Marelli-Berg, Federica

Profile

Federica Marelli-Berg qualified in Medicine and Surgery at the University of Milan in 1989, and specialized in Hematology in 1993 at the University of Pavia, Italy. In 1997 she completed her PhD studies at the Royal Postgraduate Medical School (London) under the supervision of Professor R. Lechler. In 2000 she was awarded a Governors’ lectureship by Imperial College London, where she continued her academic career to become Professor of Immunology in 2011. She joined the WHRI (Faculty of Medicine and Dentistry - FMD, QMUL) as Professor of Cardiovascular Immunology in November 2011. Since 2014 she is leading the Centre of Biochemical Pharmacology. In 2016 she was awarded the prestigious British Heart Foundation Chair of Cardiovascular Immunology.

Research

Group members

Dr Hongmei Fu (Principal Research Officer)
Ms Guosu Wang
Dr Juho Vuononvirta
Dr Thanusian Poobalasingan
Dr Carlene Dyer
Ms Anitha Nair
Ms Silvia Fanti
Dr Alexandros Protonotarios

Cardiovascular Immunology

Effective immunity relies upon the prompt localization of activated T lymphocytes to the site of pathogen invasion. While other leukocytes migrate in response to non-specific inflammatory stimuli, activated T lymphocytes must discriminate and migrate to tissues where their cognate antigen is located. To maintain immune homeostasis, the anti-inflammatory regulatory subset of T cells also localizes to the site of inflammation to prevent excessive tissue damage.

The regulation of memory and regulatory T lymphocyte trafficking is the main focus of my research. Our major contributions have been in the field of antigen-dependent recruitment, which allows selective recruitment of primed T cells to localize antigenic sites, and have unveiled key molecular mechanisms of this effect, which can be targeted pharmacologically. We have recently discovered a novel pathway which promotes selective T cell migration to the heart. In addition, we have pioneered the field of metabolic regulation of T cell motility and migration and have discovered molecules – implicated in T cell metabolism - that can be pharmacologically targeted to therapeutically modulate T lymphocyte trafficking.

The long-term plan of our research is to provide translational bridges between T cell homing mechanisms and the therapy of immune-mediated diseases, including heart transplant rejection and myocarditis.

We are currently developing these studies with an aim to provide a solid basis for imminent clinical use.

Publications

Sikking MA, Harding D, Henkens MTHM et al. (2024). Cytotoxic T Cells Drive Outcome in Inflammatory Dilated Cardiomyopathy. nameOfConference

DOI: 10.1161/circresaha.124.325183

QMRO: qmroHref
Vyas V, Sandhar B, Keane JM et al. (2024). Tissue-resident memory T cells in epicardial adipose tissue comprise transcriptionally distinct subsets that are modulated in atrial fibrillation. nameOfConference

DOI: 10.1038/s44161-024-00532-x

QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/100779
Aikawa E, Allison MA, Arispe LI et al. (2024). Honoring the Life and Legacy of Dr David A. Dichek. nameOfConference

DOI: 10.1161/atvbaha.124.321293

QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/100638
Powell JT, Marelli-Berg FM, Bendeck MP et al. (2024). Introducing Socrates’ Corner to ATVB Journal: Critical Appraisals of Animal Models of Disease. nameOfConference

DOI: 10.1161/atvbaha.124.321253

QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/100642
Martin J, Hollowood Z, Chorlton J et al. (2024). Modulating regulatory T cell migration in the treatment of autoimmunity and autoinflammation. nameOfConference

DOI: 10.1016/j.coph.2024.102466

QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/100570
Golino M, Harding D, Del Buono MG et al. (2024). Innate and adaptive immunity in acute myocarditis. nameOfConference

DOI: 10.1016/j.ijcard.2024.131901

QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/96019
Harding D, Fanti S, Marelli-Berg F (2024). Tumour necrosis factor-α in cardiac inflammation: friend or foe?. nameOfConference

DOI: 10.1093/cvr/cvad180

QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/94929
Harding D, Marelli-Berg F (2023). Interferon-gamma signs off an old heart. nameOfConference

DOI: 10.1093/cvr/cvad151

QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/91978
Fu H, Vuononvirta J, Fanti S et al. (2023). The Glucose Transporter 2 regulates CD8+ T cell function via environment sensing.. nameOfConference

DOI: 10.1038/s42255-023-00913-9

QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/92475
Bonacina F, Moregola A, Svecla M et al. (2023). The low-density lipoprotein receptor fuels cholesterol-mTORC1 axis during CD8 T cell activation. nameOfConference

DOI: 10.1016/j.atherosclerosis.2023.06.722

QMRO: qmroHref
Sikking MA, Stroeks SLVM, Marelli-Berg F et al. (2023). Immunomodulation of Myocardial Fibrosis. nameOfConference

DOI: 10.1016/j.jacbts.2023.03.015

QMRO: qmroHref
Rathod KS, Kapil V, Velmurugan S et al. (2023). Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans. nameOfConference

DOI: 10.1172/jci168068

QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/89143
Ward EJ, Bert S, Fanti S et al. (2023). Placental Inflammation Leads to Abnormal Embryonic Heart Development. nameOfConference

DOI: 10.1161/circulationaha.122.061934

QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/83242
Fanti S, Stephenson E, Rocha-Vieira E et al. (2022). Circulating c-Met–Expressing Memory T Cells Define Cardiac Autoimmunity. nameOfConference

