Professor Amrita Ahluwalia, FMedSciDean for Research - Faculty of Medicine and DentistryCentre: Cardiovascular Medicine and DevicesEmail: a.ahluwalia@qmul.ac.ukTelephone: +44(0) 20 7882 8377ProfileResearchPublicationsSponsorsCollaboratorsNewsDisclosuresProfileORCID iD: 0000-0001-7626-6399 If you are a potential volunteer interested in participating in one of the trials we are running please see: Clinical trials in Vascular Pharmacology. Amrita Ahluwalia obtained a BSc in Pharmacology from Bath University and undertook doctoral training at the William Harvey Research Institute (WHRI). In the mid-nineties she worked at St George's Hospital Medical School with Professor Patrick Vallance followed by University College London as a Lecturer before returning to the WHRI where she is currently a Professor of Vascular Pharmacology. Amrita was Deputy Director of the WHRI from 2013-2016 and then Director from 2016-2020. Her interests revolve around developing therapeutics targeting inflammation in the cardiovascular system for which she has won awards e.g. GSK Prize in Clinical Pharmacology 2012, WISE 2015 Prize for Research). In addition to her research she is committed to establishing equality in the workplace. Amrita established the first National mentoring scheme for women of a learned society (British Pharmacological Society) in 2005. She was also the first Chair of the Women in Pharmacology Committee of the same society from 2007-2010 that established the Astra Zeneca Women in Pharmacology Prize and led the award of the first Athena Swan Silver prize for Barts & The London Medical School. Amrita is the first female EiC of the internationally leading British Journal of Pharmacology (2016-current). Amrita is currently Dean for Research and Research Impact (Faculty of Medicine & Dentistry), Lead of The Vascular Pharmacology Group, Director of the Barts Cardiovascular Clinical Trials Unit. Separately she is Chair of the Basic and Translational Section of The International Union of Basic and Clinical Pharmacology. Director of the Barts Cardiovascular Clinical Trials Unit (CVCTU)Prof Ahluwalia is the Director of the Cardiovascular Clinical Trials Unit (CVCTU), a branch of the Barts Clinical Trials Unit (a UK Clinical Research Collaboration (UKCRC) registered unit). Under Prof Ahluwalia’s leadership, the CVCTU has been established to manage and coordinate clinical trials with robust systems to ensure the highest quality standards of conduct and delivery of cardiovascular clinical trials and is funded by the Barts Charity Cardiovascular Research Programme. As Director, Prof Ahluwalia as the CVCTU Steering Committee Chair, leads the strategic development, vision and work of the CVCTU, including; Delivery of clinical trials within the cardiovascular field with existing teams at the Barts Heart Centre Promotion of the CVCTU to Investigators within Barts Health NHS Trust and Queen Mary University of London, and wider clinical networks as the CV CTU develops Generation of external grant income to support the CVCTU core team Review of resources and recruitment of staff Oversight of the CVCTU trial portfolio and research management. Prof Ahluwalia is also the Chair of the CVCTU Scientific Committee, which oversees the adoption of new studies onto the CVCTU portfolio. The Scientific Committee reviews and assesses the scientific validity and justification of new studies requesting adoption to the CVCTU portfolio.ResearchVascular Pharmacology Group membersResearch staff: Jonathan Ho (Lab Manager), Vikas Kapil (Clinical Senior Lecturer/Consultant), Dan Jones (Clinical Senior Lecturer and Consultant Cardiologist), Rayomand Khambata (Lecturer), Gianmichele Massimo (Post-Doctoral Researcher), Krishnaraj Rathod (Clinical Senior Lecturer and SpR in Cardiology), Dr Claudio Raimondi (Lecturer), Dr Vahitha Abdul Salaam (Lecturer) PhD students: Nicki Dyson, Chris Primus (Cardiology SpR), Asad Shabbir (Cardiology SpR), Tipparat Parakaw, Anne-Marie Beirne (Cardiology SpR) Barts Cardiovascular Clinical Trials Unit (CVCTU) TeamCVCTU Manager: Jessica AdamsCVCTU Senior Clinical Trials Co-ordinator: Charlie MizonCVCTU Quality Assurance Manager/TC: Alexandra PapaCVCTU Database Developer/Manager: Simon MenezesCVCTU Monitor: Shahana ChowdhuryCVCTU Statistician: Tom Godec Vascular Pharmacology GroupThe main research focus of my group is the exploration of the impact of inflammation on cardiovascular function and the mechanisms involved in this phenomenon with a view to identifying novel targets and therapeutics. The group has four key areas of interest: 1. Effects of nitrite and nitrate on the cardiovascular system in health and disease A major research focus of the group is study of the bioactivity of the reductive nitrate-to nitrite to NO pathway in humans, often dubbed the enterosalivary circuit of inorganic nitrate. We made the first demonstrations of the protective effects of inorganic nitrite against myocardial ischemia-reperfusion injury implicating two enzymes in the conversion of nitrite to NO: xanthine oxidoreductase and eNOS. More recently, the vasodilator activity of nitrite has attracted much attention. In 2008 we published our findings that a dietary nitrate load, in the form of beetroot juice, reduces blood pressure and improves platelet and endothelial function in healthy volunteers. We are currently investigating the effect of a similar inorganic nitrate load in hypertensive and hypercholesterolemic patients and with Anthony Mathur the potential of intracoronary nitrite in patients suffering an acute myocardial infarction.2. Role of the kinin B1 receptor in cardiovascular diseaseAhluwalia & Perretti in 1996 published findings demonstrating the key role of the inducible kinin B1 receptor in neutrophil recruitment to a site of inflammation. Our research has focussed on the molecular pathways involved in this response and we have identified two particular pathways that play a role i.e. B1-induced endothelial chemokine generation and sensory C-fibre activation. Our most recent studies have demonstrated that laminar shear stress plays a major role in regulating endothelial kinin B1 receptor expression and that this regulation implicates the receptor in atherosclerosis.3. Sex differences in cardiovascular function and susceptibility to cardiovascular diseaseIn 2005 Ahluwalia and Hobbs published the findings demonstrating that endothelium-dependent relaxation of the resistance arteries of females is predominantly mediated by the endothelial factor endothelium-derived hyperpolarising factor, EDHF, whereas in the resistance vessels of males NO and the prostaglandin PGI2 are the primary endothelial factors. We also demonstrated that this propensity to express EDHF protected females from genetically-induced hypertension and protects females from inflammation. We have speculated that these differences may have a role to play in the reduced susceptibility of females to cardiovascular disease. We are currently investigating the pathways involved in this sex-specific upregulation of EDHF and reduced inflammatory responses in healthy volunteers to determine the relevance of our findings in pre-clinical models to humans. 4. Investigation of the role of TRPV1 in vascular reactivityIn 2004 we identified a major role for the TRPV1 channel and sensory C-fibres in mediating the constriction of resistance arteries that occurs in response to rises in intraluminal pressure; termed myogenic tone. We are currently investigating the molecular pathways involved in this response, in particular our observations have identified the arachidonate metabolite 20-hydroxyeicoasteraenois acid as an important TRPV1 activator. Beetroot study Dietary nitrate in the form of beetroot juice lowers blood pressure in healthy volunteers. SchemeWithin the blood vessel nitrite conversion to NO increases progressively with decreasing pH and oxygen tension. Our evidence suggests that both eNOS and xanthine oxidoreductase (XOR) are two key enzymes that act as nitrate reductases and are localised to both the endothelium and the red blood cell. Publications Kelham M, Beirne A-M, Rathod KS et al. (2024). CTCA Prior to Invasive Coronary Angiography in Patients With Previous Bypass Surgery: Patient-Related Outcomes, Imaging Resource Utilization, and Cardiac Events at 3 Years From the BYPASS-CTCA Trial.. nameOfConference DOI: 10.1161/circinterventions.124.014142 QMRO: qmroHref Massimo G, Dyson N, Olotu F et al. (publicationYear). Potential Opportunities for Pharmacogenetic-Based Therapeutic Exploitation of Xanthine Dehydrogenase in Cardiovascular Disease. nameOfConference DOI: 10.3390/antiox13121439 QMRO: qmroHref Rathod KS, Mathur A, Shabbir A et al. (2024). The NITRATE-OCT study-inorganic nitrate reduces in-stent restenosis in patients with stable coronary artery disease: a double-blind, randomised controlled trial. nameOfConference DOI: 10.1016/j.eclinm.2024.102885 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/101220 Insel PA, Amara SG, Ahluwalia A (2024). Introduction to the Theme “Novel Therapeutics with the Potential to Advance Health Care”. nameOfConference DOI: 10.1146/annurev-pharmtox-090324-021727 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/100643 Vyas R, Kelham M, Beirne A-M et al. (2024). OP5 Diagnostic accuracy of CTCA for graft and native disease assessment in patients with previous CABG: insights from the BYPASS-CTCA trial. OP5 Diagnostic accuracy of CTCA for graft and native disease assessment in patients with previous CABG: insights from the BYPASS-CTCA trial DOI: 10.1136/heartjnl-2024-bsci.5 QMRO: qmroHref Jones DA, Beirne A-M, Kelham M et al. (2024). Inorganic nitrate benefits contrast-induced nephropathy after coronary angiography for acute coronary syndromes: the NITRATE-CIN trial. nameOfConference DOI: 10.1093/eurheartj/ehae100 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/97501 Kelham M, Beirne A-M, Rathod KS et al. (2024). The effect of CTCA guided selective invasive graft assessment on coronary angiographic parameters and outcomes: Insights from the BYPASS-CTCA trial. nameOfConference DOI: 10.1016/j.jcct.2024.03.004 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/99981 Sienel RI, Mamrak U, Biller J et al. (publicationYear). Inhaled nitric oxide suppresses neuroinflammation in experimental ischemic stroke. nameOfConference DOI: 10.1186/s12974-023-02988-3 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/93163 Massimo G, Khambata RS, Chapman T et al. (2023). Corrigendum to “Natural mutations of human XDH promote the nitrite (NO2 −)-reductase capacity of xanthine oxidoreductase: A novel mechanism to promote redox health?” [Redox Biol. 4 (67) (2023) 102864]. nameOfConference DOI: 10.1016/j.redox.2023.102925 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/93328 Jones DA, Beirne A-M, Kelham M et al. (2023). Computed Tomography Cardiac Angiography Before Invasive Coronary Angiography in Patients With Previous Bypass Surgery: The BYPASS-CTCA Trial. nameOfConference DOI: 10.1161/circulationaha.123.064465 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/91973 Shabbir A, Chhetri I, Khambata RS et al. (publicationYear). A double-blind, randomised, placebo-controlled parallel study to investigate the effect of sex and dietary nitrate on COVID-19 vaccine-induced vascular dysfunction in healthy men and women: protocol of the DiNOVasc-COVID-19 study. nameOfConference DOI: 10.1186/s13063-023-07616-2 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/90982 Massimo G, Khambata RS, Chapman T et al. (2023). Natural mutations of human XDH promote the nitrite (NO2 −)-reductase capacity of xanthine oxidoreductase: A novel mechanism to promote redox health?. nameOfConference DOI: 10.1016/j.redox.2023.102864 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/90642 Rathod K, Warren H, Tufaro V et al. (2023). 