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Professor Adrian Hobbs

Adrian

Professor of Cardiovascular Pharmacology

Centre: Translational Medicine and Therapeutics (Deputy Centre Lead)

Email: a.j.hobbs@qmul.ac.uk
Telephone: +44(0) 20 7882 5778

Profile

ORCID iD: 0000-0002-3589-7108

I completed my B.Sc. in Pharmacology, obtaining First Class Honours, at King’s College London in 1989 and remained at the same institution to undertake a Ph.D. with Dr. Alan Gibson. During my Ph.D. research I made a significant contribution to the understanding of the role of nitric oxide (NO) as a neurotransmitter in non-adrenergic, non-cholinergic (NANC) nerves, using the rodent anococcygeus as a classical model of nitrergic innervation. I was also the first to demonstrate the importance of NO-mediated NANC transmission in regulating airway smooth muscle tone.

Having completed my Ph.D. in the autumn of 1992, I took up a post-doctoral position in the laboratory of Nobel Laureate, Prof. Louis Ignarro, at the University of California, Los Angeles. My secondment to UCLA was supported by Fulbright-Hays and American Heart Association Research Fellowships. During this time, my attention turned to NO synthase itself and the biochemical mechanisms regulating enzyme activity. In particular, I focused on the bioactivity of nitroxyl (HNO) and provided the first convincing evidence that this molecule can be generated endogenously (by NO synthase). The significance of HNO to human physiology and pathophysiology is now at the very cutting edge of NO research, as it relates to host defence & cardiac function.

In the autumn of 1996, I returned to the UK to take up a post-doctoral position at the Wolfson Institute for Biomedical Research, University College London, under the mentorship of Sir Salvador Moncada. Since that time I have established my own independent research group with extensive peer reviewed support from the Wellcome Trust and British Heart Foundation; as well as securing my own personal funding, initially being awarded a Wellcome Trust Career Development Fellowship and later a Wellcome Trust Senior Fellowship. Since returning from the US, my group has focused on the guanylyl cyclase family of enzymes and the interaction between nitric oxide (NO) and natriuretic peptides in the cardiovascular system. This area of interest has taken my research into the realm of pulmonary hypertension and heart failure, and potentially new therapeutic approaches for these debilitating diseases.

More recently, I have initiated a programme of work that has culminated in the identification of C-type natriuretic peptide (CNP) as an important endothelium-derived vasoactive peptide, regulating local blood flow, systemic blood pressure, and the formation of new blood vessels (angiogenesis). In addition, my group have contributed to the appreciation of CNP as a critical cardioprotective molecule in health and disease. This avenue of research underpins an academic drug development programme aimed at designing & characterising small molecule agonists at natriuretic peptide receptor (NPR)-C.

Within the Heart Centre at the William Harvey Research Institute, as Professor of Cardiovascular Pharmacology, I aim to harness the translational potential of the environment, exploiting the exceptional links between pre-clinical and clinical research, with the goal of developing and evaluating novel treatments for cardiovascular disease stemming from my academic research findings; this will centre on ischaemic disorders (myocardial infarction, stroke) and pulmonary hypertension/heart failure.

Research

Group members

  • Dr. Amie Moyes
  • Dr. Reshma Baliga
  • Dr. Aisah Aubdool
  • Dr. Aemun Salam
  • Ms. Yasmin Dickinson

Summary

The focus of my research is the physiological and pathological actions and interactions of a family of homologous enzymes, the guanylyl cyclases (GC), with emphasis on the cardiovascular system. These proteins act as receptors for nitric oxide (NO) and natriuretic peptides and exert complementary cytoprotective, anti-atherosclerotic effects on the heart and vasculature. In accord, loss of these signalling pathways precipitates cardiovascular disease.

My group possesses diverse expertise and employs a multi-disciplinary, molecule-to-man approach including cell and molecular biology, biochemistry, in vitro & in vivo pharmacology (including several unique transgenic lines developed in-house and experimental models of disease), and clinical studies in healthy volunteers and patients, to investigate the significance of these enzymes in health and disease. The translational aspects of my work are highlighted by our ‘drug development’ programmes that are approaching, or currently undergoing, clinical evaluation.

My major research efforts include:

  • Pharmacological and biochemical characterization of the mechanism of NO-sensitive GC activation by NO-donor drugs, non NO-based enzyme activators, nitroxyl (HNO), and hydrogen sulphide (H2S).
  • Pharmacological assessment of the interaction between soluble and particulate isoforms of GC in the vasculature, in the context of pulmonary hypertension, heart failure and stroke; development of a novel combination therapy for pulmonary hypertension.
  • Evaluation of the (patho)physiological roles of CNP as a mammalian endothelium- and cardiac- derived cytoprotective mediator.
  • Investigation of the biological roles of natriuretic peptide receptor (NPR)-C in regulating vascular smooth muscle function, cardiac morphology & contractility, and leukocyte and platelet reactivity
  • Design & development of small molecule NPR-C agonists for the treatment of cardiovascular disease.

Publications

  • de Jesus DS, Buffonge S, Abis G et al. (2024). Zinc-mediated inhibition of soluble epoxide hydrolase promotes pulmonary hypertension. nameOfConference


    QMRO: qmroHref
  • Lowe VJ, Aubdool AA, Moyes AJ et al. (2024). Cardiomyocyte-derived C-type natriuretic peptide diminishes myocardial ischaemic injury by promoting revascularisation and limiting fibrotic burden. nameOfConference


  • Dickinson YA, Moyes AJ, Hobbs AJ (2024). C-type natriuretic peptide (CNP): The cardiovascular system and beyond. nameOfConference


    QMRO: qmroHref
  • Barsha G, Hong Q, Nelson J et al. (2024). Activation of the C-Type Natriuretic Peptide Pathway Offers a Novel Therapeutic Target for Gestational Hypertension. nameOfConference


  • de Alwis N, Hannan NJ, Fato B et al. (2024). Targeting the natriuretic peptide system to treat preeclampsia. nameOfConference


  • Papaioannou I, Dritsoula A, Kang P et al. (2024). NKX2-5 regulates vessel remodelling in scleroderma-associated pulmonary arterial hypertension. nameOfConference


  • Alexander SPH, Fabbro D, Kelly E et al. (2023). The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. nameOfConference


    QMRO: qmroHref
  • Christie IN, Theparambil SM, Braga A et al. (2023). Astrocytes produce nitric oxide via nitrite reduction in mitochondria to regulate cerebral blood flow during brain hypoxia. nameOfConference


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  • Aubdool AA, Moyes AJ, Perez-Ternero C et al. (2023). Abstract 15171: Endothelium-Derived C-Type Natriuretic Peptide Prevents the Development and Progression of Abdominal Aortic Aneurysm. nameOfConference