DOI: 10.1161/circulationaha.121.055610

QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/83023
Allan ME, Fan S, Marelli-Berg FM et al. (2022). ADOPTION Study Protocol: AZD1656 in Transplantation With Diabetes to Promote Immune Tolerance. nameOfConference

DOI: 10.1681/asn.20223311s1972c

QMRO: qmroHref
Mohiddin SA, Guttmann O, Marelli‐Berg F (2022). Vaccine‐Triggered Acute Autoimmune Myocarditis: Defining, Detecting, and Managing an Apparently Novel Condition. nameOfConference

DOI: 10.1161/jaha.122.026873

QMRO: qmroHref
Bonacina F, Moregola A, Svecla M et al. (2022). The low-density lipoprotein receptor–mTORC1 axis coordinates CD8+ T cell activation. nameOfConference

DOI: 10.1083/jcb.202202011

QMRO: qmroHref
Harding D, Chong MHA, Lahoti N et al. (2023). Dilated cardiomyopathy and chronic cardiac inflammation: Pathogenesis, diagnosis and therapy. nameOfConference

DOI: 10.1111/joim.13556

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/80520
Chorlton J, Hollowood Z, Dyer C et al. (2022). A randomised, double-blind, placebo-controlled, multicentre clinical trial of AZD1656 in diabetic patients hospitalised with COVID-19: The ARCADIA Trial - implications for therapeutic immune modulation. nameOfConference

DOI: 10.1016/j.eclinm.2022.101604

QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/92669
Bonacina F, Moregola A, Coe D et al. (2022). The low-density lipoprotein receptor fuels the cellular cholesterol-mTORC1 axis required for CD8+ T cell activation. nameOfConference

DOI: 10.1016/j.atherosclerosis.2022.06.113

QMRO: qmroHref
Nath M, Romaine SPR, Koekemoer A et al. (2022). Whole blood transcriptomic profiling identifies molecular pathways related to cardiovascular mortality in heart failure. nameOfConference

DOI: 10.1002/ejhf.2540

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/78881
Coe D, Poobalasingam T, Fu H et al. (2022). Loss of hydrogen voltage-gated channel-1 expression reveals heterogeneous metabolic adaptation to intracellular acidification by T-cells. nameOfConference

DOI: 10.1172/jci.insight.147814

QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/78950
Schiattarella GG, Alcaide P, Condorelli G et al. (2022). Immunometabolic mechanisms of heart failure with preserved ejection fraction. nameOfConference

DOI: 10.1038/s44161-022-00032-w

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/78340
Bonacina F, Moregola A, Coe D et al. (2022). THE LOW-DENSITY LIPOPROTEIN RECEPTOR FUELS THE CELLULAR CHOLESTEROL-MTORC1 AXIS REQUIRED FOR CD8+T CELL ACTIVATION. nameOfConference

DOI: doi

QMRO: qmroHref
Sheikh MH, Errede M, d'Amati A et al. (2022). Impact of metabolic disorders on the structural, functional, and immunological integrity of the blood‐brain barrier: Therapeutic avenues. nameOfConference

DOI: 10.1096/fj.202101297r

QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/76033
Marino S (2021). Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC‐derived neural stem cells in glioblastoma.. nameOfConference

DOI: 10.1038/s41467-021-26297-6

QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/74928
Jangani M, Vuononvirta J, Yamani L et al. (2022). Loss of mTORC2-induced metabolic reprogramming in monocytes uncouples migration and maturation from production of proinflammatory mediators. nameOfConference

DOI: 10.1002/jlb.1a0920-588r

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/77361
Trevelin SC, Zampetaki A, Sawyer G et al. (2021). Nox2-deficient Tregs improve heart transplant outcomes via their increased graft recruitment and enhanced potency. nameOfConference

DOI: 10.1172/jci.insight.149301

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/74298
Subramanian M, Marelli-Berg FM (2021). CD36 pumps fat to defang killer T cells in tumors. nameOfConference

DOI: 10.1016/j.cmet.2021.07.004

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/74299
Bonacina F, Moregola A, Coe D et al. (2021). The low-density lipoprotein receptor (LDL-R) is an immune-metabolic checkpoint during CD8 T Lymphocytes activation. nameOfConference

DOI: 10.1016/j.atherosclerosis.2021.06.031

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/74154
Bajaj R, Sinclair HC, Patel K et al. (2021). Delayed-onset myocarditis following COVID-19. nameOfConference

DOI: 10.1016/s2213-2600(21)00085-0

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/70625
Jacob J, Nadkarni S, Volpe A et al. (2021). Evaluation of Competing Methodologies for In Vivo Tracking of Human Regulatory T Cells Intended for Adoptive Cell Therapy in Transplantation. nameOfConference

DOI: doi

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/74147
Jacob J, Nadkarni S, Volpe A et al. (2021). Spatiotemporal in vivo tracking of polyclonal human regulatory T cells (Tregs) reveals a role for innate immune cells in Treg transplant recruitment. nameOfConference

DOI: 10.1016/j.omtm.2020.12.003

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/74309
Bonacina F, Moregola A, Coe D et al. (2020). The low density lipoprotein receptor (LDLR) is crucial for the activation of CD8+ TCELLS. nameOfConference

DOI: 10.1016/j.atherosclerosis.2020.10.276

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/78341
Wood EG, Macdougall CE, Blythe H et al. (publicationYear). HIF1α activation in dendritic cells under sterile conditions promotes an anti-inflammatory phenotype through accumulation of intracellular lipids. nameOfConference