34 Investigation of the effects of dietary nitrate on vascular function, platelet reactivity and restenosis in patients with stable angina (nitrate-oct study). Acute coronary syndromes & Interventional Cardiology DOI: 10.1136/heartjnl-2023-bcs.34 QMRO: qmroHref Rathod KS, Shabbir A, Jones DA et al. (2023). D Investigation of the effects of dietary nitrate on vascular function, platelet reactivity and restenosis in patients with stable angina (NITRATE-OCT study). Young investigators award DOI: 10.1136/heartjnl-2023-bcs.302 QMRO: qmroHref Bosseboeuf E, Chikh A, Chaker AB et al. (2023). Neuropilin-1 interacts with VE-cadherin and TGFBR2 to stabilize adherens junctions and prevent activation of endothelium under flow. nameOfConference DOI: 10.1126/scisignal.abo4863 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/88719 Panettieri RA, Stanford SC, Alexander S et al. (2023). BJP recommendations for publishing research on tobacco smoke and environmental tobacco smoke exposure. nameOfConference DOI: 10.1111/bph.16089 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/89880 Stanford SC, Alexander S, Cirino G et al. (2023). Considering and reporting sex as an experimental variable II: An update on progress in the British Journal of Pharmacology. nameOfConference DOI: 10.1111/bph.16049 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/86193 Hikin LJ, Ho J, Morley SR et al. (2023). Sodium nitrite poisoning: A series of 20 fatalities in which post-mortem blood nitrite and nitrate concentrations are reported. nameOfConference DOI: 10.1016/j.forsciint.2023.111610 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/86198 Rathod KS, Kapil V, Velmurugan S et al. (2023). Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans. nameOfConference DOI: 10.1172/jci168068 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/89143 Stanford SC, Alexander S, Cirino G et al. (2023). Considering And Reporting Sex As An Experimental Variable: An Update On Progress In The British Journal Of Pharmacology. nameOfConference DOI: doi QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/91619 Khambata R, Fernandes D, Massimo G et al. (2023). Local delivery of nitric oxide prevents endothelial dysfunction in periodontitis. nameOfConference DOI: doi QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/91620 Massimo G, Khambata R, Chapman T et al. (2023). Natural Mutations Of Human Xdh Promote The Nitirte (No2-)-Reductase Capacity Of Xanthine Oxidoreductase: A Novel Mechanism To Promote Redox Health?. nameOfConference DOI: doi QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/91621 Dyson N, Khambata R, Massimo G et al. (2023). Nitrite reductase activity of liver-derived Xanthine Oxidoreductase maintains cardiovascular homeostasis. nameOfConference DOI: doi QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/91618 Fernandes D, Khambata RS, Massimo G et al. (2023). Local delivery of nitric oxide prevents endothelial dysfunction in periodontitis. nameOfConference DOI: 10.1016/j.phrs.2022.106616 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/86195 Ingrande J, Patel HH, Kendall D et al. (2023). Guidance for the use and reporting of anaesthetic agents in BJP manuscripts involving work with animals. nameOfConference DOI: 10.1111/bph.15992 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/86194 Hikin L, Ahluwalia A, Morley S et al. (2022). Sodium nitrite poisoning; A case series of 15 fatalities. nameOfConference DOI: 10.1016/j.toxac.2022.06.056 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/89879 Curtis MJ, Alexander SPH, Cirino G et al. (2022). Planning experiments: Updated guidance on experimental design and analysis and their reporting III. nameOfConference DOI: 10.1111/bph.15868 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/89878 Shabbir A, Rathod K, Primus C et al. (2022). BS37 Leukocytic nitrate reductase activity mitigates systemic inflammation-induced endothelial dysfunction in humans by accelerating resolution. Basic science DOI: 10.1136/heartjnl-2022-bcs.217 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/90350 Spitschan M, Santhi N, Ahluwalia A et al. (publicationYear). Sex differences and sex bias in human circadian and sleep physiology research. nameOfConference DOI: 10.7554/elife.65419 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/86197 Hamers A, Primus CP, Whitear C et al. (2022). 20‐hydroxyeicosatetraenoic acid (20‐HETE) is a pivotal endogenous ligand for TRPV1‐mediated neurogenic inflammation in the skin. nameOfConference DOI: 10.1111/bph.15726 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/75763 Rathod KS, Jones DA, Jain AK et al. (publicationYear). The influence of biological age and sex on long-term outcome after percutaneous coronary intervention for ST-elevation myocardial infarction.. nameOfConference DOI: doi QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/75624 Maffia P, Antoniades C, Ahluwalia A et al. (2021). Molecular imaging—The first visual themed issue published in the British Journal of Pharmacology. nameOfConference DOI: 10.1111/bph.15632 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/74941 Primus C, Masucci M, Whitear C et al. (2021). A pro-resolving phenotype underpins the anti-inflammatory effects of inorganic nitrate. nameOfConference DOI: 10.1093/eurheartj/ehab724.3352 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/75507 Lau C, Shabbir A, Rathod KS et al. (2021). Inorganic nitrate attenuates endothelial dysfunction consequent to systemic inflammation. nameOfConference DOI: 10.1093/eurheartj/ehab724.3008 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/75511 Shabbir A, Lau C, Rathod KS et al. (2021). Inorganic nitrate attenuates the systemic inflammatory response in typhoid vaccine-induced endothelial dysfunction in healthy volunteers. nameOfConference DOI: 10.1093/eurheartj/ehab724.3009 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/75510 Gee LC, Massimo G, Lau C et al. (2022). Inorganic nitrate attenuates cardiac dysfunction: roles for xanthine oxidoreductase and nitric oxide. nameOfConference DOI: 10.1111/bph.15636 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/73324 Beirne A-M, Rathod KS, Castle E et al. (2021). The BYPASS-CTCA Study: the value of Computed Tomography Cardiac Angiography (CTCA) in improving patient-related outcomes in patients with previous bypass operation undergoing invasive coronary angiography: Study Protocol of a Randomised Controlled Trial. nameOfConference DOI: 10.21037/atm-21-1455 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/73928 Wang J, Mei F, Bai L et al. (2021). Serum nitrite and nitrate: A potential biomarker for post-covid-19 complications?. nameOfConference DOI: 10.1016/j.freeradbiomed.2021.08.237 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/75225 George CH, Alexander SPH, Cirino G et al. (2021). Editorial policy regarding the citation of preprints in the British Journal of Pharmacology (BJP). nameOfConference DOI: 10.1111/bph.15589 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/75425 Beirne A-M, Mitchelmore O, Palma S et al. (2021). NITRATE-CIN Study: Protocol of a Randomized (1:1) Single-Center, UK, Double-Blind Placebo-Controlled Trial Testing the Effect of Inorganic Nitrate on Contrast-Induced Nephropathy in Patients Undergoing Coronary Angiography for Acute Coronary Syndromes. nameOfConference DOI: 10.1177/1074248421000520 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/83343 Shabbir A, Lau C, Rathod KS et al. (2021). Inorganic nitrate attenuates the systemic inflammatory response in typhoid vaccine-induced endothelial dysfunction in healthy volunteers. nameOfConference DOI: doi QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/76139 Kelham M, Choudry FA, Hamshere S et al. (2021). Therapeutic Implications of COVID-19 for the Interventional Cardiologist. nameOfConference DOI: 10.1177/1074248420982736 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/78362 Shabbir A, Ahluwalia A (2021). Second wave and second opportunity: capitalizing on cardiovascular research activity during the COVID-19 pandemic. nameOfConference DOI: 10.1093/ehjqcco/qcaa087 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/86199 Shabbir A, Rathod KS, Khambata RS et al. (2021). Sex Differences in the Inflammatory Response: Pharmacological Opportunities for Therapeutics for Coronary Artery Disease. nameOfConference DOI: 10.1146/annurev-pharmtox-010919-023229 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/86196 Lilley E, Stanford SC, Kendall DE et al. (2020). ARRIVE 2.0 and the British Journal of Pharmacology: Updated guidance for 2020. nameOfConference DOI: 10.1111/bph.15178 QMRO: qmroHref du Sert NP, Ahluwalia A, Alam S et al. (publicationYear). Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0. nameOfConference DOI: 10.1371/journal.pbio.3000411 QMRO: qmroHref Percie du Sert N, Hurst V, Ahluwalia A et al. (2020). The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. nameOfConference DOI: 10.1186/s12917-020-02451-y QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/66207 du Sert NP, Hurst V, Ahluwalia A et al. (2020). The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research*. nameOfConference DOI: 10.1177/0271678x20943823 QMRO: qmroHref du Sert NP, Hurst V, Ahluwalia A et al. (2020). The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. nameOfConference DOI: 10.1113/jp280389 QMRO: qmroHref du Sert NP, Hurst V, Ahluwalia A et al. (publicationYear). The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. nameOfConference DOI: 10.1136/bmjos-2020-100115 QMRO: qmroHref Kapil V, Khambata RS, Jones DA et al. (2020). The Noncanonical Pathway for In Vivo Nitric Oxide Generation: The Nitrate-Nitrite-Nitric Oxide Pathway. nameOfConference DOI: 10.1124/pr.120.019240 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/65767 Cirino G, Ahluwalia A (2020). The many mechanisms of action of Chloroquine: to use or not to use (in COVID‐19) that is the question. nameOfConference DOI: 10.1111/bph.15177 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/65761 Izzo AA, Teixeira M, Alexander SPH et al. (2020). A practical guide for transparent reporting of research on natural products in the British Journal of Pharmacology: Reproducibility of natural product research. nameOfConference DOI: 10.1111/bph.15054 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/67836 Lau CWZ, Hamers AJP, Rathod KS et al. (2020). Randomised, double-blind, placebo-controlled clinical trial investigating the effects of inorganic nitrate in hypertension-induced target organ damage: Protocol of the NITRATE-TOD study in the UK. nameOfConference DOI: 10.1136/bmjopen-2019-034399 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/64122 George CH, Alexander SPH, Cirino G et al. (2019). The BJP expects authors to share data. nameOfConference DOI: 10.1111/bph.14907 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/69460 Dreyer G, Kieswich J, Harwood S et al. (2019). Ergocalciferol improves endothelial vasodilatory and vasoconstrictor function in an in vivo model of mild uraemia. nameOfConference DOI: 10.1042/bsr20190711 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/68022 (2019). Natural Mutations of the Human Xdh Impact upon the Nitric Oxide-generating Capacity of Xanthine Oxidoreductase. nameOfConference DOI: 10.1016/j.freeradbiomed.2019.10.310 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/68690 Ingram JR, Ahluwalia A (2019). The pharmacology of itch. nameOfConference DOI: 10.1111/bph.14865 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/62546 Ingram JR, Ahluwalia A (2019). The pharmacology of itch. nameOfConference DOI: 10.1111/bjd.18525 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/62547 Jones DA, Mathur A, Ahluwalia A (2019). Letter by Jones et al regarding article, “Optimized treatment of ST-elevation myocardial infarction”. nameOfConference DOI: 10.1161/CIRCRESAHA.119.315692 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/63620 Docherty JR, Stanford SC, Panettieri RA et al. (2019). Sex: A change in our guidelines to authors to ensure that this is no longer an ignored experimental variable. nameOfConference DOI: 10.1111/bph.14761 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/59782 du Sert NP, Ahluwalia A, Alam S et al. (publicationYear). Reporting animal research: Explanation and Elaboration for the ARRIVE guidelines 2019. nameOfConference DOI: 10.1101/703355 QMRO: qmroHref du Sert NP, Hurst V, Ahluwalia A et al. (publicationYear). The ARRIVE guidelines 2019: updated guidelines for reporting animal research. nameOfConference DOI: 10.1101/703181 QMRO: qmroHref Jones DA, Rathod KS, Williamson A et al. (2019). Corrigendum to “The effect of intracoronary sodium nitrite on the burden of ventricular arrhythmias following primary percutaneous coronary intervention for acute myocardial infarction” [Int. J. Cardiol. 266 (2018) 1–6]. nameOfConference DOI: 10.1016/j.ijcard.2019.04.076 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/65336 Guzik TJ, Ahluwalia A (2019). Plan S: in Service or Disservice to Society?. nameOfConference DOI: 10.1093/eurheartj/ehz065 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/59062 Guzik TJ, Ahluwalia A (2019). Plan S: In service or disservice to society?. nameOfConference DOI: 10.1111/bph.14590 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/56400 Ahluwalia A (2018). P2 Inorganic Nitrate as a Regulator of Vascular Function. nameOfConference DOI: 10.1016/j.freeradbiomed.2018.10.376 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/66762 Hamers AJP, Ahluwalia A (2017). Arachidonic acid metabolites induce TRPV1‐mediated inflammation. nameOfConference DOI: 10.1096/fasebj.31.1_supplement.825.5 QMRO: qmroHref Jones DA, Rathod KS, Williamson A et al. (2018). The effect of intracoronary sodium nitrite on the burden of ventricular arrhythmias following primary percutaneous coronary intervention for acute myocardial infarction. nameOfConference DOI: 10.1016/j.ijcard.2018.01.029 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/39903 Jones DA, Whittaker P, Rathod KS et al. (2018). P2564Sodium nitrite-mediated cardioprotection in primary percutaneous coronary intervention for ST-elevation myocardial infarction: a cost-effectiveness analysis. nameOfConference DOI: 10.1093/eurheartj/ehy565.p2564 QMRO: qmroHref Curtis MJ, Ashton JC, Moon LDF et al. (2018). Clarification of the basis for the selection of requirements for publication in the British Journal of Pharmacology. nameOfConference DOI: 10.1111/bph.14443 QMRO: qmroHref AHLUWALIA A, JONES D, MATHUR A (2018). Sodium Nitrite-Mediated Cardioprotection in Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction: A Cost-Effectiveness Analysis.. nameOfConference DOI: 10.1177/1074248418784940 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/44365 Kapil V, Rathod KS, Khambata RS et al. (2018). Sex differences in the nitrate-nitrite-NO• pathway: Role of oral nitrate-reducing bacteria. nameOfConference DOI: 10.1016/j.freeradbiomed.2018.07.010 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/55110 Chen J, Hamers AJP, Finsterbusch M et al. (2018). Endogenously generated arachidonate-derived ligands for TRPV1 induce cardiac protection in sepsis.. nameOfConference DOI: 10.1096/fj.201701303R QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/50363 Ahluwalia A, Cirino G (2018). Launch of mini‐reviews in hot topics. nameOfConference DOI: 10.1111/bph.14342 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/42425 du Sert NP, Hurst V, Ahluwalia A et al. (2018). Revision of the ARRIVE guidelines: rationale and scope. nameOfConference DOI: 10.1136/bmjos-2018-000002 QMRO: qmroHref Yellon DM, He Z, Khambata R et al. (2018). The GTN patch: a simple and effective new approach to cardioprotection?. nameOfConference DOI: 10.1007/s00395-018-0681-2 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/41443 Curtis MJ, Alexander S, Cirino G et al. (2018). Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers. nameOfConference DOI: 10.1111/bph.14153 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/45345 AHLUWALIA A (2018). Goals and practicalities of immunoblotting and immunohistochemistry: A guide for submission to the British Journal of Pharmacology.. nameOfConference DOI: 10.1111/bph.14112 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/37885 Jones DA, Whittaker P, Rathod KS et al. (2018). Sodium nitrite-mediated cardioprotection in primary percutaneous coronary intervention for ST-elevation myocardial infarction: a cost-effectiveness analysis. nameOfConference DOI: doi QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/66864 Osborne NJ, Ritskes-Hoitinga M, Ahluwahlia A et al. (2017). Letter to the editor - round table unites to tackle culture change in an effort to improve animal research reporting. nameOfConference DOI: 10.1186/s12917-017-1235-9 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/74817 Kapil V (2017). Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017.. nameOfConference DOI: 10.1186/s40360-017-0170-5 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/66725 Ahluwalia A, Jones MK, Hoa N et al. (2017). NGF protects endothelial cells from indomethacin-induced injury through activation of mitochondria and upregulation of IGF-1. nameOfConference DOI: 10.1016/j.cellsig.2017.08.006 QMRO: qmroHref Rathod KS, Hamshere S, Khambata RS et al. (2017). Combined analysis of the safety of intra-coronary drug delivery during primary percutaneous coronary intervention for acute myocardial infarction: A study of three clinical trials.. nameOfConference DOI: 10.1177/2048004017725988 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/34994 George CH, Stanford SC, Alexander S et al. (2017). Updating the guidelines for data transparency in the British Journal of Pharmacology – data sharing and the use of scatter plots instead of bar charts. nameOfConference DOI: 10.1111/bph.13925 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/39843 Campo G, Pavasini R, Morciano G et al. (2017). Data on administration of cyclosporine, nicorandil, metoprolol on reperfusion related outcomes in ST-segment Elevation Myocardial Infarction treated with percutaneous coronary intervention. nameOfConference DOI: 10.1016/j.dib.2017.07.033 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/25506 Yuzugulen J, Douthwaite JA, Wood EG et al. (2017). Characterisation of preproendothelin-1 derived peptides identifies Endothelin-Like Domain Peptide as a modulator of Endothelin-1.. nameOfConference DOI: 10.1038/s41598-017-05365-2 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/25963 Campo G, Pavasini R, Morciano G et al. (2017). Clinical benefit of drugs targeting mitochondrial function as an adjunct to reperfusion in ST-segment elevation myocardial infarction: A meta-analysis of randomized clinical trials. nameOfConference DOI: 10.1016/j.ijcard.2017.06.040 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/24891 Rathod K, Kapil V, Velmurugan S et al. (2017). Sex differences in the inflammatory response and inflammation-induced vascular dysfunction. FASEB DOI: 10.1016/s0140-6736(17)30416-6 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/22462 AHLUWALIA A (2017). The anti-inflammatory actions of inorganic nitrate stabilise the atherosclerotic plaque. nameOfConference DOI: 10.1073/pnas.1613063114 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/18789 Jones DA, Rathod KS, Ahluwalia A (2017). Chapter 15 Update on Nitrite Reduction in Ischemic Disease: Mechanisms and Clinical Translation. nameOfConference DOI: 10.1016/b978-0-12-804273-1.00015-6 