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Dr Mohey Eldin El Shikh

Mohey

Senior Lecturer, Education Lead (Centre for Experimental Medicine and Rheumatology), Lead (WHRI Work Experience Programme)

Centre: Experimental Medicine and Rheumatology

Email: m.elshikh@qmul.ac.uk
Telephone: +44(0) 20 7882 8202

Research

In 2009 Dr El Shikh discovered the ability of immune-complex-loaded follicular dendritic cells (FDCs) to induce T cell-independent immunity to T cell-dependent antigens in responses co-stimulated with FDC-derived BAFF and C4bBP. He has recently described a novel pathway of antigen processing and presentation by FDCs to B cells in germinal centres that is potentially involved in autoreactive B cell activation, breach of B cell tolerance, and perpetuation of autoimmunity. His recent findings that B cell tolerance to self-TNF-alpha, -IgE, -ECDII, and -HEL can be broken in well verified models of tolerance by self-antigen presentation by FDCs support the hypothesis that presentation of self/neo-antigens to B cells by activated FDCs induces autoreactive GC formation, auto-Ab secretion, and perpetuation of B cell autoimmunity. He is currently dissecting the molecular mechanisms underpinning this hypothesis which will not only advance our understanding of the mechanisms involved in autoreactive B cell activation and breakage of tolerance but also potentially open up a novel therapeutic avenue by inducing high affinity self-regulated auto-Abs to target endogenous mediators of chronic autoimmune and hypersensitivity diseases like TNF-alpha IgE, and ECDII. 

Publications

  • Aly NAR, Rizk S, Enein AA et al. (publicationYear). The role of lymphoid tissue SPARC in the pathogenesis and response to treatment of multiple myeloma. nameOfConference


  • Shikh MEME, Sayed RE, Aly NAR et al. (publicationYear). Follicular dendritic cell differentiation is associated with distinct synovial pathotype signatures in rheumatoid arthritis. nameOfConference


  • Elsayed R, Kurago Z, Cutler CW et al. (2020). Role of dendritic cell‐mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw. nameOfConference


  • El Shikh MEM, El Sayed R, Nerviani A et al. (2019). Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis. nameOfConference


  • Rivellese F, Mauro D, Nerviani A et al. (2018). Mast cells in early rheumatoid arthritis associate with disease severity and support B cell autoantibody production. nameOfConference


  • Shikh ME, Sayed RE, Fossati-Jimack L et al. (2018). O001 Lymphoid tissue macrophages express peptidylarginine deiminase 2 and 4: new implications in citrullination and anti-citrulline antibodies production in autoimmune arthritis. Oral presentations


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  • Elsayed R, Celis E, Sultan H et al. (2018). Impaired Dendritic Cell Function and Bacterial Load Increase in the Oral Microenvironment as Contributing Factors to the Induction of MRONJ. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Altamimi A-MS, Alafeefy AM, Balode A et al. (2017). Symmetric molecules with 1,4-triazole moieties as potent inhibitors of tumour-associated lactate dehydrogenase-A. nameOfConference


  • Lownik JC, Luker AJ, Damle SR et al. (2017). ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses. nameOfConference


  • El Shikh MEM, El Sayed R, Pitzalis C (publicationYear). Isolation and Characterization of Mouse and Human Follicular Dendritic Cells.. nameOfConference


  • Rivellese F, Humby F, Kelly S et al. (2016). SYNOVIAL MAST CELLS CORRELATE WITH LOCAL AND SYSTEMIC INFLAMMATION AND ARE FUNCTIONALLY ASSOCIATED WITH ECTOPIC LYMPHOID STRUCTURES IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS. EULAR 2016

    DOI: doi

  • Cooley LF, El Shikh ME, Li W et al. (2016). Impaired immunological synapse in sperm associated antigen 6 (SPAG6) deficient mice.. nameOfConference


  • Llibre A, López-Macías C, Marafioti T et al. (2016). LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation.. nameOfConference


  • Cooley LF, Martin RK, Zellner HB et al. (2015). Increased B Cell ADAM10 in Allergic Patients and Th2 Prone Mice.. nameOfConference


  • Shikh MEME (2014). SP0011 Follicular Dendritic Cells in Immunity and Autoimmunity. nameOfConference


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  • Al-Mousawi AZ, El Shikh MEM, Pitzalis C (2014). IMMUNE COMPLEX RETENTION BY SYNOVIAL FIBROBLASTS IN RHEUMATOID ARTHRITIS. nameOfConference