  • Fato BR, de Alwis N, Hobbs AJ et al. (2023). PO3_08. C-type natriuretic peptide relaxes omental arteries in a new ex vivo model of preeclampsia. nameOfConference


    QMRO: qmroHref
  • Andresen H, Pérez‐Ternero C, Robinson J et al. (2023). Novel enhancers of guanylyl cyclase‐A activity acting via allosteric modulation. nameOfConference


  • Dignam JP, Perez-Ternero C, Aubdool AA et al. (2023). C-Type Natriuretic Peptide Signalling Attenuates the Development of Pulmonary Hypertension and Right Ventricular Remodelling. A14. THIS IS GETTING COMPLICATED: EPIGENETICS, -OMICS, AND CELL SIGNALING IN PULMONARY HYPERTENSION

    DOI: doi

    QMRO: qmroHref
  • Moyes A, Sand C, Aubdool A et al. (2023). C-type Natriuretic Peptide Attenuates Endothelial and Cardiac Dysfunction During Endotoxemia and Polymicrobial Sepsis. B45. NEW STUDIES IN SEPSIS AND INFECTIOUS DISEASES


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  • Beuve A, Brouckaert P, Burnett JC et al. (publicationYear). Receptor guanylyl cyclase (RGC) family in GtoPdb v.2023.1. nameOfConference


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  • Dignam JP, Perez-Ternero C, Aubdool A et al. (2023). C-type natriuretic peptide offsets the development of pulmonary hypertension. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Perez-Ternero C, Aubdool A, Makwana R et al. (2023). C-type natriuretic peptide regulates metabolic homeostasis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Andresen H, Perez-Ternero C, Robinson J et al. (2023). Small molecules enhance natriuretic peptide activity through a novel allosteric site on the natriuretic peptide receptor guanylyl cyclase-A. nameOfConference

    DOI: doi

  • Dignam JP, Perez-Ternero C, Aubdool A et al. (2023). C-type natriuretic peptide offsets the development of pulmonary hypertension. nameOfConference

    DOI: doi

  • Perez-Ternero C, Li W, Aubdool A et al. (2023). C-type natriuretic peptide protects against the development of non-alcoholic steatohepatitis and portal hypertension. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Perez-Ternero C, Aubdool A, Makwana R et al. (2023). C-type natriuretic peptide regulates metabolic homeostasis. nameOfConference

    DOI: doi

  • Andresen H, Perez-Ternero C, Robinson J et al. (2023). Small molecules enhance natriuretic peptide activity through a novel allosteric site on the natriuretic peptide receptor guanylyl cyclase-A. nameOfConference

    DOI: doi

  • Perez-Ternero C, Pallier PN, Tremoleda JL et al. (publicationYear). C-type natriuretic peptide preserves central neurological function by maintaining blood-brain barrier integrity. nameOfConference


  • Zarenkiewicz J, Perez-Ternero C, Kojasoy V et al. (2022). The reaction of hydropersulfides (RSSH) with S-nitrosothiols (RS-NO) and the biological/physiological implications. nameOfConference


  • Perez-Ternero C, Aubdool AA, Makwana R et al. (2022). C-type natriuretic peptide is a pivotal regulator of metabolic homeostasis.. nameOfConference


  • Smith RJ, Perez-Ternero C, Conole D et al. (2022). A Series of Substituted Bis-Aminotriazines Are Activators of the Natriuretic Peptide Receptor C. nameOfConference


  • Fukuto JM, Perez-Ternero C, Zarenkiewicz J et al. (publicationYear). Hydropersulfides (RSSH) and Nitric Oxide (NO) Signaling: Possible Effects on S-Nitrosothiols (RS-NO). nameOfConference


  • Scott TE, Qin CX, Drummond GR et al. (2021). Innovative Anti-Inflammatory and Pro-resolving Strategies for Pulmonary Hypertension: High Blood Pressure Research Council of Australia Award 2019.. nameOfConference


  • Alexander SPH, Fabbro D, Kelly E et al. (2021). THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Catalytic receptors. nameOfConference


  • Beuve A, Brouckaert P, Burnett JC et al. (2021). Receptor guanylyl cyclase (RGC) family in GtoPdb v.2021.3. nameOfConference


  • Petraina A, Nogales C, Krahn T et al. (2022). Cyclic GMP modulating drugs in cardiovascular diseases: mechanism-based network pharmacology. nameOfConference


  • Grange RMH, Preedy MEJ, Renukanthan A et al. (2022). Multidrug resistance proteins preferentially regulate natriuretic peptide‐driven cGMP signalling in the heart and vasculature. nameOfConference


  • Dignam JP, Scott TE, Kemp‐Harper BK et al. (2022). Animal models of pulmonary hypertension: Getting to the heart of the problem. nameOfConference


  • Fukuto JM, Hobbs AJ (2021). A comparison of the chemical biology of hydropersulfides (RSSH) with other protective biological antioxidants and nucleophiles. nameOfConference


  • Aziz Q, Chen J, Moyes AJ et al. (2020). Vascular KATP channels protect from cardiac dysfunction and preserve cardiac metabolism during endotoxemia. nameOfConference


  • Beuve A, Brouckaert P, Burnett JC et al. (2020). Receptor guanylyl cyclase (RGC) family (version 2020.3) in the IUPHAR/BPS Guide to Pharmacology Database. nameOfConference


  • Armstrong P, Ferreira PM, Chan M et al. (publicationYear). Combination of cyclic nucleotide modulators with P2Y12 receptor antagonists as anti-platelet therapy. nameOfConference


  • Scott TE, Ung V, Baliga RS et al. (2020). Targeting the NLRP3 Inflammasome as a Novel Approach to Treat Pulmonary Hypertension. American Thoracic Society


  • Perez-Ternero C, Aubdool AA, Moyes AJ et al. (2019). C-Type Natriuretic Peptide (CNP) Regulates Adipogenesis, Thermogenesis and Glucose Sensitivity via Natriuretic Peptide Receptor (NPR)-C Signalling. American Heart Association

    DOI: doi

  • Dukinfield M, Maniati E, Reynolds LE et al. (2019). Repurposing an anti‐cancer agent for the treatment of hypertrophic heart disease. nameOfConference


  • Beuve A, Brouckaert P, Burnett JC et al. (2019). Receptor guanylyl cyclase (RGC) family (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. nameOfConference


  • Hobbs AJ (2019). Nitric oxide biology & pathobiology (3rd edition) editors: Louis Ignarro & Bruce Freeman. nameOfConference


  • Preedy MEJ, Baliga RS, Hobbs AJ (2019). Multiplicity of Nitric Oxide and Natriuretic Peptide Signalling in Heart Failure.. nameOfConference


  • Sandner P, Zimmer DP, Milne GT et al. (2019). Correction to: Soluble Guanylate Cyclase Stimulators and Activators.. nameOfConference