QMRO: qmroHref Gee LC, Massimo G, Rathod KS et al. (2017). Effects of Dietary Nitrate on Blood Pressure-dependent and Independent Cardiac Dysfunction. nameOfConference DOI: doi QMRO: qmroHref Jones DA, Rathod KS, Ahluwalia A (2017). Update on Nitrite Reduction in Ischemic Disease: Mechanisms and Clinical Translation. nameOfConference DOI: 10.1016/B978-0-12-804273-1.00015-6 QMRO: qmroHref Rathod KS, Jones DA, Van-Eijl TJA et al. (2016). Randomised, double-blind, placebo-controlled study investigating the effects of inorganic nitrate on vascular function, platelet reactivity and restenosis in stable angina: protocol of the NITRATE-OCT study. nameOfConference DOI: 10.1136/bmjopen-2016-012728 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/18455 AHLUWALIA A (2016). Accelerated resolution underlies sex differences in the inflammatory response in human. nameOfConference DOI: 10.1172/JCI89429. QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/18792 Ahluwalia A, Jones MK, Brzozowski T et al. (2016). Nerve growth factor is critical requirement for in vitro angiogenesis in gastric endothelial cells. nameOfConference DOI: 10.1152/ajpgi.00334.2016 QMRO: qmroHref Chen J, Hamers AJP, Finsterbusch M et al. (2016). ACTIVATION OF TRPV1 BY 12(S)-HPETE AND 20-HETE RELEASES CGRP AND PROTECTS THE HEART AGAINST THE CARDIAC DYSFUNCTION CAUSED BY LPS. Exp Biology 2016 DOI: doi QMRO: qmroHref Jones DA, Khambata RS, Andiapen M et al. (2016). Intracoronary nitrite suppresses the inflammatory response following primary percutaneous coronary intervention.. nameOfConference DOI: 10.1136/heartjnl-2016-309748 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/17062 Hoa NT, Ge L, Martini F et al. (2016). Temozolomide induces the expression of the glioma Big Potassium (gBK) ion channel, while inhibiting fascin-1 expression: possible targets for glioma therapy. nameOfConference DOI: 10.1080/14728222.2016.1208172 QMRO: qmroHref Ahluwalia A, Gladwin M, Coleman GD et al. (2016). Dietary Nitrate and the Epidemiology of Cardiovascular Disease: Report From a National Heart, Lung, and Blood Institute Workshop. nameOfConference DOI: 10.1161/jaha.116.003402 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/17042 Samarasena JB, Ahluwalia A, Shinoura S et al. (2016). In vivo imaging of porcine gastric enteric nervous system using confocal laser endomicroscopy &molecular neuronal probe. nameOfConference DOI: 10.1111/jgh.13194 QMRO: qmroHref Chen J, Hamers AJP, Finsterbusch M et al. (2016). Activation of TRPV1 by 12(s)-HpETE and 20-HETE Releases CGRP and Protects the Heart Against the Cardiac Dysfunction Caused by LPS. Exp Biology (FASEB) 2016 DOI: 10.1096/fasebj.30.1_supplement.306.4 QMRO: qmroHref Khambata RS, Ghosh SM, Rathod KS et al. (2016). Dietary Nitrate Supresses Leukocyte Recruitment and Activation in Apolipoprotein E Knockout Mice. nameOfConference DOI: 10.1096/fasebj.30.1_supplement.165.2 QMRO: qmroHref Filomena F, Khambata R, Ahluwalia A (2016). Dietary nitrate suppresses platelet reactivity in Apolipoprotein E Knockout Mice. nameOfConference DOI: 10.1096/fasebj.30.1_supplement.1177.19 QMRO: qmroHref Rathod KS, Siddiqui U, Hartley A et al. (2016). Investigation of the influence of sex on cantharidin‐induced inflammation in healthy volunteers. nameOfConference DOI: 10.1096/fasebj.30.1_supplement.716.9 QMRO: qmroHref Ivanova E, Coroiu A, Ahluwalia A et al. (2016). Preliminary Findings on the Association Between Symptoms of Depression and Adherence to Antiretroviral Therapy in Individuals Born Inside Versus Outside of Canada. nameOfConference DOI: 10.1016/j.jana.2016.02.005 QMRO: qmroHref Aguinaldo JP, Ahluwalia A, Hambly K et al. (2016). Needs and Supports in Transitional Housing for People Living with HIV/AIDS in Ontario, Canada. nameOfConference DOI: 10.1080/01488376.2015.1101046 QMRO: qmroHref Gee LC, Ahluwalia A (2016). Dietary Nitrate Lowers Blood Pressure: Epidemiological, Pre-clinical Experimental and Clinical Trial Evidence. nameOfConference DOI: 10.1007/s11906-015-0623-4 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/18304 Rathod KS, Velmurugan S, Ahluwalia A (2016). A 'green' diet-based approach to cardiovascular health? Is inorganic nitrate the answer?. nameOfConference DOI: 10.1002/mnfr.201500313 QMRO: qmroHref Velmurugan S, Gan JM, Rathod KS et al. (2016). Dietary nitrate improves vascular function in patients with hypercholesterolemia: a randomized, double-blind, placebo-controlled study 1–3. nameOfConference DOI: 10.3945/ajcn.115.116244 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/14986 Fernandes D, Khambata R, Ahluwalia A (2015). Abstract 10110: Effects of Inorganic Nitrate on Endothelial Dysfunction Induced by Periodontitis. nameOfConference DOI: 10.1161/circ.132.suppl_3.10110 QMRO: qmroHref Jandhyala DM, Ahluwalia A, Schimmel JJ et al. (2016). Activation of the Classical Mitogen-Activated Protein Kinases Is Part of the Shiga Toxin-Induced Ribotoxic Stress Response and May Contribute to Shiga Toxin-Induced Inflammation. nameOfConference DOI: 10.1128/iai.00977-15 QMRO: qmroHref Rathod KS, Velmurugan S, Ahluwalia A (2016). A ‘green’ diet‐based approach to cardiovascular health? Is inorganic nitrate the answer?. nameOfConference DOI: 10.1002/mnfr.201500313 QMRO: qmroHref Samarasena JB, Tarnawski AS, Ahluwalia A et al. (2015). EUS-guided in vivo imaging of the porcine esophageal enteric nervous system by using needle-based confocal laser endomicroscopy. nameOfConference DOI: 10.1016/j.gie.2015.06.048 QMRO: qmroHref (2015). Erratum. nameOfConference DOI: 10.1111/bph.13275 QMRO: qmroHref Curtis MJ, Bond RA, Spina D et al. (2015). Experimental design and analysis and their reporting: new guidance for publication in BJP. nameOfConference DOI: 10.1111/bph.12856 QMRO: qmroHref Velmurugan S, Kapil V, Ghosh SM et al. (2015). Erratum: Antiplatelet effects of dietary nitrate in healthy volunteers: Involvement of cGMP and influence of sex (Free Radical Biology and Medicine (2013) 65 (1521-1532)). nameOfConference DOI: 10.1016/j.freeradbiomed.2015.03.015 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/10411 Tolstanova G, Deng X, Ahluwalia A et al. (2015). Role of Dopamine and D2 Dopamine Receptor in the Pathogenesis of Inflammatory Bowel Disease. nameOfConference DOI: 10.1007/s10620-015-3698-5 QMRO: qmroHref Velmurugan S, Kapil V, Ghosh SM et al. (2015). Erratum to “Antiplatelet effects of dietary nitrate in healthy volunteers: Involvement of cGMP and influence of sex” [Free Radic. Biol. Med. 65 (2013) 1521–1532]. nameOfConference DOI: 10.1016/j.freeradbiomed.2015.03.015 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/7745 Khambata RS, Ghosh SM, Ahluwalia A (2015). “Repurposing” of Xanthine Oxidoreductase as a Nitrite Reductase: A New Paradigm for Therapeutic Targeting in Hypertension. nameOfConference DOI: 10.1089/ars.2015.6254 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/6956 Macé V, Ahluwalia A, Coron E et al. (2015). Confocal laser endomicroscopy: A new gold standard for the assessment of mucosal healing in ulcerative colitis. nameOfConference DOI: 10.1111/jgh.12748 QMRO: qmroHref Lara J, Ashor AW, Oggioni C et al. (2016). Effects of inorganic nitrate and beetroot supplementation on endothelial function: a systematic review and meta-analysis. nameOfConference DOI: 10.1007/s00394-015-0872-7 QMRO: qmroHref Kapil V, Khambata RS, Robertson A et al. (2015). Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: A randomized, phase 2, double-blind, placebo-controlled study. nameOfConference DOI: 10.1161/HYPERTENSIONAHA.114.04675 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/6639 Velmurugan S, Ghosh SM, Khambata RS et al. (2015). Acute administration of dietary nitrate improves endothelial function and vascular stiffness in hypercholesterolemia. nameOfConference DOI: doi QMRO: qmroHref Fernandes D, Khambata R, Ahluwalia A (2015). Effects of Inorganic Nitrate on Endothelial Dysfunction Induced by Periodontitis. nameOfConference DOI: doi QMRO: qmroHref Jones DA, Pellaton C, Velmurugan S et al. (2015). Randomized phase 2 trial of intracoronary nitrite during acute myocardial infarction. nameOfConference DOI: 10.1161/CIRCRESAHA.116.305082 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/7741 Tarnawski AS, Ahluwalia A, Jones MK (2014). Angiogenesis in gastric mucosa: An important component of gastric erosion and ulcer healing and its impairment in aging. nameOfConference DOI: 10.1111/jgh.12734 QMRO: qmroHref Jones DA, Pellaton C, Velmurugan S et al. (2015). Randomized Phase 2 Trial of Intracoronary Nitrite During Acute Myocardial Infarction. nameOfConference DOI: 10.1161/circresaha.116.305082 QMRO: qmroHref Kapil V, Khambata RS, Robertson A et al. (2015). Dietary Nitrate Provides Sustained Blood Pressure Lowering in Hypertensive Patients. nameOfConference DOI: 10.1161/hypertensionaha.114.04675 QMRO: qmroHref Jones DA, Pellaton C, Velmurugan S et al. (2014). P141 The safety and efficacy of intra-coronary nitrite infusion during acute myocardial infarction (NITRITE-AMI): A single centre, randomised, double-blind controlled trial. nameOfConference DOI: 10.1016/j.niox.2014.09.087 QMRO: qmroHref Rathod K, Ghosh S, Khambata R et al. (2014). P175 Xanthine oxidoreductase in atherosclerotic mice: Determination of expression and nitrite reductase activity. nameOfConference DOI: 10.1016/j.niox.2014.09.119 QMRO: qmroHref Velmurugan S, Ghosh S, Khambata R et al. (2014). P200 Dietary nitrate improves endothelial function and vascular stiffness in hypercholesterolemia. nameOfConference DOI: 10.1016/j.niox.2014.09.141 QMRO: qmroHref Moyes AJ, Khambata RS, Villar I et al. (2014). Endothelial C-type natriuretic peptide maintains vascular homeostasis.. nameOfConference DOI: 10.1172/JCI74281 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/6288 Ahluwalia A, Baatar D, Jones MK et al. (2014). Novel mechanisms and signaling pathways of esophageal ulcer healing: the role of prostaglandin EP2 receptors, cAMP, and pCREB. nameOfConference DOI: 10.1152/ajpgi.00177.2014 QMRO: qmroHref Kapil V, Weitzberg E, Lundberg JO et al. (2014). Clinical evidence demonstrating the utility of inorganic nitrate in cardiovascular health. nameOfConference DOI: 10.1016/j.niox.2014.03.162 QMRO: qmroHref Kapil V, Weitzberg E, Lundberg JO et al. (2014). Clinical evidence demonstrating the utility of inorganic nitrate in cardiovascular health.. nameOfConference DOI: 10.1016/j.niox.2014.03.162 QMRO: qmroHref Khomenko T, Deng X, Ahluwalia A et al. (2014). STAT3 