DOI: 10.1038/s41598-020-77793-6

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/69661
Vuononvirta J, Marelli-Berg FM, Poobalasingam T (2021). Metabolic regulation of T lymphocyte motility and migration. nameOfConference

DOI: 10.1016/j.mam.2020.100888

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/74108
Solito E, Marelli-Berg F, Fanti S et al. (2020). Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming. nameOfConference

DOI: 10.1038/s41467-020-17329-8

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/65292
Protonotarios A, Marelli-Berg F (2021). Influenza-associated cardiac injury: a disease of the cardiac conduction system?. nameOfConference

DOI: 10.1093/cvr/cvaa174

QMRO: qmroHref
Guzik TJ, Mohiddin SA, Dimarco A et al. (2020). COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options. nameOfConference

DOI: 10.1093/cvr/cvaa106

QMRO: qmroHref
Protonotarios A, Marelli-Berg F (2020). Towards precision disease-modelling in experimental myocarditis. nameOfConference

DOI: 10.1093/cvr/cvaa057

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/66130
Marelli-Berg FM, Aksentijevic D (2019). Immunometabolic cross-talk in the inflamed heart.. nameOfConference

DOI: 10.15698/cst2019.08.194

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/61948
Macdougall CE, Wood EG, Solomou A et al. (2019). Constitutive Activation of β-Catenin in Conventional Dendritic Cells Increases the Insulin Reserve to Ameliorate the Development of Type 2 Diabetes in Mice. nameOfConference

DOI: 10.2337/db18-1243

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/66648
Fu H, Jangani M, Parmar A et al. (publicationYear). A Subset of CCL25-Induced Gut-Homing T Cells Affects Intestinal Immunity to Infection and Cancer. nameOfConference

DOI: 10.3389/fimmu.2019.00271

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/56180
Goldberg R, Scotta C, Cooper D et al. (2019). Correction of Defective T-Regulatory Cells From Patients With Crohn’s Disease by Ex Vivo Ligation of Retinoic Acid Receptor-α. nameOfConference

DOI: 10.1053/j.gastro.2019.01.025

QMRO: qmroHref
Nadkarni S, Smith J, Sferruzzi‐Perri A et al. (2017). Neutrophils Induce Pro‐angiogenic T cells with a Regulatory Phenotype in Pregnancy. nameOfConference

DOI: 10.1096/fasebj.31.1_supplement.469.10

QMRO: qmroHref
Stephenson E, Coe D, Nadkarni S et al. (2018). P4527c-Met as a novel T-cell marker in patients with acute myocarditis and dilated cardiomyopathy. nameOfConference

DOI: 10.1093/eurheartj/ehy563.p4527

QMRO: qmroHref
Bonacina F, Coe D, Wang G et al. (publicationYear). Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation. nameOfConference

DOI: 10.1038/s41467-018-05322-1

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/43824
Moregola A, Bonacina F, Coe DJ et al. (2018). Impact of LDL receptor on lymphocytes T cell differentiation and function. nameOfConference

DOI: 10.1016/j.atherosclerosis.2018.06.049

QMRO: qmroHref
Cheung KCP, Marelli-Berg FM (2018). Isolation of Microvascular Endothelial Cells.. nameOfConference

DOI: 10.21769/bioprotoc.2886

QMRO: qmroHref
Marelli-Berg FM, Nadkarni S (2018). Displacing, squeezing, and ramming: The role of nuclear lamins in leukocyte migration. nameOfConference

DOI: 10.1002/jlb.1ce0318-099r

QMRO: qmroHref
Kishore M, Cheung KCP, Fu H et al. (2018). Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis.. nameOfConference

DOI: 10.1016/j.immuni.2018.03.034

QMRO: qmroHref
Macdougall CE, Wood EG, Loschko J et al. (2018). Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets. nameOfConference

DOI: 10.1016/j.cmet.2018.02.007

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/36587
Marelli-Berg FM, Jangani M (2018). Metabolic regulation of leukocyte motility and migration. nameOfConference

DOI: 10.1002/jlb.1mr1117-472r

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/35903
CHEUNG CPK (2018). Endothelial Cells: Immunological Aspects. nameOfConference

DOI: 10.1002/9780470015902.a0000513.pub3

QMRO: qmroHref
Macdougall C, Wood E, Charalambous M et al. (2018). Investigating β-catenin signalling in conventional dendritic cells in obesity-induced tissue inflammation. nameOfConference

DOI: doi

QMRO: qmroHref
Stephenson E, Coe D, Nadkarni S et al. (2018). c-Met as a novel T-cell marker in patients with acute myocarditis and dilated cardiomyopathy. nameOfConference

DOI: doi

QMRO: qmroHref
MARELLI-BERG F (publicationYear). Regulatory T cell migration is dependent on glucokinase-mediated glycolysis.. nameOfConference

DOI: 10.1016/j.immuni.2017.10.017

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/32163
Bonacina F, Coe D, Wang G et al. (2017). Apolipoprotein E orchestrates T Naïve to T Effector memory cell polarization by modulating the crosstalk between systemic and immune cells lipid metabolism. nameOfConference

DOI: 10.1016/j.atherosclerosis.2017.06.274

QMRO: qmroHref
Moregola A, Bonacina F, Coe D et al. (2017). LDLR influence on CD4 T cells differentiation in mice and in familial hypercholesterolemia patients. nameOfConference

