Dr Claudio Raimondi

Profile

Dr Raimondi started his career in science in the cancer field as a master student in Palermo, Italy.

Dr Raimondi continued his studies in the cancer field during his PhD in Prof Marco Falasca at Queen Mary University of London and he was awarded a PhD in 2011.

After his PhD, Dr Raimondi joined Professor Ruhrberg's lab at UCL to investigate the role of the transmembrane protein Neuropilin-1 in cell-cell adhesion in endothelial cells. To continue his studies in the vascular field, Dr Raimondi successfully applied for a BHF immediate postdoctoral fellowship that gave him the opportunity to lead his research project on Neuropilin-1 signalling in the angiogenic vasculature.

Dr Raimondi research contributed to discovering new Neuropilin-1-dependent signalling pathways activated by extracellular matrix components that regulate physiological and pathological angiogenesis.

To continue to investigate Neuropilin-1-dependent signalling pathways and in adult vasculature homeostasis, Dr Raimondi successfully applied for a BHF intermediate basic science research fellowship to join the National Heart and Lung Institute at Imperial College.

More recently, Dr Raimondi joined the William Harvey Research Institute (WHRI) to investigate the interplay of NRP1 signalling, mitochondria homeostasis and EC metabolism in endothelial cell homeostasis.

Research

Group members

Miss Emy Bosseboeuf (Technician)

Summary

Dr Raimondi’s group focuses on identifying and investigating the signalling pathways regulating cellular senescence, oxidative stress and mitochondria homeostasis in endothelial cells and their relevance in vascular homeostasis and vascular diseases.

The group has a long-standing interest in Neuropilin-1 (NRP1), with a particular focus on the recently discovered functions of NRP1 (Issitt et al., 2019 iScience) in regulating premature senescence, iron homeostasis and mitochondrial function in endothelial cells.

The group is also interested in understanding the effect of shear stress on endothelial cell metabolism.

Publications

• Chikh A, Raimondi C (2024). Endothelial Neuropilin-1: a multifaced signal transducer with an emerging role in inflammation and atherosclerosis beyond angiogenesis. nameOfConference

  
  

  DOI: 10.1042/bst20230329

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/94644
• Massimo G, Khambata RS, Chapman T et al. (2023). Corrigendum to “Natural mutations of human XDH promote the nitrite (NO2 −)-reductase capacity of xanthine oxidoreductase: A novel mechanism to promote redox health?” [Redox Biol. 4 (67) (2023) 102864]. nameOfConference

  
  

  DOI: 10.1016/j.redox.2023.102925

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/93328
• Massimo G, Khambata RS, Chapman T et al. (2023). Natural mutations of human XDH promote the nitrite (NO2 −)-reductase capacity of xanthine oxidoreductase: A novel mechanism to promote redox health?. nameOfConference

  
  

  DOI: 10.1016/j.redox.2023.102864

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/90642
• Bosseboeuf E, Chikh A, Chaker AB et al. (2023). Neuropilin-1 interacts with VE-cadherin and TGFBR2 to stabilize adherens junctions and prevent activation of endothelium under flow. nameOfConference

  
  

  DOI: 10.1126/scisignal.abo4863

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/88719
• Chikh A, Sanzà P, Raimondi C et al. (2022). Retraction: iASPP is a novel autophagy inhibitor in keratinocytes. nameOfConference

  
  

  DOI: 10.1242/jcs.259757

  
  

  QMRO: qmroHref
• Dufton NP, Peghaire CR, Osuna-Almagro L et al. (2020). Author Correction: Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis (Nature Communications, (2017), 8, 1, (895), 10.1038/s41467-017-01169-0). nameOfConference

  
  

  DOI: 10.1038/s41467-017-01169-0

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/65258
• Bosseboeuf E, Raimondi C (publicationYear). Signalling, Metabolic Pathways and Iron Homeostasis in Endothelial Cells in Health, Atherosclerosis and Alzheimer’s Disease. nameOfConference

  
  

  DOI: 10.3390/cells9092055

  
  

  QMRO: qmroHref
• Peghaire C, Dufton NP, Lang M et al. (publicationYear). The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature. nameOfConference

  
  

