Professor Zudin Puthucheary

Profile

ORCID iD: 0000-0003-4267-1892

Zudin graduated from Nottingham University in 1997, and moved to London post MRCP in 2000. Following a 3-year stint in Sydney, he started his Respiratory training in Bristol, before completing his critical care training in London. His research focusses on acquired functional disability, and the use of metabolic, nutritional and exercise interventions to prevent and treat muscle. Zudin is a nationally elected Council member of the Intensive Care Society (UK) and a trustee for the National Confidential Enquiry into Patient Outcome and Death.

His work on acute muscle wasting has won awards from the European Society of Intensive Care Medicine , European Society of Anaesthesia, the British Thoracic Society, the Intensive Care Society, The American Society of Enteral and Parenteral Nutrition and Zudin was named a Global Rising Star by the Australia and New Zealand Intensive Care Society. He setup and chaired the UK National Post-Intensive Care Rehabilitation Collaborative until 2023, a multi-professional cross-disciplinary group focussing on rehabilitation and restitution of critical illness survivors.

Research

Critical Care and Perioperative Medicine Group

Our research is focused on both primary and secondary prevention of acquired functional disability following critical illness. We are primarily focused on physical disability- loss of muscle mass and the resultant decrease in physical activity, and attempts to modify this using metabolic, nutritional and exercise interventions. In addition, we seek to understand the patient population in terms of pre-existing multi-morbidity and frailty as important predisposing factors to disability, and as limiters to functional recovery. We continue to develop and refine tools for both identifying (biological signatures) and assessing (e.g the PICUPS tool) new functional disability.

Publications

• Matsumoto K, Prowle JR, Puthucheary Z et al. . Uncertainty and decision-making in critical care: lessons from managing COVID-19 ARDS in preparation for the next pandemic.

  
  

  DOI: 10.1136/bmjresp-2024-002637

  
  

  QMRO:
• Parry SM, Morris PE, Larkin J et al. (2025). Incidence and Associated Risk Factors for Falls in Adults Following Critical Illness: An Observational Study..

  
  

  DOI: 10.1097/ccm.0000000000006668

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/106414
• McWilliams D, Gustafson O, Wyer N et al. (2025). Physiotherapy and Optimised Enteral Nutrition In the post-acute phase of critical illness (PHOENIX): protocol for a mixed methods feasibility randomised controlled trial.

  
  

  DOI: 10.1136/bmjopen-2025-100803

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/106413
• Nessel I, Paul SN, Puthucheary ZA (2025). Unveiling Organ Failure in the Critically Ill: Insights through the Metabolite Lens..

  
  

  DOI: 10.1165/rcmb.2025-0036ed

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/106417
• Bachmann KF, Jenkins B, Asrani V et al. . Core outcome set of daily monitoring of gastrointestinal function in adult critically ill patients: a modified Delphi consensus process (COSMOGI).

  
  

  DOI: 10.1186/s13054-024-05192-8

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/103284
• Thomson WR, Puthucheary Z, Stavrinou P et al. (2024). Delivery of evidence-based critical care practices across the United Kingdom: A UK-wide multi-site service evaluation in adult units.

  
  

  DOI: 10.1177/17511437241293917

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/103285
• Watson N, Nazeer S, Puthucheary Z (2025). Which Outcomes Should We be Using in Critical Care Nutrition Trials?.

  
  

  DOI: 10.1016/j.ccc.2024.09.005

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/106418
• Haines RW, Granholm A, Puthucheary Z et al. (2024). The effect of high protein dosing in critically ill patients: an exploratory, secondary Bayesian analyses of the EFFORT Protein trial.

  
  

  DOI: 10.1016/j.bja.2024.08.033

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/102324
• Azzopardi G, Mekhaimar A, Haines RW et al. (2025). Clinician assessment of kidney function from plasma creatinine values during critical illness: A scenario-based international multi-professional survey.

  
  

  DOI: 10.1016/j.jcrc.2024.154926

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/101219
• Bels JLM, Thiessen S, van Gassel RJJ et al. (2024). Effect of high versus standard protein provision on functional recovery in people with critical illness (PRECISe): an investigator-initiated, double-blinded, multicentre, parallel-group, randomised controlled trial in Belgium and the Netherlands.

  
  

  DOI: 10.1016/s0140-6736(24)01304-7

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/100467

Collaborators

Internal

• Dr John Prowle
• Prof Gareth Ackland
• Prof Andrew Prendegast
• Prof Aylin Basan
• Prof Sian Henson
• Prof Adina Michael-Titus

External

International:

• Profs Linda Denehey and Sue Berney (University of Melbourne)
• Prof Stephen Olde Damick (University of Maastricht)
• Sepsis and Critical Illness Research Centre (University of Florida)
• Dr Louise Thwaites (Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh, Vietnam) 

National:

• Medical Research Council/Arthritis Research UK Centre of excellence for musculoskeletal ageing research (University of Nottingham)
• Centre of Human and Aerospace Physiological Sciences (Kings College London)
• Centre for Human Health and Performance (University College London)

Disclosures

• GlaxoSmithKline - Specialist Advisory Board for muscle wasting in critical illness
• Fresunius Kabi - Specialist Advisory Board for functional recovery post-critical illness
• Lyric Pharmaceuticals - Consultant
• Faraday Pharmaceuticals - Consultant
• Nestle - Specialist Advisory Board for muscle wasting in critical illness
• Nutricia - Specialist Advisory Board for mitochondrial dysfunction in critical illness
• Bioage - Consultant