DOI: 10.1016/j.atherosclerosis.2017.06.370

QMRO: qmroHref
Goldberg R, Scotta C, Cooper D et al. (2017). OC-066 Gut specific regulatory t cells – a new frontier for crohn’s disease therapy. nameOfConference

DOI: 10.1136/gutjnl-2017-314472.66

QMRO: qmroHref
Ward EJ, Fu H, Marelli-Berg F (2017). Monitoring Migration of Activated T Cells to Antigen-Rich Non-lymphoid Tissue.. nameOfConference

DOI: 10.1007/978-1-4939-6931-9_15

QMRO: qmroHref
Rathod K, Kapil V, Velmurugan S et al. (2017). Sex differences in the inflammatory response and inflammation-induced vascular dysfunction. FASEB

DOI: 10.1016/s0140-6736(17)30416-6

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/22462
MAURO C, Smith J, Cucchi D et al. (2017). Obesity-induced metabolic stress leads to biased effector memory CD4+ T cell differentiation via PI3K p110δ/Akt-mediated signals. nameOfConference

DOI: 10.1016/j.cmet.2017.01.008

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/19014
Goldberg R, Scotta C, Cooper D et al. (2017). OP028 Gut specific regulatory T cells – a new frontier for Crohn's disease therapy. nameOfConference

DOI: 10.1093/ecco-jcc/jjx002.027

QMRO: qmroHref
Goldberg R, Scotta C, Cooper D et al. (2017). Gut specific regulatory T cells - a new frontier for Crohn's disease therapy. nameOfConference

DOI: doi

QMRO: qmroHref
Boardman DA, Philippeos C, Fruhwirth GO et al. (2016). Expression of a chimeric antigen receptor specific for donor HLA class I enhances the potency of human regulatory T cells in preventing human skin transplant rejection.. nameOfConference

DOI: 10.1111/ajt.14185

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/19034
NADKARNI SA, Smith J, Mauro C et al. (2016). Neutrophils induce proangiogenic T cells with a regulatory phenotype in pregnancy. nameOfConference

DOI: 10.1073/pnas.1611944114

QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/18248
AHLUWALIA A (2016). Accelerated resolution underlies sex differences in the inflammatory response in human. nameOfConference

DOI: 10.1172/JCI89429.

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/18792
Stephenson E, Savvatis K, Mohiddin SA et al. (2017). T‐cell immunity in myocardial inflammation: pathogenic role and therapeutic manipulation. nameOfConference

DOI: 10.1111/bph.13613

QMRO: qmroHref
Fu H, Ward EJ, Marelli-Berg FM (2016). Mechanisms of T cell organotropism. nameOfConference

DOI: 10.1007/s00018-016-2211-4

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/19012
Smith J, Mauro C, Cucchi D et al. (2016). Saturated fatty acids-induced metabolic stress leads to biased effector memory CD4⁺ T cell differentiation via mTOR-independent, PI3K p110d/Akt-mediated signals. nameOfConference

DOI: doi

QMRO: qmroHref
Cheung K, Ma L, Wang G et al. (2015). CD31 signals confer immune privilege to the vascular endothelium. nameOfConference

DOI: 10.1073/pnas.1509627112

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/18146
Norata GD, Caligiuri G, Chavakis T et al. (2015). The Cellular and Molecular Basis of Translational Immunometabolism. nameOfConference

DOI: 10.1016/j.immuni.2015.08.023

QMRO: qmroHref
Haas R, Smith J, Rocher-Ros V et al. (publicationYear). Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions. nameOfConference

DOI: 10.1371/journal.pbio.1002202

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/8009
Komarowska I, Coe D, Wang G et al. (2015). Hepatocyte Growth Factor Receptor c-Met Instructs T Cell Cardiotropism and Promotes T Cell Migration to the Heart via Autocrine Chemokine Release. nameOfConference

DOI: 10.1016/j.immuni.2015.05.014

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/7783
Mauro C, De Rosa V, Marelli-Berg F et al. (publicationYear). Metabolic Syndrome and the Immunological Affair with the Blood–Brain Barrier. nameOfConference

DOI: 10.3389/fimmu.2014.00677

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/6569
Hondares E, Brown M, Musset B et al. (2015). Enhanced Activation of an Amino-Terminally Truncated Isoform of Voltage-Gated Proton Channel HVCN1 Enriched in Malignant B cells. nameOfConference

DOI: 10.1016/j.bpj.2014.11.133

QMRO: qmroHref
Hondares E, Brown M, Musset B et al. (2015). Enhanced activation of an amino-terminally truncated isoform of voltage-gated proton channel HVCN1 enriched in malignant B cells. nameOfConference

DOI: doi

QMRO: qmroHref
Hondares E, Brown MA, Musset B et al. (2014). Enhanced activation of an amino-terminally truncated isoform of the voltage-gated proton channel HVCN1 enriched in malignant B cells. nameOfConference

DOI: 10.1073/pnas.1411390111

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/6901
Fu H, Kishore M, Gittens B et al. (publicationYear). Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation. nameOfConference

DOI: 10.1038/ncomms4436

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/18970
Haas R, Smith J, Rocher-Ros V et al. (2014). How the microenvironment contributes to the establishment of chronic inflammatory diseases: lactate regulates metabolic and pro-inflammatory circuits in control of T cell migration and functions. nameOfConference

