Dr Lucy Norling

Profile

ORCID iD: 0000-0001-5316-9115

Lucy Norling graduated with a Masters in Research and PhD from the William Harvey Research Institute, Queen Mary University of London in 2008. Her research focused on galectin-1; an endogenous regulator of inflammatory resolution. Dr. Norling was then awarded a 3 year Arthritis Research UK Foundation Fellowship to study the generation and bioactions of novel lipid mediators derived from omega-3 fatty acids and spent two years training at Harvard Medical School, Boston, with the mentorship of Professor Charles Serhan.

In 2012 Dr Norling attained a 5 year Arthritis Research UK Career Development Fellowship to investigate the protective actions of omega-3 fatty acid derived specialized pro-resolving lipid mediators (SPM) in inflammatory arthritis. SPM provide a molecular mechanism for the beneficial effects of fish oil supplementation in patients with arthritis, and offer novel therapeutic approaches to treat inflammatory diseases.

In 2019 Dr Norling was awarded a 5 year Versus Arthritis Senior Fellowship entitled “Reprogramming Resolution in the Arthritic Joint”. Her current research aims to determine whether inflammatory joint diseases persist due to an inadequate synthesis of SPM and explores how SPM protect and repair joint tissue.

Research

Group members

Hannah Law, Silvia Oggero, Shani Austin-Williams, Chiara Cecconello, Michele Padaovan.

Summary 

Our understanding of how the inflammatory process is terminated has evolved, with the appreciation that protective mediators actively resolve inflammation. The discovery of omega-3 fatty acid derived specialized pro-resolving lipid mediators (SPM) provides a molecular mechanism for the beneficial effects of fish oil supplementation in patients with arthritis, and offer novel therapeutic approaches to treat inflammatory diseases. Supported by my Foundation Fellowship, I demonstrated that SPM inhibit PMN-endothelial interactions, dampen acute inflammation, and help fight infection. During my Career Development Fellowship I investigated the bioactions of SPM in experimental arthritis and found that resolvin D1 limits joint leukocyte infiltration, arthritis severity and protected from cartilage damage. We also determined that production of specific SPM including resolvin D3 is dysregulated in experimental arthritis, and that local SPM within murine joints can be modulated by omega-3 dietary supplementation.

There is a clear need to develop new innovative therapeutic agents for arthritis that can both reduce the inflammation that drives disease AND initiate tissue repair and regeneration. With the support of a Versus Arthritis Senior Fellowship I aim to establish how SPM reprogram innate immune cells and stromal cells within the joint tissue to switch on repair mechanisms that temper the aggressive and inappropriate behaviour of cells within the joint tissue to ultimately protect the cartilage from erosion. The overarching goal of our research is to establish novel leads for the restoration of joint function to ultimately limit disability and improve the lives of patients with arthritis.

Publications

• Thomas BL, Montero‐Melendez T, Oggero S et al. (2024). Molecular Determinants of Neutrophil Extracellular Vesicles That Drive Cartilage Regeneration in Inflammatory Arthritis. nameOfConference

  
  

  DOI: 10.1002/art.42958

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/98715
• Hussain MT, Austin-Williams S, Wright TD et al. (publicationYear). β1-Integrin-Mediated Uptake of Chondrocyte Extracellular Vesicles Regulates Chondrocyte Homeostasis. nameOfConference

  
  

  DOI: 10.3390/ijms25094756

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/97635
• Norling LV, Cooper D (2023). Being old and female is an inflammatory combination. nameOfConference

  
  

  DOI: 10.1093/jleuko/qiad077

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/95403
• Chen J, Austin-Williams S, O'Riordan CE et al. (2023). Formyl Peptide Receptor Type 2 Deficiency in Myeloid Cells Amplifies Sepsis-Induced Cardiac Dysfunction. nameOfConference

  
  

  DOI: 10.1159/000530284

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/85560
• Norling LV, Headland SE, Dalli J et al. (2023). Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis. nameOfConference

