Skip to main content
The William Harvey Research Institute - Faculty of Medicine and Dentistry
  1. WHRI
  2. People
  3. Academic staff
  4. Items

Professor Francesco Dell'Accio

Francesco

Professor of Musculoskeletal Regenerative Medicine & Rheumatology

Centre: Experimental Medicine & Rheumatology

Email: f.dellaccio@qmul.ac.uk
Telephone: +44(0) 20 7882 8204
Twitter: @TheReGenLab

Profile

ORCID iD: 0000-0003-4137-3770

Professor Dell’Accio is a clinical rheumatologist and a scientist whose interest is focused on regenerative medicine and osteoarthritis. He characterized the molecular cascade activated by injury to the articular cartilage and, starting from this screening, has identified several therapeutic targets that, in animal models, result in disease modification in osteoarthritis and in cartilage regeneration. The ultimate goal of his research is to develop pharmacological interventions to restore cartilage integrity and reduce pain in osteoarthritis and cartilage defects.

Research

Group members

  • Senior members: Prof Shafaq Sikandar (Senior Lecturer); Dr Suzanne Eldridge (Lecturer)
  • Junior members: Dr Anne-Sophie Thorup; Dr Magdalena Kaneva; Mr Jacob Wilson (Technician); Dr Manasi Sayilakshmy (Research Assistant); Dr Sara Caxaria (post-doc); Ms Petek Celik, (Research Assistant); Dr Alice Fuller, (Post-doc).
  • PhD students: Ms Aida Barawi (PhD student); Ms Sabah Bharde (PhD student); Ms Melody Deniz (PhD student); Dr Brian Herath (Clinical PhD Fellow)
  • Alumni: Dr Suzanne Eldridge; Dr Noha Eltawil; Dr Giovanna Nalesso; Professor Jessica Bertrand; Dr Joanna Sherwood; Dr Bethan Thomas; Dr Blandine Poulet

Summary

Professor Dell’Accio and his group investigate the molecular mechanisms that underpin the healing of skeletal tissues, and in particular to cartilage, with the ultimate aim of identifying possible therapeutic intervention to promote cartilage healing/supporting cartilage homeostasis in diseases such as isolated cartilage defects and osteoarthritis. Professor Dell’Accio’s group identified a distinct signalling response of adult human articular cartilage to mechanical injury. Individual signalling molecules and pathways identified by this screening are being tested in vitro and in vivo for their function in cartilage biology and joint surface repair.  In vivo models include surgical models of osteoarthritis and cartilage injury/regeneration developed in our laboratory. He is now exploring the biological function of such mechanisms for cartilage homeostasis how we can exploit them to protect cartilage from degradation in arthritis. Working in close collaboration with Dr S Sikandar, he is exploring the mechanisms of pain in osteoarthritis.

Publications

  • Thomas BL, Montero‐Melendez T, Oggero S et al. (2024). Molecular Determinants of Neutrophil Extracellular Vesicles That Drive Cartilage Regeneration in Inflammatory Arthritis. nameOfConference


  • Dajas-Bailador F, Chapman V, Lucci C et al. (2024). 069 INTRA-ARTICULAR ADMINISTRATION OF AGRIN INDUCES RAPID AND SUSTAINED PAIN RELIEF IN OSTEOARTHRITIS. nameOfConference


  • Asgarian R, Schäfer A, Gronewold R et al. (2024). 645 FUNCTIONAL INTERACTION OF CXCR2 AND β1-INTEGRIN SIGNALING IN THE REGULATION OF CARTILAGE HOMEOSTASIS. nameOfConference


  • Richter E, Lohmann CH, Dell’Accio F et al. (publicationYear). Sortilin Is Upregulated in Osteoarthritis-Dependent Cartilage Calcification and Associated with Cellular Senescence. nameOfConference


  • Dell'Accio F, De Bari C (2023). Towards disease modification in osteoarthritis. nameOfConference


    QMRO: qmroHref
  • Caxaria S, Bharde S, Fuller AM et al. (2023). Neutrophils infiltrate sensory ganglia and mediate chronic widespread pain in fibromyalgia. nameOfConference


  • Caxaria S, Kouvatsos N, Eldridge SE et al. (2022). Disease modification and symptom relief in osteoarthritis using a mutated GCP-2/CXCL6 chemokine. nameOfConference


  • Thorup A-S, Dell’Accio F, Eldridge SE (2023). A Mouse Model of Acute Cartilage Injury and Repair. nameOfConference


  • Eldridge S, Barawi A, Thorup AS et al. (2022). AB0156 INTRA-ARTICULAR AGRIN PROVIDES DIRECT PAIN RELIEF IN OSTEOARTHRITIS AND CARTILAGE DEFECTS. nameOfConference