DOI: doi

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/6636
Coe DJ, Kishore M, Marelli-Berg F (2014). Metabolic regulation of regulatory T cell development and function.. nameOfConference

DOI: 10.3389/fimmu.2014.00590

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/6634
Nicolaou A, Mauro C, Urquhart P et al. (2014). Polyunsaturated Fatty Acid-derived lipid mediators and T cell function.. nameOfConference

DOI: 10.3389/fimmu.2014.00075

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/6582
Fu H, Kishore M, Gittens B et al. (2014). Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation. nameOfConference

DOI: doi

QMRO: qmroHref
Vianello F, Cannella L, Coe D et al. (2013). Enhanced and aberrant T cell trafficking following total body irradiation: a gateway to graft‐versus‐host disease?. nameOfConference

DOI: 10.1111/bjh.12472

QMRO: qmroHref
Haas R, Marelli-Berg FM, Mauro C (2013). In the eye of the storm: T cell behavior in the inflammatory microenvironment. nameOfConference

DOI: doi

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/6580
Marelli-Berg FM, Clement M, Mauro C et al. (2013). An immunologist's guide to CD31 function in T-cells. nameOfConference

DOI: 10.1242/jcs.124099

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/6788
Cheung K, Mauro C, Marelli-Berg FM (2013). Molecular mechanisms of endothelial cytoprotection by CD31-mediated signals. nameOfConference

DOI: doi

QMRO: qmroHref
Haas R, Smith J, Marelli-Berg F et al. (2013). Omega-3 fatty acids inhibit the migration of T lymphocytes. nameOfConference

DOI: doi

QMRO: qmroHref
Fu H, Wang A, Mauro C et al. (2013). T lymphocyte trafficking: molecules and mechanisms. nameOfConference

DOI: 10.2741/4111

QMRO: qmroHref
Smith J, Coe D, Fu H et al. (2013). The effect of obesity-induced metabolic stress on T cell migration. nameOfConference

DOI: doi

QMRO: qmroHref
Fu H, Ying H, Rose ML et al. (2012). Genetic or Pharmaceutical Blockade of Phosphoinositide 3-Kinase p110δ Prevents Chronic Rejection of Heart Allografts. nameOfConference

DOI: 10.1097/00007890-201211271-00837

QMRO: qmroHref
Kishore M, Ma L, Cornish G et al. (2012). Primed T Cell Responses to Chemokines Are Regulated by the Immunoglobulin-Like Molecule CD31. nameOfConference

DOI: 10.1097/00007890-201211271-00869

QMRO: qmroHref
Ma L, Cheung KCP, Kishore M et al. (2012). CD31 Exhibits Multiple Roles in Regulating T Lymphocyte Trafficking In Vivo. nameOfConference

DOI: 10.4049/jimmunol.1201739

QMRO: qmroHref
Barry S, Chelala C, Lines K et al. (2013). S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells. nameOfConference

DOI: 10.1007/s10585-012-9532-y

QMRO: qmroHref
Mauro C, Fu H, Marelli-Berg FM (2012). T cell trafficking and metabolism: novel mechanisms and targets for immunomodulation.. nameOfConference

DOI: 10.1016/j.coph.2012.02.018

QMRO: qmroHref
Marelli‐Berg FM, Fu H, Mauro C (2012). Molecular mechanisms of metabolic reprogramming in proliferating cells: implications for T‐cell‐mediated immunity. nameOfConference

DOI: 10.1111/j.1365-2567.2012.03583.x

QMRO: qmroHref
Kishore M, Ma L, Cornish G et al. (2012). Primed T Cell Responses to Chemokines Are Regulated by the Immunoglobulin-Like Molecule CD31. nameOfConference

DOI: 10.1371/journal.pone.0039433

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/4879
Ying H, Fu H, Rose ML et al. (2012). Genetic or Pharmaceutical Blockade of Phosphoinositide 3-Kinase P110δ Prevents Chronic Rejection of Heart Allografts. nameOfConference

DOI: 10.1371/journal.pone.0032892

QMRO: qmroHref
Mirenda V, Marelli-Berg FM (2007). Understanding Cell Migration Through the Paradigm of T-Lymphocyte Homing. nameOfConference

DOI: 10.1142/9781860948312_0004

QMRO: qmroHref
Ma L, Cheung KC, Kishore M et al. (2012). CD31 exhibits multiple roles in regulating T lymphocyte trafficking in vivo.. nameOfConference

DOI: 10.4049/jimmunol.1201739

QMRO: qmroHref
Mauro C, Marelli-Berg FM (publicationYear). T Cell Immunity and Cardiovascular Metabolic Disorders: Does Metabolism Fuel Inflammation?. nameOfConference

DOI: 10.3389/fimmu.2012.00173

QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/28867
Harris SJ, Parry RV, Foster JG et al. (2011). Evidence that the lipid phosphatase SHIP-1 regulates T lymphocyte morphology and motility.. nameOfConference

DOI: 10.4049/jimmunol.1002350

QMRO: qmroHref
Ma L, Mauro C, Cornish GH et al. (2010). Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance. nameOfConference

DOI: 10.1073/pnas.1011748107

QMRO: qmroHref
Cernuda-Morollón E, Millán J, Shipman M et al. (publicationYear). Rac Activation by the T-Cell Receptor Inhibits T Cell Migration. nameOfConference

DOI: 10.1371/journal.pone.0012393

QMRO: qmroHref
Marelli‐Berg FM, Fu H, Vianello F et al. (2010). Memory T‐cell trafficking: new directions for busy commuters. nameOfConference

