by fermentation using Escherichia coli CGMCC 7.232 for all animal species. nameOfConference DOI: 10.2903/j.efsa.2018.5458 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Scientific Opinion on the safety and efficacy of Aviax 5% (semduramicin sodium) for chickens for fattening. nameOfConference DOI: 10.2903/j.efsa.2018.5341 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Assessment of the application for renewal of authorisation of Calsporin® (Bacillus subtilis DSM 15544) for chickens for fattening. nameOfConference DOI: 10.2903/j.efsa.2018.5340 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of vitamin B12 (in the form of cyanocobalamin) produced by Ensifer spp. as a feed additive for all animal species based on a dossier submitted by VITAC EEIG. nameOfConference DOI: 10.2903/j.efsa.2018.5336 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of betaine anhydrous for food‐producing animal species based on a dossier submitted by AB Vista. nameOfConference DOI: 10.2903/j.efsa.2018.5335 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of vitamin B2 (riboflavin) produced by Ashbya gossypii DSM 23096 for all animal species based on a dossier submitted by BASF SE. nameOfConference DOI: 10.2903/j.efsa.2018.5337 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Assessment of the application for renewal of authorisation of Actisaf® Sc47 (Saccharomyces cerevisiae CNCM I‐4407) for lambs for fattening, minor dairy ruminants, horses and pigs for fattening. nameOfConference DOI: 10.2903/j.efsa.2018.5339 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of COXAM® (amprolium hydrochloride) for chickens for fattening and chickens reared for laying. nameOfConference DOI: 10.2903/j.efsa.2018.5338 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of muramidase from Trichoderma reesei DSM 32338 as a feed additive for chickens for fattening and minor poultry species. nameOfConference DOI: 10.2903/j.efsa.2018.5342 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Modification of the terms of authorisation of lecithins as a feed additive for all animal species. nameOfConference DOI: 10.2903/j.efsa.2018.5334 QMRO: qmroHref Mantovani A (2018). Characterization and Management of Uncertainties in Toxicological Risk Assessment: Examples from the Opinions of the European Food Safety Authority. nameOfConference DOI: 10.1007/978-1-4939-7899-1_10 QMRO: qmroHref Street ME, Angelini S, Bernasconi S et al. (publicationYear). Current Knowledge on Endocrine Disrupting Chemicals (EDCs) from Animal Biology to Humans, from Pregnancy to Adulthood: Highlights from a National Italian Meeting. nameOfConference DOI: 10.3390/ijms19061647 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of l‐arginine produced by fermentation using Corynebacterium glutamicum KCCM 10741P for all animal species. nameOfConference DOI: 10.2903/j.efsa.2018.5277 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of l‐arginine produced by fermentation with Escherichia coli NITE BP‐02186 for all animal species. nameOfConference DOI: 10.2903/j.efsa.2018.5276 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of Hemicell® HT (endo‐1,4‐β‐mannanase) as a feed additive for chickens for fattening, chickens reared for laying, turkey for fattening, turkeys reared for breeding, weaned piglets, pigs for fattening and minor poultry and porcine species. nameOfConference DOI: 10.2903/j.efsa.2018.5270 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of Kelforce® (l‐glutamic acid, N,N‐diacetic acid, tetrasodium salt (GLDA‐Na4)) as a feed additive for chickens for fattening. nameOfConference DOI: 10.2903/j.efsa.2018.5279 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of Taminizer D (dimethylglycine sodium salt) as a feed additive for chickens for fattening. nameOfConference DOI: 10.2903/j.efsa.2018.5268 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of cumin tincture (Cuminum cyminum L.) when used as a sensory