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  • Folgosa L, Zellner HB, El Shikh ME et al. (2013). Disturbed follicular architecture in B cell A disintegrin and metalloproteinase (ADAM)10 knockouts is mediated by compensatory increases in ADAM17 and TNF-α shedding.. nameOfConference


  • El Shikh ME, Kmieciak M, Manjili MH et al. (2013). Multi-therapeutic potential of autoantibodies induced by immune complexes trapped on follicular dendritic cells.. nameOfConference


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  • Folgosa L, El Shikh M, Conrad D (2013). New implications of ADAMs in TNF{alpha} related diseases: ADAM10 deficient B cells exhibit increased ADAM17 and TNF{alpha} (P4388). nameOfConference

    DOI: doi

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  • Folgosa L, El Shikh M, Conrad D (2013). New implications of ADAMs in TNFα related diseases: ADAM10 deficient B cells exhibit increased ADAM17 and TNFα (P4388). nameOfConference


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  • El Shikh ME, Biggioggero M, El Sayed R et al. (2013). REGULATION OF AUTO-ANTIBODY PRODUCTION BY AUTO-IMMUNE COMPLEXES ON FOLLICULAR DENDRITIC CELLS. nameOfConference


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  • SUKUMAR S, EL SHIKH MEM, TEW JG et al. (2012). Methods of evaluating an immune response to an antigen. nameOfConference

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  • TEW J, EL SHIKH MEM, SINGH I et al. (2012). MODELS FOR VACCINE ASSESSMENT. nameOfConference

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  • El Shikh MEM, El Sayed R, Szakal AK et al. (2012). Rapid generation of T cell-independent antibody responses to T cell-dependent antigens. nameOfConference

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  • Tew JG, El Shikh, Mohey, Edin, M., Singh I et al. (2012). Models for vaccine assessment. nameOfConference

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  • Tew JG, El Shikh ME, El Sayed RM et al. (2012). Dendritic cells, antibodies reactive with oxLDL, and inflammation.. nameOfConference


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  • El Shikh MEM, Pitzalis C (2012). Follicular dendritic cells in health and disease.. nameOfConference


  • El Shikh MEM, Biggioggero M, El Sayed RM et al. (2012). REGULATION OF AUTO-ANTIBODY PRODUCTION BY PERSISTING AUTO-IMMUNE COMPLEXES ON FOLLICULAR DENDRITIC CELLS. nameOfConference


    QMRO: qmroHref
  • SUKUMAR S, EL SHIKH MEM, TEW JG et al. (2011). In vitro germinal centers. nameOfConference

    DOI: doi

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  • El Shikh ME, El Sayed R, Kmieciak M et al. (2011). BREAKAGE OF B CELL TOLERANCE BY ANTIGENS ON FOLLICULAR DENDRITIC CELLS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Ciurtin C, Majeed Y, Naylor J et al. (2011). Cell receptor-ligand interaction, signalling, activation and apoptosis. nameOfConference


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  • El Shikh ME, El Sayed RM, Kmieciak M et al. (2011). BREAKAGE OF B CELL TOLERANCE BY ANTIGENS ON FOLLICULAR DENDRITIC CELLS. nameOfConference


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  • Hanaa YA, El Shikh HH, Eglal AG et al. (2010). Fungal Secondary Metabolites: A Promising Source of Antineoplastic Drugs. nameOfConference


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  • Kikuchi T, Shikh MME, Sayed RME et al. (2010). Anti‐phosphorylcholine‐opsonized low‐density lipoprotein promotes rapid production of proinflammatory cytokines by dendritic cells and natural killer cells. nameOfConference


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  • El Shikh MEM, El Sayed RM, Sukumar S et al. (2010). Activation of B cells by antigens on follicular dendritic cells.. nameOfConference


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  • TEW JG, EL SHIKH MEM, SINGH I et al. (2010). Models for vaccine assessment. nameOfConference

    DOI: doi

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  • El Shikh ME, El Sayed R, Szakal A et al. (2010). Breaking B cell tolerance by multimerized self antigens on follicular dendritic cells. nameOfConference

    DOI: doi

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  • El Shikh ME, El Sayed R, Szakal A et al. (2010). Breaking B cell tolerance by multimerized self antigens on follicular dendritic cells (143.7). nameOfConference


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  • El Sayed R, El Shikh ME, Schenkein H et al. (2010). Dominance of macrophage derived IFN-{gamma} in atheromatous lesions. nameOfConference