DOI: 10.1111/j.1365-2567.2010.03278.x

QMRO: qmroHref
Zhu D, Jarmin S, Ribeiro A et al. (2010). Applying an Adaptive Watershed to the Tissue Cell Quantification During T-Cell Migration and Embryonic Development. nameOfConference

DOI: 10.1007/978-1-60761-461-6_14

QMRO: qmroHref
Gorman CL, Monaco C, Ammiratti E et al. (2010). Tracking Antigen-Experienced Effector T Cells In Vitro and In Vivo. nameOfConference

DOI: 10.1007/978-1-60761-461-6_16

QMRO: qmroHref
Ma L, Mauro C, Cornish G et al. (2010). Ig gene-like molecule CD31 plays a non-redundant role in the regulation of T cell immunity and tolerance.. nameOfConference

DOI: 10.1073/pnas.1011748107

QMRO: qmroHref
Ward SG, Marelli-Berg FM (2009). Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation. nameOfConference

DOI: 10.1042/bj20081969

QMRO: qmroHref
David R, Ma L, Ivetic A et al. (2009). T-cell receptor- and CD28-induced Vav1 activity is required for the accumulation of primed T cells into antigenic tissue.. nameOfConference

DOI: 10.1182/blood-2008-09-176511.

QMRO: qmroHref
Wang A, Dinesen L, Dazzi T et al. (2008). Prospective study of lymphocyte trafficking to the intestine, changes in lymphocyte sub-populations in peripheral blood and modification by anti-inflammatory therapy. nameOfConference

DOI: doi

QMRO: qmroHref
Lechler R, Marelli‐Berg FM (1997). Mechanisms of peripheral T‐cell tolerance. nameOfConference

DOI: 10.1111/j.1365-2893.1997.tb00174.x

QMRO: qmroHref
Dazzi F, Marelli‐Berg FM (2008). Mesenchymal stem cells for graft‐versus‐host disease: Close encounters with T cells. nameOfConference

DOI: 10.1002/eji.200838433

QMRO: qmroHref
Jarmin SJ, David R, Ma L et al. (2008). T cell receptor-induced phosphoinositide-3-kinase p110delta activity is required for T cell localization to antigenic tissue in mice.. nameOfConference

DOI: 10.1172/JCI33267

QMRO: qmroHref
Marelli-Berg FM, Cannella L, Dazzi F et al. (2008). The highway code of T cell trafficking. nameOfConference

DOI: 10.1002/path.2269

QMRO: qmroHref
Zhang Z, Gorman CL, Vermi A-C et al. (2007). TCRzetadim lymphocytes define populations of circulating effector cells that migrate to inflamed tissues.. nameOfConference

DOI: 10.1182/blood-2006-12-064170

QMRO: qmroHref
Marelli-Berg FM, Okkenhaug K, Mirenda V (2007). A two-signal model for T cell trafficking. nameOfConference

DOI: 10.1016/j.it.2007.04.008

QMRO: qmroHref
FOSTER GR, Avraamides G, Ng CY et al. (2007). IFN-alpha2 induces leukocyte integrin redistribution, increased adhesion, and migration.. nameOfConference

DOI: 10.1089/jir.2006.0107.

QMRO: qmroHref
David R, Takesono A, Ridley A et al. (2007). Loss of Vav1 results in defective retention of T cells into antigenic sites. nameOfConference

DOI: doi

QMRO: qmroHref
Gorman CL, Zhang Z, Vermi AC et al. (2007). TCR-zeta dim T cells define a population of circulating effector cells that migrate to inflamed tissues. nameOfConference

DOI: doi

QMRO: qmroHref
Mirenda V, Jarmin SJ, David R et al. (2007). Physiological and aberrant regulation of memory T cell trafficking by the co-stimulatory molecule CD28. nameOfConference

DOI: doi

QMRO: qmroHref
David R, Marelli-Berg FM (2007). Regulation of T-cell migration by co-stimulatory molecules. nameOfConference

DOI: 10.1042/BST0351114

QMRO: qmroHref
Mirenda V, Jarmin SJ, David R et al. (2007). Physiologic and aberrant regulation of memory T-cell trafficking by the costimulatory molecule CD28. nameOfConference

DOI: 10.1182/blood-2006-10-050724

QMRO: qmroHref
Gordon MY, Levicar N, Pai M et al. (2006). Characterization and clinical application of human CD34(+) stem/progenitor cell populations mobilized into the blood by granulocyte colony-stimulating factor. nameOfConference

DOI: 10.1634/stemcells.2005-0629

QMRO: qmroHref
Marelli‐Berg FM, Nourshargh S (2005). Mechanisms of Leukocyte Transmigration: Role of Immunoglobulin Superfamily Molecules. nameOfConference

DOI: 10.1002/352760779x.ch5

QMRO: qmroHref
Murelii‐Berg FM, Lechler RI (1999). Antigen presentation by parenchymal cells: a route to peripheral tolerance?. nameOfConference

DOI: 10.1111/j.1600-065x.1999.tb01374.x

QMRO: qmroHref
Garden OA, Reynolds PR, Yates J et al. (2006). A rapid method for labelling CD4⁺ T cells with ultrasmall paramagnetic iron oxide nanoparticles for magnetic resonance imaging that preserves proliferative, regulatory and migratory behaviour in vitro. nameOfConference