and Importins Are Novel Mediators of Early Molecular and Cellular Responses in Experimental Duodenal Ulceration. nameOfConference DOI: 10.1007/s10620-013-2807-6 QMRO: qmroHref Ghosh S, Khambata R, Ahluwalia A (2014). DIETARY INORGANIC NITRATE REDUCES INFLAMMATORY CELL RECRUITMENT IN MICE. nameOfConference DOI: doi QMRO: qmroHref Velmurugan S, Ghosh SM, Khambata RS et al. (2014). Dietary nitrate improves endothelial function, vascular stiffness and modifies platelet markers of atherogenesis in hypercholesterolemia. nameOfConference DOI: doi QMRO: qmroHref Tarnawski AS, Ahluwalia A, Jones MK (2014). Increased susceptibility of aging gastric mucosa to injury: The mechanisms and clinical implications. nameOfConference DOI: 10.3748/wjg.v20.i16.4467 QMRO: qmroHref Jones DA, Pellaton C, Velmurugan S et al. (2014). The safety and efficacy of intracoronary nitrite infusion during acute myocardial infarction (NITRITE-AMI): a single centre, randomised, double-blind controlled trial. nameOfConference DOI: doi QMRO: qmroHref Ahluwalia A, Jones MK, Matysiak-Budnik T et al. (2014). VEGF and colon cancer growth beyond angiogenesis: does VEGF directly mediate colon cancer growth via a non-angiogenic mechanism?. nameOfConference DOI: 10.2174/1381612819999131218175905 QMRO: qmroHref Ahluwalia A, Jones MK, Tarnawski AS (2014). Key role of endothelial importin-α in VEGF expression and gastric angiogenesis: novel insight into aging gastropathy. nameOfConference DOI: 10.1152/ajpgi.00382.2013 QMRO: qmroHref Velmurugan S, Kapil V, Ghosh SM et al. (2013). Antiplatelet effects of dietary nitrate in healthy volunteers: involvement of cGMP and influence of sex.. nameOfConference DOI: 10.1016/j.freeradbiomed.2013.06.031 QMRO: qmroHref Yuzugulen J, Wood EG, Villar IC et al. (2013). Characterisation of the “Endothelin-Like Domain Peptide” (ELDP) co-synthesised with Endothelin-1 from the EDN1 gene. nameOfConference DOI: 10.1016/j.lfs.2013.12.037 QMRO: qmroHref Ahluwalia A, Gokulan K, Nath I et al. (1997). Modification of Delivery System Enhances MHC Nonrestricted Immunogenicity of V3 Loop Region of HIV‐1 gp120. nameOfConference DOI: 10.1111/j.1348-0421.1997.tb01926.x QMRO: qmroHref Bubb KJ, Wen H, Panayiotou CM et al. (2013). Activation of neuronal transient receptor potential vanilloid 1 channel underlies 20-hydroxyeicosatetraenoic acid-induced vasoactivity: role for protein kinase A.. nameOfConference DOI: 10.1161/HYPERTENSIONAHA.111.00942 QMRO: qmroHref Ahluwalia A, Jones MK, Szabo S et al. (2013). Aberrant, ectopic expression of VEGF and VEGF receptors 1 and 2 in malignant colonic epithelial cells. Implications for these cells growth via an autocrine mechanism. nameOfConference DOI: 10.1016/j.bbrc.2013.06.096 QMRO: qmroHref Ahluwalia A, Jones MK, Deng X et al. (2013). An imbalance between VEGF and endostatin underlies impaired angiogenesis in gastric mucosa of aging rats. nameOfConference DOI: 10.1152/ajpgi.00127.2013 QMRO: qmroHref Ghosh SM, Kapil V, Fuentes-Calvo I et al. (2013). Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential.. nameOfConference DOI: 10.1161/HYPERTENSIONAHA.111.00933 QMRO: qmroHref Kapil V, Haydar SMA, Pearl V et al. (2013). Physiological role for nitrate-reducing oral bacteria in blood pressure control.. nameOfConference DOI: 10.1016/j.freeradbiomed.2012.11.013 QMRO: qmroHref Velmurugan S, Kapil V, Ghosh SM et al. (2013). Antiplatelet effects of dietary nitrate in healthy volunteers: Involvement of cGMP and influence of sex. nameOfConference DOI: 10.1016/j.freeradbiomed.2013.06.031 QMRO: qmroHref Rousselle A, Qadri F, Leukel L et al. (2013). CXCL5 limits macrophage foam cell formation in atherosclerosis. nameOfConference DOI: 10.1172/JCI66580 QMRO: qmroHref Martin K, Perretti M, Ahluwalia A (2013). Kinin B1 receptor regulates inflammatory cell recruitment during low laminar shear stress. nameOfConference DOI: 10.1096/fasebj.27.1_supplement.646.4 QMRO: qmroHref Ahluwalia A, Hobbs AJ (2013). Letter by Ahluwalia and Hobbs Regarding Article, "Nitrate-Nitrite-Nitric Oxide Pathway in Pulmonary Arterial Hypertension Therapeutics". nameOfConference DOI: 10.1161/CIRCULATIONAHA.112.118356 QMRO: qmroHref Ghosh SM, Kapil V, Bubb K et al. (2013). Mechanisms underlying nitrite reduction in hypertension: Role for erythrocytic xanthine oxidoreductase. nameOfConference DOI: 10.1016/j.niox.2013.02.030 QMRO: qmroHref Jones DA, Khambata RS, Mathur A et al. (2013). Sodium nitrite promotes the viability and proliferation of endothelial cells but inhibits the growth of smooth muscle cells under hypoxia. nameOfConference DOI: 10.1016/j.niox.2013.02.024 QMRO: qmroHref Jones DA, Andiapen M, Van-Eijl TJA et al. (2013). The safety and efficacy of intracoronary nitrite infusion during acute myocardial infarction (NITRITE-AMI): study protocol of a randomised controlled trial.. nameOfConference DOI: 10.1136/bmjopen-2013-002813 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/7759 Yuzugulen J, Wood EG, Douthwaite JA et al. (2012). Abstract 18898: Characterization of Proendothelin-1 Derived Peptides Identifies a Co-secreted Modulator of ET-1 Vasoconstriction, and Provides Insights for Biomarker Measurements. nameOfConference DOI: 10.1161/circ.126.suppl_21.a18898 QMRO: qmroHref Chan MV, Bubb KJ, Noyce A et al. (2012). Distinct endothelial pathways underlie sexual dimorphism in vascular auto-regulation.. nameOfConference DOI: 10.1111/j.1476-5381.2012.02012.x QMRO: qmroHref Bubb KJ, Khambata RS, Ahluwalia A (2012). Sexual dimorphism in rodent models of hypertension and atherosclerosis.. nameOfConference DOI: 10.1111/j.1476-5381.2012.02036.x QMRO: qmroHref Perretti M, Ahluwalia A, Harris JG et al. (1996). Acute inflammatory response in the mouse: exacerbation by immunoneutralization of lipocortin 1. nameOfConference DOI: 10.1111/j.1476-5381.1996.tb16709.x QMRO: qmroHref Ahluwalia A, Maggi CA, Santicioli P et al. (1994). Characterization of the capsaicin‐sensitive component of cyclophosphamide‐induced inflammation in the rat urinary bladder. nameOfConference DOI: 10.1111/j.1476-5381.1994.tb14845.x QMRO: qmroHref Ahluwalia A, Giuliani S, Maggi CA (1995). Demonstration of a ‘septide‐sensitive’ inflammatory response in rat skin. nameOfConference DOI: 10.1111/j.1476-5381.1995.tb15050.x QMRO: qmroHref Ahluwalia A, Flower RJ (1993). Investigations into the mechanism of vasoconstrictor action of the topical steroid betamethasone‐17‐valerate in the rat. nameOfConference DOI: 10.1111/j.1476-5381.1993.tb12838.x QMRO: qmroHref Ahluwalia A, Peers SH, Flower RJ (1992). Steroid inhibition of oedema formation in the rat skin. nameOfConference DOI: 10.1111/j.1476-5381.1992.tb14386.x QMRO: qmroHref Baliga RS, Milsom AB, Ghosh SM et al. (2012). Dietary nitrate ameliorates pulmonary hypertension: cytoprotective role for endothelial nitric oxide synthase and xanthine oxidoreductase.. nameOfConference DOI: 10.1161/CIRCULATIONAHA.112.100586 QMRO: qmroHref Bahra M, Kapil V, Pearl V et al. (2012). Inorganic nitrate ingestion improves vascular compliance but does not alter flow-mediated dilatation in healthy volunteers.. nameOfConference DOI: 10.1016/j.niox.2012.01.004 QMRO: qmroHref Baliga RS, Milsom AB, Trinder SL et al. (2012). Dietary Nitrate: A Novel Therapy For Pulmonary Hypertension. B63. EXPERIMENTAL MODELS IN PULMONARY HYPERTENSION I DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3413 QMRO: qmroHref Wen H, Östman J, Bubb KJ et al. (2012). 20-Hydroxyeicosatetraenoic acid (20-HETE) is a novel activator of transient receptor potential vanilloid 1 (TRPV1) channel.. nameOfConference DOI: 10.1074/jbc.M111.334896 QMRO: qmroHref Colom B, Poitelon Y, Huang W et al. (2012). Schwann cell-specific JAM-C-deficient mice reveal novel expression and functions for JAM-C in peripheral nerves.. nameOfConference DOI: 10.1096/fj.11-196220 QMRO: qmroHref Bubb KJ, Ahluwalia A (2012). 20-HETE-induced activation of TRPV1: a novel pathway influencing blood pressure and coronary resistance. nameOfConference DOI: doi QMRO: qmroHref Moyes AJ, Khambata RS, Ahluwalia A et al. (2012). Accelerated Atherogenesis and Diminished Vascular Integrity in Mice Lacking Endothelial C-Type Natriuretic Peptide. nameOfConference DOI: doi QMRO: qmroHref Yuzugulen J, Wood EG, Douthwaite JA et al. (2012). Characterization of Proendothelin-1 Derived Peptides Identifies a Co-secreted Modulator of ET-1 Vasoconstriction, and Provides Insights for Biomarker Measurements. nameOfConference DOI: doi QMRO: qmroHref Velmurugan S, Pearl V, Ghosh SM et al. (2012). Inorganic Nitrate Attenuates Platelet Reactivity in Healthy Males but not Females: Role of the Erythrocyte and Cyclic GMP. nameOfConference DOI: doi QMRO: qmroHref Bahra M, Kapil V, Pearl V et al. (2012). Inorganic nitrate ingestion decreases blood pressure and improves vascular compliance in healthy volunteers. nameOfConference DOI: doi QMRO: qmroHref Velmurugan S, Pearl V, Davies S et al. (2012). Inorganic nitrate supplementation attenuates platelet reactivity in healthy male volunteers. nameOfConference DOI: 10.1016/j.niox.2012.04.099 QMRO: qmroHref Ghosh S, Kapil V, Bubb K et al. (2012). Mechanisms underlying nitrite reduction in hypertension: Role for erythrocyte xanthine oxidoreductase. nameOfConference DOI: 10.1016/j.niox.2012.04.109 QMRO: qmroHref Fuentes-Calvo I, Bubb K, Ghosh S et al. (2012). Nitrite induced-hypotension is enhanced in hypertension: Role for xanthine oxidoreductase. nameOfConference DOI: 10.1016/j.niox.2012.04.110 QMRO: qmroHref Khambata R, Ghosh S, Ahluwalia A (2012). Nitrite superfusion reduces leukocyte-endothelial interactions in the mouse cremaster model. nameOfConference DOI: 10.1016/j.niox.2012.04.055 QMRO: qmroHref Stone SM, Thorpe CM, Ahluwalia A et al. (publicationYear). Shiga toxin 2-induced intestinal pathology in infant rabbits is A-subunit dependent and responsive to the tyrosine kinase and potential ZAK inhibitor imatinib. nameOfConference DOI: 10.3389/fcimb.2012.00135 QMRO: qmroHref Duchene J, Ahluwalia A (2011). Kallikrein-kinin system in inflammation. nameOfConference DOI: 10.1515/9783110252354 QMRO: qmroHref Duchene J, Ahluwalia A (2011). 