  • Moyes AJ, Hobbs AJ (publicationYear). C-Type Natriuretic Peptide: A Multifaceted Paracrine Regulator in the Heart and Vasculature. nameOfConference


  • Hobbs AJ, Moyes AJ, Baliga RS et al. (2019). Neprilysin inhibition for pulmonary arterial hypertension: a randomized, double‐blind, placebo‐controlled, proof‐of‐concept trial. nameOfConference


  • Moyes AJ, Chu SM, Aubdool AA et al. (2020). C-type natriuretic peptide co-ordinates cardiac structure and function. nameOfConference


  • Sandner P, Zimmer DP, Milne GT et al. (2019). Soluble Guanylate Cyclase Stimulators and Activators.. nameOfConference


  • Bubb KJ, Aubdool AA, Moyes AJ et al. (publicationYear). Endothelial C-Type Natriuretic Peptide is a Critical Regulator of Angiogenesis and Vascular Remodeling.. nameOfConference


  • Conole D, Myers SH, Mota F et al. (2019). Biophysical screening methods for extracellular domain peptide receptors, application to natriuretic peptide receptor C ligands. nameOfConference


  • Baliga RS, Preedy MEJ, Dukinfield MS et al. (2018). Phosphodiesterase 2 inhibition preferentially promotes NO/guanylyl cyclase/cGMP signaling to reverse the development of heart failure.. nameOfConference


  • Scott TE, Kemp‐Harper BK, Hobbs AJ (2019). Inflammasomes: a novel therapeutic target in pulmonary hypertension?. nameOfConference


  • Fukuto JM, Ignarro LJ, Nagy P et al. (2018). Biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology. nameOfConference


  • Barrese V, Stott JB, Figueiredo HB et al. (2018). Angiotensin II Promotes KV7.4 Channels Degradation Through Reduced Interaction With HSP90 (Heat Shock Protein 90). nameOfConference


  • Motwani MP, Bennett F, Norris PC et al. (2018). Potent Anti‐Inflammatory and Pro‐Resolving Effects of Anabasum in a Human Model of Self‐Resolving Acute Inflammation. nameOfConference


  • Alexander SPH, Kelly E, Marrion NV et al. (2017). THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview. nameOfConference


  • Kapil V (2017). Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017.. nameOfConference


  • Ren M, Ng FL, Warren HR et al. (2018). The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle. nameOfConference


  • Villar IC, Bubb KJ, Moyes AJ et al. (2016). Functional pharmacological characterization of SER100 in cardiovascular health and disease. nameOfConference


  • Ren M, Ng F, Witkowska K et al. (2016). [OP.7C.08] BLOOD-PRESSURE ASSOCIATED VARIANTS IN NPR3 AFFECT HUMAN VASCULAR SMOOTH MUSCLE CELLS PROLIFERATION AND CALCIUM RESPONSE TO ANGIOTENSIN II.. nameOfConference


  • Hobbs AJ (2016). A Janus-Faced Role for Atrial Natriuretic Peptide in Myocardial Infarction?. nameOfConference


  • Hobbs AJ (2016). Guanylyl cyclase can't stand the HETE.. nameOfConference


  • Chen J, Kieswich J, Chiazza F et al. (publicationYear). IkB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD. nameOfConference


  • Moyes AJ, Stanford SC, Hosford PS et al. (2016). Raised arterial blood pressure in neurokinin-1 receptor-deficient mice ( NK1R −/− ): evidence for a neural rather than a vascular mechanism. nameOfConference


    QMRO: qmroHref
  • Oettrich JM, Dao VT, Frijhoff J et al. (2016). Clinical Relevance of Cyclic GMP Modulators: A Translational Success Story of Network Pharmacology. nameOfConference


    QMRO: qmroHref
  • Baliga RS, Moyes AJ, Villar IC et al. (2016). Therapeutic Proof-Of-Concept For Novel Sirna Technology In Experimental Pulmonary Hypertension. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Moyes AJ, Chu SM, Baliga RS et al. (2015). Abstract 19478: Endothelial and Cardiomyocyte -derived C-type Natriuretic Peptide Coordinate Heart Structure and Function. nameOfConference


    QMRO: qmroHref
  • Sand CA, Hobbs AJ (2016). The nuances of NO synthase regulation in sepsis: Could targeting BH4 be the answer?. nameOfConference


  • Allen RMH, Renukanthan A, Bubb KJ et al. (2015). Investigation of the role of multidrug resistance proteins (MRPs) in vascular homeostasis. nameOfConference


    QMRO: qmroHref
  • Hobbs AJ (2015). Pivotal vascular homeostatic role for endothelium-derived C-type natriuretic peptide (CNP). nameOfConference


    QMRO: qmroHref
  • Ren M, Ng FL, Witkowska K et al. (2015). Abstract P048: Blood-Pressure Associated Variants in Natriuretic Peptide Receptor C Affect Human Vascular Smooth Muscle Cells Proliferation and Calcium Flux in Response to Angiotensin II. nameOfConference


    QMRO: qmroHref
  • Peake NJ, Bader DL, Vessillier S et al. (2015). C-type natriuretic peptide signalling drives homeostatic effects in human chondrocytes. nameOfConference


    QMRO: qmroHref
  • O'Brien A, China L, Massey KA et al. (2016). Bile duct‐ligated mice exhibit multiple phenotypic similarities to acute decompensation patients despite histological differences. nameOfConference


  • Ren M, Ng F, Witkowska K et al. (2015). PP.LB03.07. nameOfConference


    QMRO: qmroHref
  • Allen R, Renukanthan A, Bubb K et al. (2015). Investigation of the Role of Multidrug Resistance Proteins (MRPs) in Vascular Homeostasis. nameOfConference


    QMRO: qmroHref
  • Peake N, Pavlov A, D'Souza A et al. (2015). Polyelectrolyte microencapsules loaded with C-type natriuretic peptide protect cartilage from IL-1B induced damage. nameOfConference


    QMRO: qmroHref
  • Papapetropoulos A, Hobbs AJ, Topouzis S (2015). Extending the translational potential of targeting NO/cGMP‐regulated pathways in the CVS. nameOfConference


    QMRO: qmroHref
  • Peake NJ, Pavlov AM, D'Souza A et al. (2015). Controlled Release of C-Type Natriuretic Peptide by Microencapsulation Dampens Proinflammatory Effects Induced by IL-1β in Cartilage Explants.. nameOfConference


  • Ren M, Ng FL, Witkowska K et al. (2015). Blood-pressure associated variants in NPR3 affect human vascular smooth muscle cells proliferation and calcium response to angiotensin II. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Moyes AJ, Chu SM, Baliga RS et al. (2015). Endothelial and Cardiomyocyte-derived C-type Natriuretic Peptide Coordinate Heart Structure and Function. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Bubb KJ, Hobbs AJ, Klinger JR (2015). Modulation of cGMP Synthesis and Metabolism. nameOfConference