DOI: 10.1016/j.jim.2006.06.010

QMRO: qmroHref
Datta A, David R, Glennie S et al. (2006). Differential effects of immunosuppressive drugs on T-cell motility. nameOfConference

DOI: 10.1111/j.1600-6143.2006.01553.x

QMRO: qmroHref
Mirenda V, Jarmin SJ, David R et al. (2005). CD28 engagement promotes T cell migration and antigen-independent T cell: dendritic cell interactions. nameOfConference

DOI: doi

QMRO: qmroHref
Mirenda V, Millington O, Lechler RI et al. (2005). Tolerant T cells display impaired trafficking ability. nameOfConference

DOI: doi

QMRO: qmroHref
Mirenda V, Millington O, Lechler RI et al. (2005). Tolerant T cells display impaired trafficking ability. nameOfConference

DOI: 10.1002/eji.200425823

QMRO: qmroHref
Cannella L, Laylor R, Marelli-Berg F et al. (2005). Irradiation influences endothelial cell function in vitro and in vivo: a possible role of IP10. nameOfConference

DOI: doi

QMRO: qmroHref
Nourshargh S, Marelli-Berg FM (2005). Transmigration through venular walls: a key regulator of leukocyte phenotype and function. nameOfConference

DOI: 10.1016/j.it.2005.01.006

QMRO: qmroHref
Cannella L, Laylor R, Marelli-Berg F et al. (2005). Irradiation influences endothelial cell function in vitro and in vivo: A possible role for IP10. nameOfConference

DOI: 10.1016/j.bbmt.2004.12.132

QMRO: qmroHref
Elliott JI, Surprenant A, Marelli-Berg FM et al. (2005). Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes. nameOfConference

DOI: 10.1038/ncb1279

QMRO: qmroHref
Herrera OB, Golshayan D, Tibbott R et al. (2004). A Novel Pathway of Alloantigen Presentation by Dendritic Cells. nameOfConference

DOI: 10.4049/jimmunol.173.8.4828

QMRO: qmroHref
FOSTER GR, Lombardi G, Jones M et al. (2004). IFN-alpha subtypes differentially affect human T cell motility. nameOfConference

DOI: 10.4049/jimmunol.173.3.1663

QMRO: qmroHref
Foster GR, Masri SH, David R et al. (2004). IFN-α subtypes differentially affect human T cell motility. nameOfConference

DOI: 10.4049/jimmunol.173.3.1663

QMRO: qmroHref
Chandrasekar B, Marelli-Berg FM, Tone M et al. (2004). β-Adrenergic stimulation induces interleukin-18 expression via β2-AR, PI3K, Akt, IKK, and NF-κB. nameOfConference

DOI: 10.1016/j.bbrc.2004.04.185

QMRO: qmroHref
Marelli-Berg FM, Jarmin SJ (2004). Antigen presentation by the endothelium: a green light for antigen-specific T cell trafficking?. nameOfConference

DOI: 10.1016/j.imlet.2004.03.014

QMRO: qmroHref
Cannella L, Laylor R, Dewchand H et al. (2004). The conditioning regimen influences migration of donor T-cells in recipient tissues. nameOfConference

DOI: doi

QMRO: qmroHref
Marelli-Berg FM, James MJ, Dangerfield J et al. (2004). Cognate recognition of the endothelium induces HY-specific CD8+T-lymphocyte transendothelial migration (diapedesis) in vivo. nameOfConference

DOI: 10.1182/blood-2003-08-2717

QMRO: qmroHref
James MJ, Belaramani L, Prodromidou K et al. (2003). Anergic T cells exert antigen-independent inhibition of cell-cell interactions via chemokine metabolism. nameOfConference

DOI: 10.1182/blood-2003-02-0637

QMRO: qmroHref
Dong R, Cwynarski K, Entwistle A et al. (2003). Dendritic cells from CML patients have altered actin organization, reduced antigen processing, and impaired migration.. nameOfConference

DOI: 10.1182/blood-2002-06-1841

QMRO: qmroHref
Chandrasekar B, Melby PC, Sarau HM et al. (2003). Chemokine-Cytokine Cross-talk THE ELR+ CXC CHEMOKINE LIX (CXCL5) AMPLIFIES A PROINFLAMMATORY CYTOKINE RESPONSE VIA A PHOSPHATIDYLINOSITOL 3-KINASE-NF-κB PATHWAY*. nameOfConference

DOI: 10.1074/jbc.m207006200

QMRO: qmroHref
Berg L-P, James MJ, Alvarez-Iglesias M et al. (2002). Functional Consequences of Noncognate Interactions Between CD4+ Memory T Lymphocytes and the Endothelium. nameOfConference

DOI: 10.4049/jimmunol.168.7.3227

QMRO: qmroHref
Lidington EA, Rao RM, Marelli-Berg FM et al. (2002). Conditional immortalization of growth factor-responsive cardiac endothelial cells from H-2Kb-tsA58 mice. nameOfConference

DOI: 10.1152/ajpcell.2002.282.1.c67

QMRO: qmroHref
Lechler R, Chai JG, Marelli-Berg F et al. (2001). The contributions of T-cell anergy to peripheral T-cell tolerance.. nameOfConference

DOI: 10.1046/j.1365-2567.2001.01250.x

QMRO: qmroHref
Lechler R, Chai J-G, Marelli-Berg F et al. (2001). Appropriate targets for monoclonal antibodies in the induction of transplantation tolerance. nameOfConference