  
  

  DOI: 10.1172/jci.insight.168728

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/88868
• Norling LV, Halade GV (2022). Helpful inflammation turned harmful in non-communicable diseases. nameOfConference

  
  

  DOI: 10.1016/j.coph.2022.102317

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/83342
• Qin CX, Norling LV, Vecchio EA et al. (2022). Formylpeptide receptor 2: Nomenclature, structure, signalling and translational perspectives: IUPHAR review 35. nameOfConference

  
  

  DOI: 10.1111/bph.15919

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/82714
• Oggero S, Godec T, van Gorp R et al. (2022). Role of plasma extracellular vesicles in prediction of cardiovascular risk and alterations in response to statin therapy in hypertensive patients. nameOfConference

  
  

  DOI: 10.1097/hjh.0000000000003178

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/79497
• Cecconello C, Ribas PC, Norling LV (2022). Chapter 4 Resolving acute inflammation; what happens when inflammation goes haywire? How can it get back in line?. nameOfConference

  
  

  DOI: 10.1016/b978-0-12-822130-3.00018-1

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/85555
• Iqbal AJ, Krautter F, Blacksell IA et al. (2022). Galectin‐9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin‐dependent manner. nameOfConference

  
  

  DOI: 10.1096/fj.202100832r

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/76220
• Chen J, Norling LV, Mesa JG et al. (2021). Annexin A1 attenuates cardiac diastolic dysfunction in mice with inflammatory arthritis. nameOfConference

  
  

  DOI: 10.1073/pnas.2020385118

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/74989
• Austin-Williams S, Hussain MT, Oggero S et al. (2021). Enhancing Extracellular Vesicles for therapeutic treatment of arthritic joints. nameOfConference

  
  

  DOI: 10.1016/j.freeradbiomed.2021.08.235

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/83340
• Oggero S, de Gaetano M, Marcone S et al. (2021). Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque reactivity. nameOfConference

  
  

  DOI: 10.1002/jev2.12084

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/72444
• Chen J, Norling LV, Cooper D (publicationYear). Cardiac Dysfunction in Rheumatoid Arthritis: The Role of Inflammation. nameOfConference

  
  

  DOI: 10.3390/cells10040881

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/76222
• Brouwers H, Jónasdóttir HS, Kuipers ME et al. (2020). Anti-Inflammatory and Proresolving Effects of the Omega-6 Polyunsaturated Fatty Acid Adrenic Acid.. nameOfConference

  
  

  DOI: 10.4049/jimmunol.1801653

  
  

  QMRO: qmroHref
• Souza PR, Walker ME, Goulding NJ et al. (2020). The GPR40 Agonist GW9508 Enhances Neutrophil Function to Aid Bacterial Clearance During E. coli Infections. nameOfConference

  
  

  DOI: 10.3389/fimmu.2020.573019

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/67519
• Hussain MT, Iqbal AJ, Norling LV (publicationYear). The Role and Impact of Extracellular Vesicles in the Modulation and Delivery of Cytokines during Autoimmunity. nameOfConference

  
  

  DOI: 10.3390/ijms21197096

  
  

  QMRO: qmroHref
• Oggero S, Norling L, Perretti M (2018). Microvesicles in cardiovascular inflammation: markers or mediators of cardiovascular diseases?. nameOfConference

  
  

  DOI: 10.1254/jpssuppl.wcp2018.0_po1-2-71

  
  

  QMRO: qmroHref
• Norling LV, Perretti M (2020). Proresolving lipid mediators enhance PMN-mediated bacterial clearance. nameOfConference

  
  

  DOI: 10.1073/pnas.2004241117

  
  

  QMRO: qmroHref
• Norling L, Cooper D, Law H et al. (2020). A pro-resolving role for Galectin-1 in acute inflammation. nameOfConference

  
  