    QMRO: qmroHref
  • Thorup AS, Wilson J, Cutillas P et al. (2022). POS0229 ELUCIDATING THE MECHANISM OF ACTION DOWNSTREAM OF ROR2 BLOCKADE: A PHOSPHOPROTEOMIC APPROACH. nameOfConference


    QMRO: qmroHref
  • Thorup A-S, Wilson J, Strachan D et al. (2022). BLOCKING ROR2 IMPROVES CARTILAGE INTEGRITY AND PROVIDES PAIN RELIEF IN OSTEOARTHRITIS, IN PART BY MODULATING YAP SIGNALLING. nameOfConference


  • Held A, Bollmann M, Hansen U et al. (2022). INHIBITION OF LOX MEDIATED EXTRACELLULAR MATRIX STIFFENING PREVENTS WNT3A INDUCED CHONDROCYTE DIFFERENTIATION VIA THE YAP/ TAZ PATHWAY. nameOfConference


    QMRO: qmroHref
  • Deniz M, Thorup A-S, Dell'Accio F (2022). SCREENING SIRNA EFFICACY USING HIGH THROUGHPUT FLUORESCENCE SYSTEM IN VITRO.. nameOfConference


  • THORUP A, Caxaria S, Dell'Accio F et al. (2022). In vivo potency assay for the screening of bioactive molecules on cartilage formation. nameOfConference


  • Deniz M, Thorup A-S, Dell'Accio F (2022). SCREENING SIRNA EFFICACY USING HIGH THROUGHPUT FLUORESCENCE SYSTEM IN VITRO. nameOfConference

    DOI: doi

  • Deniz M, Thorup AS, Dell'Accio F (2022). Screening siRNA efficacy using high throughput fluorescence system in vitro. nameOfConference

    DOI: doi

  • Eldridge S, Barawi A, Wang H et al. (2021). AB0039 AGRIN REPAIRS BONE AND CARTILAGE IN VIVO. nameOfConference


  • Thorup AS, Strachan D, Caxaria S et al. (2021). OP0200 BLOCKING ROR2 IMPROVES CARTILAGE INTEGRITY AND PROVIDES PAIN RELIEF IN OSTEOARTHRITIS. nameOfConference


    QMRO: qmroHref
  • Thomas B, Eldridge S, Nosrati B et al. (2021). WNT3A-loaded exosomes enable cartilage repair. nameOfConference


  • Bharde S, Caxaria S, Dell’Accio F et al. (2021). Update on pain in arthritis. nameOfConference


    QMRO: qmroHref
  • Kaneva MK, Muley MM, Krustev E et al. (2021). Alpha‐1‐antitrypsin reduces inflammation and exerts chondroprotection in arthritis. nameOfConference


  • Nalesso G, Thorup A-S, Eldridge SE et al. (publicationYear). Calcium calmodulin kinase II activity is required for cartilage homeostasis in osteoarthritis. nameOfConference


  • Chia S-L, Stott B, Miotla-Zarebska J et al. (2021). In a surgical model of OA female mice compared to males display pain at an early stage of disease and differential regulation of pain sensitizers. nameOfConference

    DOI: doi

  • Zhu L, Donhou S, Burleigh A et al. (2021). TNF alpha-stimulated gene 6 (TSG-6) is weakly chondroprotective in murine OA but does not account for FGF2-mediated joint protection. nameOfConference

    DOI: doi

  • von Loga IS, Batchelor V, Driscoll C et al. (2020). Does Pain at an Earlier Stage of Chondropathy Protect Female Mice Against Structural Progression After Surgically Induced Osteoarthritis?. nameOfConference


  • Zhu L, Donhou S, Burleigh A et al. (2020). TSG-6 is weakly chondroprotective in murine OA but does not account for FGF2-mediated joint protection. nameOfConference


  • Thorup A-S, Strachan D, Caxaria S et al. (2020). ROR2 blockade as a therapy for osteoarthritis. nameOfConference


  • Eldridge SE, Barawi A, Wang H et al. (2020). Agrin induces long term osteochondral regeneration by supporting repair morphogenesis. nameOfConference


  • Thorup A, Dell'Accio F, Eldridge SE (2021). Lessons from joint development for cartilage repair in the clinic. nameOfConference


  • Bertrand J, Kräft T, Gronau T et al. (2020). BCP crystals promote chondrocyte hypertrophic differentiation in OA cartilage by sequestering Wnt3a. nameOfConference


  • Kania K, Colella F, Riemen AH et al. (2020). Expression of growth and differentiation factor 5 during joint repair and osteoarthritis. nameOfConference


