Dr Suchita Nadkarni

Profile

ORCID iD: 0000-0002-4549-3983

Suchita obtained her BSc in Biomedical Science at King’s College London. She then went on to obtain her PhD at University College London, under the supervision of Profs Michael Ehrenstein and Claudia Mauri, where she investigated the role of regulatory T-cells in anti-TNF-treated rheumatoid arthritis patients. Following a brief post-doc in New York, Suchita left lab-based research for a year to work as a Senior Science Adviser to the Government. In 2009, she then returned to lab research, undertaking post-doc project with Prof Mauro Perretti at the WHRI looking into the role of neutrophils in patients with Giant Cell Arteritis. It was during this time that Suchita developed her interests in neutrophils, combining it with her background in T-cell immunology.

In 2013 Suchita joined Prof Federica Marelli-Berg’s group, where she developed her niche investigating the importance of neutrophil-T cell interactions during pregnancy. In 2017 Suchita was awarded a 5-year intermediate research fellowship from the British Heart Foundation.

Research

Group members

Dr Eleanor Ward (Postdoctoral Researcher); Dr Alice Christensen (Clinical Fellow); Ms Serena Bert (PhD student)

Summary 

Suchita’s work focuses on the role of the maternal immune system in shaping pregnancy outcomes. Suchita is specifically interested in how maternal neutrophils can influence T-cell responses and how such interactions can regulate placental development (see image) and her main disease area of interest is pre-eclampsia In addition to their roles in placental development, Suchita is also interested in how neutrophil-T cell interactions can influence maternal cardiovascular responses during pregnancy and fetal development.

The Placenta Rainbow  - Wellcome Image Award 2017 and National Geographic 2018

Using wide-field confocal scanning microscopy, The Placenta Rainbow, depicts 9 different mouse placentas that have been individually imaged and arranged in PhotoShop.  Each placenta derives from a distinct mouse pregnancy in which the mother’s immune system has been manipulated to assess the architecture of the placentas. Following extraction, the placentas are labelled with different coloured antibodies that bind to specific proteins.  The varying colours denotes specific structures within the placenta and allows us to assess whether manipulation of the mother’s immune system affects development of the placenta.  Such assessments could help identify targets for complications arising in human pregnancies.

Publications

• Artinger K, Russo S, Gutjahr J et al. (2023). #4574 ATYPICAL CHEMOKINE RECEPTOR 4 IS EXPRESSED IN GLOMERULAR PARIETAL EPITHELIAL CELLS AND MITIGATES THE SEVERITY OF EXPERIMENTAL GLOMERULONEPHRITIS. nameOfConference

  
  

  DOI: 10.1093/ndt/gfad063c_4574

  
  

  QMRO: qmroHref
• Ward EJ, Bert S, Fanti S et al. (2023). Placental Inflammation Leads to Abnormal Embryonic Heart Development. nameOfConference

  
  

  DOI: 10.1161/circulationaha.122.061934

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/83242
• Bert S, Nadkarni S, Perretti M (2023). Neutrophil‐T cell crosstalk and the control of the host inflammatory response. nameOfConference

  
  

  DOI: 10.1111/imr.13162

  
  

  QMRO: qmroHref
• Coe D, Poobalasingam T, Fu H et al. (2022). Loss of hydrogen voltage-gated channel-1 expression reveals heterogeneous metabolic adaptation to intracellular acidification by T-cells. nameOfConference

  
  

  DOI: 10.1172/jci.insight.147814

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/78950
• Volpato LK, Nadkarni S, Horevicz VV et al. (2022). Contribution of plasma, placental, inflammatory and pro-resolving mediators in labor induction. nameOfConference

  
  

  DOI: 10.1016/j.placenta.2022.03.014

  
  

  QMRO: qmroHref
• Marino S (2021). Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC‐derived neural stem cells in glioblastoma.. nameOfConference

  
  

  DOI: 10.1038/s41467-021-26297-6

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/74928
• Jangani M, Vuononvirta J, Yamani L et al. (2022). Loss of mTORC2-induced metabolic reprogramming in monocytes uncouples migration and maturation from production of proinflammatory mediators. nameOfConference

  
  

  DOI: 10.1002/jlb.1a0920-588r

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/77361
• Man F, Nadkarni S, Kanabar V et al. (2021). A peptide derived from chaperonin 60.1, IRL201104, inhibits LPS-induced acute lung inflammation. nameOfConference

  
  

  DOI: 10.1152/ajplung.00155.2021

  
  

  QMRO: qmroHref
• Bert S, Ward EJ, Nadkarni S (2021). Neutrophils in pregnancy: New insights into innate and adaptive immune regulation. nameOfConference

  
  

  DOI: 10.1111/imm.13392

  
  

  QMRO: qmroHref
• Jacob J, Nadkarni S, Volpe A et al. (2021). Spatiotemporal in vivo tracking of polyclonal human regulatory T cells (Tregs) reveals a role for innate immune cells in Treg transplant recruitment. nameOfConference

  
  

  DOI: 10.1016/j.omtm.2020.12.003

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/74309
• Molás RB, Ribeiro MR, Ramalho Dos Santos MJC et al. (2020). The involvement of annexin A1 in human placental response to maternal Zika virus infection. nameOfConference

  
  

  DOI: 10.1016/j.antiviral.2020.104809

  
  