  DOI: 10.1038/s41467-019-12897-w

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/67650
• Issitt T, Bosseboeuf E, De Winter N et al. (2019). Neuropilin-1 Controls Endothelial Homeostasis by Regulating Mitochondrial Function and Iron-Dependent Oxidative Stress. nameOfConference

  
  

  DOI: 10.1016/j.isci.2018.12.005

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/56399
• Dufton NP, Peghaire CR, Osuna-Almagro L et al. (publicationYear). Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis. nameOfConference

  
  

  DOI: 10.1038/s41467-017-01169-0

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/64570
• Fantin A, Lampropoulou A, Senatore V et al. (2017). VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation. nameOfConference

  
  

  DOI: 10.1084/jem.20160311

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/69655
• Raimondi C, Chikh A, Wheeler AP et al. (2017). Correction: A novel regulatory mechanism links PLCγ1 to PDK1. nameOfConference

  
  

  DOI: 10.1242/jcs.201491

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/27583
• Raimondi C, Calleja V, Ferro R et al. (2016). A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion. nameOfConference

  
  

  DOI: 10.1038/srep26142

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/12725
• Raimondi C, Fantin A, Lampropoulou A et al. (2014). Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells.. nameOfConference

  
  

  DOI: 10.1084/jem.20132330

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/69740
• Chikh A, Sanza P, Raimondi C et al. (2014). IASPP is a novel autophagy mudulator in keratinocytes. nameOfConference

  
  

  DOI: 10.1242/​jcs.144816

  
  

  QMRO: qmroHref
• Ruban EL, Balogun MA, Martins V et al. (2014). Phospholipase C beta4 regulates invasion and proliferation in cutaneous SCC in vivo. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Ruban EL, Martins VL, Caley M et al. (2013). Phospholipase C-beta 4 regulates proliferation and invasion in cutaneous SCC. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Raimondi C, Chikh A, Wheeler AP et al. (2012). A novel regulatory mechanism links PLCγ1 to PDK1.. nameOfConference

  
  

  DOI: 10.1242/jcs.100511

  
  

  QMRO: qmroHref
• Raimondi C, Falasca M (2012). Phosphoinositides signalling in cancer: focus on PI3K and PLC.. nameOfConference

  
  

  DOI: 10.1016/j.advenzreg.2011.09.016

  
  

  QMRO: qmroHref
• Chikh A, Matin RNH, Senatore V et al. (2011). iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia.. nameOfConference

  
  

  DOI: 10.1038/emboj.2011.302

  
  

  QMRO: qmroHref
• Dominguez V, Raimondi C, Somanath S et al. (2011). Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells.. nameOfConference

  
  

  DOI: 10.1074/jbc.M110.200295

  
  

  QMRO: qmroHref
• Falasca M, Raimondi C, Maffucci T (2011). Boyden chamber.. nameOfConference

  
  

  DOI: 10.1007/978-1-61779-207-6_7

  
  

  QMRO: qmroHref
• Raimondi C, Falasca M (2011). Targeting PDK1 in cancer.. nameOfConference

  
  

  DOI: 10.2174/092986711796011238

  
  

  QMRO: qmroHref
• Raimondi C, Maffucci T, Potter BVI et al. (2010). A novel and selective PDK1 inhibitor reduces breast cancer cell invasion and tumour growth. nameOfConference

  
  

  DOI: 10.1186/bcr2500

  
  

  QMRO: qmroHref
• Maffucci T, Raimondi C, Abu-Hayyeh S et al. (2009). A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation.. nameOfConference

  
  

  DOI: 10.1371/journal.pone.0008285

  
  

  QMRO: qmroHref
• Sala G, Dituri F, Raimondi C et al. (2008). Phospholipase Cgamma1 is required for metastasis development and progression.. nameOfConference

  
  

  DOI: 10.1158/0008-5472.CAN-08-1181

  
  

  QMRO: qmroHref
• Astorri E, Ferrari O, Lima G et al. (1992). Prognostic significance of thallium-201 scintigraphy in patients with previous myocardial infarct.. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref

Collaborators

Internal

• Prof Amrita Ahluwalia (WHRI)
• Dr Katiuscia Bianchi (BCI)

External 

• Prof Michael Duchen (UCL)
• Dr Christina Warboys (RVC)
• Prof Justin Mason (Imperial College)