    QMRO: qmroHref
  • Bollmann M, Brinkema H, Piatek S et al. (2020). Short term il1ra treatment reduces post-traumatic OA in mouse in vivo and, in vitro, in human cartilage. nameOfConference


    QMRO: qmroHref
  • Kania K, Colella F, Riemen AHK et al. (2020). Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis. nameOfConference


  • Batchelor V, von Loga IS, Driscoll C et al. (2020). IDENTIFICATION OF PUTATIVE SEX-DEPENDENT PAIN PATHWAYS THAT MAY EXPLAIN WHY FEMALE MICE DEVLOP PAIN BEHAVIOUR DESPITE LOWER CHONDROPATHY SCORES. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Behler-Janbeck F, Schmidt T, Eldridge S et al. (2020). LIVER X RECEPTOR ACTIVATION PROTECTS FROM SURGICALLY-INDUCED KNEE OSTEOARTHRITIS IN MICE. nameOfConference

    DOI: doi

  • Held A, Bollmann M, Hansen U et al. (2019). Inhibition of SDC4-LOX mediated extracellular matrix stiffening prevents chondrocyte differentiation in OA cartilage via increased YAP/TAZ signaling. nameOfConference


    QMRO: qmroHref
  • Muhammad H, Khan SN, Scammahorn JJ et al. (2019). FGF2 promotes regeneration of cartilage in vivo by promoting MSC chemokinesis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Khan SN, Muhammad H, Scammahorn JJ et al. (2018). Fibroblast growth factor 2 promotes regeneration of cartilage by attracting mesenchymal stem cells to the site of cartilage injury. nameOfConference


    QMRO: qmroHref
  • Thomas BL, Jones HR, Norling LV et al. (2018). Neutrophil extracellular vesicles have a cartilage protective effect during inflammatory arthritis. nameOfConference


    QMRO: qmroHref
  • Fallas MA, Caxaria S, Sherwood J et al. (2018). The role of GCP-2 in cartilage differentiation and repair. nameOfConference


    QMRO: qmroHref
  • Sherwood J, Sambale M, Bertrand J et al. (2018). Transient receptor potential cation channel (TRPC6) as a regulator of CXCR2-mediated articular cartilage homeostasis. nameOfConference


    QMRO: qmroHref
  • Rhys HI, Dell'Accio F, Pitzalis C et al. (2018). Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages. nameOfConference


  • Kouvatsos N, Dodd R, Mahmood F et al. (2018). CXCL6: a glycosaminoglycan-binding chemokine with pro-inflammatory activities that are modulated by heparin and TSG-6. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Dell'Accio F, Cailotto F (2018). Pharmacological blockade of the WNT-beta-catenin signaling: a possible first-in-kind DMOAD. nameOfConference


  • Luyten FP, Bierma-Zeinstra S, Dell'Accio F et al. (2017). Towards Classification Criteria for Early Osteoarthritis of the Knee. nameOfConference


  • Thorup A-S, Eldridge SE, Caxaria S et al. (2017). A Potency Assay for Assessing the Chondrogenic Efficiency of Bioactive Molecules in Human Cartilage in vivo. nameOfConference


    QMRO: qmroHref
  • Eldridge SE, Thomas BL, Shanmuganathan K et al. (2017). Agrin inhibits canonical WNT signalling through LRP4. nameOfConference


    QMRO: qmroHref
  • Dell'Accio F (2017). In Vivo Models of Cartilage Repair and Chondrogenesis. nameOfConference


    QMRO: qmroHref
  • Caxaria S, Sherwood J, Roeder E et al. (2017). The Role of CXCl6 in Cartilage Development and Homeostasis. nameOfConference


    QMRO: qmroHref
  • Sherwood J, Bertrand J, Dell'Accio F et al. (2017). The role of transient receptor potential cation channel trpc6 activity in cxcr2-mediated chondrocyte phenotypic stability. nameOfConference


    QMRO: qmroHref
  • Thomas BL, Nalesso G, Eldridge SE et al. (2017). WNT16 is up-regulated in the joint following inflammation. nameOfConference


    QMRO: qmroHref
  • Luyten FP, De Bari C, Dell'Accio F (2017). Chapter 7 Regenerative Medicine and Tissue Engineering. nameOfConference


    QMRO: qmroHref
  • Sherwood J, Bertrand J, Dell'Accio F et al. (2017). THE ROLE OF TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL TRPC6 ACTIVITY IN CXCR2-MEDIATED CHONDROCYTE PHENOTYPIC STABILITY. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Lin NY, Distler A, Beyer C et al. (2016). OP0072 Inhibition of Notch1 Promotes Hedgehog Signaling in A HES1-Dependent Manner and Exacerbates Experimental Osteoarthritis. nameOfConference