additive for all animal species. nameOfConference DOI: 10.2903/j.efsa.2018.5273 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of fumonisin esterase from Komagataella phaffii DSM 32159 as a technological feed additive for pigs and poultry. nameOfConference DOI: 10.2903/j.efsa.2018.5269 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of Amylofeed® (endo‐1,3(4)‐β‐glucanase and endo‐1,4‐β‐xylanase and α‐amylase) as a feed additive for piglets and minor growing porcine species. nameOfConference DOI: 10.2903/j.efsa.2018.5271 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of Lactobacillus acidophilus D2/CSL (Lactobacillus acidophilus CECT 4529) as a feed additive for cats and dogs. nameOfConference DOI: 10.2903/j.efsa.2018.5278 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Guidance on the assessment of the efficacy of feed additives. nameOfConference DOI: 10.2903/j.efsa.2018.5274 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of Bacillus subtilis KCCM 10673P and Aspergillus oryzae KCTC 10258BP when used as a technological feed additive for all animal species. nameOfConference DOI: 10.2903/j.efsa.2018.5275 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety of natural mixture of dolomite plus magnesite and magnesium‐phyllosilicates (Fluidol) for all animal species. nameOfConference DOI: 10.2903/j.efsa.2018.5272 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of alpha‐amylase from Bacillus amyloliquefaciens DSM 9553, Bacillus amyloliquefaciens NCIMB 30251, Aspergillus oryzae CBS 585.94 and Aspergillus oryzae ATTC SD‐5374, endo‐1,4‐beta‐glucanase from Trichoderma reesei ATCC PTA‐10001, Trichoderma reesei ATCC SD‐6331 and Aspergillus niger CBS 120604, endo‐1,4‐beta‐xylanase from Trichoderma koningii MUCL 39203 and Trichoderma citrinoviride CBS 614.94 and endo‐1,3(4)‐beta‐glucanase from Aspergillus tubingensis MUCL 39199 as silage additives for all animal species. nameOfConference DOI: 10.2903/j.efsa.2018.5224 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of EB15 10 (Bacillus subtilis DSM 25841) as a feed additive for weaned piglets and minor porcine species. nameOfConference DOI: 10.2903/j.efsa.2018.5199 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of ZM16 10 (Bacillus amyloliquefaciens DSM 25840) as a feed additive for weaned piglets and minor porcine species. nameOfConference DOI: 10.2903/j.efsa.2018.5200 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of Coxar® (nicarbazin) for turkeys for fattening. nameOfConference DOI: 10.2903/j.efsa.2018.5214 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of Bacillus subtilis DSM 28343 as a feed additive for calves for rearing. nameOfConference DOI: 10.2903/j.efsa.2018.5220 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of Coxiril® (diclazuril) for chickens reared for laying. nameOfConference DOI: 10.2903/j.efsa.2018.5195 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Azimonti G et al. (publicationYear). Safety and efficacy of ponceau 4R for cats, dogs and ornamental fish. nameOfConference DOI: 10.2903/j.efsa.2018.5222 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Guidance on the characterisation of microorganisms used as feed additives or as production organisms. nameOfConference DOI: 10.2903/j.efsa.2018.5206 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of Bacillus subtilis DSM 28343 as a feed additive for piglets. nameOfConference DOI: 10.2903/j.efsa.2018.5221 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of Calsporin® (Bacillus subtilis DSM 15544) as a feed additive for pigs for fattening. nameOfConference DOI: 10.2903/j.efsa.2018.5219 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of ECONASE® XT (endo‐1,4‐β‐xylanase) as a feed additive for laying hens. nameOfConference DOI: 10.2903/j.efsa.2018.5216 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of ECONASE® XT (endo‐1,4‐β‐xylanase) as a feed additive for pigs for fattening. nameOfConference