  QMRO: qmroHref
• Molás RB, Ribeiro MR, Oliani DCMV et al. (2019). The involvement of Annexin A1 in human placental response to maternal Zika virus infection. nameOfConference

  
  

  DOI: 10.1016/j.placenta.2019.06.137

  
  

  QMRO: qmroHref
• Nadkarni S, Lashin H, Hollywood J et al. (2019). Identification of an activated neutrophil phenotype in polymyalgia rheumatica during steroid treatment: potential involvement of immune cell cross talk. nameOfConference

  
  

  DOI: 10.1042/cs20180415

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/57637
• Burja B, Hočevar A, Sodin Šemrl S et al. (publicationYear). Zgodnji gigantocelični arteritis. nameOfConference

  
  

  DOI: 10.6016/zdravvestn.2642

  
  

  QMRO: qmroHref
• Stephenson E, Coe D, Nadkarni S et al. (2018). P4527c-Met as a novel T-cell marker in patients with acute myocarditis and dilated cardiomyopathy. nameOfConference

  
  

  DOI: 10.1093/eurheartj/ehy563.p4527

  
  

  QMRO: qmroHref
• Marelli-Berg FM, Nadkarni S (2018). Displacing, squeezing, and ramming: The role of nuclear lamins in leukocyte migration. nameOfConference

  
  

  DOI: 10.1002/jlb.1ce0318-099r

  
  

  QMRO: qmroHref
• Lashin HMS, Nadkarni S, Oggero S et al. (2018). Microvesicle Subsets in Sepsis Due to Community Acquired Pneumonia Compared to Faecal Peritonitis.. nameOfConference

  
  

  DOI: 10.1097/SHK.0000000000000989

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/44531
• Hebeda CB, Machado ID, Reif‐Silva I et al. (2018). Endogenous annexin A1 (AnxA1) modulates early‐phase gestation and offspring sex‐ratio skewing. nameOfConference

  
  

  DOI: 10.1002/jcp.26258

  
  

  QMRO: qmroHref
• NADKARNI SA, Smith J, Mauro C et al. (2016). Neutrophils induce proangiogenic T cells with a regulatory phenotype in pregnancy. nameOfConference

  
  

  DOI: 10.1073/pnas.1611944114

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/18248
• Haas R, Smith J, Rocher-Ros V et al. (publicationYear). Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions. nameOfConference

  
  

  DOI: 10.1371/journal.pbio.1002202

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/8009
• Komarowska I, Coe D, Wang G et al. (2015). Hepatocyte Growth Factor Receptor c-Met Instructs T Cell Cardiotropism and Promotes T Cell Migration to the Heart via Autocrine Chemokine Release. nameOfConference

  
  

  DOI: 10.1016/j.immuni.2015.05.014

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/7783
• Nadkarni S, Dalli J, Hollywood J et al. (2014). 15. Neutrophils in GCA. nameOfConference

  
  

  DOI: 10.1093/rheumatology/keu200

  
  

  QMRO: qmroHref
• Old EA, Nadkarni S, Grist J et al. (2014). Monocytes expressing CX3CR1 orchestrate the development of vincristine-induced pain. nameOfConference

  
  

  DOI: 10.1172/jci71389

  
  

  QMRO: qmroHref
• Nadkarni S, Dalli J, Hollywood J et al. (2014). Investigational Analysis Reveals a Potential Role for Neutrophils in Giant-Cell Arteritis Disease Progression. nameOfConference

  
  

  DOI: 10.1161/circresaha.114.301374

  
  

  QMRO: qmroHref
• Nadkarni S, McArthur S (2013). Oestrogen and immunomodulation: new mechanisms that impact on peripheral and central immunity. nameOfConference

  
  

  DOI: 10.1016/j.coph.2013.05.007

  
  

  QMRO: qmroHref
• Nadkarni S, Cooper D, Brancaleone V et al. (2011). Activation of the Annexin A1 Pathway Underlies the Protective Effects Exerted by Estrogen in Polymorphonuclear Leukocytes. nameOfConference

  
  

  DOI: 10.1161/atvbaha.111.235176

  
  

  QMRO: qmroHref
• Spurr L, Nadkarni S, Pederzoli-Ribeil M et al. (2010). Comparative analysis of Annexin A1-Formyl Peptide Receptor 2/ALX expression in human leukocyte subsets. nameOfConference

  
  

  DOI: 10.1016/j.intimp.2010.10.006

  
  

  QMRO: qmroHref
• Nadkarni S, Mauri C, Ehrenstein MR (2007). CORRECTION. nameOfConference

  
  

  DOI: 10.1084/jem.20061531010407c

  
  

  QMRO: qmroHref
• Nadkarni S, Mauri C, Ehrenstein MR (2007). Anti–TNF-α therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-β. nameOfConference

  
  

  DOI: 10.1084/jem.20061531

  
  

  QMRO: qmroHref

Collaborators

Internal

• Prof Federica Marelli-Berg (WHRI)

Clinical collaborators

• Dr Elena Greco
• Dr Stamatina Iliodromiti
• Prof Steve Thornton
• Dr Anna Herrey
• Dr Neha Sekhri

News

• The Placenta May Hold Clues to a Deadly Pregnancy Illness
  National Geographic, March 2018
  
  
• Wellcome image awards 2017
  Wellcome, March 2017
  
  
• The Wellcome image awards 2017: the shortlist of the years best science visions
  The Observer, March 2017