  DOI: 10.3389/fphar.2020.00274

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/64197
• Topping LM, Thomas BL, Rhys HI et al. (2020). Targeting Extracellular Vesicles to the Arthritic Joint Using a Damaged Cartilage-Specific Antibody. nameOfConference

  
  

  DOI: 10.3389/fimmu.2020.00010

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/63161
• Padovan MG, Norling LV (2020). Pro-resolving lipid mediators in sepsis and critical illness. nameOfConference

  
  

  DOI: 10.1097/mco.0000000000000633

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/62319
• Oggero S, Austin-Williams S, Norling LV (2019). The contrasting role of extracellular vesicles in vascular inflammation and tissue repair. nameOfConference

  
  

  DOI: 10.3389/fphar.2019.01479

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/62780
• Oggero S, Van Gorp R, Cooper D et al. (2019). Monocyte and not Neutrophil derived microvesicles are able to activate endothelial cells and smooth muscle cells and to enhance recruitment of PMN in a Flow Chamber based assay. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Oggero S, Van Gorp R, Norling LV et al. (2019). Stimulation of monocyte-platelet aggregation drives formation of microvesicle subsets to promote vascular inflammation. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Topping LM, Vinci C, Rhys H et al. (2018). OP0260 Targeting neutrophil microvesicles to damaged cartilage using antibodies to post-translationally modified collagen ii. FRIDAY, 15 JUNE 2018

  
  

  DOI: 10.1136/annrheumdis-2018-eular.6744

  
  

  QMRO: qmroHref
• Thomas BL, Jones HR, Norling LV et al. (2018). Neutrophil extracellular vesicles have a cartilage protective effect during inflammatory arthritis. nameOfConference

  
  

  DOI: 10.1016/j.joca.2018.02.273

  
  

  QMRO: qmroHref
• Rhys HI, Dell'Accio F, Pitzalis C et al. (2018). Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages. nameOfConference

  
  

  DOI: 10.1016/j.ebiom.2018.02.003

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/36528
• Topping L, Rhys H, Norling L et al. (2017). FRI0011 Targeting neutrophil microvesicles to damaged cartilage using antibodies to post translationally modified collagen ii. Poster Presentations

  
  

  DOI: 10.1136/annrheumdis-2017-eular.4842

  
  

  QMRO: qmroHref
• Perretti M, Norling LV (2017). Actions of SPM in regulating host responses in arthritis. nameOfConference

  
  

  DOI: 10.1016/j.mam.2017.04.005

  
  

  QMRO: qmroHref
• Piovezan AP, Batisti AP, Benevides MLACS et al. (2017). Hydroalcoholic crude extract of Casearia sylvestris Sw. reduces chronic post-ischemic pain by activation of pro-resolving pathways. nameOfConference

  
  

  DOI: 10.1016/j.jep.2017.03.059

  
  

  QMRO: qmroHref
• Norling LV, Ly L, Dalli J (2017). Resolving inflammation by using nutrition therapy: roles for specialized proresolving mediators.. nameOfConference

  
  

  DOI: 10.1097/MCO.0000000000000353

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/18759
• Perretti M, Cooper D, Dalli J et al. (2017). Immune resolution mechanisms in inflammatory arthritis.. nameOfConference

  
  

  DOI: 10.1038/nrrheum.2016.193

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/18889
• Souza PR, Jones HR, Norling LV (2017). Novel immunoregulatory mediators produced from omega-3 fatty acids. nameOfConference

  
  

  DOI: 10.1201/9781315118901

  
  

  QMRO: qmroHref
• Wright RD, Souza PR, Flak MB et al. (publicationYear). Galectin-3-null mice display defective neutrophil clearance during acute inflammation.. nameOfConference

  
  

  DOI: 10.1189/jlb.3A0116-026RR

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/18859
• Ross EA, Naylor AJ, O'Neil JD et al. (2017). Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression. nameOfConference

  
  

  DOI: 10.1136/annrheumdis-2016-209424

  
  