DOI: 10.2903/j.efsa.2018.5217 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of Lactococcus lactis NCIMB 30160 as a feed additive for all animal species. nameOfConference DOI: 10.2903/j.efsa.2018.5218 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of butylated hydroxyanisole (BHA) as a feed additive for all animal species. nameOfConference DOI: 10.2903/j.efsa.2018.5215 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety of vitamin B2 (80%) as riboflavin produced by Bacillus subtilis KCCM‐10445 for all animal species. nameOfConference DOI: 10.2903/j.efsa.2018.5223 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of Coxiril® (diclazuril) for pheasants. nameOfConference DOI: 10.2903/j.efsa.2018.5196 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of Sacox® microGranulate (salinomycin sodium) for rabbits for fattening. nameOfConference DOI: 10.2903/j.efsa.2018.5209 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of sodium saccharin when used as a feed flavour for piglets, pigs for fattening, calves for rearing and calves for fattening. nameOfConference DOI: 10.2903/j.efsa.2018.5208 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Efficacy of Cylactin® (Enterococcus faecium NCIMB 10415) as a feed additive for pigs for fattening. nameOfConference DOI: 10.2903/j.efsa.2018.5201 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of Alterion NE® (Bacillus subtilis DSM 29784) as a feed additive for minor poultry species for fattening and reared for laying. nameOfConference DOI: 10.2903/j.efsa.2018.5204 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of Pediococcus pentosaceus DSM 32291 as a silage additive for all animal species. nameOfConference DOI: 10.2903/j.efsa.2018.5202 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of hydroxy analogue of methionine and its calcium salt (ADRY+®) for all animal species. nameOfConference DOI: 10.2903/j.efsa.2018.5198 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of natural mixtures of talc (steatite) and chlorite (E 560) as a feed additive for all animal species. nameOfConference DOI: 10.2903/j.efsa.2018.5205 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of Zinc‐l‐Selenomethionine as feed additive for all animal species. nameOfConference DOI: 10.2903/j.efsa.2018.5197 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of benzoic acid for pigs and poultry. nameOfConference DOI: 10.2903/j.efsa.2018.5210 QMRO: qmroHref Feed EPOAAPOSUIA, Rychen G, Aquilina G et al. (publicationYear). Safety and efficacy of 3‐phytase FLF1000 as a feed additive for chickens reared for laying and minor poultry species. nameOfConference DOI: 10.2903/j.efsa.2018.5203 QMRO: qmroHref Mantovani A (2018). The inflammation – cancer connection. nameOfConference DOI: 10.1111/febs.14395 QMRO: qmroHref Garlanda C, Bottazzi B, Magrini E et al. (2018). PTX3, a Humoral Pattern Recognition Molecule, in Innate Immunity, Tissue Repair, and Cancer. nameOfConference DOI: 10.1152/physrev.00016.2017 QMRO: qmroHref Bonecchi R, Massara M, Bonavita O et al. (2018). ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and antimetastatic activity. nameOfConference DOI: 10.1038/s41467-018-03080-8 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/33803 Mantovani A, Santoni A (2018). Mandatory vaccination in Italy: Time for engagement of immunologists. nameOfConference DOI: 10.1002/eji.201870016 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/37984 Mantovani A (2018). Redundancy and robustness versus division of labour and specialization in innate immunity. nameOfConference DOI: 10.1016/j.smim.2017.12.006 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/50103 Mantovani A, Barajon I, Garlanda C (2018). IL‐1 and IL‐1 regulatory pathways in cancer progression and therapy. nameOfConference DOI: 10.1111/imr.12614 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/31491 Molgora M, Supino D, Mantovani A et al. (2018). Tuning