Dr William J Young

Profile

Dr William Young is a Clinical Lecturer in Cardiology within the centre of Clinical Pharmacology and Precision Medicine at the William Harvey Research Institute and an Electrophysiology Cardiology Registrar at St Bartholomew’s Hospital, Barts Heart Centre. 

Dr Young completed his medical degree at University College London in 2011 along with an intercalated BSc in Human Genetics for which he received 1^st class honours. He entered Cardiology specialty training after securing a NIHR funded Academic Clinical Fellow post in the North Central – East Thames Deanery. He completed his PhD in Cardiology at Queen Mary University of London in 2022. During this time, he completed the largest genetic studies to date for electrocardiographic-derived measures of ventricular repolarisation and depolarisation. In September 2022, he secured a position as a NIHR funded Academic Clinical Lecturer in the centre of Clinical Pharmacology and Precision Medicine.

His research interests include the genetic basis of cardiac electrophysiology and arrhythmogenesis, risk stratification using polygenic risk scores and inherited channelopathies.

Prizes and awards

• Associate Fellow of the Higher Education Academy (AFHEA), July 2022
• Early Career Award, CHARGE consortium, May 2021
• MRC funded Clinical Research Training Fellowship (2018 –2021)
• Certificate of special commendation for teaching, University College London, 2010
• Heaysman Prize for best BSc Final Year project, University College London, 2008

Research

Dr William J Young is a Clinical Lecturer at the Centre for Clinical Pharmacology and Precision Medicine working with Professor Patricia Munroe.

His research utilises genomics to improve our understanding of the underlying biology of cardiac electrophysiology and arrhythmia mechanisms. His interest extends to the utility of these findings in arrhythmic risk stratification including polygenic risks scores.

Publications

• Burns R, Young WJ, Aung N et al. (publicationYear). Genetic basis of right and left ventricular heart shape. nameOfConference

  
  

  DOI: 10.1038/s41467-024-53594-7

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/101921
• Shah R, Kirkby C, Ives C et al. (2024). Can variants of genes associated with familial heart block predict conduction disease in the general population? A UK Biobank study.. nameOfConference

  
  

  DOI: 10.1093/eurheartj/ehae666.319

  
  

  QMRO: qmroHref
• Ramirez J, Martinez JP, Van Duijvenboden S et al. (2024). Long-term time-to-ventricular arrhythmic event prediction using a deep learning based model on the electrocardiogram signal. nameOfConference

  
  

  DOI: 10.1093/eurheartj/ehae666.3434

  
  

  QMRO: qmroHref
• Van Duijvenboden S, Nicholson G, Smith-Byrne K et al. (2024). The genetic architecture of exercise-induced ventricular ectopy. nameOfConference

  
  

  DOI: 10.1093/eurheartj/ehae666.3668

  
  

  QMRO: qmroHref
• Young WJ, van der Most PJ, Bartz TM et al. (2024). Genome-Wide Interaction Analyses of Serum Calcium on Ventricular Repolarization Time in 125 393 Participants.. nameOfConference

  
  

  DOI: 10.1161/jaha.123.034760

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/99885
• Ramírez J, van Duijvenboden S, Young WJ et al. (2024). Fine mapping of candidate effector genes for heart rate. nameOfConference

  
  

  DOI: 10.1007/s00439-024-02684-z

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/98893
• Ramírez J, Young WJ, van Duijvenboden S et al. (2024). PO-01-089 PREDICTION OF ATRIAL AND VENTRICULAR ARRHYTHMIAS USING MULTIPLE CARDIOVASCULAR RISK FACTOR POLYGENIC RISK SCORES. nameOfConference

  
  

  DOI: 10.1016/j.hrthm.2024.03.680

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/100702
• Keaton JM, Kamali Z, Xie T et al. (2024). Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits. nameOfConference

  
  

  DOI: 10.1038/s41588-024-01714-w

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/99886
• Hughes G, Young WJ, Bern H et al. (2024). T-wave morphology abnormalities in the STREAM stage 1 trial. nameOfConference

  
  

  DOI: 10.1080/14740338.2024.2322116

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/100785
• Young WJ, Maung S, Ahmet S et al. (2024). The frequency of gene variant reclassification and its impact on clinical management in the inherited arrhythmia clinic. nameOfConference