16 Kallikrein-kinin system in infl ammation. nameOfConference DOI: 10.1515/9783110252354.261 QMRO: qmroHref Paunovic B, Deng X, Khomenko T et al. (2011). Molecular Mechanisms of Basic Fibroblast Growth Factor Effect on Healing of Ulcerative Colitis in Rats. nameOfConference DOI: 10.1124/jpet.111.183665 QMRO: qmroHref Rourke SB, Sobota M, Tucker R et al. (2011). Social determinants of health associated with hepatitis C co-infection among people living with HIV: results from the Positive Spaces, Healthy Places study.. nameOfConference DOI: doi QMRO: qmroHref Florkiewicz RZ, Ahluwalia A, Sandor Z et al. (2011). Gastric mucosal injury activates bFGF gene expression and triggers preferential translation of high molecular weight bFGF isoforms through CUG-initiated, non-canonical codons. nameOfConference DOI: 10.1016/j.bbrc.2011.05.033 QMRO: qmroHref Velmurugan S, Kapil V, McKnight AHO et al. (2011). Dietary nitrate attenuates platelet reactivity: Role of the erythrocyte and influence of sex. nameOfConference DOI: 10.1016/j.niox.2011.03.285 QMRO: qmroHref Monette LE, Rourke SB, Gibson K et al. (2011). Inequalities in Determinants of Health Among Aboriginal and Caucasian Persons Living With HIV/AIDS in Ontario: Results From the Positive Spaces, Healthy Places Study. nameOfConference DOI: 10.1007/bf03404900 QMRO: qmroHref Kapil V, Syed M, Pearl V et al. (2011). Interruption of the entero-salivary metabolism of nitrate to nitrite increases blood pressure in healthy volunteers. nameOfConference DOI: 10.1016/j.niox.2011.03.282 QMRO: qmroHref Villar IC, Scotland RS, Khambata RS et al. (2011). Suppression of endothelial P-selectin expression contributes to reduced cell trafficking in females: an effect independent of NO and prostacyclin.. nameOfConference DOI: 10.1161/ATVBAHA.111.223545 QMRO: qmroHref Kapil V, Benjamin N, Hobbs A et al. (2011). Response to Inorganic Nitrate for Blood Pressure Lowering?. nameOfConference DOI: 10.1161/HYPERTENSIONAHA.110.164814 QMRO: qmroHref Kapil V, Webb AJ, Ahluwalia A (2010). Inorganic nitrate and the cardiovascular system.. nameOfConference DOI: 10.1136/hrt.2009.180372 QMRO: qmroHref Yamashiro K, Milsom AB, Duchene J et al. (2010). Alterations in nitric oxide and endothelin-1 bioactivity underlie cerebrovascular dysfunction in ApoE-deficient mice.. nameOfConference DOI: 10.1038/jcbfm.2010.34 QMRO: qmroHref Kapil V, Milsom AB, Okorie M et al. (2010). Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO.. nameOfConference DOI: 10.1161/HYPERTENSIONAHA.110.153536 QMRO: qmroHref Kapil V, Maleki-Toyserkani S, Rehman F et al. (2010). Oral inorganic nitrate lowers blood pressure in healthy male, but not female, volunteers, via bioconversion to nitrite. nameOfConference DOI: doi QMRO: qmroHref Tarnawski AS, Pai R, Tanigawa T et al. (2010). PTEN silencing reverses aging-related impairment of angiogenesis in microvascular endothelial cells. nameOfConference DOI: 10.1016/j.bbrc.2010.02.161 QMRO: qmroHref Milsom AB, Patel NSA, Mazzon E et al. (2010). Role for endothelial nitric oxide synthase in nitrite-induced protection against renal ischemia-reperfusion injury in mice. nameOfConference DOI: 10.1016/j.niox.2009.10.010 QMRO: qmroHref PERRETTI M, AHLUWALIA A (2000). The Microcirculation and Inflammation: Site of Action for Glucocorticoids. nameOfConference DOI: 10.1111/j.1549-8719.2000.tb00117.x QMRO: qmroHref (2010). A Role of Matrix Metalloproteinase-8 in Atherosclerosis: Correction. nameOfConference DOI: 10.1161/res.0b013e3181cdee32 QMRO: qmroHref Webb A, Ahluwalia A (2010). Chapter 17 Mechanisms of Nitrite Reduction in Ischemia in the Cardiovascular System. nameOfConference DOI: 10.1016/b978-0-12-373866-0.00017-4 QMRO: qmroHref WEBB A, Webb A, Ahluwalia A (2010). Mechanisms of Nitrite Reduction in Ischemia in the Cardiovascular System. nameOfConference DOI: 10.1016/B978-0-12-373866-0.00017-4 QMRO: qmroHref Webb AJ, Ahluwalia A (2010). Mechanisms of nitrite reduction in ischemia in the cardiovascular system. nameOfConference DOI: 10.1016/B978-0-12-373866-0.00017-4 QMRO: qmroHref Lundberg JO, Gladwin MT, Ahluwalia A et al. (2009). Nitrate and nitrite in biology, nutrition and therapeutics. nameOfConference DOI: 10.1038/nchembio.260 QMRO: qmroHref Vessillier S, Duchene J, Vojnovic I et al. (2009). THERAPEUTIC TARGETTING OF ATHEROSCLEROTIC PLAQUES WITH LATENT INTERLEUKIN-4. nameOfConference DOI: 10.1136/hrt.2009.178129h QMRO: qmroHref Duchene J, Cayla C, Vessillier S et al. (2009). Laminar shear stress regulates endothelial kinin B1 receptor expression and function: potential implication in atherogenesis.. nameOfConference DOI: 10.1161/ATVBAHA.109.191775 QMRO: qmroHref Laxton RC, Hu Y, Duchene J et al. (2009). A role of matrix metalloproteinase-8 in atherosclerosis.. nameOfConference DOI: 10.1161/CIRCRESAHA.109.200279 QMRO: qmroHref Greene S, Ahluwalia A, Watson J et al. (2009). Between skepticism and empowerment: the experiences of peer research assistants in HIV/AIDS, housing and homelessness community‐based research. nameOfConference DOI: 10.1080/13645570802553780 QMRO: qmroHref Greene S, Tucker R, Rourke SB et al. (2010). “Under My Umbrella”: The housing experiences of HIV positive parents who live with and care for their children in Ontario. nameOfConference DOI: 10.1007/s00737-009-0090-5 QMRO: qmroHref Kapil V, Rehman F, Arghandawi S et al. (2009). BLOOD PRESSURE LOWERING EFFECTS OF ORAL INORGANIC NITRATE VIA BIOCONVERSION TO NITRITE. nameOfConference DOI: doi QMRO: qmroHref Okorie M, Akram F, Loukogeorgakis S et al. (2009). ORAL INORGANIC NITRATE PROTECTS AGAINST ENDOTHELIAL ISCHAEMIA-REPERFUSION INJURY IN HUMANS. nameOfConference DOI: doi QMRO: qmroHref Ahluwalia A (2009). Erthrocyte and endothelial nitrite in hypoxia: role for NOS and XOR. nameOfConference DOI: doi QMRO: qmroHref Kapil V, Okorie M, Akram F et al. (2009). Oral inorganic nitrate lowers blood pressure and protects against endothelial ischaemia-reperfusion injury in humans. nameOfConference DOI: doi QMRO: qmroHref Milsom A, Patel N, Storey A et al. (2009). Role for endothelial nitric oxide synthase in nitrite-induced protection against renal ischaemia-reperfusion injury in mice. nameOfConference DOI: 10.1016/j.niox.2009.10.010 QMRO: qmroHref Duchene J, Ahluwalia A (2009). The kinin B(1) receptor and inflammation: new therapeutic target for cardiovascular disease.. nameOfConference DOI: 10.1016/j.coph.2008.11.011 QMRO: qmroHref Ahluwalia A, De Felipe C, O'Brien J et al. (1998). Impaired IL‐1β‐induced neutrophil accumulation in tachykinin NK1 receptor knockout mice. nameOfConference DOI: 10.1038/sj.bjp.0701978 QMRO: qmroHref Kakuyama M, Vallance P, Ahluwalia A (1998). Endothelium‐dependent sensory NANC vasodilatation: involvement of ATP, CGRP and a possible NO store. nameOfConference DOI: 10.1038/sj.bjp.0701610 QMRO: qmroHref Ahluwalia A, Giuliani S, Scotland R et al. (1998). Ovalbumin‐induced neurogenic inflammation in the bladder of sensitized rats. nameOfConference DOI: 10.1038/sj.bjp.0701793 QMRO: qmroHref Scotland R, Vallance P, Ahluwalia A (1999). Endothelin alters the reactivity of vasa vasorum: mechanisms and implications for conduit vessel physiology and pathophysiology. nameOfConference DOI: 10.1038/sj.bjp.0702930 QMRO: qmroHref Bogle RG, McLean PG, Ahluwalia A et al. (2000). Impaired vascular sensitivity to nitric oxide in the coronary microvasculature after endotoxaemia. nameOfConference DOI: 10.1038/sj.bjp.0703267 QMRO: qmroHref McLean PG, Perretti M, Ahluwalia A (1999). Inducible expression of the kinin B1 receptor in the endotoxemic heart: mechanisms of des‐Arg9bradykinin‐induced coronary vasodilation. nameOfConference DOI: 10.1038/sj.bjp.0702743 QMRO: qmroHref Klein J, Gonzalez J, Duchene J et al. (2009). Delayed blockade of the kinin B1 receptor reduces renal inflammation and fibrosis in obstructive nephropathy. nameOfConference DOI: 10.1096/fj.08-115600 QMRO: qmroHref Hobbs AJ, Gane P, Lumsden N et al. (2009). Design and development of novel non-peptide agonists at natriuretic peptide receptor-C. nameOfConference DOI: 10.1096/fasebj.23.1_supplement.756.8 QMRO: qmroHref Tolstanova G, Khomenko T, Deng X et al. (2009). Neutralizing Anti-Vascular Endothelial Growth Factor (VEGF) Antibody Reduces Severity of Experimental Ulcerative Colitis in Rats: Direct Evidence for the Pathogenic Role of VEGF. nameOfConference DOI: 10.1124/jpet.108.145128 QMRO: qmroHref Webb AJ, Milsom AB, Rathod KS et al. (2008). Mechanisms Underlying Erythrocyte and Endothelial Nitrite Reduction to Nitric Oxide in Hypoxia Role for Xanthine Oxidoreductase and Endothelial Nitric Oxide Synthase. nameOfConference DOI: 10.1161/CIRCRESAHA.108.175810 QMRO: qmroHref Vessillier S, Duchene J, Vojnovic I et al. (2008). Stabilisation of atherosclerotic plaques: The latent targeting cytokines strategy. nameOfConference DOI: doi QMRO: qmroHref Chan MV, Hobbs AJ, Scotland RS et al. (2008). Nitric oxide-induced relaxation in female resistance arteries is endothelium-dependent. nameOfConference DOI: doi QMRO: qmroHref Villar IC, Hobbs AJ, Ahluwalia A (2008). Sex differences in vascular function: implication of endothelium-derived hyperpolarizing factor. nameOfConference DOI: 10.1677/JOE-08-0070 QMRO: qmroHref Aboud Z, Misra S, Warner T et al. (2008). The enterosalivary bioconversion of nitrate to nitrite underlies the blood pressure (BP) lowering and anti-platelet effects of a dietary nitrate load. nameOfConference DOI: doi QMRO: qmroHref Jandhyala DM, Ahluwalia A, Obrig T et al. (2008). ZAK: a MAP3Kinase that transduces Shiga toxin‐ and ricin‐induced proinflammatory cytokine expression. nameOfConference DOI: 10.1111/j.1462-5822.2008.01139.x QMRO: qmroHref Webb A, Patel N, Loukogeorgakis S et al. (2008). Acute blood pressure lowering and vasoprotective effects of dietary nitrate. nameOfConference DOI: 10.1096/fasebj.22.1_supplement.737.30 QMRO: qmroHref Webb AJ, Patel N, Loukogeorgakis S et al. (2008). Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite.. nameOfConference DOI: 10.1161/HYPERTENSIONAHA.107.103523 QMRO: qmroHref Webb AJ, Patel N, Loukogeorgakis S et al. (2008). Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite.. nameOfConference DOI: 10.1161/HYPERTENSIONAHA.107.103523 QMRO: qmroHref Milsom AB, Hobbs AJ, Ahluwalia A (2008). Endothelial nitric oxide synthase acts as a nitrite reductase in human endotheliall cells. nameOfConference DOI: 10.1016/j.niox.2008.06.134 QMRO: qmroHref Chan M, Villar I, Scotland R et al. (2008). Endothelium-derived hyperpolarising factor (EDHF) underlies sex-differences in the pressure-induced myogenic response. nameOfConference DOI: 10.1096/fasebj.22.1_supplement.719.4 QMRO: qmroHref Ahluwalia A (2008). Mechanisms of nitrite reduction in the cardiovascular system. nameOfConference DOI: 10.1016/j.niox.2008.06.034 QMRO: qmroHref Duchene J, Francis S, Lecomte F et al. (2008). Opposing effects of the kinin B1 and B2 receptors in LPS-induced hypotension. nameOfConference DOI: 10.1096/fasebj.22.1_supplement.912.26 QMRO: qmroHref Scotland RS, Roy B, Duchene J et al. (2008). Selective regulation of chemokine CXCL6 by estrogen receptorβ (ERβ). nameOfConference DOI: 10.1096/fasebj.22.1_supplement.718.3 QMRO: qmroHref Duchene J, Lecomte F, Ahmed S et al. (2007). A novel inflammatory pathway involved in leukocyte recruitment: role for the kinin B1 receptor and the chemokine CXCL5.. nameOfConference DOI: 10.4049/jimmunol.179.7.4849 QMRO: qmroHref Webb AJ, Patel N, Loukogeorgakis S et al. (2007). Acute blood pressure (BP) lowering and vasoprotective effects of beetroot juice: relationship to nitrite derived from dietary nitrate. nameOfConference DOI: doi QMRO: qmroHref Sexton A, McDonald M, Cayla C et al. (2007). 