Dr Ezra Aksoy

Profile

ORCID ID: 0000-0002-6962-1572

Ezra Aksoy obtained her BSc degree in Microbiology at the Kansas State University (USA) and her PhD in Biomedical Sciences from Université Libre de Bruxelles (Belgium). Having obtained EMBO Long-term Fellowship and Marie Curie Intra-European Fellowship, she then moved to London to carry out her postdoctoral studies in the field of PI3K biology together with Prof Bart Vanhaesebroeck at the Barts Cancer Institute, QMUL. In 2013, she was appointed as a Lecturer to start the “Mucosal Immunity and Signalling” group within the William Harvey Research Institute.

Research

Group members

• Post-doctoral Researchers & Fellows: Luiz Ricardo Vasconcellos
• PhD students: Laura Medrano

Publications

• Reglero-Real N, Pérez-Gutiérrez L, Yoshimura A et al. (2021). Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation. nameOfConference

  
  

  DOI: 10.1016/j.immuni.2021.07.012

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/74480
• Thibault B, Ramos‐Delgado F, Pons‐Tostivint E et al. (2021). Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component. nameOfConference

  
  

  DOI: 10.15252/emmm.202013502

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/72919
• Wood TE, Aksoy E, Hachani A (publicationYear). From Welfare to Warfare: The Arbitration of Host-Microbiota Interplay by the Type VI Secretion System. nameOfConference

  
  

  DOI: 10.3389/fcimb.2020.587948

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/69455
• Ferguson MS, Chard Dunmall LS, Gangeswaran R et al. (2020). Transient Inhibition of PI3Kδ Enhances the Therapeutic Effect of Intravenous Delivery of Oncolytic Vaccinia Virus. nameOfConference

  
  

  DOI: 10.1016/j.ymthe.2020.02.017

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/68481
• Aksoy E (2019). TLRs toll for Tregs. nameOfConference

  
  

  DOI: 10.1002/jlb.2ce0619-184r

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/73079
• Sun D, Stopka-Farooqui U, Barry S et al. (2019). Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation. nameOfConference

  
  

  DOI: 10.1016/j.celrep.2019.04.014

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/57415
• Mogilenko DA, Haas JT, L'homme L et al. (2019). Erratum: Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR (Cell (2019) 177(5) (1201–1216.e19), (S0092867419302806), (10.1016/j.cell.2019.03.018)). nameOfConference

  
  

  DOI: 10.1016/j.cell.2019.06.017

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/73059
• Mogilenko DA, Haas JT, L'homme L et al. (2019). Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR. nameOfConference

  
  

  DOI: 10.1016/j.cell.2019.03.018

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/58280
• Aksoy E, Saveanu L, Manoury B (2018). The Isoform Selective Roles of PI3Ks in Dendritic Cell Biology and Function. nameOfConference

  
  

  DOI: 10.3389/fimmu.2018.02574

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/57825
• Simeoli R, Mattace Raso G, Lama A et al. (2015). Preventive and Therapeutic Effects of Lactobacillus Paracasei B21060–Based Synbiotic Treatment on Gut Inflammation and Barrier Integrity in Colitic Mice 1–3. nameOfConference

  
  

  DOI: 10.3945/jn.114.205989

  
  

  QMRO: qmroHref
• Bontems P, Aksoy E, Burette A et al. (2014). NF‐κB Activation and Severity of Gastritis in Helicobacter pylori‐Infected Children and Adults. nameOfConference

  
  

  DOI: 10.1111/hel.12118

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/19662
• Aksoy E, Taboubi S, Torres D et al. (2013). Erratum: Corrigendum: The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock. nameOfConference

  
  

  DOI: 10.1038/ni0813-877d

  
  

  QMRO: qmroHref
• Aksoy E, Taboubi S, Torres D et al. (2012). The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock. nameOfConference

  
  

  DOI: 10.1038/ni.2426

  
  

  QMRO: qmroHref
• AKSOY-POISTER E, Taboubi S, Torres D et al. (2012). The p110´ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.. nameOfConference

  
  

  DOI: 10.1038/ni.2426

  
  

  QMRO: qmroHref
• Johnson J, Molle C, Aksoy E et al. (2011). A conventional protein kinase C inhibitor targeting IRF-3-dependent genes differentially regulates IL-12 family members. nameOfConference

  
  

  DOI: 10.1016/j.molimm.2011.04.006

  
  

  QMRO: qmroHref
• Langlet C, Springael C, Johnson J et al. (2010). PKC‐α controls MYD88‐dependent TLR/IL‐1R signaling and cytokine production in mouse and human dendritic cells. nameOfConference

  
  

  DOI: 10.1002/eji.200939391

  
  

  QMRO: qmroHref
• Goriely S, Aksoy E, De Wit D et al. (2008). Toll-like Receptor Responses in Neonatal Dendritic Cells. nameOfConference

  
  

  DOI: 10.1016/B978-141603158-1.10008-3

  
  

  QMRO: qmroHref
• Johnson J, Albarani V, Nguyen M et al. (2007). Protein Kinase Cα Is Involved in Interferon Regulatory Factor 3 Activation and Type I Interferon-β Synthesis*. nameOfConference