    QMRO: qmroHref
  • Wei W, Bastiaansen-Jenniskens YM, Suijkerbuijk M et al. (2016). High fat diet accelerates cartilage repair in DBA/1 mice. nameOfConference


  • nalesso, thomas, sherwood JC et al. (publicationYear). WNT16 antagonises excessive canonical WNT activation and protects cartilage in osteoarthritis. nameOfConference


  • Sherwood J, Bertrand J, Seidemann M et al. (2016). Activation of the Transient Receptor Potential Cation Channel TRPC6 is Required for Chondrocyte Phenotypic Stability. 2016 OARSI World Congress on Osteoarthritis — Promoting Clinical and Basic Research in Osteoarthritis


    QMRO: qmroHref
  • Eldridge SE, Petrycki E, Pitzalis C et al. (2016). MMP3 cleaves agrin in cartilage and reduces its chondrogenic potency. nameOfConference


    QMRO: qmroHref
  • Nalesso G, Wagner K, Bertrand J et al. (2016). Pharmacological Blockade of CAMKII is Detrimental for Osteoarthritis Progression. 2016 OARSI World Congress on Osteoarthritis


    QMRO: qmroHref
  • Lin N-Y, Distler A, Beyer C et al. (2016). Inhibition of Notch1 promotes hedgehog signalling in a HES1-dependent manner in chondrocytes and exacerbates experimental osteoarthritis. nameOfConference


    QMRO: qmroHref
  • Sherwood J, Bertrand J, Dell'Accio F et al. (2016). Maintenance of Chondrocyte Phenotypic Stability By TRPC6 Calcium Channel Activity. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Luyten FP, De Bari C, Dell'Accio F (2016). Regenerative Medicine and Tissue Engineering. nameOfConference


    QMRO: qmroHref
  • Sherwood J, Bertrand J, Nalesso G et al. (2015). A homeostatic function of CXCR2 signalling in articular cartilage.. nameOfConference


  • Headland SE, Jones HR, Norling LV et al. (2015). Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis. nameOfConference


    QMRO: qmroHref
  • Eldridge S, Nalesso G, Ismail H et al. (2016). Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo. nameOfConference


  • Wei W, Bastiaansen-Jenniskens YM, Bos KP et al. (2015). Obesity does not negatively influence cartilage repair or cause osteoarthritis in DBA/1 mice. nameOfConference


    QMRO: qmroHref
  • Clarke CK, Hansen U, Stange R et al. (2015). Syndecan-4 regulates chondrocyte extracellular matrix architecture and modulates WNT3A-induced matrix remodeling. nameOfConference


    QMRO: qmroHref
  • Sherwood J, Bertrand J, Dell'Accio F et al. (2015). TRPC6 plays a role in CXCR2-mediated chondrocyte phenotypic stability. nameOfConference


    QMRO: qmroHref
  • Driscoll C, Watt FE, Dell'Accio F et al. (2015). The acute response to joint destabilisation is differentially regulated between male and female mice. nameOfConference


    QMRO: qmroHref
  • Clarke C, Held A, Stange R et al. (2015). A4.11 Syndecan-4 is an important player in regulating the WNT signalling pathway in articular cartilage. nameOfConference


    QMRO: qmroHref
  • Dell'Accio F, Sherwood J (2015). PPARγ/mTOR signalling: striking the right balance in cartilage homeostasis. nameOfConference


  • Sherwood J, Bertrand J, Dell'Accio F et al. (2015). The Role of TRPC6 in CXCR2-Mediated Chondrocyte Phenotypic Stability. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Greco KV, Nalesso G, Kaneva MK et al. (2014). Analyses on the mechanisms that underlie the chondroprotective properties of calcitonin.. nameOfConference


    QMRO: qmroHref
  • Sherwood JC, Bertrand J, Eldridge SE et al. (2014). Cellular and molecular mechanisms of cartilage damage and repair.. nameOfConference


    QMRO: qmroHref
  • Marcus P, De Bari C, Dell’Accio F et al. (2014). Articular Chondroprogenitor Cells Maintain Chondrogenic Potential but Fail to Form a Functional Matrix When Implanted Into Muscles of SCID Mice. nameOfConference


  • Headland S, Norling L, Patel H et al. (2014). A novel mechanism for protecting the arthritic joint: microparticles deliver Annexin A1 into cartilage (146.8). nameOfConference


    QMRO: qmroHref
  • Heywood HK, Nalesso G, Lee DA et al. (2014). Culture expansion in low-glucose conditions preserves chondrocyte differentiation and enhances their subsequent capacity to form cartilage tissue in three-dimensional culture.. nameOfConference


