Caitlin Fierheller, PhD

Profile

I joined the Women’s Precision Prevention (WPP) team with Prof Ranjit Manchanda as a postdoctoral research associate in February 2023. I am currently working across clinical trials in the WPP team which focus on population-based genetic testing, targeted screening, cancer prevention (including surgical) and health economics. I am a co-investigator on the PROTECT-C (Population based germline testing for early detection and prevention of cancer) and DETECT-2 (Direct to patient testing at cancer diagnosis for precision prevention-2). I also work on the Jewish Hereditary Cancer Review, PRESCORES (Preventing Endometrial Cancers: Comparing Risk-Reducing Strategies), PROTECTOR (Prevention ovarian cancer through early excision of tubes and late ovarian removal), and other studies.

I completed my PhD in Human Genetics at McGill University, Montreal, Canada in 2023. My research focused on the molecular genetics of germline potentially pathogenic variants in DNA repair pathway genes in familial ovarian cancer. I obtained my BSc in 2016 in Genetics and Biochemistry from Western University, London, Canada.

Research

Research Interests:

Cancer prevention

Cancer genetics

Population-based genetic testing

Publications

• Fierheller C, Sarig K, Oxley S et al. (2024). BRCA awareness and testing experience in the UK Jewish population: A qualitative study. nameOfConference

  
  

  DOI: 10.1016/j.ygyno.2024.07.238

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/100560
• Fierheller C, Gootzen T, Kalra A et al. (2024). BRCA1 and BRCA2 information provision online: An occasion for improvement. nameOfConference

  
  

  DOI: 10.1016/j.ygyno.2024.07.234

  
  

  QMRO: qmroHref
• Manchanda R, Wei X, Sun L et al. (2024). Cost-effectiveness analysis of cancer susceptibility gene-specific prevention strategies for ovarian and breast cancer. nameOfConference

  
  

  DOI: 10.1016/j.ygyno.2024.07.233

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/100488
• Fierheller C, Sun L, Wei X et al. (2024). Population-based BRCA1 and BRCA2 genetic testing is cost-effective in Canada. nameOfConference

  
  

  DOI: 10.1016/j.ygyno.2024.07.067

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/100552
• Kalra A, Ganesan S, Sia J et al. (2024). EV186/#1233 Patient-related outcomes of mainstreaming genetic testing – a systematic review and meta-analysis. E-Poster Viewing Abstracts

  
  

  DOI: 10.1136/ijgc-2024-igcs.305

  
  

  QMRO: qmroHref
• Sun L, Wei X, Fierheller CT et al. (2024). Economic Evaluation of Population-Based BRCA1 and BRCA2 Testing in Canada. nameOfConference

  
  

  DOI: 10.1001/jamanetworkopen.2024.32725

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/98325
• Manchanda R (2024). Online Provision of BRCA1 and BRCA2 Health Information: A Search Engine Driven Systematic Web-Based Analysis. nameOfConference

  
  

  DOI: 10.3390/cancers16132324

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/97698
• Manchanda R, Sun L, Wei X et al. (2024). Cost-effectiveness of unselected multigene germline and somatic genetic testing for epithelial ovarian cancer. nameOfConference

  
  

  DOI: 10.6004/jnccn.2023.7331

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/95917
• Oxley S, Manchanda R (2024). BRCA awareness and testing experience in the UK Jewish population: a qualitative study. nameOfConference

  
  

  DOI: 10.1136/jmg-2023-109576

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/95916
• Oxley S, Manchanda R (2024). Utility Scores for Risk-Reducing Mastectomy and Risk-Reducing Salpingo-Oophorectomy: Mapping to EQ-5D. nameOfConference

  
  

  DOI: 10.3390/cancers16071358

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/95918
• Sideris M, Brincat MR, Blyuss O et al. (2024). 1033 Validation of P-POSSUM scale in ovarian cancer (OC) cytoreductive surgery. Poster and E-Posters

  
  

  DOI: 10.1136/ijgc-2024-esgo.766

  
  

  QMRO: qmroHref
• Gootzen TA, Kalra A, Sarig K et al. (2024). 405 Analysis of BRCA1 and BRCA2 information provision online. Poster and E-Posters

  
  

  DOI: 10.1136/ijgc-2024-esgo.884

  
  

  QMRO: qmroHref
• Sun L, Wei X, Fierheller CT et al. (2024). 406 Population-based BRCA1 and BRCA2 testing in Canada: an economic evaluation. Young Investigator Session

  
  

  DOI: 10.1136/ijgc-2024-esgo.66

  
  