    DOI: doi

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  • El Sayed R, El Shikh ME, Schenkein H et al. (2010). Dominance of macrophage derived IFN-γ in atheromatous lesions (35.3). nameOfConference


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  • Gibb DR, El Shikh M, Kang D et al. (2010). ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo. nameOfConference


  • Gibb DR, El Shikh M, Kang D-J et al. (2010). ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo. nameOfConference


    QMRO: qmroHref
  • El Shikh ME, Sayed RM, Tew JG et al. (2010). Follicular Dendritic Cells (B Lymphocyte Stimulating). nameOfConference


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  • Wu Y, El Shikh MEM, El Sayed RM et al. (2009). IL-6 produced by immune complex-activated follicular dendritic cells promotes germinal center reactions, IgG responses and somatic hypermutation.. nameOfConference


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  • TEW JG, EL SHIKH, Mohey, Edin, M., SINGH I et al. (2009). MODELS FOR VACCINE ASSESSMENT. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Gibb DR, El Shikh M, Kang D et al. (2009). ADAM10 regulates B cell development and immunoglobulin production. nameOfConference

    DOI: doi

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  • Gibb DR, El Shikh M, Kang D-J et al. (2009). ADAM10 regulates B cell development and immunoglobulin production (138.6). nameOfConference


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  • El Shikh MEM, El Sayed RM, Szakal AK et al. (2009). T-independent antibody responses to T-dependent antigens: a novel follicular dendritic cell-dependent activity.. nameOfConference


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  • Abu Seadah AA, El Shikh ME (2008). RAPD typing of Aspergillus chevalieri, Aspergillus nidulans, Aspergillus tetrazonus (quadrilineatus) and their teleomorphs using 5'-d[AACGCGCAAC]-3' and 5'-d[CCCGTCAGCA]-3' primers.. nameOfConference


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  • Shikh MEE, Sayed RE, Szakal AK et al. (2008). Conversion of T-dependent (TD) antigens to T-independent (TI) antigens: A novel follicular dendritic cell (FDC)-dependent activity. nameOfConference

    DOI: doi

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  • John DV, Crisa L, Cauvi G et al. (2008). Primary human immune response to dendritic cell inoculation in humanized mice. nameOfConference

    DOI: doi

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  • Sukumar S, El Shikh ME, Tew JG et al. (2008). Ultrastructural study of highly enriched follicular dendritic cells reveals their morphology and the periodicity of immune complex binding.. nameOfConference


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  • Tew JG, El Shikh MEM, Singh I et al. (2008). Models for vaccine assessment. nameOfConference

    DOI: doi

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  • Wu YZ, Sukumar S, El Shikh ME et al. (2008). Immune complex-bearing follicular dendritic cells deliver a late antigenic signal that promotes somatic hypermutation. nameOfConference


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  • El Shikh MEM, El Sayed RM, Wu Y et al. (2007). TLR4 on follicular dendritic cells: an activation pathway that promotes accessory activity.. nameOfConference


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  • Sukumar S, El Shikh MEM, Warren WL et al. (2007). In Vitro germinal centers. nameOfConference

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  • El Shikh ME, El Sayed RM, Tew JG et al. (2007). Follicular dendritic cells stimulated by collagen type I develop dendrites and networks in vitro.. nameOfConference


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  • Shikh MEME, Sayed RME, Wu Y et al. (2007). Induction of human primary antibody responses in vitro by ovalbumin (OVA) or anthrax (rPA) on dendritic cells (DCs) and follicular dendritic cells (FDCs) in temporally controlled germinal center reactions (GCRs). nameOfConference

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  • El Shikh ME, El Sayed R, Szakal AK et al. (2006). Follicular dendritic cell (FDC)-FcgammaRIIB engagement via immune complexes induces the activated FDC phenotype associated with secondary follicle development.. nameOfConference


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  • Szakal AK, El Shikh ME, Elsayed R et al. (2006). Influence of collagen on follicular dendritic cells to develop dendrites and reticula in vitro. nameOfConference

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  • El Shikh ME, Elsayed R, Szakal AK et al. (2006). Interaction of immune complexes with Fc gamma RIIB on follicular dendritic cells upregulates Fc gamma RIIB expression as well as VCAM-1, ICAM-1 and CD320. nameOfConference

    DOI: doi

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  • El Shikh ME, Wu YZ, Elsayed R et al. (2006). Interaction of poly(I : C) and LPS with toll receptors upregulates CR1/2, Fc gamma RIIB and VCAM-1 expression on follicular dendritic cells via NF-kappa B. nameOfConference

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