  
  

  DOI: 10.1074/jbc.m700421200

  
  

  QMRO: qmroHref
• Moore F, Buonocore S, Aksoy E et al. (2007). An Alternative Pathway of NF-κB Activation Results in Maturation and T Cell Priming Activity of Dendritic Cells Overexpressing a Mutated IκBα. nameOfConference

  
  

  DOI: 10.4049/jimmunol.178.3.1301

  
  

  QMRO: qmroHref
• Aksoy E, Albarani V, Nguyen M et al. (2007). Interferon regulatory factor 3-dependent responses to lipopolysaccharide are selectively blunted in cord blood cells. nameOfConference

  
  

  DOI: 10.1182/blood-2006-06-027862

  
  

  QMRO: qmroHref
• Aksoy E, Berghe WV, Detienne S et al. (2005). Inhibition of phosphoinositide 3‐kinase enhances TRIF‐dependent NF‐κB activation and IFN‐β synthesis downstream of Toll‐like receptor 3 and 4. nameOfConference

  
  

  DOI: 10.1002/eji.200425801

  
  

  QMRO: qmroHref
• Aksoy E, Zouain CS, Vanhoutte F et al. (2005). Double-stranded RNAs from the Helminth Parasite Schistosoma Activate TLR3 in Dendritic Cells*. nameOfConference

  
  

  DOI: 10.1074/jbc.m411223200

  
  

  QMRO: qmroHref
• Vosters O, Beuneu C, Nagy N et al. (2004). CD40 expression on human pancreatic duct cells: role in nuclear factor-kappa B activation and production of pro-inflammatory cytokines. nameOfConference

  
  

  DOI: 10.1007/s00125-004-1363-1

  
  

  QMRO: qmroHref
• Aksoy E, Goldman M, Willems F (2004). Protein kinase C epsilon: a new target to control inflammation and immune-mediated disorders. nameOfConference

  
  

  DOI: 10.1016/s1357-2725(03)00210-3

  
  

  QMRO: qmroHref
• Tonon S, Goriely S, Aksoy E et al. (2002). Bordetella pertussis toxin induces the release of inflammatory cytokines and dendritic cell activation in whole blood: impaired responses in human newborns. nameOfConference

  
  

  DOI: 10.1002/1521-4141(200211)32:11<3118::aid-immu3118>3.0.co;2-b

  
  

  QMRO: qmroHref
• Aksoy E, Amraoui Z, Goriely S et al. (2002). Critical role of protein kinase C ϵ for lipopolysaccharide‐induced IL‐12 synthesis in monocyte‐derived dendritic cells. nameOfConference

  
  

  DOI: 10.1002/1521-4141(200211)32:11<3040::aid-immu3040>3.0.co;2-m

  
  

  QMRO: qmroHref
• Ismaili J, Rennesson J, Aksoy E et al. (2002). Monophosphoryl Lipid A Activates Both Human Dendritic Cells and T Cells. nameOfConference

  
  

  DOI: 10.4049/jimmunol.168.2.926

  
  

  QMRO: qmroHref
• Vanderheyde N, Aksoy E, Amraoui Z et al. (2001). Tumoricidal Activity of Monocyte-Derived Dendritic Cells: Evidence for a Caspase-8-Dependent, Fas-Associated Death Domain-Independent Mechanism. nameOfConference

  
  

  DOI: 10.4049/jimmunol.167.7.3565

  
  

  QMRO: qmroHref
• Willems F, Amraoui Z, Vanderheyde N et al. (2000). Expression of c-FLIP(L) and resistance to CD95-mediated apoptosis of monocyte-derived dendritic cells: inhibition by bisindolylmaleimide.. nameOfConference

  
  

  DOI: 10.1182/blood.v95.11.3478.011k10_3478_3482

  
  

  QMRO: qmroHref

Collaborators

News

• Luiz Ricardo Vasconcellos successfully completed a European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant and joins Prof. Michael Way Lab at The Francis Crick Institute.
• Dr. Ezra Aksoy will act as an expert an International expert evaluator of the Doctoral INPhINIT fellowship programme in 2022.
• Dr. Ezra Aksoy was selected as the Jury full member for the AstraZeneca Award - Regenerative Medicine 2021 of AstraZeneca Foundation, the Funds for Scientific Research in Belgium (FNRS/FWO)  to reward an innovative scientific research on new strategies in regenerative medicine.
• Awarded Bart’s charity grant for the development of a new IBD stratification strategy (2019)
• Luiz Ricardo Vasconcellos (Brazil) joins the group as a postdoc fellow with the project ‘PI3K role in dendritic cell antigen processing and presentation to control gut tolerance (PI3K in gut immune tolerance), which has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 845908”.
• Alba Bosquet (Spain) joins the group (2018)
• Awarded Willoughby PhD studentship (2016)
• Dr Maria Gonzalez (Spain) joins the group and is awarded a Marie Curie EU Horizon CoFund grant (2015)
• Awarded EU-COFUND (2016)
• Awarded MRC New Investigator award (2015)