  QMRO: qmroHref
• Wei X, Sun L, Slade E et al. (2024). 443 Cost-effectiveness analysis of cancer susceptibility gene-specific prevention strategies for ovarian and breast cancer. Oral Sessions

  
  

  DOI: 10.1136/ijgc-2024-esgo.50

  
  

  QMRO: qmroHref
• Kalra A, Gootzen TA, Fierheller CT et al. (2024). 461 HBOC and lynch syndrome: ai-powered multi-platform analysis of social media activity. Poster and E-Posters

  
  

  DOI: 10.1136/ijgc-2024-esgo.503

  
  

  QMRO: qmroHref
• Oxley S, Sia J, Samuels A et al. (2024). 583 Experiences of women following risk-reducing early-salpingectomy and delayed-oophorectomy and salpingo-oophorectomy on the PROTECTOR trial: a qualitative study. Poster and E-Posters

  
  

  DOI: 10.1136/ijgc-2024-esgo.895

  
  

  QMRO: qmroHref
• Oxley S, Wei X, Sideris M et al. (2024). 948 EQ-5D utility scores for risk-reducing mastectomy and risk-reducing salpingo-oophorectomy: mapping from SF-12 and SF-36. Poster and E-Posters

  
  

  DOI: 10.1136/ijgc-2024-esgo.904

  
  

  QMRO: qmroHref
• Wei X, Sun L, Slade E et al. (2024). Cost-Effectiveness of Gene-Specific Prevention Strategies for Ovarian and Breast Cancer. nameOfConference

  
  

  DOI: 10.1001/jamanetworkopen.2023.55324

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/94579
• Wei X, Sun L, Slade E et al. (2023). EE675 Cost-Effectiveness Analysis of Cancer Susceptibility Gene-Specific Prevention and Surveillance Strategies for Ovarian and Breast Cancer. nameOfConference

  
  

  DOI: 10.1016/j.jval.2023.09.940

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/93539
• Sobocan M, Chandrasekaran D, Sideris M et al. (2024). Patient decision aids in mainstreaming genetic testing for women with ovarian cancer: A prospective cohort study. nameOfConference

  
  

  DOI: 10.1111/1471-0528.17675

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/91563
• Alenezi WM, Fierheller CT, Serruya C et al. (publicationYear). Genetic analyses of DNA repair pathway associated genes implicate new candidate cancer predisposing genes in ancestrally defined ovarian cancer cases. nameOfConference

  
  

  DOI: 10.3389/fonc.2023.1111191

  
  

  QMRO: qmroHref
• Fierheller CT, Alenezi WM, Serruya C et al. (publicationYear). Molecular Genetic Characteristics of FANCI, a Proposed New Ovarian Cancer Predisposing Gene. nameOfConference

  
  

  DOI: 10.3390/genes14020277

  
  

  QMRO: qmroHref
• Alenezi WM, Milano L, Fierheller CT et al. (publicationYear). The Genetic and Molecular Analyses of RAD51C and RAD51D Identifies Rare Variants Implicated in Hereditary Ovarian Cancer from a Genetically Unique Population. nameOfConference

  
  

  DOI: 10.3390/cancers14092251

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/93779
• Alenezi WM, Fierheller CT, Revil T et al. (publicationYear). Case Review: Whole-Exome Sequencing Analyses Identify Carriers of a Known Likely Pathogenic Intronic BRCA1 Variant in Ovarian Cancer Cases Clinically Negative for Pathogenic BRCA1 and BRCA2 Variants. nameOfConference

  
  

  DOI: 10.3390/genes13040697

  
  

  QMRO: qmroHref
• Fierheller CT, Guitton-Sert L, Alenezi WM et al. (2021). A functionally impaired missense variant identified in French Canadian families implicates FANCI as a candidate ovarian cancer-predisposing gene. nameOfConference

  
  

  DOI: 10.1186/s13073-021-00998-5

  
  

  QMRO: qmroHref
• Fierheller CT, Alenezi WM, Tonin PN (publicationYear). The Genetic Analyses of French Canadians of Quebec Facilitate the Characterization of New Cancer Predisposing Genes Implicated in Hereditary Breast and/or Ovarian Cancer Syndrome Families. nameOfConference

  
  

  DOI: 10.3390/cancers13143406

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/93792
• Alenezi WM, Fierheller CT, Recio N et al. (publicationYear). Literature Review of BARD1 as a Cancer Predisposing Gene with a Focus on Breast and Ovarian Cancers. nameOfConference

  
  

  DOI: 10.3390/genes11080856

  
  

  QMRO: qmroHref