    QMRO: qmroHref
  • Ono K, Akaike T, Sawa T et al. (2014). Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications of their possible biological activity and utility.. nameOfConference


  • Peake NJ, Hobbs AJ, Pingguan-Murphy B et al. (2014). Role of C-type natriuretic peptide signalling in maintaining cartilage and bone function.. nameOfConference


    QMRO: qmroHref
  • Moyes AJ, Khambata RS, Villar I et al. (2014). Endothelial C-type natriuretic peptide maintains vascular homeostasis.. nameOfConference


  • Bubb KJ, Trinder SL, Baliga RS et al. (2014). Inhibition of phosphodiesterase 2 augments cGMP and cAMP signaling to ameliorate pulmonary hypertension.. nameOfConference


    QMRO: qmroHref
  • Baliga RS, Scotton CJ, Trinder SL et al. (2014). Intrinsic defence capacity and therapeutic potential of natriuretic peptides in pulmonary hypertension associated with lung fibrosis.. nameOfConference


  • Gonzales MA, Han H, Moyes A et al. (2014). Light-triggered carbon monoxide delivery with Al-MCM-41-based nanoparticles bearing a designed manganese carbonyl complex. nameOfConference


    QMRO: qmroHref
  • Hobbs AJ (2014). Natriuretic peptide receptors and heart failure: to B or not to B blocked?. nameOfConference


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  • Peake N, Su N, Ramachandran M et al. (2014). Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo model. nameOfConference

    DOI: doi

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  • Alexander SPH, Benson HE, Faccenda E et al. (2013). The Concise Guide to PHARMACOLOGY 2013/14: Overview. nameOfConference


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  • Derrett-Smith EC, Dooley A, Gilbane AJ et al. (2013). Endothelial injury in a transforming growth factor β-dependent mouse model of scleroderma induces pulmonary arterial hypertension.. nameOfConference


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  • Baliga RS, MacAllister RJ, Hobbs AJ (2013). Vasoactive Peptides and the Pathogenesis of Pulmonary Hypertension: Role and Potential Therapeutic Application. nameOfConference


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  • Ghosh SM, Kapil V, Fuentes-Calvo I et al. (2013). Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential.. nameOfConference


    QMRO: qmroHref
  • Sciarretta S, Marchitti S, Bianchi F et al. (2013). C2238 Atrial Natriuretic Peptide Molecular Variant Is Associated With Endothelial Damage and Dysfunction Through Natriuretic Peptide Receptor C Signaling. nameOfConference


    QMRO: qmroHref
  • Ahluwalia A, Hobbs AJ (2013). Letter by Ahluwalia and Hobbs Regarding Article, "Nitrate-Nitrite-Nitric Oxide Pathway in Pulmonary Arterial Hypertension Therapeutics". nameOfConference


    QMRO: qmroHref
  • Peake N, Su N, Ramachandran M et al. (2013). Natriuretic peptide receptors regulate cytoprotective effects in an ex vivo human 3D / bioreactor model. nameOfConference


  • Bubb KJ, Trinder S, Baliga R et al. (2013). Validation Of Phosphodiesterase 2 As A Novel Therapeutic Target In Pulmonary Hypertension. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Baliga RS, Macallister RJ, Hobbs AJ (2013). Vasoactive peptides and the pathogenesis of pulmonary hypertension: role and potential therapeutic application.. nameOfConference


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  • Chan MV, Bubb KJ, Noyce A et al. (2012). Distinct endothelial pathways underlie sexual dimorphism in vascular auto-regulation.. nameOfConference


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  • Baliga RS, Milsom AB, Ghosh SM et al. (2012). Dietary nitrate ameliorates pulmonary hypertension: cytoprotective role for endothelial nitric oxide synthase and xanthine oxidoreductase.. nameOfConference


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  • Baliga RS, Milsom AB, Trinder SL et al. (2012). Dietary Nitrate: A Novel Therapy For Pulmonary Hypertension. B63. EXPERIMENTAL MODELS IN PULMONARY HYPERTENSION I


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  • Moyes AJ, Khambata RS, Ahluwalia A et al. (2012). Accelerated Atherogenesis and Diminished Vascular Integrity in Mice Lacking Endothelial C-Type Natriuretic Peptide. nameOfConference

    DOI: doi

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  • Gonzalez MA, Yim MA, Cheng S et al. (2012). Manganese Carbonyls Bearing Tripodal Polypyridine Ligands as Photoactive Carbon Monoxide-Releasing Molecules. nameOfConference


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  • Derrett-Smith E, Dooley A, Baliga R et al. (2012). SYSTEMIC VEGF INHIBITION INDUCES PULMONARY ARTERIAL HYPERTENSION IN A TRANSGENIC MOUSE MODEL OF SCLERODERMA. nameOfConference

    DOI: doi

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  • Hobbs AJ, Ignarro LJ (1999). Chemistry and Molecular Biology of Nitric Oxide Synthesis. nameOfConference


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  • Khambata RS, Panayiotou CM, Hobbs AJ (2011). Natriuretic peptide receptor-3 underpins the disparate regulation of endothelial and vascular smooth muscle cell proliferation by C-type natriuretic peptide.. nameOfConference


  • Pourcet B, Feig JE, Vengrenyuk Y et al. (2011). LXRα regulates macrophage arginase 1 through PU.1 and interferon regulatory factor 8.. nameOfConference


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  • Quinteiro FM, Gane P, Rebstock A-S et al. (2011). Design and development of novel non-peptide agonists at NPR-C. nameOfConference


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  • Baliga RS, Trinder SL, Scotton CJ et al. (2011). Enhancing natriuretic peptide bioactivity prevents bleomycin-induced pulmonary fibrosis. nameOfConference


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  • Velmurugan S, Kapil V, McKnight AHO et al. (2011). Dietary nitrate attenuates platelet reactivity: Role of the erythrocyte and influence of sex. nameOfConference


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  • Baliga RS, MacAllister RJ, Hobbs AJ (2011). New perspectives for the treatment of pulmonary hypertension.. nameOfConference


  • Baliga RS, Scotton CJ, Trinder SL et al. (2011). Protective Role Of Natriuretic Peptides In Pulmonary Fibrosis: A Novel Therapeutic Target?. C61. PULMONARY HYPERTENSION: EXPERIMENTAL MODELS II


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  • Villar IC, Scotland RS, Khambata RS et al. (2011). Suppression of endothelial P-selectin expression contributes to reduced cell trafficking in females: an effect independent of NO and prostacyclin.. nameOfConference


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  • Gonzalez MA, Fry NL, Burt R et al. (2011). Designed Iron Carbonyls as Carbon Monoxide (CO) Releasing Molecules: Rapid CO Release and Delivery to Myoglobin in Aqueous Buffer, and Vasorelaxation of Mouse Aorta. nameOfConference


