Dr Elisa Corsiero

Profile

ORCID iD: 0000-0003-2092-6778 

I am a Senior Lecturer at the Centre for Experimental Medicine & Rheumatology in the Immuno-Rheumatology group led by Prof Michele Bombardieri. I graduated from University of Milan (Italy) with an MSc in Industrial Biotechnology. In 2009, I joined the group of Prof Pitzalis and Prof Bombardieri in London for my PhD which I completed in 2013 with a thesis entitled: “Characterization of peripheral and lesional single B cell autoreactivity in patients with Sjögren’s syndrome and rheumatoid arthritis”. In 2014, I was awarded an Arthritis Research UK Foundation Fellowship which I completed in 2018. In November 2019, I was awarded with a competitive Career Development Fellowship from Versus Arthritis, which is funding my research. In 2022, I was awarded as PI a Large Project Grant from the Barts Charity on the generation of human antibodies specific to Sjögren’s Syndrome (SS) diseased tissue specific neoepitops for development of novel diagnostic and targeted immunotherapies.

Research

Group members

• Post-doctoral Fellows: Dr Lucas Jagemann
• PhD Students: Dr Mattia Caliste, Miss Mareike Werle
• Visiting Research Fellows: Miss Nia Sciucca

Summary

My major research interests focus on the elucidation of the cellular and molecular mechanisms regulating autoreactive B cell activation, breach of self-tolerance and perpetuation of autoimmunity in Sjögren’s syndrome and rheumatoid arthritis. In particular, my research is focused on characterizing the fine specificity and function of monoclonal antibodies derived from single B cells and from antibody phage display technology in patients with rheumatic autoimmune diseases and cancer.

Point of contact for Biacore 1K+ SPR Instrument – Booking: iLab Centre for Experimental Medicine & Rheumatology.

Publications

• Jagemann L, Sciucca N, Bombardieri M et al. (publicationYear). Efficient generation of a stable CHO-K1 cell line overexpressing the human water channel aquaporin-5 as tool to generate therapeutic antibodies. nameOfConference

  
  

  DOI: 10.1038/s41598-024-67147-x

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/97920
• Corsiero E, Caliste M, Pontarini E et al. (2024). POS0250 GENERATION AND VALIDATION OF A HUMAN IMMUNE scFv LIBRARY FROM SJÖGREN’S SYNDROME SALIVARY GLAND B-CELLS. Scientific Abstracts

  
  

  DOI: 10.1136/annrheumdis-2024-eular.3146

  
  

  QMRO: qmroHref
• Corsiero E, Caliste M, Jagemann L et al. (2024). Autoimmunity to stromal-derived autoantigens in rheumatoid ectopic germinal centers exacerbates arthritis and affects clinical response. nameOfConference

  
  

  DOI: 10.1172/jci169754

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/96472
• Mancuso S, Giacomassi C, Truglia S et al. (2023). POS1425 ANTIB2GLYCOPROTEIN I ANTIBODIES CAN INDUCE NETOSIS. nameOfConference

  
  

  DOI: 10.1136/annrheumdis-2023-eular.5467

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/92488
• Carlotti E, Murray-Brown W, Blighe K et al. (2022). High-throughput sequencing of IgH gene in minor salivary glands from Sjögren's syndrome patients reveals dynamic B cell recirculation between ectopic lymphoid structures.. nameOfConference

  
  

  DOI: 10.55563/clinexprheumatol/82u3cs

  
  

  QMRO: qmroHref
• Prediletto E, Cubuk C, Pontarini E et al. (2022). POS0138 RHEUMATOID SYNOVIAL FIBROBLASTS DISPLAY IMPRINTED MEMORY OF THEIR SYNOVIAL ENDOTYPE WHICH CAN BE PLASTICALLY MODULATED BY B-CELLS CROSSTALK. nameOfConference

  
  