  
  

  DOI: 10.1016/j.hrthm.2024.01.008

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/100774
• Lambiase PD, Young WJ (2024). Genomic basis of heart rate and rhythm generation. nameOfConference

  
  

  DOI: 10.1016/B978-0-12-822951-4.00004-7

  
  

  QMRO: qmroHref
• Ramírez J, Miguel A, van Duijvenboden S et al. (2023). A Multilayer CNN Using the ECG, Age and Sex Predicts Ventricular Arrhythmias in the General Population. 2023 Computing in Cardiology Conference (CinC)

  
  

  DOI: 10.22489/cinc.2023.342

  
  

  QMRO: qmroHref
• Orini M, van Duijvenboden S, Ramírez J et al. (2023). Ultra-Short Beat-to-Beat Repolarization Variability Predicts Cardiovascular Events in Individuals Without Cardiovascular Disease. 2023 Computing in Cardiology Conference (CinC)

  
  

  DOI: 10.22489/cinc.2023.178

  
  

  QMRO: qmroHref
• Orini M, Van Duijvenboden S, Young WJ et al. (2023). Ultra-short heart rate variability over 15 seconds is associated with increased long-term risk of cardiovascular disease. nameOfConference

  
  

  DOI: 10.1093/eurheartj/ehad655.2912

  
  

  QMRO: qmroHref
• Orini M, van Duijvenboden S, Young WJ et al. (publicationYear). Long-term association of ultra-short heart rate variability with cardiovascular events. nameOfConference

  
  

  DOI: 10.1038/s41598-023-45988-2

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/92007
• van Duijvenboden S, Ramírez J, Young WJ et al. (2023). Integration of genetic fine-mapping and multi-omics data reveals candidate effector genes for hypertension. nameOfConference

  
  

  DOI: 10.1016/j.ajhg.2023.08.009

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/91151
• Young WJ, Vyas S, Wragg A et al. (2023). Right coronary artery compromise following radiofrequency catheter ablation for supraventricular tachycardia: cases reports. nameOfConference

  
  

  DOI: 10.1093/ehjcr/ytad411

  
  

  QMRO: qmroHref
• Young WJ, Haessler J, Benjamins J-W et al. (publicationYear). Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease. nameOfConference

  
  

  DOI: 10.1038/s41467-023-36997-w

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/88700
• Orini M, van Duijvenboden S, Young WJ et al. (2023). Premature atrial and ventricular contractions detected on wearable-format electrocardiograms and prediction of cardiovascular events. nameOfConference

  
  

  DOI: 10.1093/ehjdh/ztad007

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/88698
• Young WJ, Lahrouchi N, Isaacs A et al. (publicationYear). Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways. nameOfConference

  
  

  DOI: 10.1038/s41467-022-32821-z

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/82522
• Ramírez J, Van Duijvenboden S, Young W et al. (2022). Prediction of coronary artery disease and major adverse cardiovascular events using clinical and genetic risk scores for cardiovascular risk factors. nameOfConference

  
  

  DOI: 10.1016/j.atherosclerosis.2022.06.012

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/80606
• Carrington M, Creta A, Young WJ et al. (2022). Defining electrocardiographic criteria to differentiate non‐type 1 Brugada ECG variants from normal incomplete RBBB patterns in the young SCD‐SOS cohort. nameOfConference

  
  

  DOI: 10.1111/jce.15615

  
  

  QMRO: qmroHref
• Ramírez J, van Duijvenboden S, Young WJ et al. (publicationYear). Prediction of Coronary Artery Disease and Major Adverse Cardiovascular Events Using Clinical and Genetic Risk Scores for Cardiovascular Risk Factors. nameOfConference

  
  

  DOI: 10.1161/circgen.121.003441

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/80125
• Maung S, Young W, Ives C et al. (2022). 84 Variants of uncertain significance: a real-world experience of reclassification from the inherited arrhythmia clinic. Cardiac rhythm management

  
  

  DOI: 10.1136/heartjnl-2022-bcs.84

  
  