  • Eldridge S, Vicente-Greco K, Nalesso G et al. (2014). Agrin expression is downregulated in OA and is required for chondrocyte differentiation. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Clarke CK, Held A, Stange R et al. (2014). Syndecan-4 Regulates Chondrocyte Phenotype and Cartilage Homeostasis Via the WNT Signaling Pathway.. nameOfConference

    DOI: doi

  • Nalesso G, Thomas B, Wagner K et al. (2014). The WNT/CaMKII pathway is activated in human and experimental osteoarthritis and promotes chondrocyte de-differentiation. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Nalesso G, Thomas BL, Sherwood J et al. (2014). WNT16 IS INDUCED BY OXIDATIVE STRESS FOLLOWING CARTILAGE INJURY AND CONTRIBUTES TO CARTILAGE HOMEOSTASIS IN OSTEOARTHRITIS. nameOfConference


    QMRO: qmroHref
  • Thomas BL, Nalesso G, Sherwood J et al. (2014). WNT16 SUPPORTS THE PHENOTYPE OF THE SUPERFICIAL ZONE CELLS IN CARTILAGE. nameOfConference


    QMRO: qmroHref
  • Eldridge S, Vicent-Greco K, Nalesso G et al. (2013). Agrin expression is downregulated in OA and is required for chondrocyte differentiation. nameOfConference


    QMRO: qmroHref
  • Bertrand J, Stange R, Nalesso G et al. (2013). SYNDECAN-4 DEFICIENT CHONDROCYTES EXHIBIT ALTERATIONS IN ACTIVATION OF WNT SIGNALING PATHWAYS LEADING TO HIGHER PHENOTYPIC STABILITY. World Congress of the Osteoarthritis-Research-Society-International (OARSI)


    QMRO: qmroHref
  • Dell'Accio F (2013). TARGETING WNT SIGNALLING IN OSTEOARTHRITIS. Annual Meeting of the British-Society-for-Rheumatology and British-Health-Professionals-in-Rheumatology

    DOI: doi

    QMRO: qmroHref
  • Bertrand J, Stange R, Hidding H et al. (2013). SYNDECAN-4 FUNCTION IS ESSENTIAL FOR MATRIX REMODELLING UNDER INFLAMMATORY CONDITIONS, BUT DISPENSABLE DURING EMBRYOGENESIS. 33rd European Workshop for Rheumatology Research


    QMRO: qmroHref
  • Bertrand J, Stange R, Hidding H et al. (2013). Syndecan 4 supports bone fracture repair, but not fetal skeletal development, in mice.. nameOfConference


    QMRO: qmroHref
  • Sherwood J, Nalesso G, Bertrand J et al. (2013). A NOVEL ROLE FOR ELR plus CXC CHEMOKINE SIGNALING IN CARTILAGE HOMEOSTASIS. nameOfConference


    QMRO: qmroHref
  • Sherwood J, Nalesso G, Bertrand J et al. (2013). A homoeostatic role for ELR plus CXC chemokine signalling in articular and epiphyseal cartilage. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Bertrand J, Stange R, Hidding H et al. (2013). Influences of Syndecan-2 and 4 on bone fracture repair and foetal skeletal development. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Headland SE, Dell'Accio F, Perretti M (2013). Neutrophil-Derived Microparticles as Novel Effectors in Joint Disease. nameOfConference


    QMRO: qmroHref
  • Sherwood J, Bertrand J, Nalesso G et al. (2013). THE ROLE OF CXCR2 SIGNALING IN ARTICULAR CARTILAGE HOMEOSTASIS. nameOfConference


    QMRO: qmroHref
  • Sherwood J, Bertrand J, Nalesso G et al. (2013). THE ROLE OF CXCR2 SIGNALLING IN ARTICULAR CARTILAGE HOMEOSTASIS. nameOfConference


    QMRO: qmroHref
  • Nalesso G, Thomas BL, Eldridge SE et al. (2013). WNT5A/CAMKII PATHWAY IS ACTIVATED IN OSTEOARTHRITIS AND PROMOTES LOSS OF CHONDROCYTE PHENOTYPE. nameOfConference


    QMRO: qmroHref
  • Vincent TL, Williams RO, Maciewicz R et al. (2012). Mapping pathogenesis of arthritis through small animal models.. nameOfConference


    QMRO: qmroHref
  • Bertrand J, Nitschke Y, Fuerst M et al. (2012). Decreased levels of nucleotide pyrophosphatase phosphodiesterase 1 are associated with cartilage calcification in osteoarthritis and trigger osteoarthritic changes in mice.. nameOfConference


    QMRO: qmroHref
  • Hughes C, Faurholm B, Dell'Accio F et al. (2012). Targeting therapeutics to arthritic joints by antibody specific to post-translationally modified collagen type II. nameOfConference