  DOI: 10.1136/annrheumdis-2022-eular.2758

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/92599
• Corsiero E, Caliste M, Jagemann L et al. (2022). POS0399 CHARACTERIZATION OF HSP60, A STROMAL-DERIVED AUTOANTIGEN, RECOGNIZED BY RA SYNOVIAL RECOMBINANT MONOCLONAL ANTIBODIES. nameOfConference

  
  

  DOI: 10.1136/annrheumdis-2022-eular.2633

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/79770
• Caliste M, Prediletto E, Corsiero E et al. (2022). POS0439 STROMAL B-CELL CROSSTALK PROMOTES THE ESTABLISHMENT OF SYNOVIAL B CELL NICHES THROUGH THE SELECTION, ACTIVATION OF NATURALLY OCCURRING EBV+ B CELLS. nameOfConference

  
  

  DOI: 10.1136/annrheumdis-2022-eular.4387

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/79769
• Meednu N, Rangel-Moreno J, Zhang F et al. (2022). Dynamic spectrum of ectopic lymphoid B cell activation and hypermutation in the RA synovium characterized by NR4A nuclear receptor expression. nameOfConference

  
  

  DOI: 10.1016/j.celrep.2022.110766

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/79771
• Vomero M, Caliste M, Barbati C et al. (publicationYear). Tofacitinib Decreases Autophagy of Fibroblast-Like Synoviocytes From Rheumatoid Arthritis Patients. nameOfConference

  
  

  DOI: 10.3389/fphar.2022.852802

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/79772
• Prediletto E, Cubuk C, Pontarini E et al. (2022). Rheumatoid Synovial Fibroblasts Display Imprinted Memory of Their Synovial Endotype Which Can Be Plastically Modulated by B-cells Crosstalk. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/83754
• Colombo F, Corsiero E, Lewis MJ et al. (publicationYear). Generation of restriction endonucleases barcode map to trace SARS-CoV-2 origin and evolution. nameOfConference

  
  

  DOI: 10.1038/s41598-021-91264-6

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/72991
• Meednu N, Rangel-Moreno J, Zhang F et al. (publicationYear). Single cell analysis of RA synovial B cells reveals a dynamic spectrum of ectopic lymphoid B cell activation and hypermutation characterized by NR4A nuclear receptor expression. nameOfConference

  
  

  DOI: 10.1101/2021.05.14.443150

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/79768
• Pontarini E, Murray-Brown WJ, Croia C et al. (2020). Unique expansion of IL-21+ Tfh and Tph cells under control of ICOS identifies Sjögren’s syndrome with ectopic germinal centres and MALT lymphoma. nameOfConference

  
  

  DOI: 10.1136/annrheumdis-2020-217646

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/66848
• Corsiero E, Carlotti E, Jagemann L et al. (2020). H and L Chain Affinity Maturation and/or Fab N-Glycosylation Influence Immunoreactivity toward Neutrophil Extracellular Trap Antigens in Rheumatoid Arthritis Synovial B Cell Clones. nameOfConference

  
  

  DOI: 10.4049/jimmunol.1901457

  
  

  QMRO: qmroHref
• Meednu N, Zhang F, Escalera-Rivera K et al. (2020). Role of NR4A Nuclear Receptor Family in RA Synovial Ectopic Lymphoid Neogenesis Revealed by Single Cell Profiling. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Pontarini E, Brown WM, Croia C et al. (2019). OP0279 A UNIQUE IL-21 SIGNATURE CHARACTERIZES LESIONAL AND CIRCULATING T-FOLLICULAR HELPER CELLS IN SJÖGREN’S SYNDROME PATIENTS WITH ECTOPIC GERMINAL CENTRES AND MALT LYMPHOMA. Oral Presentations

  
  

  DOI: 10.1136/annrheumdis-2019-eular.7644

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/65452
• PITZALIS C, CORSIERO E, DELVECCHIO F et al. (2019). B cells in the formation of Tertiary Lymphoid Organs in autoimmunity, transplantation and tumorigenesis.. nameOfConference