12-Lipoxygenase-derived eicosanoids protect against myocardial ischemia/reperfusion injury via activation of neuronal TRPV1.. nameOfConference DOI: 10.1096/fj.06-7828com QMRO: qmroHref Tarnawski A, Pai R, Deng X et al. (2007). Aging Gastropathy—Novel Mechanisms: Hypoxia, Up-regulation of Multifunctional Phosphatase PTEN, and Proapoptotic Factors. nameOfConference DOI: 10.1053/j.gastro.2007.08.037 QMRO: qmroHref Villar IC, Panayiotou CM, Sheraz A et al. (2007). Definitive role for natriuretic peptide receptor-C in mediating the vasorelaxant activity of C-type natriuretic peptide and endothelium-derived hyperpolarising factor. nameOfConference DOI: 10.1016/j.cardiores.2007.02.032 QMRO: qmroHref Tripatara P, Patel NSA, Webb A et al. (2007). Nitrite-derived nitric oxide protects the rat kidney against ischemia/reperfusion injury in vivo: role for xanthine oxidoreductase.. nameOfConference DOI: 10.1681/ASN.2006050450 QMRO: qmroHref Webb AJ, Patel N, Loukogeorgakis S et al. (2007). Acute blood pressure lowering and vasoprotective effects of beetroot juice: relationship to nitrite derived from dietary nitrate. nameOfConference DOI: doi QMRO: qmroHref Rathod KS, Webb AJ, Lovell MJ et al. (2006). Nitrite is reduced to nitric oxide by xanthine oxidoreductase and nitric oxide synthase in the erythrocyte membrane in hypoxemia.. nameOfConference DOI: 10.1182/blood.v108.11.1560.1560 QMRO: qmroHref Villar IC, Ahluwalia A, Hobbs AJ (2006). Distinct pathways regulate endothelium derived hyperpolarising factor-mediated responses in rat mesenteric arteries. nameOfConference DOI: doi QMRO: qmroHref Villar IC, Francis S, Webb A et al. (2006). Novel aspects of endothelium-dependent regulation of vascular tone. nameOfConference DOI: 10.1038/sj.ki.5001680 QMRO: qmroHref Halpern SM, Ahluwalia A, Makunura CN et al. (1996). Investigation of notalgia paraesthetica using laser Doppler velocimetry and immunohistochemistry before and after treatment with topical capsaicin. nameOfConference DOI: 10.1111/j.1468-3083.1996.tb00575.x QMRO: qmroHref Scotland RS, Duchene J, Hobbs A et al. (2006). Gender-differences in leukocyte activation in vivo: role of endothelium-derived mediators. nameOfConference DOI: 10.1096/fasebj.20.5.a1193-b QMRO: qmroHref Goddard A, McDonald M, Thiemermann C et al. (2006). Identification of an endogenous cardioprotective pathway involving 12-lipoxygenase (12-LOX), C-fibers and the non-selective cation channel TRPV1. nameOfConference DOI: 10.1096/fasebj.20.4.a230 QMRO: qmroHref Duchene J, Lecomte F, Perretti M et al. (2006). Inflammatory chemokine CXCL5 expression by endothelial cells is dependent upon kinin B1 receptor activation. nameOfConference DOI: 10.1096/fasebj.20.4.a702-c QMRO: qmroHref Scotland RS, Cohen M, Foster P et al. (2005). C-type natriuretic peptide inhibits leukocyte recruitment and platelet-leukocyte interactions via suppression of P-selectin expression. nameOfConference DOI: 10.1073/pnas.0504961102 QMRO: qmroHref Webb A, Qureshi S, Benjamin N et al. (2005). Xanthine oxidase activity provides an alternative source of no during ischaemia from inorganic nitrite in rat blood vessels. nameOfConference DOI: doi QMRO: qmroHref Duchene J, Perretti M, Ahluwalia A (2005). Chemokine involvement in kinin B1 receptor-mediated leukocyte recruitment. nameOfConference DOI: doi QMRO: qmroHref Ahluwalia A, Villar I, Scotland RS et al. (2005). The natriuretic peptide receptor-C antagonist, M372049, blocks C-type natriuretic peptide and endothelium-derived hyperpolarizing factor-induced relaxation of resistance arteries. nameOfConference DOI: doi QMRO: qmroHref Ahluwalia A, Hobbs AJ (2005). Endothelium-derived C-type natriuretic peptide: more than just a hyperpolarizing factor.. nameOfConference DOI: 10.1016/j.tips.2005.01.005 QMRO: qmroHref McLean PG, Perretti M, Ahluwalia A (2000). Kinin B1 receptors as novel anti-inflammatory targets. nameOfConference DOI: 10.1517/14728222.4.2.127 QMRO: qmroHref Vo PA, Lad B, Tomlinson JAP et al. (2005). autoregulatory role of endothelium-derived nitric oxide (NO) on Lipopolysaccharide-induced vascular inducible NO synthase expression and function.. nameOfConference DOI: 10.1074/jbc.M411317200 QMRO: qmroHref Scotland RS, Madhani M, Chauhan S et al. (2005). Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice - Key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo. nameOfConference DOI: 10.1161/01.CIR.0000155238.70797.4E QMRO: qmroHref Scotland RS, Ahluwalia A, Hobbs AJ (2005). C-type natniuretic peptide in vascular physiology and disease. nameOfConference DOI: 10.1016/j.pharmthera.2004.08.011 QMRO: qmroHref Ahluwalia A, SCOTLAND RS, Andersen J et al. (2005). Investigation of Vascular Responses in Endothelial Nitric Oxide Synthase/Cyclooxygenase-1 Double-Knockout Mice: Key Role for Endothelium-Derived Hyperpolarizing Factor in the Regulation of Blood Pressure in Vivo. nameOfConference DOI: 10.1161/01.CIR.0000155238.70797.4E QMRO: qmroHref AHLUWALIA A, Mathur A, Lovell M et al. (2005). C-type natriuretic peptide inhibits leukocyte recruitment and platelet aggregation. nameOfConference DOI: doi QMRO: qmroHref AHLUWALIA A, Scotland RS, Hobbs AJ et al. (2005). Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice: key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo.. nameOfConference DOI: doi QMRO: qmroHref AHLUWALIA A, Francis S, Tomlinson JA et al. (2005). role of endothelium-derived nitric oxide (NO) on Lipopolysaccharide-induced vascular inducible NO synthase expression and function.. nameOfConference DOI: doi QMRO: qmroHref Scotland RS, Chauhan S, Davis C et al. (2004). Vanilloid receptor TRPV1, sensory C-fibers, and vascular autoregulation: a novel mechanism involved in myogenic constriction.. nameOfConference DOI: 10.1161/01.RES.0000148633.93110.24 QMRO: qmroHref AHLUWALIA A, Oh U, Kabir J et al. (2004). Vanilloid receptor TRPV1, sensory C-fibers, and vascular autoregulation: a novel mechanism involved in myogenic constriction. nameOfConference DOI: 10.1161/01.RES.0000148633.93110.24 QMRO: qmroHref Scotland R, Foster P, Ahluwalia A et al. (2004). C-type natriuretic peptide inhibits leukocyte recruitment in vivo via natriuretic peptide receptor-C activation. nameOfConference DOI: doi QMRO: qmroHref Ahluwalia A, Foster P, Prescott C et al. (2004). Endothelial C-type natriuretic peptide regulates coronary blood flow and prevents ischemia-reperfusion injury. nameOfConference DOI: doi QMRO: qmroHref Chauhan SD, Hobbs AJ, Ahluwalia A (2004). C-type natriuretic peptide: new candidate for endothelium-derived hyperpolarising factor. nameOfConference DOI: 10.1016/j.biocel.2003.09.009 QMRO: qmroHref Webb A, Bond R, McLean P et al. (2004). Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage. nameOfConference DOI: 10.1073/pnas.0402927101 QMRO: qmroHref Hobbs A, Foster P, Prescott C et al. (2004). Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury - Novel cardioprotective role for endothelium-derived C-type natriuretic peptide. nameOfConference DOI: 10.1161/01.CIR.0000141802.29945.34 QMRO: qmroHref Webb AJ, Bond R, Uppal R et al. (2004). Human and rat myocardium reduces nitrite to nitric oxide under ischaemic conditions, in a process dependent on xanthine oxidoreductase. nameOfConference DOI: 10.1097/00004872-200406002-00054 QMRO: qmroHref Foster P, Mathur A, Ahluwalia A (2004). Bradykinin protects against ischemia/reperfusion injury by opening mitochondrial KATP channels in the endothelial cell: a role for nitric oxide. nameOfConference DOI: doi QMRO: qmroHref AHLUWALIA A (2004). DICHOTOMOUS ROLE OF THE ENDOTHELIUM IN LPS-INDUCED ENDOTHELIAL DYSFUNCTION. nameOfConference DOI: 10.1097/00024382-200403001-00579 QMRO: qmroHref Ahluwalia A, MacAllister RJ, Hobbs AJ (2004). Vascular actions of natriuretic peptides - Cyclic GMP-dependent and -independent mechanisms. nameOfConference DOI: 10.1007/s00395-004-0459-6 QMRO: qmroHref Ahluwalia A, Foster P, Scotland RS et al. (2004). Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment.. nameOfConference DOI: 10.1073/pnas.0304264101 QMRO: qmroHref Phuong AV, Ladd B, Tomlinson JAP et al. (2004). Essential role for endothelium-derived NO in lipopolysaccharide-induced iNOS expression and function. nameOfConference DOI: 10.1097/00024382-200403001-00381 QMRO: qmroHref Ahluwalia A, PERRETTI M, Mathur A et al. (2004). Inhibition of leukocyte-endothelial cell interactions by nitric oxide via a cGMP-mediated down-regulation of P-selectin expression.. nameOfConference DOI: doi QMRO: qmroHref AHLUWALIA A, Hobbs A, Prescott C et al. (2004). Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide.. nameOfConference DOI: 10.1161/01.CIR.0000141802.29945.34 QMRO: qmroHref AHLUWALIA A, Sarkar D, Aston D et al. (2004). Protease-activated receptor (PAR)-2 causes endothelium-dependant, NO-independant coronary vasodilatation: involvement of C-fibres and EDHF.. nameOfConference DOI: doi QMRO: qmroHref Ahluwalia A (2003). To b'EET or not to b'EET? That is the question!. nameOfConference DOI: 10.1042/CS20030232 QMRO: qmroHref Webb A, McLean P, Ahluwalia A et al. (2003). Inorganic nitrite: Protector against ischaemia reperfusion injury in the heart?. nameOfConference DOI: doi QMRO: qmroHref Chauhan SD, Seggara G, Vo PA et al. (2003). Protection against lipopolysaccharide-induced endothelial dysfunction in resistance and conduit vasculature of iNOS knockout mice.. nameOfConference DOI: 10.1096/fj.02-0668fje QMRO: qmroHref Vo PA, Tomlinson JAP, Chauhan SD et al. (2003). The role of the endothelium and constitutive NO in LPS-induced vasorelaxation. nameOfConference DOI: doi QMRO: qmroHref Foster P, Mathur A, McLean P et al. (2003). Anti-leukocyte properties of a novel non NO-based soluble guanylate cyclase activator, BAY 41-2272. nameOfConference DOI: doi QMRO: qmroHref Vo PA, Syed I, McLean P et al. (2003). Regulation of kinin B1 receptors in emlothelial cells by laminar shear stress. nameOfConference DOI: doi QMRO: qmroHref Scotland RS, Chauhan SD, Hobbs AJ et al. (2003). Characterisation of eNOS/COX-1 double knockout mice: a novel model for the study of endothelium-derived hyperpolarising factor. nameOfConference DOI: doi QMRO: qmroHref Hobbs AJ, Chauhan SD, Nilsson H et al. (2003). Endothelium-derived hyperpolarising factor (EDHF) is C-type natriuretic peptide (CNP) in mesenteric resistance arteries. nameOfConference DOI: doi QMRO: qmroHref Chauhan SD, Nilsson H, Ahluwalia A et al. (2003). Release of C-type natriuretic peptide accounts for the biological activity of endothelium-derived hyperpolarizing factor. nameOfConference DOI: 10.1073/pnas.0336365100 QMRO: qmroHref Chauhan S, Rahman A, Nilsson H et al. (2003). NO contributes to EDHF-like responses in rat small arteries: a role for NO stores.. nameOfConference DOI: 10.1016/s0008-6363(02)00611-9 QMRO: qmroHref Chauhan SD, MacAllister RJ, Hobbs AJ et al. (2002). Mechanisms underlying the vasorelaxant activity of C-type natriuretic peptide (CNP) in rat mesenteric resistance arteries. nameOfConference DOI: doi QMRO: qmroHref McLean P, Ahluwalia A (2002). Protease-activated receptor (PAR)-2 activation causes EDHF-like coronary vasodilation: selective preservation in ischemia-reperfusion injury, involvement of lipoxygenase products, VR1 receptors and C-fibers. nameOfConference DOI: doi QMRO: qmroHref McLean PG, Aston D, Sarkar D et al. (2002). Protease-activated receptor-2 activation causes EDHF-like coronary vasodilation - Selective preservation in ischemia/reperfusion injury: Involvement of lipoxygenase products, VR1 receptors, and C-fibers. nameOfConference DOI: 10.1161/hh0402.105372 QMRO: qmroHref Hesslinger C, Chen Z, Ahluwalia A et al. (2002). Regulation of GTP Cyclohydrolase I by Estrogen. nameOfConference DOI: 10.1007/978-1-4615-0945-5_26 QMRO: qmroHref Scotland RS, Chauhan S, Vallance PJ et al. (2001). An endothelium-derived hyperpolarizing factor-like factor moderates myogenic constriction of mesenteric resistance arteries in the absence of endothelial nitric oxide synthase-derived nitric oxide.. nameOfConference DOI: 10.1161/hy1001.092651 QMRO: qmroHref Ahluwalia A (2001). Nepadutant Menarini Richerche.. nameOfConference DOI: doi QMRO: qmroHref Ahluwalia A, SCOTLAND RS, Vallance PJ et al. (2001). An EDHF-like factor moderates myogenic constriction of mesenteric resistance arteries in the absence of eNOS-derived nitric oxide. nameOfConference DOI: doi QMRO: qmroHref McLean PG, Perretti M, Ahluwalia A (2000). Kinin B1 receptors and the cardiovascular system: regulation of expression and function. nameOfConference DOI: 10.1016/s0008-6363(00)00184-x QMRO: qmroHref McLean PG, Ahluwalia A, Perretti M (2000). Association between Kinin B1 Receptor Expression and Leukocyte Trafficking across Mouse Mesenteric Postcapillary Venules. nameOfConference DOI: 10.1084/jem.192.3.367 QMRO: qmroHref Scotland RS, Vallance PJT, Ahluwalia A (2000). Endogenous factors involved in regulation of tone of arterial vasa vasorum: implications for conduit vessel physiology. nameOfConference DOI: 10.1016/s0008-6363(00)00023-7 QMRO: qmroHref Ahluwalia A, Scotland R (2000). Activation of sensory C-fibres partially mediates the vascular myogenic response. nameOfConference DOI: doi QMRO: qmroHref Chauhan SD, MacAllister RJ, Clapp LH et al. (2000). Evidence that no may contribute to "EDHF-like" responses in rat mesenteric and hepatic small arteries. nameOfConference DOI: doi QMRO: qmroHref KAKUYAMA M, AHLUWALIA A, RODRIGO J et al. (1999). Cholinergic Contraction Is Altered in nNOS Knockouts. nameOfConference DOI: 10.1164/ajrccm.160.6.9808105 QMRO: qmroHref Ahluwalia A, Perretti M (1999). B1 receptors as a new inflammatory target. Could this B the 1?. nameOfConference DOI: 10.1016/s0165-6147(99)01321-8 QMRO: qmroHref Varsani M, MacAllister R, Ahluwalia A et al. (1999). Investigation of the α1 adrenoceptor subtype(s) mediating contraction in the human internal mammary artery. nameOfConference DOI: doi QMRO: qmroHref Scotland R, Vallance P, Ahluwalia A (1999). On the regulation of tone in vasa vasorum. nameOfConference DOI: 10.1016/s0008-6363(98)00223-5 QMRO: qmroHref McLean PG, Perretti M, Ahluwalia A (1999). The involvement of kinin B1 receptors in the hypotensive response to endotoxin in rats. nameOfConference DOI: doi QMRO: qmroHref McLean PG, Perretti M, Ahluwalia A (1998). Investigation of endotoxin-inducible B1 and constitutive B2 kinin receptors mediating coronary vasodilation in the rat isolated heart.. nameOfConference DOI: doi QMRO: qmroHref Ahluwalia A (1998). Topical glucocorticoids and the skin‐mechanisms of action: an update. nameOfConference DOI: 10.1080/09629359891126 QMRO: qmroHref Ahluwalia A, Bhagat K (1997). An insight into recent developmens in understanding the mechanisms and management of septic shock. nameOfConference DOI: doi QMRO: qmroHref Ahluwalia A, Vallance P (1997). Evidence for functional responses to sensory nerve stimulation of rat small mesenteric veins.. nameOfConference DOI: doi QMRO: qmroHref Ahluwalia A, Giuliani S, Maggi CA (1997). Allergic inflammation in the rat urinary bladder: Involvement of mast cells and C-fibres. nameOfConference DOI: doi QMRO: qmroHref Scotland RS, Vallance PJ, Ahluwalia A (1997). Comparison of vascular reactivity of porcine aorta and its vasa vasorum. nameOfConference DOI: doi QMRO: qmroHref Kakuyama M, Vallance PJ, Ahluwalia A (1997). P-30 Non-adrenergic non-cholinergic relaxation of the rabbit mesenteric small artery: Involvement of NO. nameOfConference DOI: 10.1016/s0021-5198(19)41531-x QMRO: qmroHref Ahluwalia A, Cellek S (1997). Regulation of the cardiovascular system by non-adrenergic non-chollnergic nerves. nameOfConference DOI: 10.1097/00041552-199701000-00014 QMRO: qmroHref Ahluwalia A, Vallance P (1996). Interaction between sympathetic and sensory nerves in rat small arteries: involvement of nitric oxide. nameOfConference DOI: 10.1152/ajpheart.1996.271.3.h969 QMRO: qmroHref Ahluwalia A, Perretti M (1996). Involvement of bradykinin B1 receptors in the polymorphonuclear leukocyte accumulation induced by IL-1 beta in vivo in the mouse.. nameOfConference DOI: 10.4049/jimmunol.156.1.269 QMRO: qmroHref Ahluwalia A, Vallance PJ (1996). Reactivity of the vasa vasorum. nameOfConference DOI: doi QMRO: qmroHref Ahluwalia A, Newbold P, Brain SD et al. (1995). Topical glucocorticoids inhibit neurogenic inflammation: involvement of lipocortin 1. nameOfConference DOI: 10.1016/0014-2999(95)00350-t QMRO: qmroHref AHLUWALIA A, GIULIANI S, MAGGI CA (1995). DEMONSTRATION OF A SEPTIDE-SENSITIVE INFLAMMATORY RESPONSE IN RAT SKIN. nameOfConference DOI: doi QMRO: qmroHref AHLUWALIA A, NEWBOLD P, FLOWER RJ (1995). TOPICAL GLUCOCORTICOIDS INHIBIT NEUROGENIC INFLAMMATION - INVOLVEMENT OF LIPOCORTIN-1. nameOfConference DOI: doi QMRO: qmroHref Ahluwalia A, Perretti M (1994). Calcitonin gene-related peptides modulate the acute inflammatory response induced by interleukin-1 in the mouse. nameOfConference DOI: 10.1016/0014-2999(94)00503-6 QMRO: qmroHref Ahluwalia A, Mohamed RW, Flower RJ (1994). Induction of lipocortin 1 by topical steroid in rat skin. nameOfConference DOI: 10.1016/0006-2952(94)90210-0 QMRO: qmroHref Ahluwalia A, Perretti M (1994). Anti-inflammatory effect of prostanoids in mouse and rat skin: evidence for a role of EP3-receptors.. nameOfConference DOI: doi QMRO: qmroHref AHLUWALIA A, FLOWER RJ (1994). CHARACTERIZATION OF CAPSAICIN-INDUCED VASODILATION OF THE PERFUSED RABBIT EAR AND ITS MODULATION BY DEXAMETHASONE. nameOfConference DOI: doi QMRO: qmroHref Perretti M, Ahluwalia A, Harris JG et al. (1993). Lipocortin-1 fragments inhibit neutrophil accumulation and neutrophil-dependent edema in the mouse. A qualitative comparison with an anti-CD11b monoclonal antibody.. nameOfConference DOI: 10.4049/jimmunol.151.8.4306 QMRO: qmroHref Perretti M, Ahluwalia A, Flower RJ et al. (1993). Endogenous tachykinins play a role in IL-1-induced neutrophil accumulation: involvement of NK-1 receptors.. nameOfConference DOI: doi QMRO: qmroHref Ahluwalia A, Flower RJ (1993). Effect of chronic capsaicin and guanethidine treatment on skin blood flow of the rat. nameOfConference DOI: 10.1007/bf01991123 QMRO: qmroHref AHLUWALIA A, FLOWER RJ, PERRETTI M (1993). DUAL-ACTION OF PROSTAGLANDINS (PGS) IN THE MOUSE SKIN EDEMA TEST. nameOfConference DOI: doi QMRO: qmroHref AHLUWALIA A, FLOWER RJ (1993). Topical betamethasone‐17‐valerate inhibits heat‐induced vasodilatation in man. nameOfConference DOI: 10.1111/j.1365-2133.1993.tb00146.x QMRO: qmroHref AHLUWALIA A, FLOWER RJ (1992). TOPICAL STEROIDS AND ACE INHIBITORS - A COMMON LINK. nameOfConference DOI: doi QMRO: qmroHref Sponsors British Heart Foundation Medical Research Council National Institute for Health Research Barts Charity Heart Research UK CollaboratorsInternalProfessor Adrian Hobbs (WHRI); Professor Mauro Perretti (WHRI) ExternalMark D Baker (ICMS); Fernand Gobeil; Raymond MacallisterNews Beetroot juice to improve failing heartbeats (BBC Inside Science), August 2018 Amrita Ahluwalia awarded Women in Science and Engineering prize, November 2015 Amrita Ahluwalia to become the next Editor-in-Chief of the British Journal of Pharmacology (Queen Mary University of London), June 2015 Beetroot 'can lower blood pressure' (BBC News), April 2013 Nitrate content 'behind benefits of beetroot juice' (BBC News), June 2010 Drinking beetroot juice dramatically lowers risk of heart disease and strokes (Mail Online), June 2010 Beetroot juice lowers blood pressure (Hindustan Times), June 2010 Beetroot 'may cut blood pressure' (BBC News), February 2008 Disclosures 2024: Director of IoNa Therapeutics Ltd 2023: Patents filed - WO2024160924A1; WO2024160921A1 2019: Prof Ahluwalia has received consultancy funds from Palatin Inc 2018: Prof Ahluwalia has received consultancy funds from Resync Inc 2016-2020: Prof Ahluwalia was EiC for British Journal of Pharmacology 2013: has received consultancy funds from KalVista Pharmaceuticals 2008-2015: Prof Ahluwalia was a Senior Editor for British Journal of Pharmacology 2012-current: Prof Ahluwalia is a Co-Director of Heartbeet Ltd (a start-up established to identify commercial opportunities for inorganic nitrate and nitrite) 2005: Prof Ahluwalia received consultancy funds from Sosei Co Ltd Back to top