    QMRO: qmroHref
  • De Bari C, Pitzalis C, Dell'Accio F (2007). Joint Tissue Engineering. nameOfConference


    QMRO: qmroHref
  • Bertrand J, Stange R, Hidding H et al. (2012). BONE FRACTURE REPAIR, BUT NOT FETAL SKELETAL DEVELOPMENT IS SUPPORTED BY SYNDECAN-4. nameOfConference


    QMRO: qmroHref
  • Sherwood J, Nalesso G, Bertrand J et al. (2012). ELR plus CXC CHEMOKINE SIGNALLING IN ARTICULAR CHONDROCYTE PHENOTYPIC STABILITY. nameOfConference


    QMRO: qmroHref
  • Sherwood J, Nalesso G, Bertrand J et al. (2012). ELR plus CXC CHEMOKINE SIGNALLING IN CARTILAGE HOMEOSTASIS. nameOfConference


    QMRO: qmroHref
  • Sherwood J, Nalesso G, Bertrand J et al. (2012). ELR plus CXC chemokine signaling is required for phenotypic stability of human articular chondrocytes. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Lin N-Y, Distler A, Beyer C et al. (2012). Inhibition of Notch Signaling Increases the Severity of Experimental Osteoarthritis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Bertrand J, Stange R, Hidding H et al. (2012). SYNDECAN-4 IS CRITICALLY INVOLVED IN INFLAMMATORY DRIVEN BONE FRACTURE REPAIR, BUT NOT FETAL SKELETAL DEVELOPMENT. nameOfConference


    QMRO: qmroHref
  • Bertrand J, Stange R, Nalesso G et al. (2012). Syndecan-4 Regulates Activation of WNT Signaling in Chondrocytes.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Nalesso G, Sherwood J, Bertrand J et al. (2012). WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Greco KV, Iqbal AJ, Rattazzi L et al. (2011). High density micromass cultures of a human chondrocyte cell line: a reliable assay system to reveal the modulatory functions of pharmacological agents.. nameOfConference


    QMRO: qmroHref
  • Greco KV, Moore A, Dell'Accio F et al. (2011). 3D CULTURES OF C-28/I2 CHONDROCYTES TO STUDY CHONDROCYTE BIOLOGY AND THERAPEUTIC DEVELOPMENT. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Nalesso G, Sherwood J, Bertrand J et al. (2011). WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways.. nameOfConference


  • Kurth TB, Dell'accio F, Crouch V et al. (2011). Functional mesenchymal stem cell niches in adult mouse knee joint synovium in vivo.. nameOfConference


    QMRO: qmroHref
  • Pringle S, De Bari C, Dell'Accio F et al. (2011). Mesenchymal differentiation propensity of a human embryonic stem cell line.. nameOfConference


    QMRO: qmroHref
  • Hughes C, Faurholm B, Dell'Accio F et al. (2011). TARGETING THERAPEUTICS TO ARTHRITIC JOINTS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Nalesso G, Sherwood J, Ramachandran M et al. (2011). Biology of bone, cartilage and connectve tissue disease. nameOfConference


    QMRO: qmroHref
  • Bertrand J, Furst M, Ruther W et al. (2011). LOSS OF NPP1 INDUCES CARTILAGE REMODELLING INTO BONE AND OA-LIKE CHANGES IN MICE. nameOfConference


    QMRO: qmroHref
  • Kurth TB, Dell'accio F, Crouch V et al. (2011). Functional mesenchymal stem cell niches in the adult knee joint synovium in vivo.. nameOfConference


    QMRO: qmroHref
  • Bertrand J, Nitschke Y, Fuerst M et al. (2011). CYTOKINES DOWNREGULATE NPP1 AND THEREFORE INDUCE CARTILAGE MINERALIZATION IN OA. nameOfConference


    QMRO: qmroHref
  • Hughes C, Faurholm B, Dell'Accio F et al. (2011). Targeting therapeutics to arthritic joints. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Nalesso G, Sherwood J, Ramachandran M et al. (2011). WNT3A MODULATES CHONDROCYTE PHENOTYPE THROUGH ACTIVATION OF BOTH CANONICAL AND NON-CANONICAL PATHWAYS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Sherwood J, Key S, Achan P et al. (2010). CXCR1 AND CXCR2 SIGNALLING IS REQUIRED BUT IS NOT SUFFICIENT TO MAINTAIN THE PHENOTYPIC STABILITY OF HUMAN ARTICULAR CHONDROCYTES. nameOfConference