  
  

  DOI: 10.1016/j.coi.2019.01.004

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/56179
• Corsiero E, Jagemann L, Bombardieri M et al. (2018). Generation of Recombinant Monoclonal Antibodies from Single B Cells Isolated from Synovial Tissue of Rheumatoid Arthritis Patients.. nameOfConference

  
  

  DOI: 10.1007/978-1-4939-8709-2_10

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/58930
• PITZALIS C, CORSIERO E, JAGEMANN L et al. (2018). Characterization of a synovial B cell-derived 1 recombinant monoclonal antibody 2 targeting stromal calreticulin in the rheumatoid joints. nameOfConference

  
  

  DOI: 10.4049/jimmunol.1800346

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/43433
• Corsiero E, Jagemann L, Pontarini E et al. (2018). Single-cell VH and VL Ig gene analysis reveal clonal relationship between IgM plus neoplastic B cells and plasmablasts in SS patients with parotid MALT lymphoma. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Corsiero E, Jagemann L, Prediletto E et al. (2017). OP0175 Characterization of novel stromal-derived autoantigens recognized by ra synovial monoclonal antibodies. Oral Presentations

  
  

  DOI: 10.1136/annrheumdis-2017-eular.3870

  
  

  QMRO: qmroHref
• Corsiero E, Jagemann L, Prediletto E et al. (2017). 08.34 Ra synovial recombinant monoclonal antibodies from single b cells target citrullinated calreticulin. Autoimmune inflammation

  
  

  DOI: 10.1136/annrheumdis-2016-211055.34

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/64681
• Corsiero E, Jagemann L, Pitzalis C et al. (2017). Characterization of Novel Stromal-Derived Autoantigens Recognized By RA Synovial Monoclonal Antibodies. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Pontarini E, Brown WM, Croia C et al. (2017). T Follicular- Helper CELLS (TFH) Enrichment and T Follicular-Regulatory CELLS (TFR) Exclusion from Ectopic Germinal Centers in Salivary Glands of Sjogren's Syndrome Patients. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/66168
• Corsiero E, Pratesi F, Prediletto E et al. (2016). NETosis as Source of Autoantigens in Rheumatoid Arthritis.. nameOfConference

  
  

  DOI: 10.3389/fimmu.2016.00485

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/63345
• Corsiero E, Nerviani A, Bombardieri M et al. (2016). Ectopic Lymphoid Structures: Powerhouse of Autoimmunity.. nameOfConference

  
  

  DOI: 10.3389/fimmu.2016.00430

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/31464
• Corsiero E, Carlotti E, Prediletto E et al. (2016). A2.04 The role of somatic hypermutation and n-glycosylation in the anti-nets immunoreactivity of ra synovial monoclonal antibodies. nameOfConference

  
  

  DOI: 10.1136/annrheumdis-2016-209124.39

  
  

  QMRO: qmroHref
• Corsiero E, Bombardieri M, Carlotti E et al. (2015). Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal frequent targeting of citrullinated histones of NETs. nameOfConference

  
  

  DOI: 10.1136/annrheumdis-2015-208356

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/15745
• Headland SE, Jones HR, Norling LV et al. (2015). Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis. nameOfConference

  
  

  DOI: 10.1126/scitranslmed.aac5608

  
  

  QMRO: qmroHref
• Corsiero E, Carlotti E, Pitzalis C et al. (2015). FRI0007 The Importance of Somatic Hypermutation for the Immunoreactivity Towards Neutrophil Extracellular Traps (NETS)-Citrullinated Autoantigens of Ra Synovial Monoclonal Antibodies. nameOfConference

  
  

  DOI: 10.1136/annrheumdis-2015-eular.4932

  
  

  QMRO: qmroHref
• Corsiero E, Sutcliffe N, Pitzalis C et al. (publicationYear). Accumulation of Self-Reactive Naïve and Memory B Cell Reveals Sequential Defects in B Cell Tolerance Checkpoints in Sjögren’s Syndrome. nameOfConference

