Dr Elisa Corsiero

Profile

ORCID iD: 0000-0003-2092-6778 

I am a Senior Lecturer at the Centre for Experimental Medicine & Rheumatology in the Immuno-Rheumatology group led by Prof Michele Bombardieri. I graduated from University of Milan (Italy) with an MSc in Industrial Biotechnology. In 2009, I joined the group of Prof Pitzalis and Prof Bombardieri in London for my PhD which I completed in 2013 with a thesis entitled: “Characterization of peripheral and lesional single B cell autoreactivity in patients with Sjögren’s syndrome and rheumatoid arthritis”. In 2014, I was awarded an Arthritis Research UK Foundation Fellowship which I completed in 2018. In November 2019, I was awarded with a competitive Career Development Fellowship from Versus Arthritis, which is funding my research. In 2022, I was awarded as PI a Large Project Grant from the Barts Charity on the generation of human antibodies specific to Sjögren’s Syndrome (SS) diseased tissue specific neoepitops for development of novel diagnostic and targeted immunotherapies.

Research

Group members

• Post-doctoral Fellows: Dr Lucas Jagemann
• PhD Students: Dr Mattia Caliste, Miss Mareike Werle
• Visiting Research Fellows: Miss Nia Sciucca

Summary

My major research interests focus on the elucidation of the cellular and molecular mechanisms regulating autoreactive B cell activation, breach of self-tolerance and perpetuation of autoimmunity in Sjögren’s syndrome and rheumatoid arthritis. In particular, my research is focused on characterizing the fine specificity and function of monoclonal antibodies derived from single B cells and from antibody phage display technology in patients with rheumatic autoimmune diseases and cancer.

Point of contact for Biacore 1K+ SPR Instrument – Booking: iLab Centre for Experimental Medicine & Rheumatology.

Publications

• Jagemann L, Sciucca N, Bombardieri M et al. . Efficient generation of a stable CHO-K1 cell line overexpressing the human water channel aquaporin-5 as tool to generate therapeutic antibodies.

  
  

  DOI: 10.1038/s41598-024-67147-x

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/97920
• Corsiero E, Caliste M, Pontarini E et al. (2024). POS0250 GENERATION AND VALIDATION OF A HUMAN IMMUNE scFv LIBRARY FROM SJÖGREN’S SYNDROME SALIVARY GLAND B-CELLS.

  
  

  DOI: 10.1136/annrheumdis-2024-eular.3146

  
  

  QMRO:
• Corsiero E, Caliste M, Jagemann L et al. (2024). Autoimmunity to stromal-derived autoantigens in rheumatoid ectopic germinal centers exacerbates arthritis and affects clinical response.

  
  

  DOI: 10.1172/jci169754

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/96472
• Mancuso S, Giacomassi C, Truglia S et al. (2023). POS1425 ANTIB2GLYCOPROTEIN I ANTIBODIES CAN INDUCE NETOSIS.

  
  

  DOI: 10.1136/annrheumdis-2023-eular.5467

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/92488
• Carlotti E, Murray-Brown W, Blighe K et al. (2022). High-throughput sequencing of IgH gene in minor salivary glands from Sjögren's syndrome patients reveals dynamic B cell recirculation between ectopic lymphoid structures..

  
  

  DOI: 10.55563/clinexprheumatol/82u3cs

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/92481
• Prediletto E, Cubuk C, Pontarini E et al. (2022). POS0138 RHEUMATOID SYNOVIAL FIBROBLASTS DISPLAY IMPRINTED MEMORY OF THEIR SYNOVIAL ENDOTYPE WHICH CAN BE PLASTICALLY MODULATED BY B-CELLS CROSSTALK.

  
  

  DOI: 10.1136/annrheumdis-2022-eular.2758

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/92599
• Corsiero E, Caliste M, Jagemann L et al. (2022). POS0399 CHARACTERIZATION OF HSP60, A STROMAL-DERIVED AUTOANTIGEN, RECOGNIZED BY RA SYNOVIAL RECOMBINANT MONOCLONAL ANTIBODIES.

  
  

  DOI: 10.1136/annrheumdis-2022-eular.2633

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/79770
• Caliste M, Prediletto E, Corsiero E et al. (2022). POS0439 STROMAL B-CELL CROSSTALK PROMOTES THE ESTABLISHMENT OF SYNOVIAL B CELL NICHES THROUGH THE SELECTION, ACTIVATION OF NATURALLY OCCURRING EBV+ B CELLS.

  
  

  DOI: 10.1136/annrheumdis-2022-eular.4387

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/79769
• Meednu N, Rangel-Moreno J, Zhang F et al. (2022). Dynamic spectrum of ectopic lymphoid B cell activation and hypermutation in the RA synovium characterized by NR4A nuclear receptor expression.

  
  

  DOI: 10.1016/j.celrep.2022.110766

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/79771
• Vomero M, Caliste M, Barbati C et al. . Tofacitinib Decreases Autophagy of Fibroblast-Like Synoviocytes From Rheumatoid Arthritis Patients.

  
  

  DOI: 10.3389/fphar.2022.852802

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/79772

Collaborators

Internal

• Prof Michele Bombardieri
• Prof Ahuva Nissim

External

• Prof Paola Migliorini (Pisa University)
• Dr Mariangela Figini (IRCSS Instituto Tumori, Milan)

Teaching

I am actively engaged in undergraduate teaching including: i) Module Lead of the BMD375 module and Lecturer for BMD171 of the BSc degree in Pharmacology & Innovative Therapeutics; ii) Tutor of BSc Pharmacology students; iii) PBL Facilitator.

Disclosures

No disclosures.