inflammation and immunity by the negative regulators IL‐1R2 and IL‐1R8. nameOfConference DOI: 10.1111/imr.12609 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/51284 Molgora M, Bonavita E, Ponzetta A et al. (2017). IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity. nameOfConference DOI: 10.1038/nature24293 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/31492 Mantovani A (2017). Wandering pathways in the regulation of innate immunity and inflammation. nameOfConference DOI: 10.1016/j.jaut.2017.10.007 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/29843 Erreni M, Manfredi AA, Garlanda C et al. (2017). The long pentraxin PTX3: A prototypical sensor of tissue injury and a regulator of homeostasis. nameOfConference DOI: 10.1111/imr.12570 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/51224 Del Prete A, Martínez-Muñoz L, Mazzon C et al. (2017). The atypical receptor CCRL2 is required for CXCR2-dependent neutrophil recruitment and tissue damage.. nameOfConference DOI: 10.1182/blood-2017-04-777680 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/29746 Bergamo P, Volpe MG, Lorenzetti S et al. (2016). Human semen as an early, sensitive biomarker of highly polluted living environment in healthy men: A pilot biomonitoring study on trace elements in blood and semen and their relationship with sperm quality and RedOx status. nameOfConference DOI: 10.1016/j.reprotox.2016.07.018 QMRO: qmroHref Frazzoli C, Pouokam GB, Mantovani A et al. (2016). Health risks from lost awareness of cultural behaviours rooted in traditional medicine: An insight in geophagy and mineral intake. nameOfConference DOI: 10.1016/j.scitotenv.2016.06.028 QMRO: qmroHref Garlanda C, Jaillon S, Doni A et al. (2016). PTX3, a humoral pattern recognition molecule at the interface between microbe and matrix recognition. nameOfConference DOI: 10.1016/j.coi.2015.11.002 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/32450 La Rocca C, Tait S, Guerranti C et al. (2015). Exposure to Endocrine Disruptors and Nuclear Receptors Gene Expression in Infertile and Fertile Men from Italian Areas with Different Environmental Features. nameOfConference DOI: 10.3390/ijerph121012426 QMRO: qmroHref Proietti I, Frazzoli C, Mantovani A (publicationYear). Exploiting Nutritional Value of Staple Foods in the World’s Semi-Arid Areas: Risks, Benefits, Challenges and Opportunities of Sorghum. nameOfConference DOI: 10.3390/healthcare3020172 QMRO: qmroHref La Rocca C, Tait S, Guerranti C et al. (2014). Exposure to Endocrine Disrupters and Nuclear Receptor Gene Expression in Infertile and Fertile Women from Different Italian Areas. nameOfConference DOI: 10.3390/ijerph111010146 QMRO: qmroHref Mantovani A, Garlanda C, Allavena P (2010). Molecular pathways and targets in cancer-related inflammation. nameOfConference DOI: 10.3109/07853890903405753 QMRO: qmroHref Mantovani A, Sica A (2010). Macrophages, innate immunity and cancer: balance, tolerance, and diversity. nameOfConference DOI: 10.1016/j.coi.2010.01.009 QMRO: qmroHref Mantovani A (2010). La mala educación of Tumor-Associated Macrophages: Diverse Pathways and New Players. nameOfConference DOI: 10.1016/j.ccr.2010.01.019 QMRO: qmroHref Mantovani A, Savino B, Locati M et al. (2010). The chemokine system in cancer biology and therapy. nameOfConference DOI: 10.1016/j.cytogfr.2009.11.007 QMRO: qmroHref Mantovani A (2009). The Yin-Yang of Tumor-Associated Neutrophils. nameOfConference DOI: 10.1016/j.ccr.2009.08.014 QMRO: qmroHref Mantovani A, Garlanda C, Locati M (2009). Macrophage Diversity and Polarization in Atherosclerosis. nameOfConference DOI: 10.1161/atvbaha.108.180497 QMRO: qmroHref Mantovani A (2008). From phagocyte diversity and activation to probiotics: Back to Metchnikoff. nameOfConference DOI: 10.1002/eji.200838918 QMRO: qmroHref Mantovani A, Frazzoli C, La Rocca C (2009). Risk assessment of endocrine-active compounds in feeds. nameOfConference DOI: 