  QMRO: qmroHref
• Arnardottir HH, Dalli J, Norling LV et al. (2016). Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation.. nameOfConference

  
  

  DOI: 10.4049/jimmunol.1502268

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/23490
• Souza PR, Norling LV (2016). Implications for eicosapentaenoic acid- and docosahexaenoic acid-derived resolvins as therapeutics for arthritis. nameOfConference

  
  

  DOI: 10.1016/j.ejphar.2015.05.072

  
  

  QMRO: qmroHref
• Norling L, Headland S, Dalli J et al. (2016). PRO-RESOLVING AND CARTILAGE-PROTECTIVE ACTIONS OF RESOLVIN D1 IN INFLAMMATORY ARTHRITIS. EULAR

  
  

  DOI: 10.1136/annrheumdis-2016-eular.6116

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/24545
• Norling LV, Headland SE, Dalli J et al. (2016). Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis. nameOfConference

  
  

  DOI: 10.1172/jci.insight.85922

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/12017
• Headland SE, Jones HR, Norling LV et al. (2015). Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis. nameOfConference

  
  

  DOI: 10.1126/scitranslmed.aac5608

  
  

  QMRO: qmroHref
• Canova DF, Pavlov AM, Norling LV et al. (2015). Alpha-2-macroglobulin loaded microcapsules enhance human leukocyte functions and innate immune response. nameOfConference

  
  

  DOI: 10.1016/j.jconrel.2015.09.021

  
  

  QMRO: qmroHref
• Headland SE, Norling LV (2015). The resolution of inflammation: Principles and challenges. nameOfConference

  
  

  DOI: 10.1016/j.smim.2015.03.014

  
  

  QMRO: qmroHref
• Headland S, Norling L, Kim A et al. (2015). Neutrophil‐Derived Microvesicles Migrate into Cell‐Impenetrable Cartilage to Protect the Joint During Inflammatory Arthritis. nameOfConference

  
  

  DOI: 10.1096/fasebj.29.1_supplement.285.11

  
  

  QMRO: qmroHref
• Ross E, Smallie T, Naylor A et al. (2015). A8.1 Tristetraprolin is a novel therapeutic target for rheumatoid arthritis. nameOfConference

  
  

  DOI: 10.1136/annrheumdis-2015-207259.186

  
  

  QMRO: qmroHref
• Burgmaier M, Schutters K, Willems B et al. (2014). AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE−/− mice. nameOfConference

  
  

  DOI: 10.1111/jcmm.12374

  
  

  QMRO: qmroHref
• Montero-Melendez T, Madeira MFM, Norling LV et al. (2014). Association between periodontal disease and inflammatory arthritis reveals modulatory functions by melanocortin receptor type 3.. nameOfConference

  
  

  DOI: 10.1016/j.ajpath.2014.04.009

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/43046
• Cash JL, Norling LV, Perretti M (2014). Resolution of inflammation: targeting GPCRs that interact with lipids and peptides.. nameOfConference

  
  

  DOI: 10.1016/j.drudis.2014.06.023

  
  

  QMRO: qmroHref
• Headland SE, Jones HR, D'Sa ASV et al. (2014). Cutting-edge analysis of extracellular microparticles using ImageStream(X) imaging flow cytometry.. nameOfConference

  
  

  DOI: 10.1038/srep05237

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/10076
• Ayoub SS, Norling LV, Leoni G et al. (2010). Cell Adhesion Molecules. nameOfConference

  
  

  DOI: 10.1017/cbo9781139195737.018

  
  

  QMRO: qmroHref
• Headland S, Norling L, Patel H et al. (2014). A novel mechanism for protecting the arthritic joint: microparticles deliver Annexin A1 into cartilage (146.8). nameOfConference

  
  

  DOI: 10.1096/fasebj.28.1_supplement.146.8

  
  

  QMRO: qmroHref
• Norling L, Headland S, Dalli J et al. (2014). Resolvin D1 protects from neutrophil mediated joint destruction in inflammatory arthritis (146.5). nameOfConference