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  • Derrett-Smith EC, Dooley A, Baliga R et al. (2011). AN EXPLORATION OF PULMONARY VASCULAR VEGF SIGNALLING IN A TGF beta-DEPENDENT MOUSE MODEL OF SYSTEMIC SCLEROSIS. nameOfConference

    DOI: doi

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  • Kapil V, Benjamin N, Hobbs A et al. (2011). Response to Inorganic Nitrate for Blood Pressure Lowering?. nameOfConference


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  • Derrett-Smith E, Dooley A, Baliga R et al. (2011). Intermittent Systemic VEGF Inhibition Induces Pulmonary Arterial Hypertension In a Transgenic Mouse Model of Scleroderma. nameOfConference

    DOI: doi

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  • Derrett-Smith EC, Dooley A, Baliga R et al. (2010). Perturbed VEGF signalling within the pulmonary vasculature of a TGF beta dependent mouse model of systemic sclerosis. nameOfConference

    DOI: doi

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  • Madhani M, Hall AR, Cuello F et al. (2010). Phospholemman Ser69 phosphorylation contributes to sildenafil-induced cardioprotection against reperfusion injury. nameOfConference


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  • Kapil V, Milsom AB, Okorie M et al. (2010). Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO.. nameOfConference


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  • Kapil V, Maleki-Toyserkani S, Rehman F et al. (2010). Oral inorganic nitrate lowers blood pressure in healthy male, but not female, volunteers, via bioconversion to nitrite. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Panayiotou CM, Baliga R, Stidwill R et al. (2010). Resistance to endotoxic shock in mice lacking natriuretic peptide receptor-A.. nameOfConference


  • Milsom AB, Patel NSA, Mazzon E et al. (2010). Role for endothelial nitric oxide synthase in nitrite-induced protection against renal ischemia-reperfusion injury in mice. nameOfConference


    QMRO: qmroHref
  • Lumsden NG, Khambata RS, Hobbs AJ (2010). C-type Natriuretic Peptide (CNP): Cardiovascular Roles and Potential as a Therapeutic Target. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Lumsden NG, Khambata RS, Hobbs AJ (2010). C-type natriuretic peptide (CNP): cardiovascular roles and potential as a therapeutic target.. nameOfConference


    QMRO: qmroHref
  • Hobbs AJ, Stasch J-P (2010). Chapter 9 Soluble Guanylate Cyclase Allosteric Activation and Redox Regulation. nameOfConference


    QMRO: qmroHref
  • Hobbs AJ, Stasch JP (2010). Soluble Guanylate Cyclase. Allosteric Activation and Redox Regulation.. nameOfConference


    QMRO: qmroHref
  • Khambata RS, Panayiotou CM, Xiao F et al. (2010). The anti-atherogenic potential of C-type natriuretic peptide: Disparate regulation of endothelial and vascular smooth muscle cell proliferation via natriuretic peptide receptor-C. nameOfConference


    QMRO: qmroHref
  • Duchene J, Cayla C, Vessillier S et al. (2009). Laminar shear stress regulates endothelial kinin B1 receptor expression and function: potential implication in atherogenesis.. nameOfConference


    QMRO: qmroHref
  • Miller TW, Cherney MM, Lee AJ et al. (2009). The Effects of Nitroxyl (HNO) on Soluble Guanylate Cyclase Activity INTERACTIONS AT FERROUS HEME AND CYSTEINE THIOLS. nameOfConference


  • Baliga RS, Trinder S, Scotton CJ et al. (2009). Manipulating the natriuretic peptide system for the treatment of pulmonary hypertension. nameOfConference


    QMRO: qmroHref
  • Kapil V, Rehman F, Arghandawi S et al. (2009). BLOOD PRESSURE LOWERING EFFECTS OF ORAL INORGANIC NITRATE VIA BIOCONVERSION TO NITRITE. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Morris T, Stables M, Hobbs A et al. (2009). Effects of Low-Dose Aspirin on Acute Inflammatory Responses in Humans. nameOfConference


    QMRO: qmroHref
  • Okorie M, Akram F, Loukogeorgakis S et al. (2009). ORAL INORGANIC NITRATE PROTECTS AGAINST ENDOTHELIAL ISCHAEMIA-REPERFUSION INJURY IN HUMANS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Kapil V, Okorie M, Akram F et al. (2009). Oral inorganic nitrate lowers blood pressure and protects against endothelial ischaemia-reperfusion injury in humans. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Milsom A, Patel N, Storey A et al. (2009). Role for endothelial nitric oxide synthase in nitrite-induced protection against renal ischaemia-reperfusion injury in mice. nameOfConference


    QMRO: qmroHref
  • Diller GP, Bedard E, Wort SJ et al. (2009). Response to Letter Regarding Article, "Circulating Endothelial Progenitor Cells in Patients With Eisenmenger Syndrome and Idiopathic Pulmonary Arterial Hypertension". nameOfConference


    QMRO: qmroHref
  • Hobbs AJ, Gane P, Lumsden N et al. (2009). Design and development of novel non-peptide agonists at natriuretic peptide receptor-C. nameOfConference


    QMRO: qmroHref
  • Hajihosseini MK, Ramasamy S, De Langhe S et al. (2009). Involvement of Fibroblast growth factor 10 (Fgf10) in the anterior-posterior patterning and specification of muscle and tendon progenitors in the developing mouse limbs. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Stasch J-P, Hobbs AJ (2009). NO-Independent, Haem-Dependent Soluble Guanylate Cyclase Stimulators. nameOfConference


    QMRO: qmroHref
  • Webb AJ, Milsom AB, Rathod KS et al. (2008). Mechanisms underlying erythrocyte and endothelial nitrite reduction to nitric oxide in hypoxia: role for xanthine oxidoreductase and endothelial nitric oxide synthase.. nameOfConference


    QMRO: qmroHref
  • Baliga RS, Zhao L, Madhani M et al. (2008). Synergy between natriuretic peptides and phosphodiesterase 5 inhibitors ameliorates pulmonary arterial hypertension.. nameOfConference


    QMRO: qmroHref
  • Marro ML, Peiro C, Panayiotou CM et al. (2008). Characterization of the human alpha(1)beta(1) soluble guanylyl cyclase promoter - Key role for NF-kappa B(p50) and CCAAT-binding factors in regulating expression of the nitric oxide receptor. nameOfConference


  • Diller GP, van Eijl S, Okonko DO et al. (2008). Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension. nameOfConference


    QMRO: qmroHref
  • Chan MV, Hobbs AJ, Scotland RS et al. (2008). Nitric oxide-induced relaxation in female resistance arteries is endothelium-dependent. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Villar IC, Hobbs AJ, Ahluwalia A (2008). Sex differences in vascular function: implication of endothelium-derived hyperpolarizing factor. nameOfConference