10.1016/j.tvjl.2008.08.005 QMRO: qmroHref Mantovani A, Maranghi F, La Rocca C et al. (2008). The role of toxicology to characterize biomarkers for agrochemicals with potential endocrine activities. nameOfConference DOI: 10.1016/j.reprotox.2008.05.063 QMRO: qmroHref Mantovani A, Allavena P, Sica A et al. (2008). Cancer-related inflammation. nameOfConference DOI: 10.1038/nature07205 QMRO: qmroHref Mantovani A, Garlanda C, Doni A et al. (2008). Pentraxins in Innate Immunity: From C-Reactive Protein to the Long Pentraxin PTX3. nameOfConference DOI: 10.1007/s10875-007-9126-7 QMRO: qmroHref Mantovani A, Marchesi F, Porta C et al. (2007). Inflammation and cancer: Breast cancer as a prototype. nameOfConference DOI: 10.1016/j.breast.2007.07.013 QMRO: qmroHref Mantovani A, Garlanda C, Locati M et al. (2007). Regulatory pathways in inflammation. nameOfConference DOI: 10.1016/j.autrev.2007.03.002 QMRO: qmroHref Mantovani A, Sica A, Locati M (2007). New vistas on macrophage differentiation and activation. nameOfConference DOI: 10.1002/eji.200636910 QMRO: qmroHref Mantovani A, Bonecchi R, Locati M (2006). Tuning inflammation and immunity by chemokine sequestration: decoys and more. nameOfConference DOI: 10.1038/nri1964 QMRO: qmroHref Mantovani A, Balkwill F (2006). RalB Signaling: A Bridge between Inflammation and Cancer. nameOfConference DOI: 10.1016/j.cell.2006.09.019 QMRO: qmroHref Mantovani A, Schioppa T, Porta C et al. (2006). Role of tumor-associated macrophages in tumor progression and invasion. nameOfConference DOI: 10.1007/s10555-006-9001-7 QMRO: qmroHref Mantovani A, Garlanda C, Bottazzi B et al. (2006). The long pentraxin PTX3 in vascular pathology. nameOfConference DOI: 10.1016/j.vph.2006.08.011 QMRO: qmroHref Mantovani A, Maranghi F, Purificato I et al. (2006). Assessment of feed additives and contaminants: an essential component of food safety.. nameOfConference DOI: doi QMRO: qmroHref NewsContribution to Public Awareness of Science Alberto Mantovani has been actively involved in the fostering of science and scientific policies in Italy at various levels, with a focus on Immunology, Vaccines, Oncology and Public Health, taking public stands on several issues including quackery whenever appropriate. He regularly contributes to the most authoritative italian daily newspapers (eg Corriere della Sera; La Repubblica; La Stampa; Il Sole 24 Ore) and magazines (Espresso and Panorama). As of January 2020 he has been at the forfront in raising public awareness of Covid-19. He wrote five books on Immunology and Science targeted to the lay public (I Guardiani della Vita, Baldini e Castoldi, 2011; Immunità e Vaccini, Mondadori, 2016; Non avere Paura di Sognare, La Nave di Teseo, 2016; Bersaglio Mobile, Mondadori, 2018; Il Fuoco Interiore. Immunità e malattie, Mondadori 2020). He contributed to scientific (eg SuperQuark; TGR Leonardo; Radiotre Scienza; Sapiens) and general radio and television (eg Geo; Che Tempo che Fa; general national news) programs. To promote science awareness and policy together with astrophysicist Tommaso Maccacaro he founded the website http://www.scienzainrete.it. He represented Accademia dei Lincei in the European Academies Science Advisory Council (EASAC) working group on homeopathy and in the formulation of the final EASAC statement on it. Together with Guido Forni, Lorenzo Moretta and Giovanni Rezza he wrote the position paper “Vaccines. A position paper from the Accademia Nazionale dei Lincei” (2018). A revised version is now published as a book with a section on Covid-19 (I vaccini fanno bene. Perchè dobbiamo credere nella scienza per difenderci da virus e batteri; La Nave di Teseo, 2020). Together with Maurizio Cecconi and Guido Forni on behalf of the Health Commission of the Accademia dei Lincei he prepared and updates a report on COVID-19 https://www.lincei.it/sites/default/files/documenti/Commissioni/Health_committee_Covid19_Summer_report_July2020.pdf Back to top