  
  

  DOI: 10.1371/journal.pone.0114575

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/6743
• Corsiero E, Carlotti E, Pratesi F et al. (2014). OP0266 Monoclonal Antibodies Derived from Single CD19+ Synovial B Cells of RA Patients with Tertiary Lymphoid Structures Display Preferential Immunoreactivity towards Citrullinated Proteins of Nets. nameOfConference

  
  

  DOI: 10.1136/annrheumdis-2014-eular.4422

  
  

  QMRO: qmroHref
• Corsiero E, Pitzalis C, Bombardieri M (2014). Peripheral and synovial mechanisms of humoral autoimmunity in rheumatoid arthritis. nameOfConference

  
  

  DOI: 10.1016/j.drudis.2014.05.017

  
  

  QMRO: qmroHref
• Corsiero E, Carlotti E, Wardemann H et al. (2014). A1.31 Monoclonal antibodies from CD19+ synovial B cells of RA patients with tertiary lymphoid structures display a strong immunoreactivity towards citrullinated histones from neutrophils NETs. nameOfConference

  
  

  DOI: 10.1136/annrheumdis-2013-205124.30

  
  

  QMRO: qmroHref
• Corsiero E, Sutcliffe N, Wardemann H et al. (2013). AB0022 Accumulation of circulating autoreactive naïve b cells reveal defects of early b cell tolerance checkpoints in patients with sjögren’s syndrome. nameOfConference

  
  

  DOI: 10.1136/annrheumdis-2013-eular.2345

  
  

  QMRO: qmroHref
• Corsiero E, Sutcliffe N, Wardemann H et al. (2013). AB0044 Analysis of recombinant monoclonal antibodies from single B cells reveals early defects of B cell tolerance checkpoints in patients with sjÖgren’s syndrome. nameOfConference

  
  

  DOI: 10.1136/annrheumdis-2012-eular.44

  
  

  QMRO: qmroHref
• Corsiero E, Sutcliffe N, Wardemann H et al. (2013). ACCUMULATION OF CIRCULATING AUTOREACTIVE NAIVE B CELLS REVEALS DEFECTS OF EARLY B-CELL TOLERANCE CHECKPOINTS IN PATIENTS WITH SJOGREN'S SYNDROME. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Corsiero E, Sutcliffe N, Wardemann H et al. (2013). A5.2 Accumulation of Circulating Autoreactive Naïve B Cells Reveal Defects of Early B Cell Tolerance Checkpoints in Patients with Sjögren’s Syndrome. nameOfConference

  
  

  DOI: 10.1136/annrheumdis-2013-203219.2

  
  

  QMRO: qmroHref
• Corsiero E, Bombardieri M, Manzo A et al. (2012). Role of lymphoid chemokines in the development of functional ectopic lymphoid structures in rheumatic autoimmune diseases. nameOfConference

  
  

  DOI: 10.1016/j.imlet.2012.04.013

  
  

  QMRO: qmroHref
• Bombardieri M, Astorri E, Corsiero E et al. (2010). Molecular and cellular evolution of functional tertiary lymphoid structures in salivary glands of NOD mice. nameOfConference

  
  

  DOI: 10.1136/ard.2010.129585e

  
  

  QMRO: qmroHref

Collaborators

Internal

• Prof Michele Bombardieri
• Prof Ahuva Nissim

External

• Prof Paola Migliorini (Pisa University)
• Dr Mariangela Figini (IRCSS Instituto Tumori, Milan)

Teaching

I am actively engaged in undergraduate teaching including: i) Module Lead of the BMD375 module and Lecturer for BMD171 of the BSc degree in Pharmacology & Innovative Therapeutics; ii) Tutor of BSc Pharmacology students; iii) PBL Facilitator.

Disclosures

No disclosures.