    QMRO: qmroHref
  • Aboud Z, Misra S, Warner T et al. (2008). The enterosalivary bioconversion of nitrate to nitrite underlies the blood pressure (BP) lowering and anti-platelet effects of a dietary nitrate load. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Morton J, Coles B, Wright K et al. (2008). Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFN gamma-dependent iNOS expression in the vasculature of healthy mice. nameOfConference


    QMRO: qmroHref
  • Webb AJ, Patel N, Loukogeorgakis S et al. (2008). Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. nameOfConference


    QMRO: qmroHref
  • Webb A, Patel N, Loukogeorgakis S et al. (2008). Acute blood pressure lowering and vasoprotective effects of dietary nitrate. nameOfConference


    QMRO: qmroHref
  • Milsom AB, Hobbs AJ, Ahluwalia A (2008). Endothelial nitric oxide synthase acts as a nitrite reductase in human endotheliall cells. nameOfConference


    QMRO: qmroHref
  • Panayiotou CM, Stidwill R, Taylor V et al. (2008). Resistance to endotoxic shock in mice lacking natriuretic peptide receptor-A. nameOfConference


    QMRO: qmroHref
  • Baliga R, Zhao L, Wilkins MR et al. (2007). Selective modulation of ANP-dependent dilation in the pulmonary vasculature by PDE 5 inhibitors: A novel combination therapy for pulmonary hypertension?. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Webb AJ, Patel N, Loukogeorgakis S et al. (2007). Acute blood pressure (BP) lowering and vasoprotective effects of beetroot juice: relationship to nitrite derived from dietary nitrate. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Hobbs AJ (2007). Exploiting the natriuretic peptide system for the treatment of pulmonary hypertension. nameOfConference


    QMRO: qmroHref
  • Panayiotou CM, Hobbs AJ (2007). NPR-A gene deletion reverses vascular dysfunction associated with sepsis. nameOfConference


    QMRO: qmroHref
  • Baliga RS, Zhao L, Wilkins MR et al. (2007). Selective modulation of ANP-dependent dilatation in the pulmonary vasculature by PDE 5 inhibitors: a novel combination therapy for pulmonary hypertension?. nameOfConference


    QMRO: qmroHref
  • Villar IC, Panayiotou CM, Sheraz A et al. (2007). Definitive role for natriuretic peptide receptor-C in mediating the vasorelaxant activity of C-type natriuretic peptide and endothelium-derived hyperpolarising factor. nameOfConference


    QMRO: qmroHref
  • Webb AJ, Patel N, Loukogeorgakis S et al. (2007). Acute blood pressure lowering and vasoprotective effects of beetroot juice: relationship to nitrite derived from dietary nitrate. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Paolocci N, Jackson MI, Lopez BE et al. (2007). The pharmacology of nitroxyl (HNO) and its therapeutic potential: Not just the janus face of NO. nameOfConference


    QMRO: qmroHref
  • Madhani M, Patra AK, Miller TW et al. (2006). Biological activity of designed photolabile metal nitrosyls: light-dependent activation of soluble guanylate cyclase and vasorelaxant properties in rat aorta.. nameOfConference


    QMRO: qmroHref
  • Madhani M, Okorie M, Hobbs AJ et al. (2006). Reciprocal regulation of human soluble and particulate guanylate cyclases in vivo.. nameOfConference


    QMRO: qmroHref
  • Villar IC, Ahluwalia A, Hobbs AJ (2006). Distinct pathways regulate endothelium derived hyperpolarising factor-mediated responses in rat mesenteric arteries. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Villar IC, Francis S, Webb A et al. (2006). Novel aspects of endothelium-dependent regulation of vascular tone. nameOfConference


    QMRO: qmroHref
  • Panayiotou CM, Hobbs AJ (2006). C-Type natriuretic peptide mediates ERK1/2 phosphorylation via Gi-coupled natriuretic peptide receptor-C in rat aortic smooth muscle cells. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Marro M, Panayiotou C, Hobbs A (2006). Vascular inflammation modulates alpha 1 and beta 1 soluble guanylate cyclase promoter activity in human aortic smooth muscle cells (HASMCs). nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Miller TW, Franco NE, Hobbs AJ et al. (2006). Effect of changing redox status on the activation of soluble guanylate cyclase by nitrogen oxides. nameOfConference


    QMRO: qmroHref
  • Scotland RS, Duchene J, Hobbs A et al. (2006). Gender-differences in leukocyte activation in vivo: role of endothelium-derived mediators. nameOfConference


    QMRO: qmroHref
  • Scotland RS, Cohen M, Foster P et al. (2005). C-type natriuretic peptide inhibits leukocyte recruitment and platelet-leukocyte interactions via suppression of P-selectin expression. nameOfConference


    QMRO: qmroHref
  • Marro ML, Hobbs AJ (2005). Characterisation of human a1 and b1 soluble guanylate cyclase promoter activity in human aortic smooth muscle cells. nameOfConference


    QMRO: qmroHref
  • Connelly L, Madhani M, Hobbs AJ (2005). Resistance to endotoxic shock in endothelial nitric-oxide synthase (eNOS) knock-out mice: a pro-inflammatory role for eNOS-derived no in vivo.. nameOfConference


    QMRO: qmroHref
  • Ahluwalia A, Villar I, Scotland RS et al. (2005). The natriuretic peptide receptor-C antagonist, M372049, blocks C-type natriuretic peptide and endothelium-derived hyperpolarizing factor-induced relaxation of resistance arteries. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Ahluwalia A, Hobbs AJ (2005). Endothelium-derived C-type natriuretic peptide: more than just a hyperpolarizing factor. nameOfConference


    QMRO: qmroHref
  • Hobbs AJ (2000). Soluble guanylate cyclase. nameOfConference


    QMRO: qmroHref
  • Scotland RS, Madhani M, Chauhan S et al. (2005). Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice - Key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo. nameOfConference


    QMRO: qmroHref
  • Scotland RS, Ahluwalia A, Hobbs AJ (2005). C-type natniuretic peptide in vascular physiology and disease. nameOfConference


    QMRO: qmroHref
  • Scotland R, Foster P, Ahluwalia A et al. (2004). C-type natriuretic peptide inhibits leukocyte recruitment in vivo via natriuretic peptide receptor-C activation. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Ahluwalia A, Foster P, Prescott C et al. (2004). Endothelial C-type natriuretic peptide regulates coronary blood flow and prevents ischemia-reperfusion injury. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Chauhan SD, Hobbs AJ, Ahluwalia A (2004). C-type natriuretic peptide: new candidate for endothelium-derived hyperpolarising factor.. nameOfConference