DOI: 10.1098/rstb.2001.0841

QMRO: qmroHref
Lechler R, Chai JG, Marelli-Berg F et al. (2001). T-cell anergy and peripheral T-cell tolerance.. nameOfConference

DOI: 10.1098/rstb.2001.0844

QMRO: qmroHref
Lidington EA, Rao RM, Marelli-Berg F et al. (2001). Isolation and characterisation of conditionally immortal growth factor responsive cardiac endothelial cells (EC) from H-2K(b)-tsA58 transgenic mice. nameOfConference

DOI: doi

QMRO: qmroHref
Marelli-Berg FM, Scott D, Bartok I et al. (2001). Antigen presentation by murine endothelial cells. nameOfConference

DOI: 10.1016/s0041-1345(00)02024-8

QMRO: qmroHref
Marelli-Berg FM, Alvarez-Iglesias M, Prodromidou K et al. (2001). T cell receptor engagement can influence T cell motility. nameOfConference

DOI: 10.1016/s0041-1345(00)02265-x

QMRO: qmroHref
Lidington EA, Rao RM, Marelli-Berg F et al. (2000). Establishment and characterisation of a conditionally transformed immortalised murine cardiac endothelial cell line isolated from H2kb-tsA58 transgenic mice.. nameOfConference

DOI: doi

QMRO: qmroHref
Marelli-Berg FM, Scott D, Bartok I et al. (2000). Activated Murine Endothelial Cells Have Reduced Immunogenicity for CD8+ T Cells: A Mechanism of Immunoregulation?. nameOfConference

DOI: 10.4049/jimmunol.165.8.4182

QMRO: qmroHref
Marelli-Berg FM, Peek E, Lidington EA et al. (2000). Isolation of endothelial cells from murine tissue. nameOfConference

DOI: 10.1016/s0022-1759(00)00258-1

QMRO: qmroHref
Marelli-Berg FM, Frasca L, Imami N et al. (1999). LACK OF T CELL PROLIFERATION WITHOUT INDUCTION OF NONRESPONSIVENESS AFTER ANTIGEN PRESENTATION BY ENDOTHELIAL CELLS1. nameOfConference

DOI: 10.1097/00007890-199907270-00021

QMRO: qmroHref
Marelli-Berg FM, Barroso-Herrera O, Lechler RI (1999). Recently Activated T Cells Are Costimulation-Dependent in Vitro. nameOfConference

DOI: 10.1006/cimm.1999.1521

QMRO: qmroHref
Marelli-Berg FM, Frasca L, Weng L et al. (1999). Antigen recognition influences transendothelial migration of CD4+ T cells.. nameOfConference

DOI: 10.4049/jimmunol.162.2.696

QMRO: qmroHref
Frasca L, Amendola A, Hornick P et al. (1998). Role of donor and recipient antigen-presenting cells in priming and maintaining T cells with indirect allospecificity.. nameOfConference

DOI: 10.1097/00007890-199811150-00020

QMRO: qmroHref
Metcalfe RA, McIntosh RS, Marelli-Berg F et al. (1998). Detection of CD40 on human thyroid follicular cells: analysis of expression and function.. nameOfConference

DOI: 10.1210/jcem.83.4.4732

QMRO: qmroHref
Frasca L, Marelli-Berg F, Imami N et al. (1998). Interferon-gamma-treated renal tubular epithelial cells induce allospecific tolerance.. nameOfConference

DOI: 10.1046/j.1523-1755.1998.00800.x

QMRO: qmroHref
Marelli-Berg FM, Weetman A, Frasca L et al. (1997). Antigen presentation by epithelial cells induces anergic immunoregulatory CD45RO+ T cells and deletion of CD45RA+ T cells.. nameOfConference

DOI: 10.4049/jimmunol.159.12.5853

QMRO: qmroHref
Lechler RI, Marelli-Berg FM (1997). Do endothelial cells fit the paradigm of antigen-presenting cells?. nameOfConference

DOI: 10.1042/bst0250723

QMRO: qmroHref
Lombardi G, Arnold K, Uren J et al. (1997). Antigen presentation by interferon-gamma-treated thyroid follicular cells inhibits interleukin-2 (IL-2) and supports IL-4 production by B7-dependent human T cells.. nameOfConference

DOI: 10.1002/eji.1830270110

QMRO: qmroHref
Marelli-Berg FM, Hargreaves RE, Carmichael P et al. (1996). Major histocompatibility complex class II-expressing endothelial cells induce allospecific nonresponsiveness in naive T cells.. nameOfConference

DOI: 10.1084/jem.183.4.1603

QMRO: qmroHref

Collaborators

Internal

External

Dr Klaus Okkenhaug (Babraham Institute)
Prof Giovanna Lombardi (KCL)
Prof Anne Ridley (KCL)
Prof Robert Lechler (KCL)
Prof Julian Dyson (ICL)

Disclosures

Associate Editor British Journal of Cardiology (2023- )
Consultant AstraZeneca (2023)
Consultant Serepta (2022)
Associate Editor ATVB (2022- )
Associate Editor Immunometabolism (2020- )
Consulting Editor Cardiovascular Res. (2017-)
Associate Editor Cell Stress (2017-)
Associate Editor Curr Opin Pharmacology (2012-)
Associate Editor Frontiers in Immunology (2012-)
Associate Editor Am. J. Immunology (2012-)
Associate Editor Frontiers in Pharmacology (2012-)
Associate Editor Immunology (2010-)

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Experience Queen Mary

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