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Professor Sussan Nourshargh

Sussan

Head, Centre for Microvascular Research

Centre: Microvascular Research

Email: s.nourshargh@qmul.ac.uk
Telephone: +44(0) 20 7882 8240 

Website: https://www.centre-for-microvascular-research.com/
Twitter: @NoursharghLab

Profile

ORCID iD: 0000-0001-5677-1806

Sussan Nourshargh is a pharmacologist who studied at University College London (BSc) and King’s College London (PhD) and became Professor of Immunopharmacology at Imperial College London in 2006. In 2007 she joined Queen Mary University of London where she established the Centre for Microvascular Research within the William Harvey Research Institute. 

Awards

  • The Gabor Kaley Prize in Microcirculation Research from the American Societies of Physiology and Microcirculation (2016)
  • The Astra Zeneca Prize for Women in Pharmacology from the British Pharmacology Society (2014)
  • Quintiles Prize for outstanding contribution to Immunopharmacology from the British Pharmacology Society (2001)

Fellowships

  • Wellcome Trust Investigator Award (2020)
  • Wellcome Trust Senior Investigator Award (2012)
  • Fellow of the Academy of Medical Sciences (2012)
  • Fellow of the Society of Biology (2010)
  • Fellow of the British Pharmacological Society (2005)
  • Wellcome Trust University Award (1996)
  • Wellcome Trust Career Development Fellowship (1990) 

Memberships

  • International Scientific Advisory Board of the Institute of Cardiovascular Science, University of Birmingham (2023 to date).
  • International Scientific Advisory Board of the DFG-funded Neutrophil Consortium, University of Munster, Germany (2022 to date).
  • British Heart Foundation Board of Trustees and Advisory Council (2015 - 2021)
  • Wellcome Trust’s Biomedical Resources & Multi-User Equipment Committee (2015-2018)
  • Academy of Medical Sciences Springboard Panel (2015-2017)
  • Chair and Member of the Academy of Medical Sciences Committee (SC3) for selection of new Fellows (2012-2017)
  • Royal Society’s Newton Advanced Fellowship Panel (2014-2016)
  • British Heart Foundation Fellowship Committee (2011-2014)
  • Wellcome Trust’s Peer Review College (2012-2016)
  • Treasurer of the UK Adhesion Society (2007-2016)
  • Editor, European Journal of Immunology (2013-2020)
  • Editor, British Journal of Pharmacology (2010-2013) 

Research

Group members

  • Post-doctoral Researchers: Loïc Rolas, Clare Latta, Hai tao Wang, Yue Yang
  • PhD students: Navid Mousavi
  • Support staff: Laura Vasquez Martinez (Research Assistant), Matthew Golding (Lab Manager), Joana Mateu (PA & Centre Administrator)

Summary 

The principal objective of our research is to investigate the mode, dynamics and mechanisms of leukocyte transmigration, the final stage in the leukocyte adhesion cascade, that describes the movement of leukocytes from the vascular lumen into inflamed and/or injured tissues. To achieve this goal, we employ a multi-disciplinary approach to investigate the associated molecular and cellular pathways involved in neutrophil-vessel wall interactions. A key approach is the application of confocal intravital microscopy that enables rigorous and direct means of investigating the interactions of leukocytes with different components of microvessel walls (endothelial cells, pericytes and the vascular basement membrane) in real-time in vivo. We employ models for analysis of both physiologically relevant as well as pathological inflammatory models and a key component of our work is a research programme that investigates how pathological inflammatory insults impact the dynamics of neutrophil-vessel wall interactions and the implications of disrupted modes of neutrophil transmigration (e.g. neutrophil reverse transendothelial cell migration) on inflammatory disease development and dissemination. Collectively through the application of molecular and cellular assays, and advanced imaging platforms, our work aims to unravel previously unexplored cellular and molecular physiological concepts and identify disease-specific phenomena in immunity, inflammation and vascular biology. 

Our work is largely funded by the Wellcome Trust (Investigator Award), UKRI MRC, and the British Heart Foundation. 