  QMRO: qmroHref
• Naderi H, Ramírez J, Van Duijvenboden S et al. (2022). PREDICTING THE PATTERN OF ANATOMICAL LEFT VENTRICULAR HYPERTROPHY USING ELECTROPHYSIOLOGICAL BIOMARKERS FROM THE ECG QRS COMPLEX IN HYPERTENSIVE INDIVIDUALS FROM UK BIOBANK. nameOfConference

  
  

  DOI: 10.1097/01.hjh.0000835328.40233.c1

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/83590
• Ramirez J, van Duijvenboden S, Young WJ et al. (2022). Prediction of coronary artery disease: Do risk factor genetic risk scores add value?. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Young WJ, Munroe PB, Tereshchenko L (2022). Trans-ancestry GWAS of 118,780 individuals reveals biological mechanisms underlying the spatial QRS-T angle, a marker of arrhythmogenesis. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Young W, Isaacs A, Lahrouchi N et al. (2021). B-011-01 TRANS-ANCESTRY GWAS OF 252,730 INDIVIDUALS IDENTIFIES 114 NOVEL LOCI ASSOCIATED WITH THE QT INTERVAL. nameOfConference

  
  

  DOI: 10.1016/j.hrthm.2021.07.014

  
  

  QMRO: qmroHref
• Young W, Isaacs A, Lahrouchi N et al. (2021). B-AB13-01 TRANS-ANCESTRY GWAS OF 252,730 INDIVIDUALS IDENTIFIES 114 NOVEL LOCI ASSOCIATED WITH THE QT INTERVAL. nameOfConference

  
  

  DOI: 10.1016/j.hrthm.2021.06.076

  
  

  QMRO: qmroHref
• van Duijvenboden S, Ramírez J, Young WJ et al. (2021). Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders. nameOfConference

  
  

  DOI: 10.1093/hmg/ddab197

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/74481
• Ramírez J, van Duijvenboden S, Young WJ et al. (2021). Analysing electrocardiographic traits and predicting cardiac risk in UK biobank. nameOfConference

  
  

  DOI: 10.1177/20480040211023664

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/73022
• Young W, Warren H, Mook-Kanamori D et al. (2021). BS8 Genetically-determined serum calcium levels influence markers of ventricular repolarisation: a mendelian randomisation study. Basic science

  
  

  DOI: 10.1136/heartjnl-2021-bcs.206

  
  

  QMRO: qmroHref
• Young WJ, Warren HR, Mook-Kanamori DO et al. (2021). Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization. nameOfConference

  
  

  DOI: 10.1161/circgen.120.003231

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/71688
• Chasapi A, Mbonye KA, Bajomo O et al. (2021). Clinical and echocardiographic predictors of decompensation in acute severe aortic regurgitation due to infective endocarditis. nameOfConference

  
  

  DOI: 10.1111/echo.15028

  
  

  QMRO: qmroHref
• Ramirez J, van Duijvenboden S, Young WJ et al. (2021). Prediction of Coronary Artery Disease using Traditional and Genetic Risk Scores for Cardiovascular Risk Factors. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Young WJ, Srinivasan N, Tinker A et al. (2020). Comparisons of the Spatial QRS-T Angle With Intra-cardiac Markers of Depolarization and Repolarization. 2020 Computing in Cardiology Conference (CinC)

  
  

  DOI: 10.22489/cinc.2020.414

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/71768
• van Duijvenboden S, Ramírez J, Young WJ et al. (2020). Evaluating the Impact of Physiological Variability in Genome-Wide Association Studies of Resting Heart Rate. 2020 Computing in Cardiology Conference (CinC)

  
  

  DOI: 10.22489/cinc.2020.483

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/71389
• Aung N, Young WJ, van Duijvenboden S et al. (2020). Genetic Architecture of Quantitative Cardiovascular Traits: Blood Pressure, ECG and Imaging Phenotypes. 2020 Computing in Cardiology Conference (CinC)

  
  

  DOI: 10.22489/cinc.2020.477

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/71388
• Young WJ, Ramírez J, van Duijvenboden S et al. (2020). Will Genetic Data Significantly Change Cardiovascular Risk Prediction in Daily Practice?. 2020 Computing in Cardiology Conference (CinC)

  
  

  DOI: 10.22489/cinc.2020.481

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/71749
• Young WJ, Hoare D, Bvekerwa I et al. (2021). Association of Vegetation Size With Valve Destruction, Embolism and Mortality. nameOfConference