    QMRO: qmroHref
  • Hobbs A, Foster P, Prescott C et al. (2004). Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury - Novel cardioprotective role for endothelium-derived C-type natriuretic peptide. nameOfConference


    QMRO: qmroHref
  • Connelly L, Hobbs AJ (2004). Endothelial nitric oxide synthase promotes inducible NOS expression in LPS-challenged mice in vivo. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Madhani M, MacAllister RJ, Hobbs AJ (2004). Reciprocal interaction between soluble and particulate guanylate cyclases in vivo. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Ahluwalia A, MacAllister RJ, Hobbs AJ (2004). Vascular actions of natriuretic peptides. Cyclic GMP-dependent and -independent mechanisms.. nameOfConference


    QMRO: qmroHref
  • Ahluwalia A, Foster P, Scotland RS et al. (2004). Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment. nameOfConference


    QMRO: qmroHref
  • AHLUWALIA A, Hobbs A, Prescott C et al. (2004). Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide.. nameOfConference


    QMRO: qmroHref
  • Hobbs AJ, Moncada S (2003). Antiplatelet properties of a novel, non-NO-based soluble guanylate cyclase activator, BAY 41-2272.. nameOfConference


    QMRO: qmroHref
  • Madhani M, Scotland RS, MacAllister RJ et al. (2003). Vascular natriuretic peptide receptor-linked particulate guanylate cyclases are modulated by nitric oxide-cyclic GMP signalling.. nameOfConference


    QMRO: qmroHref
  • Connelly L, Jacobs AT, Palacios-Callender M et al. (2003). Macrophage endothelial nitric-oxide synthase autoregulates cellular activation and pro-inflammatory protein expression.. nameOfConference


    QMRO: qmroHref
  • Madhani M, MacAllister R, Hobbs A (publicationYear). Interactions between soluble guanylate cyclase and natriuretic peptide receptor-linked particulate guanylate cyclases in the mammalian vasculature. nameOfConference


    QMRO: qmroHref
  • Madhani M, MacAllister R, Hobbs A (2003). Vascular natriuretic peptide receptors modulated by NO-cyclic GMP signalling. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Foster P, Mathur A, McLean P et al. (2003). Anti-leukocyte properties of a novel non NO-based soluble guanylate cyclase activator, BAY 41-2272. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Scotland RS, Chauhan SD, Hobbs AJ et al. (2003). Characterisation of eNOS/COX-1 double knockout mice: a novel model for the study of endothelium-derived hyperpolarising factor. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Hobbs AJ, Chauhan SD, Nilsson H et al. (2003). Endothelium-derived hyperpolarising factor (EDHF) is C-type natriuretic peptide (CNP) in mesenteric resistance arteries. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Chauhan SD, Nilsson H, Ahluwalia A et al. (2003). Release of C-type natriuretic peptide accounts for the biological activity of endothelium-derived hyperpolarizing factor. nameOfConference


    QMRO: qmroHref
  • KALSI JS, REES RW, HOBBS AJ et al. (2003). BAY41-2272, a Novel Nitric Oxide Independent Soluble Guanylate Cyclase Activator, Relaxes Human and Rabbit Corpus Cavernosum In Vitro. nameOfConference


    QMRO: qmroHref
  • Kalsi JS, Rees RW, Hobbs AJ et al. (2003). BAY41-2272, a novel nitric oxide independent soluble guanylate cyclase activator, relaxes human and rabbit corpus cavernosum in vitro.. nameOfConference


    QMRO: qmroHref
  • AHLUWALIA A, Hobbs AJ, Seggara G et al. (2003). Protection against liposaccharide-induced endothelial dysfunction in resistance and conduit vasculature of iNOS knockout mice.. nameOfConference


    QMRO: qmroHref
  • Hobbs AJ, Gladwin MT, Patel RP et al. (2002). Haemoglobin: NO transporter, NO inactivator or NOne of the above?. nameOfConference


    QMRO: qmroHref
  • Hobbs AJ, Gladwin MT, Patel RP et al. (2002). Haernoglobin: NO transporter, NO inactivator or NOne of the above?. nameOfConference


    QMRO: qmroHref
  • Hobbs AJ (2002). Soluble guanylate cyclase: an old therapeutic target re-visited.. nameOfConference


    QMRO: qmroHref
  • Chauhan SD, MacAllister RJ, Hobbs AJ et al. (2002). Mechanisms underlying the vasorelaxant activity of C-type natriuretic peptide (CNP) in rat mesenteric resistance arteries. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Connelly L, Palacios-Callender M, Ameixa C et al. (2001). Biphasic regulation of NF-kappa B activity underlies the pro- and anti-inflammatory actions of nitric oxide.. nameOfConference


    QMRO: qmroHref
  • Hussain MB, MacAllister RJ, Hobbs AJ (2001). Reciprocal regulation of cGMP-mediated vasorelaxation by soluble and particulate guanylate cyclases.. nameOfConference


    QMRO: qmroHref
  • Selwood DL, Brummell DG, Budworth J et al. (2001). Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor, soluble guanylate cyclase. nameOfConference


    QMRO: qmroHref
  • Cavero M, Hobbs A, Madge D et al. (2000). Synthesis and biological evaluation of enantiopure thionitrites: the solid-phase synthesis and nitrosation of D-glutathione as a molecular probe.. nameOfConference


    QMRO: qmroHref
  • Shah S, Hobbs A, Singh R et al. (2000). Gastrointestinal motility during pregnancy: role of nitrergic component of NANC nerves. nameOfConference


    QMRO: qmroHref
  • Hussain MB, MacAllister RJ, Hobbs AJ (2000). Regulation of cGMP-mediated vasorelaxation in mouse thoracic aorta: Interactions of the soluble and particulate guanylate cyclases. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Hussain MB, Hobbs AJ, MacAllister RJ (1999). Autoregulation of nitric oxide-soluble guanylate cyclase-cyclic GMP signalling in mouse thoracic aorta.. nameOfConference


    QMRO: qmroHref
  • Wolzt M, MacAllister RJ, Davis D et al. (1999). Biochemical characterization of S-nitrosohemoglobin. Mechanisms underlying synthesis, no release, and biological activity.. nameOfConference


    QMRO: qmroHref
  • Hussain MB, Hobbs AJ, MacAllister RJ (1999). Enhanced sensitivity of the soluble guanylate cyclase/cyclic GMP system in the eNOS knockout mouse. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Hobbs AJ, Moncada S (1999). Inducible nitric oxide synthase and inflammation. nameOfConference


    QMRO: qmroHref
  • Hobbs AJ, Higgs A, Moncada S (1999). Inhibition of nitric oxide synthase as a potential therapeutic target.. nameOfConference


    QMRO: qmroHref
  • Hobbs AJ (1997). Soluble guanylate cyclase: the forgotten sibling.. nameOfConference