Publications

  • Reglero-Real N, Pérez-Gutiérrez L, Saleeb RS et al. (2024). Protocol for volume correlative light X-ray and electron microscopy of endothelial cells in mouse tissue. nameOfConference


  • Rolas L, Stein M, Barkaway A et al. (2024). Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues. nameOfConference


  • Benedicto I, Carmona RM, Barettino A et al. (2024). Exacerbated atherosclerosis in progeria is prevented by progerin elimination in vascular smooth muscle cells but not endothelial cells. nameOfConference


  • Vignarajah M, Wood AJT, Nelmes E et al. (2024). Regulation of ICAM-1 in human neutrophils. nameOfConference


  • Cacho-Navas C, López-Pujante C, Reglero-Real N et al. (publicationYear). ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin. nameOfConference


  • Vestweber D, Claesson-Welsh L, McDonald DM et al. (2023). Report from the 2023 workshop on endothelial permeability, edema and inflammation. nameOfConference


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  • Joulia R, Guerrero-Fonseca IM, Girbl T et al. (publicationYear). Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A. nameOfConference


  • Reglero-Real N, Pérez-Gutiérrez L, Nourshargh S (publicationYear). Endothelial cell autophagy keeps neutrophil trafficking under control. nameOfConference


  • Sánchez-López A, Espinós-Estévez C, González-Gómez C et al. (2021). Cardiovascular Progerin Suppression and Lamin A Restoration Rescue Hutchinson-Gilford Progeria Syndrome. nameOfConference


  • Reglero-Real N, Pérez-Gutiérrez L, Yoshimura A et al. (2021). Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation. nameOfConference


  • Marcos-Ramiro B, Gil-Ordóñez A, Marín-Ramos NI et al. (2021). Isoprenylcysteine Carboxylmethyltransferase-Based Therapy for Hutchinson–Gilford Progeria Syndrome. nameOfConference


  • Li W, Long L, Yang X et al. (2021). Circulating BMP9 Protects the Pulmonary Endothelium during Inflammation-induced Lung Injury in Mice. nameOfConference


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  • Barkaway A, Rolas L, Joulia R et al. (2021). Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage. nameOfConference


  • Owen-Woods C, Joulia R, Barkaway A et al. (2020). Local microvascular leakage promotes trafficking of activated neutrophils to remote organs. nameOfConference


  • Kostelnik KB, Barker A, Schultz C et al. (publicationYear). Dynamic trafficking and turnover of JAM-C is essential for endothelial cell migration. nameOfConference


  • Cossarizza A, Chang H-D, Radbruch A et al. (2019). Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). nameOfConference


  • Arokiasamy S, King R, Boulaghrasse H et al. (2019). Heparanase-dependent Remodelling of Initial Lymphatic Glycocalyx 1 Regulates Tissue-fluid Drainage during Acute Inflammation in vivo. nameOfConference


  • VOISIN M, leoni G, WOODFIN A et al. (2019). Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post ischemia/reperfusion injury. nameOfConference


  • NOURSHARGH S, ROLAS L, BARKAWAY A (2019). Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome. nameOfConference


  • Voisin M, Nourshargh S (2019). Neutrophil trafficking to lymphoid tissues: physiological and pathological implications. nameOfConference


  • Reglero-Real N, Rolas L, Nourshargh S (2019). Leukocyte Trafficking: Time to Take Time Seriously. nameOfConference


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  • GIRBL T, Lenn T, Perez L et al. (publicationYear). Distinct compartmentalization of the chemokines CXCL1 and CXCL2 and the atypical receptor ACKR1 determine discrete stages of neutrophil diapedesis. nameOfConference


  • Cabrera CP, Manson J, Shepherd JM et al. (2018). Correction: Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study.. nameOfConference


  • Cossarizza A, Chang H-D, Radbruch A et al. (2018). Guidelines for the use of flow cytometry and cell sorting in immunological studies.. nameOfConference


  • Wen G, An W, Chen J et al. (2018). Genetic and Pharmacologic Inhibition of the Neutrophil Elastase Inhibits Experimental Atherosclerosis.. nameOfConference


  • Schulz-Fincke A-C, Tikhomirov AS, Braune A et al. (2018). Design of an Activity-Based Probe for Human Neutrophil Elastase: Implementation of the Lossen Rearrangement To Induce Förster Resonance Energy Transfers.. nameOfConference


  • Callender LA, carroll EC, beal R et al. (2017). Human CD8+ EMRA T cells display a senescent-associated secretory phenotype regulated by p38 MAPK.. nameOfConference


  • CABRERA CP, MANSON J, SHEPHERD JM et al. (2017). Signatures of Inflammation and Impending Multiple Organ Dysfunction in the Hyperacute Phase of Trauma. nameOfConference


