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PRESCORES

Preventing Endometrial Cancers: Comparing Risk-Reducing Strategies (PRESCORES)

What is the aim of this research?

This research study aims to help prevent cancer of the lining of the womb (also known as endometrial cancer).

Some people are at increased risk of womb cancer. This could be because they have an alteration or fault in their DNA or genetic code, such as Lynch Syndrome. Other common conditions such diabetes and obesity also increase the risk of this cancer.

Some people have an operation to remove their womb to prevent this cancer before it develops. This is called a hysterectomy. We want to understand the impact of this operation on a person’s quality of life. Once we know this, we can see if more people should be offered this operation to prevent womb cancer. Finally, we want to know if people would be willing to have this operation, or other cancer preventions, if they found out they had an increased risk of womb cancer.

We hope to prevent many more womb cancers in the future, instead of only treating them once they develop. These surveys are very important for us to do that.

Survey for people with Lynch Syndrome

We have developed a survey for people with Lynch Syndrome. This aims to find out the quality of life of people who have had an operation to prevent womb cancer, and those who have not. We would like as many people with Lynch Syndrome as possible to complete this, whether they have had this operation or not. We can then see what impact this operation has.

If you have Lynch Syndrome, are aged over 18 years and live in the UK then we would be very grateful if you would consider taking part in this survey. However, if you have previously had womb, ovarian or cervical cancer then you would not be eligible.

Please read the PRESCORES Participant Information Sheet [DOC 187KB] for more information

If you would like to, please participate in the study here. 

Research Team

This research project will be run by health professionals under the leadership of Professor Ranjit Manchanda at the Wolfson Institute of Population Health, Queen Mary University of London. The people involved are:

  • Professor Ranjit Manchanda - Consultant Gynaecological Oncologist, Royal London Hospital & Professor, Queen Mary University of London
  • Professor Rosa Legood - Assistant Professor, London School of Hygiene and Tropical Medicine
  • Dr Samuel Oxley - Clinical Research Fellow Gynaecological Oncology, Queen Mary University of London
  • Dr Adam Brentnall - Senior Lecturer in Statistics, Queen Mary University of London
  • Dr Kevin Monahan - Consultant Gastroenterologist at the Family Cancer Clinic, St Marks Hospital
  • Dr Alison Kraus - Consultant in Clinical Genetics, Leeds Teaching Hospitals NHS Trust
  • Dr Vishakha Tripathi - Consultant Genetic Counsellor in Cancer Genetics, Guys and St Thomas’ Hospital
  • Dr Saba Sharif - Consultant Clinical Geneticist, Great Ormond Street Hospital 
  • Dr Dimitra Repana - Consultant Medical Oncologist, St George’s University Hospital
  • Dr Fiona Lalloo - Consultant in Cancer Genetics, Manchester University NHS Trust
  • Dr Helen Hanson - Consultant in Cancer Genetics, Royal Devon University Healthcare NHS Foundation Trust
  • Dr Lucy Side - Consultant in Clinical Genetics, Southampton General Hospital
  • Mr Janos Balega - Consultant Gynaecological Oncologist, Birmingham City Hospital
  • Professor Sadaf Ghaem-Maghami - Consultant Gynaecological Oncologist, Imperial College Healthcare NHS Trust
  • Dr Amy Watford - Research Genetic Counsellor, St Michaels Hospital, Bristol
  • Dr Kai Ren Ong - Consultant in Clinical Genetics, Birmingham Women's and Children's NHS Foundation Trust
  • Dr Esther Moss - Consultant Gynaecological Oncologist, University Hospitals of Leicester NHS Trust
  • Dr Rachel Hart - Consultant in Clinical Genetics, Liverpool Women's NHS Foundation Trust
  • Dr Rachel Harrison - Consultant Clinical Geneticist, Nottingham City Hospital
  • Dr Jackie Cook - Consultant Clinical Geneticist, Sheffield Children’s NHS Foundation Trust

Funding

This research is funded by the Rosetrees Trust, a UK charity 

Contact the team

If you have any questions, queries or concerns regarding the research, please contact the study team using the contact details below.

Email: wpp-prescores@qmul.ac.uk

Write to:

PRESCORES Research Team, Wolfson Institute for Population Health, Centre for Prevention, Detection and Diagnosis, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ   

Thank you for your interest in and help with our research.

 

For further information or support please contact:

Lynch Syndrome UK have helped develop and support this study

 

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