    QMRO: qmroHref
  • Hobbs AJ (1997). Soluble guanylate cyclase: the forgotten sibling. nameOfConference


    QMRO: qmroHref
  • Cohen GA, Hobbs AJ, Fitch RM et al. (1996). Nitric oxide regulates endothelium-dependent vasodilator responses in rabbit hindquarters vascular bed in vivo.. nameOfConference


    QMRO: qmroHref
  • Hobbs AJ, Ignarro LJ (1996). Nitric oxide cyclic GMP signal transduction system. nameOfConference


    QMRO: qmroHref
  • SHAH SN, CUEVAS JM, HOBBS AJ et al. (1995). ENHANCED ACTIONS OF NITRIC-OXIDE IN MODULATING GASTROINTESTINAL SMOOTH-MUSCLE FUNCTION DURING PREGNANCY. nameOfConference


    QMRO: qmroHref
  • SHAH SN, CUEVAS JM, HOBBS AJ et al. (1995). CHANGES IN GASTROINTESTINAL SMOOTH-MUSCLE REACTIVITY DURING PREGNANCY MAY BE INDUCED BY NITRIC-OXIDE. nameOfConference


    QMRO: qmroHref
  • HOBBS AJ, COHEN GA, FITCH RM et al. (1995). DIFFERENTIAL INHIBITORY EFFECT OF L-NAME ON ENDOTHELIUM-DEPENDENT RELAXATION IN-VITRO AND IN-VIVO. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Griscavage JM, Hobbs AJ, Ignarro LJ (1995). Negative modulation of nitric oxide synthase by nitric oxide and nitroso compounds.. nameOfConference


    QMRO: qmroHref
  • COHEN GA, HOBBS AJ, FITCH RM et al. (1995). STIMULATED RELEASE OF NITRIC-OXIDE (NO) IS LINKED TO ALPHA-ADRENOCEPTOR ACTIVATION IN-VIVO. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • SHAH SN, CUEVAS JM, HOBBS AJ et al. (1995). THE ROLE OF NITRIC-OXIDE IN MODULATING GASTROINTESTINAL SMOOTH-MUSCLE REACTIVITY DURING PREGNANCY. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • HOBBS AJ, GRISCAVAGE JM, ROGERS NE et al. (1994). FORMATION OF FREE NITRIC OXIDE FROM L-ARGININE BY NITRIC OXIDE SYNTHASE AND ENHANCEMENT OF GENERATION BY SUPEROXIDE DISMUTASE. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • HOBBS AJ, FUKUTO JM, IGNARRO LJ (1994). FORMATION OF FREE NITRIC-OXIDE FROM L-ARGININE BY NITRIC-OXIDE SYNTHASE - DIRECT ENHANCEMENT OF GENERATION BY SUPEROXIDE-DISMUTASE. nameOfConference


    QMRO: qmroHref
  • HOBBS AJ, GRISCAVAGE JM, ROGERS NE et al. (1994). FORMATION OF FREE NITRIC-OXIDE FROM L-ARGININE BY NITRIC-OXIDE SYNTHASE AND ENHANCEMENT OF GENERATION BY SUPEROXIDE-DISMUTASE. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Fukuto JM, Hobbs AJ, Ignarro LJ (1993). Conversion of nitroxyl (HNO) to nitric oxide (NO) in biological systems: the role of physiological oxidants and relevance to the biological activity of HNO.. nameOfConference


    QMRO: qmroHref
  • Brave SR, Bhat S, Hobbs AJ et al. (1993). The influence of L-NG-nitro-arginine on sympathetic nerve induced contraction and noradrenaline release in the rat isolated anococcygeus muscle.. nameOfConference


    QMRO: qmroHref
  • Gibson A, Babbedge R, Brave SR et al. (1992). An investigation of some S-nitrosothiols, and of hydroxy-arginine, on the mouse anococcygeus.. nameOfConference


    QMRO: qmroHref
  • Hobbs AJ, Tucker JF, Gibson A (1991). Differentiation by hydroquinone of relaxations induced by exogenous and endogenous nitrates in non-vascular smooth muscle: role of superoxide anions.. nameOfConference


    QMRO: qmroHref
  • Brave SR, Hobbs AJ, Gibson A et al. (1991). The influence of L-NG-nitro-arginine on field stimulation induced contractions and acetylcholine release in guinea pig isolated tracheal smooth muscle.. nameOfConference


    QMRO: qmroHref
  • Mirzazadeh S, Hobbs AJ, Tucker JF et al. (1991). Cyclic nucleotide content of the rat anococcygeus during relaxations induced by drugs or by non-adrenergic, non-cholinergic field stimulation.. nameOfConference


    QMRO: qmroHref
  • Tucker JF, Brave SR, Charalambous L et al. (1990). L-NG-nitro arginine inhibits non-adrenergic, non-cholinergic relaxations of guinea-pig isolated tracheal smooth muscle.. nameOfConference


    QMRO: qmroHref
  • Hobbs AJ, Gibson A (1990). L-NG-nitro-arginine and its methyl ester are potent inhibitors of non-adrenergic, non-cholinergic transmission in the rat anococcygeus.. nameOfConference


    QMRO: qmroHref
  • Gibson A, Hobbs AJ, Mirzazadeh S (1990). L-NG-nitroarginine is a potent inhibitor of non-adrenergic, non-cholinergic relaxations in the rat anococcygeus muscle. nameOfConference


    QMRO: qmroHref
  • Gibson A, Mirzazadeh S, Hobbs AJ et al. (1990). L-NG-monomethyl arginine and L-NG-nitro arginine inhibit non-adrenergic, non-cholinergic relaxation of the mouse anococcygeus muscle.. nameOfConference


    QMRO: qmroHref

Sponsors

Collaborators

Internal

External

  • L. Ignarro Nobel Laureate (UCLA)
  • J. Fukuto (Sonoma State)
  • G. Coghlan (Royal Free Hospital)
  • B. Schreiber (Royal Free Hospital)
  • J. Tsui (Royal Free Hospital)
  • D. Abraham (Royal Free Hospital)
  • D. Selwood (University College London)
  • M. Wilkins (Imperial College London)
  • Lan Zhao (Imperial College London)
  • J. Klinger (Providence)
  • Ralph Schermuly (University of Giessen)
  • H. Schmidt (University of Maastricht)
  • B. Kemp-Harper (Monash University)
  • Kristen Bubb (Sydney University)
  • F.-O. Levy (University of Oslo)

Teaching

  • BHF 4-year PhD scheme MRes coordinator
  • SSc tutor
  • PBL facilitator
  • BSc Pharmacology and Innovative Therapeutics lecturer

Disclosures

  • Consultant/advisory board member for Palatin Technologies Inc. Novo Nordisk and Bionevix Ltd. Research income received from Palatin Technologies Inc and Bionevix Ltd.
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