  • Cabrera CP, Manson J, Shepherd JM et al. (2017). Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study.. nameOfConference


  • Gittens BR, Bodkin JV, Nourshargh S et al. (2017). Galectin-3: A Positive Regulator of Leukocyte Recruitment in the Inflamed Microcirculation. nameOfConference


  • VOISIN M (2017). Endogenous TNFα orchestrates the trafficking of neutrophils into and within lymphatic vessels during acute inflammation. nameOfConference


  • Barzilai S, Yadav SK, Morrell S et al. (2017). Leukocytes Breach Endothelial Barriers by Insertion of Nuclear Lobes and Disassembly of Endothelial Actin Filaments. nameOfConference


  • Herrera C, Voisin M-B, Escalante T et al. (2016). Effects of PI and PIII Snake Venom Haemorrhagic Metalloproteinases on the Microvasculature: A Confocal Microscopy Study on the Mouse Cremaster Muscle.. nameOfConference


  • Reglero-Real N, Colom B, Bodkin JV et al. (2016). Endothelial Cell Junctional Adhesion Molecules. nameOfConference


  • WHITEFORD J, Ma B, Woodfin et al. (2016). Underlying chronic inflammation alters the profile and mechanisms of acute neutrophil recruitment. nameOfConference


  • Nourshargh S, Renshaw SA, Imhof BA (publicationYear). Reverse Migration of Neutrophils: Where, When, How, and Why?. nameOfConference


  • Woodfin A, Beyrau M, Voisin M-B et al. (2016). ICAM-1–expressing neutrophils exhibit enhanced effector functions in murine models of endotoxemia. nameOfConference


  • Madalli S, Beyrau M, Whiteford J et al. (2015). Sex-specific regulation of chemokine Cxcl5/6 controls neutrophil recruitment and tissue injury in acute inflammatory states. nameOfConference


  • Armstrong PCJ, Kirkby NS, Chan MV et al. (2015). Novel whole blood assay for phenotyping platelet reactivity in mice identifies ICAM-1 as a mediator of platelet-monocyte interaction. nameOfConference


  • Yeh JS-M, Sennoga CA, McConnell E et al. (publicationYear). A Targeting Microbubble for Ultrasound Molecular Imaging. nameOfConference


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  • Colom B, Bodkin JV, Beyrau M et al. (2015). Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration InVivo. nameOfConference


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  • Colom B, Bodkin JV, Beyrau M et al. (2015). Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration In Vivo. nameOfConference


  • Yeh JS-M, Sennoga CA, McConnell E et al. (2015). Quantitative Ultrasound Molecular Imaging. nameOfConference


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  • Herrera C, Escalante T, Voisin M-B et al. (publicationYear). Tissue Localization and Extracellular Matrix Degradation by PI, PII and PIII Snake Venom Metalloproteinases: Clues on the Mechanisms of Venom-Induced Hemorrhage. nameOfConference


  • Nourshargh S, Alon R (2014). Leukocyte Migration into Inflamed Tissues. nameOfConference


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  • De Rossi G, Evans AR, Kay E et al. (2014). Shed syndecan-2 inhibits angiogenesis.. nameOfConference


  • Finsterbusch M, Voisin M-B, Beyrau M et al. (2014). Neutrophils recruited by chemoattractants in vivo induce microvascular plasma protein leakage through secretion of TNF.. nameOfConference


  • Halai K, Whiteford J, Ma B et al. (2014). ICAM-2 facilitates luminal interactions between neutrophils and endothelial cells in vivo.. nameOfConference


  • Leinster DA, Colom B, Whiteford JR et al. (2013). Endothelial cell junctional adhesion molecule C plays a key role in the development of tumors in a murine model of ovarian cancer.. nameOfConference


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  • Brancaleone V, Gobbetti T, Cenac N et al. (2013). A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation.. nameOfConference


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  • Alazawi W, Heath H, Waters JA et al. (2013). Stat2 loss leads to cytokine-independent, cell-mediated lethality in LPS-induced sepsis.. nameOfConference


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  • Nourshargh S (2013). L2. Neutrophil transmigration in vivo: mechanisms, dynamics and contribution to dissemination of systemic inflammation.. nameOfConference


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  • Alon R, Nourshargh S (2013). Learning in motion: pericytes instruct migrating innate leukocytes.. nameOfConference