  
  

  DOI: 10.1096/fasebj.28.1_supplement.146.5

  
  

  QMRO: qmroHref
• Dalli J, Norling LV, Montero-Melendez T et al. (2014). Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis.. nameOfConference

  
  

  DOI: 10.1002/emmm.201303503

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/10756
• Dalli J, Montero-Melendez T, Norling LV et al. (2013). Heterogeneity in neutrophil microparticles reveals distinct proteome and functional properties.. nameOfConference

  
  

  DOI: 10.1074/mcp.M113.028589

  
  

  QMRO: qmroHref
• Norling LV, Dalli J (2013). Microparticles are novel effectors of immunity.. nameOfConference

  
  

  DOI: 10.1016/j.coph.2013.05.008

  
  

  QMRO: qmroHref
• Norling LV, Perretti M (2013). The role of omega-3 derived resolvins in arthritis.. nameOfConference

  
  

  DOI: 10.1016/j.coph.2013.02.003

  
  

  QMRO: qmroHref
• Norling LV, Perretti M (2013). Control of myeloid cell trafficking in resolution.. nameOfConference

  
  

  DOI: 10.1159/000350612

  
  

  QMRO: qmroHref
• Perretti M, Dalli J, Norling LV et al. (2013). Neutrophil Microparticles are heterogenous in content and function. nameOfConference

  
  

  DOI: 10.1096/fasebj.27.1_supplement.138.5

  
  

  QMRO: qmroHref
• Norling LV, Perretti M (2013). Omega-3 derived Resolvin D1 reduces the severity of inflammatory arthritis. nameOfConference

  
  

  DOI: 10.1096/fasebj.27.1_supplement.649.1

  
  

  QMRO: qmroHref
• Yazid S, Norling LV, Flower RJ (2012). Anti-inflammatory drugs, eicosanoids and the annexin A1/FPR2 anti-inflammatory system.. nameOfConference

  
  

  DOI: 10.1016/j.prostaglandins.2011.11.005

  
  

  QMRO: qmroHref
• Norling LV, Dalli J, Flower RJ et al. (2012). Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions.. nameOfConference

  
  

  DOI: 10.1161/ATVBAHA.112.249508

  
  

  QMRO: qmroHref
• Gil-Villa AM, Norling LV, Serhan CN et al. (2012). Aspirin triggered-lipoxin A4 reduces the adhesion of human polymorphonuclear neutrophils to endothelial cells initiated by preeclamptic plasma.. nameOfConference

  
  

  DOI: 10.1016/j.plefa.2012.08.003

  
  

  QMRO: qmroHref
• Norling L, Dalli J, Flower R et al. (2012). RESOLVIN D1 LIMITS PMN RECRUITMENT TO INFLAMMATORY LOCI: RECEPTOR DEPENDENT BIOACTIONS. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Norling LV, Dalli J, Flower RJ et al. (2012). Resolvin D1 limits PMN recruitment to inflammatory loci: receptor dependent bioactions. nameOfConference

  
  

  DOI: 10.1096/fasebj.26.1_supplement.835.17

  
  

  QMRO: qmroHref
• Norling LV, Dalli J, Serhan CN et al. (2011). RESOLVIN D1 LIMITS PMN RECRUITMENT TO INFLAMMATORY LOCI: RECEPTOR DEPENDENT BIOACTIONS. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Norling LV, Spite M, Yang R et al. (2011). Cutting Edge: Humanized Nano-Proresolving Medicines Mimic Inflammation-Resolution and Enhance Wound Healing. nameOfConference

  
  

  DOI: 10.4049/jimmunol.1003865

  
  

  QMRO: qmroHref
• Norling LV, Spite M, Yang R et al. (2011). Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing.. nameOfConference

  
  

  DOI: 10.4049/jimmunol.1003865

  
  