    QMRO: qmroHref
  • Nalesso G, Achan P, Pitzalis C et al. (2010). WNT3A MODULATES CHONDROCYTE PHENOTYPE THROUGH ACTIVATION OF BOTH CANONICAL AND NON-CANONICAL PATHWAYS. nameOfConference


    QMRO: qmroHref
  • Dell'accio F, Vincent TL (2010). Joint surface defects: clinical course and cellular response in spontaneous and experimental lesions.. nameOfConference


    QMRO: qmroHref
  • Sherwood JC, Achan P, Ramachandran M et al. (2010). CXCR1/2 SIGNALLING IS REQUIRED FOR THE PHENOTYPIC STABILITY OF HUMAN ARTICULAR CHONDROCYTES. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Sherwood JC, Pitzalis C, Dell'Accio F (2010). CXCR1/2 signalling in the phenotypic stability of in vitro expanded adult human articular chondrocytes. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Nalesso G, Eltawil NM, Pitzalis C et al. (2010). Effects of the modulation of Wnt-canonical pathway on the phenotypic stability of human articular chondrocytes. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Hughes C, Faurholm B, Dell'Accio F et al. (2010). Human single-chain variable fragment that specifically targets arthritic cartilage.. nameOfConference


  • Eltawil N, Pitzalis C, Dell'Accio F (2010). Molecular response of articular cartilage to injury: Wnt signaling in an in vivo model of joint surface injury. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Gillespie J, Savic S, Wong C et al. (2010). Concurrent Oral 4 – Basic Science [OP24–OP31]. nameOfConference


    QMRO: qmroHref
  • Dell'Accio F (2010). Molecular mechanisms of cartilage regeneration. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Dell'accio F, Vincent TL (2010). Understanding tissue response to cartilage injury. nameOfConference


    QMRO: qmroHref
  • Karystinou A, Dell'Accio F, Kurth TBA et al. (2009). Distinct mesenchymal progenitor cell subsets in the adult human synovium.. nameOfConference


    QMRO: qmroHref
  • Eltawil NM, De Bari C, Achan P et al. (2009). A novel in vivo murine model of cartilage regeneration. Age and strain-dependent outcome after joint surface injury.. nameOfConference


    QMRO: qmroHref
  • Dell'Accio F, Eltawil NM, De Bari C et al. (2009). WNT16 in joint surface injury and osteoarthritis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Guillot PV, De Bari C, Dell'Accio F et al. (2008). Comparative osteogenic transcription profiling of various fetal and adult mesenchymal stem cell sources. nameOfConference


    QMRO: qmroHref
  • Manzo A, Vitolo B, Humby F et al. (2008). Mature Antigen-Experienced T Helper Cells Synthesize and Secrete the B Cell Chemoattractant CXCL13 in the Inflammatory Environment of the Rheumatoid Joint. nameOfConference


    QMRO: qmroHref
  • El Tawil NM, De Bari C, Pitzalis C et al. (2008). A mouse model of joint surface injury and repair in mice. Age and strain-dependent outcome. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Dell'Accio F, De Bari C, Eltawil NA et al. (2008). Identification of the molecular response of articular cartilage to injury, by microarray screening. nameOfConference


    QMRO: qmroHref
  • Dell'Accio F, Eltawil NM, De Bari C et al. (2008). Wnt16 in joint surface injury and osteoarthritis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • De BC, Dell'accio F, Karystinou A et al. (2008). A biomarker-based mathematical model to predict bone-forming potency of human synovial and periosteal mesenchymal stem cells. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • De Bari C, Dell'Accio F, Karystinou A et al. (2008). A biomarker-based mathematical model to predict bone-forming potency of human synovial and periosteal mesenchymal stem cells.. nameOfConference


    QMRO: qmroHref
  • De Bari C, Dell'accio F (2008). Cell therapy: a challenge in modern medicine.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • De Bari C, Dell'Accio F (2007). Mesenchymal stem cells in rheumatology: a regenerative approach to joint repair. nameOfConference


    QMRO: qmroHref
  • de Bari C, Guillot PV, Fisk NM et al. (2007). Mathematical modeling to predict bone forming potency of human mesenchymal stem cells. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • De Bari C, Pringle S, Pitzalis C et al. (2006). The stem cell niche: a new target in medicine. nameOfConference


    QMRO: qmroHref
  • DELL'ACCIO F, Pitzalis C, Barone F et al. (2006). Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury. nameOfConference


  • Marcus P, de Bari C, Dell'Accio F et al. (2006). The in vivo fate of implanted chondroprogenitor cells in SCID mice. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Van Damme A, Thorrez L, Ma L et al. (2006). Efficient lentiviral transduction and improved engraftment of human bone marrow mesenchymal cells.. nameOfConference