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  • Voisin M-B, Nourshargh S (2013). Neutrophil transmigration: emergence of an adhesive cascade within venular walls.. nameOfConference


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  • Beyrau M, Bodkin JV, Nourshargh S (2012). Neutrophil heterogeneity in health and disease: a revitalized avenue in inflammation and immunity.. nameOfConference


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  • Kishore M, Ma L, Cornish G et al. (2012). Primed T Cell Responses to Chemokines Are Regulated by the Immunoglobulin-Like Molecule CD31. nameOfConference


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  • Ma L, Cheung KCP, Kishore M et al. (2012). CD31 exhibits multiple roles in regulating T lymphocyte trafficking in vivo.. nameOfConference


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  • Sanz MJ, Weg VB, Walsh DT et al. (1994). Differential effects of the PAF receptor antagonist UK‐74,505 on neutrophil and eosinophil accumulation in guinea‐pig skin. nameOfConference


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  • Nourshargh S, Hoult JRS (1987). Divergent effects of co‐carcinogenic phorbol esters and a synthetic diacylglycerol on human neutrophil chemokinesis and granular enzyme secretion. nameOfConference


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  • Yarwood H, Nourshargh S, Brain S et al. (1993). Effect of dexamethasone on neutrophil accumulation and oedema formation in rabbit skin: an investigation of site of action. nameOfConference


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  • Seale JP, Nourshargh S, Hellewell PG et al. (1991). Mechanism of action of platelet activating factor in the pulmonary circulation: an investigation using a novel isotopic system in rabbit isolated lung. nameOfConference


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  • Hoult JRS, Nourshargh S (1985). Phorbol myristate acetate enhances human polymorphonuclear neutrophil release of granular enzymes but inhibits chemokinesis. nameOfConference


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  • Pons F, Rossi AG, Norman KE et al. (1993). Role of platelet‐activating factor (PAF) in platelet accumulation in rabbit skin: effect of the novel long‐acting PAF antagonist, UK‐74,505. nameOfConference


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  • Walsh DT, Weg VB, Williams TJ et al. (1995). Substance P‐induced inflammatory responses in guinea‐pig skin: The effect of specific NK1 receptor antagonists and the role of endogenous mediators. nameOfConference


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  • Avari P, Huang W, Averill S et al. (2012). The spatiotemporal localization of JAM-C following sciatic nerve crush in adult rats.. nameOfConference


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  • Proebstl D, Voisin M-B, Woodfin A et al. (2012). Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo.. nameOfConference


  • Leinster DA, Kulbe H, Everitt G et al. (2012). The peritoneal tumour microenvironment of high-grade serous ovarian cancer.. nameOfConference


  • Colom B, Poitelon Y, Huang W et al. (2012). Schwann cell-specific JAM-C-deficient mice reveal novel expression and functions for JAM-C in peripheral nerves.. nameOfConference


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  • Kishore M, Ma L, Cornish G et al. (2012). Primed T cell responses to chemokines are regulated by the immunoglobulin-like molecule CD31.. nameOfConference


  • Whiteford JR, Xian X, Chaussade C et al. (2011). Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148.. nameOfConference


  • Woodfin A, Voisin M-B, Beyrau M et al. (2011). The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo.. nameOfConference


  • Veninga H, de Groot DM, McCloskey N et al. (2011). CD97 antibody depletes granulocytes in mice under conditions of acute inflammation via a Fc receptor-dependent mechanism.. nameOfConference


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  • Ma L, Mauro C, Cornish GH et al. (2010). Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance.. nameOfConference


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  • Nourshargh S, Hordijk PL, Sixt M (2010). Breaching multiple barriers: leukocyte motility through venular walls and the interstitium.. nameOfConference


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  • Leoni G, Voisin M-B, Carlson K et al. (2010). The melanocortin MC(1) receptor agonist BMS-470539 inhibits leucocyte trafficking in the inflamed vasculature.. nameOfConference


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  • Woodfin A, Voisin M-B, Nourshargh S (2010). Recent developments and complexities in neutrophil transmigration.. nameOfConference


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  • Voisin M-B, Pröbstl D, Nourshargh S (2010). Venular basement membranes ubiquitously express matrix protein low-expression regions: characterization in multiple tissues and remodeling during inflammation.. nameOfConference