  QMRO: qmroHref
• Canaider S, Vettraino M, Norling LV et al. (2010). Human RCAN3 gene expression and cell growth in endothelial cells. nameOfConference

  
  

  DOI: 10.3892/ijmm_00000542

  
  

  QMRO: qmroHref
• Canaider S, Vettraino M, Norling LV et al. (2010). Human RCAN3 gene expression and cell growth in endothelial cells.. nameOfConference

  
  

  DOI: 10.3892/ijmm_00000542

  
  

  QMRO: qmroHref
• Norling LV, Serhan CN (2010). Profiling in resolving inflammatory exudates identifies novel anti-inflammatory and pro-resolving mediators and signals for termination.. nameOfConference

  
  

  DOI: 10.1111/j.1365-2796.2010.02235.x

  
  

  QMRO: qmroHref
• Norling LV, Dalli J, Flower RJ et al. (2010). Resolvin D1 limits PMN recruitment to inflammatory loci: receptor dependent bioactions. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Canaider S, Vettraino M, Norling LV et al. (2010). Human RCAN3 gene expression and cell growth in endothelial cells. nameOfConference

  
  

  DOI: 10.3892/ijmm_00000542

  
  

  QMRO: qmroHref
• Spite M, Norling LV, Summers L et al. (2009). Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis.. nameOfConference

  
  

  DOI: 10.1038/nature08541

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/19168
• Piqueras L, Sanz MJ, Perretti M et al. (2009). Activation of PPAR beta/delta inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine release. nameOfConference

  
  

  DOI: 10.1189/JLB.0508284

  
  

  QMRO: qmroHref
• Norling LV, Perretti M, Cooper D (2009). Endogenous galectins and the control of the host inflammatory response.. nameOfConference

  
  

  DOI: 10.1677/JOE-08-0512

  
  

  QMRO: qmroHref
• Dalli J, Norling LV, Renshaw D et al. (2008). Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles. nameOfConference

  
  

  DOI: 10.1182/blood-2008-02-140533

  
  

  QMRO: qmroHref
• Cooper D, Norling LV, Perretti M (2008). Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow.. nameOfConference

  
  

  DOI: 10.1189/jlb.1207831

  
  

  QMRO: qmroHref
• Dasgupta B, Dalli J, Norling L et al. (2008). Altered expression of annexin 1 and its receptor in neutrophils of patients with giant cell arteritis (GCA) and ANCA associated vasculitis (AAV). nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Norling LV, Sampaio ALF, Cooper D et al. (2008). Inhibitory control of endothelial galectin-1 on in vitro and in vivo lymphocyte trafficking. nameOfConference

  
  

  DOI: 10.1096/fj.07-9268com

  
  

  QMRO: qmroHref
• Harrington LS, Evans RJ, Wray J et al. (2007). Purinergic 2X(1) receptors mediate endothelial dependent vasodilation to ATP. nameOfConference

  
  

  DOI: 10.1124/mol.107.037325

  
  

  QMRO: qmroHref
• Norling LV, Cooper D, Perretti M (2006). Endogenous Galectn-1 inhibits lymphocyte-endothelial cell interactions as determined by small interference RNA. nameOfConference

  
  

  DOI: 10.1096/fasebj.20.4.a647-a

  
  

  QMRO: qmroHref

Collaborators

Internal

• Prof. Jesmond Dalli (QMUL)
• Dr. Tina Chowdury (QMUL)

External

• Prof. Charles Serhan, Brigham & Women’s Hospital & Harvard Medical School, USA
• Dr. Daniel Irimia, Massachusetts General Hospital, Boston, USA
• Prof. Philippa Hulley, NDORMS, University of Oxford

News

• Isolated white blood cell packages from patients with rheumatoid arthritis shown to be protective against inflammation
  Queen Mary University of London, November 2018
• How microvesicles could revolutionise arthritis treatment, The Conversation, November 2015
• Injection to end pain of arthritis: New Treatment will stop agony without side-effects, Express, November 2015