    QMRO: qmroHref
  • De Bari C, Dell'Accio F, Vanlauwe J et al. (2006). Mesenchymal multipotency of adult human periosteal cells demonstrated by single-cell lineage analysis.. nameOfConference


    QMRO: qmroHref
  • (2003). Erratum. nameOfConference


    QMRO: qmroHref
  • De Bari C, Pitzalis C, Dell'Accio F (2006). Reparative medicine: from tissue engineering to joint surface regeneration.. nameOfConference


    QMRO: qmroHref
  • De Bari C, Dell'Accio F, Vanlauwe J et al. (2005). Distinct biological properties of human mesenchymal stem cells from different sources. nameOfConference


    QMRO: qmroHref
  • Dell'Accio F, De Bari C, Pitzalis C (2005). Molecular response to cartilage injury. nameOfConference


    QMRO: qmroHref
  • De Bari C, Dell'Accio F, Luyten FP (2004). Failure of in vitro-differentiated mesenchymal stem cells from the synovial membrane to form ectopic stable cartilage in vivo.. nameOfConference


    QMRO: qmroHref
  • DELL'ACCIO F, Luyten FP, De Bari C (2003). Microenvironment and phenotypic stability specify tissue formation by human articular cartilage-derived cells in vivo. nameOfConference


    QMRO: qmroHref
  • Van Damme A, Chuah MKL, Dell'Accio F et al. (2003). Erratum: Bone marrow mesenchymal cells for haemophilia. A gene therapy using retroviral vectors with modified long-terminal repeats (Haemophilia (2003) vol 9 (94-103)). nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Vandenabeele F, De Bari C, Moreels M et al. (2003). Morphological and immunocytochemical characterization of cultured fibroblast-like cells derived from adult human synovial membrane.. nameOfConference


    QMRO: qmroHref
  • De Bari C, Dell'Accio F, Vandenabeele F et al. (2003). Skeletal muscle repair by adult human mesenchymal stem cells from synovial membrane.. nameOfConference


  • Van Damme A, Chuah MKL, Dell'accio F et al. (2003). Bone marrow mesenchymal cells for haemophilia A gene therapy using retroviral vectors with modified long-terminal repeats.. nameOfConference


    QMRO: qmroHref
  • DELL'ACCIO F, Vanlauwe J, De Bari C et al. (2003). Expanded phenotypically stable chondrocytes persist in the repair tissue and contribute to cartilage matrix formation and structural integration in a goat model of autologous chondrocyte implantation. nameOfConference


    QMRO: qmroHref
  • Iannone F, De Bari C, Dell'Accio F et al. (2002). Increased expression of nerve growth factor (NGF) and high affinity NGF receptor (p140 TrkA) in human osteoarthritic chondrocytes.. nameOfConference


    QMRO: qmroHref
  • Luyten FP, Dell'Accio F, De Bari C (2001). Skeletal tissue engineering: opportunities and challenges.. nameOfConference


    QMRO: qmroHref
  • De Bari C, Dell'Accio F, Tylzanowski P et al. (2001). Multipotent mesenchymal stem cells from adult human synovial membrane.. nameOfConference


    QMRO: qmroHref
  • DELL'ACCIO F, Luyten FP, De Bari C (2001). Molecular markers predictive of the capacity of expanded human articular chondrocytes to form stable cartilage in vivo. nameOfConference


    QMRO: qmroHref
  • De Bari C, Dell'Accio F, Luyten FP (2001). Human periosteum-derived cells maintain phenotypic stability and chondrogenic potential throughout expansion regardless of donor age.. nameOfConference


    QMRO: qmroHref
  • Iannone F, De Bari C, Dell'Accio F et al. (2001). Interleukin-10 and interleukin-10 receptor in human osteoarthritic and healthy chondrocytes.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Cantatore FP, Dell'Accio F, Lapadula G (1997). Carpal tunnel syndrome: a review.. nameOfConference


    QMRO: qmroHref
  • Lapadula G, De Bari C, Acquista CA et al. (1997). Isolated thrombocytopenia associated with low dose methotrexate therapy.. nameOfConference


    QMRO: qmroHref
  • Lapadula G, Iannone F, Dell'Accio F et al. (1995). Interleukin-10 in rheumatoid arthritis.. nameOfConference

    DOI: doi

    QMRO: qmroHref

Sponsors

 

Collaborators

Internal

External

  • Dr Tonia Vincent (Oxford)
  • Dr George Bou-Gharios (Oxford)
  • Professor Thomas Pap (Muenster, Germany)
  • Professor Georg Schett (Erlangen, Germany)
  • Professor Cosimo De Bari (Aberdeen)
  • Professor Andrew McMahon (Harvard, US)

News

September 2020

Back to top