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  • Scheiermann C, Colom B, Meda P et al. (2009). Junctional adhesion molecule-C mediates leukocyte infiltration in response to ischemia reperfusion injury.. nameOfConference


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  • Voisin M-B, Woodfin A, Nourshargh S (2009). Monocytes and neutrophils exhibit both distinct and common mechanisms in penetrating the vascular basement membrane in vivo.. nameOfConference


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  • Woodfin A, Voisin MB, Imhof BA et al. (2009). Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1. nameOfConference


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  • Woodfin A, Voisin M-B, Imhof BA et al. (2009). Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1.. nameOfConference


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  • Little MA, Smyth L, Salama AD et al. (2009). Experimental autoimmune vasculitis: an animal model of anti-neutrophil cytoplasmic autoantibody-associated systemic vasculitis.. nameOfConference


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  • Woodfin A, Voisin M-B, Nourshargh S (2007). PECAM-1: a multi-functional molecule in inflammation and vascular biology.. nameOfConference


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  • Scheiermann C, Meda P, Aurrand-Lions M et al. (2007). Expression and function of junctional adhesion molecule-C in myelinated peripheral nerves.. nameOfConference


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  • Bradfield PF, Nourshargh S, Aurrand-Lions M et al. (2007). JAM family and related proteins in leukocyte migration (Vestweber series).. nameOfConference


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  • Bradfield PF, Scheiermann C, Nourshargh S et al. (2007). JAM-C regulates unidirectional monocyte transendothelial migration in inflammation.. nameOfConference


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  • Woodfin A, Reichel CA, Khandoga A et al. (2007). JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration.. nameOfConference


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  • Ley K, Laudanna C, Cybulsky MI et al. (2007). Getting to the site of inflammation: the leukocyte adhesion cascade updated.. nameOfConference


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  • NOURSHARGH S, Krombach F, Dejana E et al. (2007). JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: Evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration. nameOfConference


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  • Young RE, Voisin M-B, Wang S et al. (2007). Role of neutrophil elastase in LTB4-induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice.. nameOfConference


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  • Voisin MB, Woodfin A, Nourshargh S (2007). Neutrophil and monocyte transmigration elicited by ischemia/reperfusion (I/R) injury and CCL2 is associated with remodelling of the venular basement membrane (BM) in vivo. nameOfConference


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  • Woodfin A, Larbi K, Krombach F et al. (2007). PECAM-1 & JAM-A mediate leukocyte transmigration in a stimulus-specific manner: Is this phenomenon governed by the strain of mice investigated?. nameOfConference


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  • Potter PK, Larbi KY, Nourshargh S et al. (2007). Efficient clearance of opsonised apoptotic cells in the absence of PECAM-1.. nameOfConference


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  • Voisin M-B, Nourshargh S (2007). Role of α6β1 integrin in leukocyte adhesion and transmigration. nameOfConference


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  • WILLIAMS TJ, DAS A, von UEXKULL C et al. (1991). Neutrophils in Asthmaa. nameOfConference


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  • Nourshargh S, Krombach F, Dejana E (2006). The role of JAM-A and PECAM-1 in modulating leukocyte infiltration in inflamed and ischemic tissues.. nameOfConference


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  • Wang S, Voisin M-B, Larbi KY et al. (2006). Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils. nameOfConference


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  • Huang M-T, Larbi KY, Scheiermann C et al. (2006). ICAM-2 mediates neutrophil transmigration in vivo: evidence for stimulus specificity and a role in PECAM-1-independent transmigration.. nameOfConference


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  • Wang S, Voisin M-B, Larbi KY et al. (2006). Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils.. nameOfConference


  • Marelli‐Berg FM, Nourshargh S (2005). Mechanisms of Leukocyte Transmigration: Role of Immunoglobulin Superfamily Molecules. nameOfConference


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  • Woodfin A, Reichel C, Khandoga A et al. (2006). JAM-A mediates leukocyte transmigration in a stimulus-specific manner. nameOfConference


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  • Voisin MB, Woodfin A, Dawes T et al. (2006). Neutrophil elastase (NE) deficient mice exhibit reduced leukocyte transmigration in response to ischaemia/reperfusion (I/R) injury. nameOfConference


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  • Voisin MB, Wang SJ, Larbi K et al. (2006). Neutrophils play a direct role in enhancing the size of venular basement membrane (BM) matrix protein low expression regions. nameOfConference


