Professor Sussan Nourshargh

Profile

ORCID iD: 0000-0001-5677-1806

Sussan Nourshargh is a pharmacologist who studied at University College London (BSc) and King’s College London (PhD) and became Professor of Immunopharmacology at Imperial College London in 2006. In 2007 she joined Queen Mary University of London where she established the Centre for Microvascular Research within the William Harvey Research Institute. 

Awards

• The Gabor Kaley Prize in Microcirculation Research from the American Societies of Physiology and Microcirculation (2016)
• The Astra Zeneca Prize for Women in Pharmacology from the British Pharmacology Society (2014)
• Quintiles Prize for outstanding contribution to Immunopharmacology from the British Pharmacology Society (2001)

Fellowships

• Wellcome Trust Investigator Award (2020)
• Wellcome Trust Senior Investigator Award (2012)
• Fellow of the Academy of Medical Sciences (2012)
• Fellow of the Society of Biology (2010)
• Fellow of the British Pharmacological Society (2005)
• Wellcome Trust University Award (1996)
• Wellcome Trust Career Development Fellowship (1990) 

Memberships

• International Scientific Advisory Board of the Institute of Cardiovascular Science, University of Birmingham (2023 to date).
• International Scientific Advisory Board of the DFG-funded Neutrophil Consortium, University of Munster, Germany (2022 to date).
• British Heart Foundation Board of Trustees and Advisory Council (2015 - 2021)
• Wellcome Trust’s Biomedical Resources & Multi-User Equipment Committee (2015-2018)
• Academy of Medical Sciences Springboard Panel (2015-2017)
• Chair and Member of the Academy of Medical Sciences Committee (SC3) for selection of new Fellows (2012-2017)
• Royal Society’s Newton Advanced Fellowship Panel (2014-2016)
• British Heart Foundation Fellowship Committee (2011-2014)
• Wellcome Trust’s Peer Review College (2012-2016)
• Treasurer of the UK Adhesion Society (2007-2016)
• Editor, European Journal of Immunology (2013-2020)
• Editor, British Journal of Pharmacology (2010-2013) 
  
  

Research

Group members

Summary 

Publications

• Kono Y, Pack C-G, Ichikawa T et al. (2024). Roles of the lamin A-specific tail region in the localization to sites of nuclear envelope rupture.

  
  

  DOI: 10.1093/pnasnexus/pgae527

  
  

  QMRO:
• Reglero-Real N, Pérez-Gutiérrez L, Saleeb RS et al. (2024). Protocol for volume correlative light X-ray and electron microscopy of endothelial cells in mouse tissue.

  
  

  DOI: 10.1016/j.xpro.2024.103257

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/98714
• Rolas L, Stein M, Barkaway A et al. (2024). Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues.

  
  

  DOI: 10.1038/s44319-024-00182-x

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/98188
• Benedicto I, Carmona RM, Barettino A et al. (2024). Exacerbated atherosclerosis in progeria is prevented by progerin elimination in vascular smooth muscle cells but not endothelial cells.

  
  

  DOI: 10.1073/pnas.240075212

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/95878
• Vignarajah M, Wood AJT, Nelmes E et al. (2024). Regulation of ICAM-1 in human neutrophils.

  
  

  DOI: 10.1093/jleuko/qiae090

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/100727
• Cacho-Navas C, López-Pujante C, Reglero-Real N et al. . ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin.

  
  

  DOI: 10.7554/elife.89261

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/96079
• Vestweber D, Claesson-Welsh L, McDonald DM et al. (2023). Report from the 2023 workshop on endothelial permeability, edema and inflammation.

  
  

  DOI: 10.1038/s44161-023-00385-w

  
  

  QMRO:
• Joulia R, Guerrero-Fonseca IM, Girbl T et al. . Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A.

  
  

  DOI: 10.1038/s41467-022-34695-7

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/82420
• Reglero-Real N, Pérez-Gutiérrez L, Nourshargh S . Endothelial cell autophagy keeps neutrophil trafficking under control.

  
  

  DOI: 10.1080/15548627.2021.1987675

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/77366
• Sánchez-López A, Espinós-Estévez C, González-Gómez C et al. (2021). Cardiovascular Progerin Suppression and Lamin A Restoration Rescue Hutchinson-Gilford Progeria Syndrome.

  
  

  DOI: 10.1161/CIRCULATIONAHA.121.055313

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/74909

Collaborators

• Professor Myles Lewis, Centre for Translational Bioinformatics, WHRI, QMUL  
• Dr Tim Lammermann, Max Planck Institute of Immunobiology & Epigenetics, Freiburg, Germany 
• Dr Lucy Collinson, Crick Institute, London
• Professor Dietmar Vestweber, Max Planck Institute, Munster, Germany.
• Professor Uli von Andrian, Harvard Medical School, Boston, USA
• Professor Antal Rot, Centre for Microvascular Research, WHRI, QMUL
• Professor Carlos Lopez Otin, University of Oviedo, Spain

News

• 2022: Dr Loic Rolas receives a prestigious BHF Intermediate Basic Science Research Fellowship (5 years).
• The team published two papers in Immunity in 2021; Reglero-Real N, Pérez-Gutiérrez L, et al., (2021). Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation. Immunity, 54: 1989-2004, and, Barkaway A, Rolas L, et al., (2021). Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage. Immunity, 54: 1494 - 1510.
• Awarded a Wellcome Trust Investigator Award (2020).
• Awarded an MRC Programme Grant in collaboration with Prof Paul Martin and Dr Helen Weaver from University of Bristol (2020).