  
  

  DOI: 10.1016/j.hlc.2020.10.028

  
  

  QMRO: qmroHref
• Carrington M, Creta A, Young W et al. (2020). Non Type-1 Brugada pattern, diagnostic yield of 5 ECG criteria in a young adult cohort. nameOfConference

  
  

  DOI: 10.1093/ehjci/ehaa946.0373

  
  

  QMRO: qmroHref
• Young WJ, van Duijvenboden S, Ramírez J et al. (2021). A Method to Minimise the Impact of ECG Marker Inaccuracies on the Spatial QRS-T angle: Evaluation on 1,512 Manually Annotated ECGs. nameOfConference

  
  

  DOI: 10.1016/j.bspc.2020.102305

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/68931
• Ramirez J, Van Duijvenboden S, Young WJ et al. (2020). Interaction between ECG and Genetic Markers of Coronary Artery Disease. CinC 2020

  
  

  DOI: 10.22489/CinC.2020.478

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/71387
• Hoare D, Bhattacharyya S, Lloyd G et al. (2020). 11 Impact of transthoracic versus transoesophageal echocardiography measurement of vegetation length in infective endocarditis on indications for surgery. ACHD/Valve Disease/Pericardial Disease/Cardiomyopathy

  
  

  DOI: 10.1136/heartjnl-2020-bcs.11

  
  

  QMRO: qmroHref
• van Duijvenboden S, Ramírez J, Young WJ et al. (2020). Genetic Basis and Prognostic Value of Exercise QT Dynamics. nameOfConference

  
  

  DOI: 10.1161/circgen.119.002774

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/67014
• Ramírez J, van Duijvenboden S, Young WJ et al. (2020). Common Genetic Variants Modulate the Electrocardiographic Tpeak-to-Tend Interval. nameOfConference

  
  

  DOI: 10.1016/j.ajhg.2020.04.009

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/65500
• Noordam R, Young WJ, Munroe PB (2019). Electrolytes and electrophysiology: What's next?. nameOfConference

  
  

  DOI: 10.18632/aging.102267

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/60958
• Noordam R, Young WJ, Salman R et al. (2019). Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals. nameOfConference

  
  

  DOI: 10.1016/j.jacc.2019.03.519

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/62235
• Lambiase PD, Young WJ (2019). Sudden cardiac death risk prediction - As easy as ECG?. nameOfConference

  
  

  DOI: 10.1016/j.ijcard.2018.10.100

  
  

  QMRO: qmroHref
• Young WJ, Jeffery DA, Hua A et al. (2018). Echocardiography in Patients With Infective Endocarditis and the Impact of Diagnostic Delays on Clinical Outcomes. nameOfConference

  
  

  DOI: 10.1016/j.amjcard.2018.04.039

  
  

  QMRO: qmroHref
• Javaid MR, Baca G, Dyall L et al. (2017). 13 Keeping up the beat: a quality improvement project on heart failure monitoring & management. nameOfConference

  
  

  DOI: 10.1136/heartjnl-2017-311726.13

  
  

  QMRO: qmroHref
• Young W, Ibrahim M, Gall N (2015). 66 The Management of Syncope on the Acute Medical Take. An Experience at a District General Hospital. nameOfConference

  
  

  DOI: 10.1136/heartjnl-2015-308066.66

  
  

  QMRO: qmroHref
• Young W, Bhichhyan R, Kabir A et al. (publicationYear). ST-elevation myocardial infarction secondary to coronary artery spasm provoked by food. nameOfConference

  
  

  DOI: 10.1136/bcr-2014-205222

  
  

  QMRO: qmroHref

Collaborators

External

• Dr Borbala Mifsud (University of Qatar)
• Dr Raymond Noordam (Leiden University Medical Center)

CHARGE consortium

• Dr Christopher Newton-Cheh (Broad Institute of Harvard and MIT)
• Dr Nona Sotoodehnia (Washington University)
• Dr Larisa Tereschenko (John Hopkins University)
• Dr Jerry Rotter & Dr Henry Lin (The Lundquist Institute UCLA Medical Center)

News

• Researchers discover new genetic loci, pathways, therapeutic targets, and relationships with cardiovascular disease based on QT interval anomalies