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  • Tharp WG, Yadav R, Irimia D et al. (2006). Neutrophil chemorepulsion in defined interleukin-8 gradients in vitro and in vivo.. nameOfConference


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  • Reichel CA, Khandoga A, Woodfin A et al. (2006). JAM-A mediates leukocyte transmigration dynamically and in a stimulus-specific manner. nameOfConference

    DOI: doi

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  • Little MA, Bhangal G, Smyth CL et al. (2006). Therapeutic effect of anti-TNF-alpha antibodies in an experimental model of anti-neutrophil cytoplasm antibody-associated systemic vasculitis.. nameOfConference


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  • Ambrose LR, Little MA, Nourshargh S et al. (2005). Anti-proteinase 3 antibody binding to neutrophils as demonstrated by confocal microscopy.. nameOfConference


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  • Little MA, Pusey CD, Nourshargh S (2005). Intravital microscopy in the study of ANCA-associated systemic vasculitis.. nameOfConference


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  • Little MA, Smyth CL, Yadav R et al. (2005). Antineutrophil cytoplasm antibodies directed against myeloperoxidase augment leukocyte-microvascular interactions in vivo.. nameOfConference


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  • Chatterjee BE, Yona S, Rosignoli G et al. (2005). Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro.. nameOfConference


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  • Aurrand-Lions M, Lamagna C, Dangerfield JP et al. (2005). Junctional adhesion molecule-C regulates the early influx of leukocytes into tissues during inflammation.. nameOfConference


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  • Wang S, Dangerfield JP, Young RE et al. (2005). PECAM-1, alpha6 integrins and neutrophil elastase cooperate in mediating neutrophil transmigration.. nameOfConference


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  • Huang MT, Larbi KY, Gerwin N et al. (2005). ICAM-2 mediates PECAM-1-independent neutrophil transmigration in vivo. nameOfConference

    DOI: doi

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  • Voisin MB, Young R, Dangerfield J et al. (2005). LTB4 is a potent inducer of cell surface neutrophil elastase (NE), a response that appears to play a role in LTB4-induced neutrophil transmigration in vivo. nameOfConference

    DOI: doi

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  • Wang SJ, Dangerfield J, Voisin MB et al. (2005). Pre-formed matrix protein "low expression" regions act as exit points for leukocytes migrating through the venular perivascular basement membrane. nameOfConference

    DOI: doi

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  • Nourshargh S, Marelli-Berg FM (2005). Transmigration through venular walls: a key regulator of leukocyte phenotype and function.. nameOfConference


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  • Dangerfield JP, Wang S, Nourshargh S (2005). Blockade of alpha6 integrin inhibits IL-1beta- but not TNF-alpha-induced neutrophil transmigration in vivo.. nameOfConference


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  • Marelli-Berg FM, James MJ, Dangerfield J et al. (2004). Cognate recognition of the endothelium induces HY-specific CD8+ T-lymphocyte transendothelial migration (diapedesis) in vivo.. nameOfConference


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  • Young RE, Thompson RD, Larbi KY et al. (2004). Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo.. nameOfConference


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  • Norsworthy PJ, Fossati-Jimack L, Cortes-Hernandez J et al. (2004). Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis.. nameOfConference


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  • McMillan SJ, Kearley J, Campbell JD et al. (2004). Matrix metalloproteinase-9 deficiency results in enhanced allergen-induced airway inflammation.. nameOfConference


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  • Yadav R, Larbi KY, Young RE et al. (2003). Migration of leukocytes through the vessel wall and beyond. nameOfConference


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  • James MJ, Belaramani L, Prodromidou K et al. (2003). Anergic T cells exert antigen-independent inhibition of cell-cell interactions via chemokine metabolism.. nameOfConference


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  • Marshall D, Dangerfield JP, Bhatia VK et al. (2003). MRL/lpr lupus-prone mice show exaggerated ICAM-1-dependent leucocyte adhesion and transendothelial migration in response to TNF-alpha.. nameOfConference


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  • Larbi KY, Dangerfield JP, Nourshargh S (2003). MMP-9 regulates eosinophil transmigration and expression of CCR3 on transmigrated eosinophils in vivo. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Young RE, Thompson RD, Larbi KY et al. (2003). Neutrophil elastase (NE) plays a non-redundant role in zymosan-induced leukocyte migration. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Larbi KY, Dangerfield JP, Culley FJ et al. (2003). P-selectin mediates IL-13-induced eosinophil transmigration but not eotaxin generation in vivo: a comparative study with IL-4-elicited responses.. nameOfConference


    QMRO: qmroHref
  • Young RE, Thompson RD, Nourshargh S (2002). Divergent mechanisms of action of the inflammatory cytokines interleukin 1-beta and tumour necrosis factor-alpha in mouse cremasteric venules.. nameOfConference


    QMRO: qmroHref
  • Dangerfield J, Larbi KY, Huang M-T et al. (2002). PECAM-1 (CD31) homophilic interaction up-regulates alpha6beta1 on transmigrated neutrophils in vivo and plays a functional role in the ability of alpha6 integrins to mediate leukocyte migration through the perivascular basement membrane.. nameOfConference


    QMRO: qmroHref
  • Marshall D, Dangerfield JD, Bhatia VK et al. (2002). MRL/lpr LUPUS-PRONE MICE SHOW EXAGGERATED ICAM-1 DEPENDENT LEUKOCYTE-ENDOTHELIAL INTERACTIONS IN RESPONSE TO TNF alpha. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Young RE, Thompson RD, Nourshargh S (2002). Divergent mechanisms of action of the inflammatory cytokines interleukin 1-beta (IL-1 beta) and factor-alpha (TNF alpha) in mouse cremasteric venules.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • NAGAI, LARKIN§, HARTNELL et al. (1999). Human eotaxin induces eosinophil extravasation through rat mesenteric venules: role of α4 integrins and vascular cell adhesion molecule‐1. nameOfConference


    QMRO: qmroHref
  • DAVIES¶, LARBI, ALLEN et al. (1999). VCAM‐1 contributes to rapid eosinophil accumulation induced by the chemoattractants PAF and LTB4: evidence for basal expression of functional VCAM‐1 in rat skin. nameOfConference


    QMRO: qmroHref
  • Thompson RD, Noble KE, Larbi KY et al. (2001). Platelet-endothelial cell adhesion molecule-1 (PECAM-1)-deficient mice demonstrate a transient and cytokine-specific role for PECAM-1 in leukocyte migration through the perivascular basement membrane.. nameOfConference


    QMRO: qmroHref
  • Marshall D, Bhatia VK, Ahmed S et al. (2001). Expression of P- but not E-selectin in peritoneal microvasculature during inflammatory peritonitis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Larbi KY, Allen AR, Tam FWK et al. (2000). VCAM-1 has a tissue-specific role in mediating interleukin-4-induced eosinophil accumulation in rat models: evidence for a dissociation between endothelial-cell VCAM-1 expression and a functional role in eosinophil migration.. nameOfConference


    QMRO: qmroHref
  • Asimakopoulos G, Thompson R, Nourshargh S et al. (2000). An anti-inflammatory property of aprotinin detected at the level of leukocyte extravasation. nameOfConference


    QMRO: qmroHref
  • Thompson RD, Wakelin MW, Larbi KY et al. (2000). Divergent Effects of Platelet-Endothelial Cell Adhesion Molecule-1 and β3 Integrin Blockade on Leukocyte Transmigration In Vivo. nameOfConference


    QMRO: qmroHref
  • Sanz M-J, Marinova-Mutafchieva L, Green P et al. (1998). IL-4-induced eosinophil accumulation in rat skin is dependent on endogenous TNF-alpha and alpha 4 integrin/VCAM-1 adhesion pathways.. nameOfConference


    QMRO: qmroHref
  • Sanz M-J, Ponath PD, Mackay CR et al. (1998). Human eotaxin induces alpha 4 and beta 2 integrin-dependent eosinophil accumulation in rat skin in vivo: delayed generation of eotaxin in response to IL-4.. nameOfConference


    QMRO: qmroHref
  • Wakelin MW, Nourshargh S (1997). TNFα and IFNγ act synergistically to induce leukocyte rolling and adhesion but not extravasation in vivo. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Sanz M-J, Hartnell A, Chisholm P et al. (1997). Tumor Necrosis Factor α-Induced Eosinophil Accumulation in Rat Skin Is Dependent on α4 Integrin/Vascular Cell Adhesion Molecule-1 Adhesion Pathways. nameOfConference


    QMRO: qmroHref
  • Nourshargh S (1997). Adhesion molecules and asthma.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Wakelin MW, Sanz MJ, Dewar A et al. (1996). An anti-platelet-endothelial cell adhesion molecule-1 antibody inhibits leukocyte extravasation from mesenteric microvessels in vivo by blocking the passage through the basement membrane.. nameOfConference


    QMRO: qmroHref
  • Nourshargh S, Williams TJ (1995). Molecular and cellular interactions mediating granulocyteaccumulation in vivo. nameOfConference


    QMRO: qmroHref
  • Nourshargh S, Larkin SW, Das A et al. (1995). Interleukin-1-Induced Leukocyte Extravasation Across Rat Mesenteric Microvessels Is Mediated by Platelet-Activating Factor. nameOfConference


    QMRO: qmroHref
  • Sanz MJ, Weg VB, Bolanowski MA et al. (1995). IL-1 is a potent inducer of eosinophil accumulation in rat skin. Inhibition of response by a platelet-activating factor antagonist and an anti-human IL-8 antibody.. nameOfConference


    QMRO: qmroHref
  • Weg VB, Walsh DT, Faccioli LH et al. (1995). LPS-induced 111In-eosinophil accumulation in guinea-pig skin: evidence for a role for TNF-alpha.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Das AM, Williams TJ, Lobb R et al. (1995). Lung eosinophilia is dependent on IL-5 and the adhesion molecules CD18 and VLA-4, in a guinea-pig model.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Rossi AG, Pons F, Norman KE et al. (1994). The role of PAF in platelet accumulation and oedema formation in rabbit skin. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Nourshargh S (1993). Mechanisms of Neutrophil and Eosinophil Accumulation In Vivo. nameOfConference


    QMRO: qmroHref
  • Weg VB, Williams TJ, Lobb RR et al. (1993). A monoclonal antibody recognizing very late activation antigen-4 inhibits eosinophil accumulation in vivo.. nameOfConference


    QMRO: qmroHref
  • von Uexküll C, Nourshargh S, Williams TJ (1992). Comparative responses of human and rabbit interleukin-1 in vivo: effect of a recombinant interleukin-1 receptor antagonist.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Nourshargh S, Perkins JA, Showell HJ et al. (1992). A comparative study of the neutrophil stimulatory activity in vitro and pro-inflammatory properties in vivo of 72 amino acid and 77 amino acid IL-8.. nameOfConference


    QMRO: qmroHref
  • Faccioli LH, Nourshargh S, Moqbel R et al. (1991). The accumulation of 111In-eosinophils induced by inflammatory mediators, in vivo.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Nourshargh S, Williams TJ (1990). Evidence that a receptor-operated event on the neutrophil mediates neutrophil accumulation in vivo. Pretreatment of 111In-neutrophils with pertussis toxin in vitro inhibits their accumulation in vivo.. nameOfConference


    QMRO: qmroHref
  • Williams TJ, Von Uexkull C, Nourshargh S (1990). Neutrophil-endothelial cell interactions in microvascular tone and permeability changes. nameOfConference


    QMRO: qmroHref
  • Nourshargh S, Rampart M, Hellewell PG et al. (1989). Accumulation of 111In-neutrophils in rabbit skin in allergic and non-allergic inflammatory reactions in vivo. Inhibition by neutrophil pretreatment in vitro with a monoclonal antibody recognizing the CD18 antigen.. nameOfConference


    QMRO: qmroHref
  • Williams TJ, Brain SD, Hellewell PG et al. (1988). Alteration in microvascular permeability induced by products released during inflammation.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Nourshargh S, Hoult JRS (1986). Inhibition of human neurophil degranulation by forskolin in the presence of phosphodiesterase inhibitors. nameOfConference


    QMRO: qmroHref

Sponsors

Collaborators

  • Professor Myles Lewis, Centre for Translational Bioinformatics, WHRI, QMUL  
  • Dr Tim Lammermann, Max Planck Institute of Immunobiology & Epigenetics, Freiburg, Germany 
  • Dr Lucy Collinson, Crick Institute, London
  • Professor Dietmar Vestweber, Max Planck Institute, Munster, Germany.
  • Professor Uli von Andrian, Harvard Medical School, Boston, USA
  • Professor Antal Rot, Centre for Microvascular Research, WHRI, QMUL
  • Professor Carlos Lopez Otin, University of Oviedo, Spain

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