Professor Sir Mark CaulfieldVice Principal for Health for Queen Mary’s Faculty of Medicine and DentistryCentre: Clinical Pharmacology and Precision MedicineEmail: m.j.caulfield@qmul.ac.ukTelephone: +44(0) 20 7882 3403ProfileResearchPublicationsSponsorsCollaboratorsNewsProfile ORCID iD: 0000-0001-9295-3594 Professor Sir Mark Caulfield is Professor of Clinical Pharmacology at Queen Mary University of London and the Vice Principal for Health for Queen Mary’s Faculty of Medicine and Dentistry. Professor Caulfield graduated in Medicine in 1984 from the London Hospital Medical College and trained in Clinical Pharmacology at St Bartholomew’s Hospital, he developed a research programme in molecular genetics of hypertension and translational clinical research. At Queen Mary University of London Professor Caulfield has made contributions to the discovery of genes related to blood pressure, cardiovascular health, cancer and rare diseases. His research has changed national and international guidance for high blood pressure. He has won the Lily Prize of the British Pharmacology Society, the Bjorn Folkow Award of the European Society of Hypertension 2016 and the Franz Volhard Award of the International Society of Hypertension in 2018. Professor Caulfield was appointed Chief Scientist for Genomics England in 2013, charged with delivery of the 100,000 Genomes Project on whole genome sequencing in rare disease, cancer and infection. He was instrumental in delivering the 100,000 Genomes Project which has delivered life-changing results for many patients. He worked with NHS England to co-create the National Genomic Test Directory, which offers equitable access for 56 million people to appropriate genomic tests. Professor Caulfield was awarded a knighthood in 2019 for his leadership of the 100,000 Genomes Project. He is a member of the Barts Health NHS Trust Board, the Barking, Havering and Redbridge University Hospitals NHS Trust, the MedCity Board and is the President Elect of the British Pharmacological Society ResearchGroup members NIHR Barts Biomedical Research Centre Director’s OfficeClare Birch (Executive Assistant); John Whiteley (Chief Operating Officer for the NIHR Barts Biomedical Research Centre). Cardiovascular Genetics and GenomicsDr Helen Warren (Lecturer); Dr Claudia Cabrera (Lecturer); Prof Mike Barnes (Director of Bioinformatics); Dr Emma Forton Macgavern (Academic Clinical Fellow); Dr Arianna Tucci (MRC Clinician Scientist); Dr Kristina Ibanez Garikano (Lecturer). William Harvey Clinical Research CentreDr David Collier (Clinical Director); Dr Manish Saxena (Clinical Fellow); Dr Julian Shiel (Clinical Fellow); Marion Benford (Quality Assurance); Mike Taylor (Recruitment); Patrizia Ebano; Ania Michalska (Research Sisters). Summary Cardiovascular GenomicsMy leadership of international research collaborations of 350 researchers from 24 countries has discovered over 1200 gene regions influencing blood pressure and generated a polygenic risk scores for hypertension published in Nature and Nature Genetics and recognised by two of the most prestigious prizes in cardiovascular research. Genomics EnglandIn 2013 I was asked to become Chief Scientist for Genomics England (GEL) to lead scientific strategy and delivery of the 100,000 Genomes Project. I drew on my extensive experience of collaborative working as a researcher, as an NIHR Biomedical Research Centre Director and Senior Investigator to create the vital coalition of 5000 healthcare professionals, 3400 researchers and 97,000 participants, in partnership with the NHS, to deliver the 100,000 Genomes Project on target creating the platform for a new Genomic Medicine Service (GMS). Cardiovascular Clinical ResearchI have undertaken internationally leading translational and outcomes trials research e.g. the ASCOT trial, which changed international and NICE guidance for lipid lowering and hypertension and the PATHWAY Study which changed European Guidance. From this Barts and The London now have a major clinical trials programme and a partnership with IQVIA where we coordinate and enhance clinical research across UCLP Partners Academic Health Sciences Centre. Publications Bailey C, Pich O, Thol K et al. (2024). Origins and impact of extrachromosomal DNA. nameOfConference DOI: 10.1038/s41586-024-08107-3 QMRO: qmroHref Leong IUS, Cabrera CP, Cipriani V et al. (2024). Large-Scale Pharmacogenomics Analysis of Patients With Cancer Within the 100,000 Genomes Project Combining Whole-Genome Sequencing and Medical Records to Inform Clinical Practice.. nameOfConference DOI: 10.1200/jco.23.02761 QMRO: qmroHref Hepburn D, Hitchings AW, Wilson K et al. (2024). Importance of the UK Prescribing Safety Assessment as a component of undergraduate medical assessment. nameOfConference DOI: 10.1111/bcp.16324 QMRO: qmroHref Ibañez K, Jadhav B, Zanovello M et al. (2024). Increased frequency of repeat expansion mutations across different populations. nameOfConference DOI: 10.1038/s41591-024-03190-5 QMRO: qmroHref Thompson DJ, Wells D, Selzam S et al. (publicationYear). A systematic evaluation of the performance and properties of the UK Biobank Polygenic Risk Score (PRS) Release. nameOfConference DOI: 10.1371/journal.pone.0307270 QMRO: qmroHref Magavern EF, McDermott JH, Caulfield MJ et al. (2024). CYP2C19 genetic testing for Mavacamten and ischaemic stroke treatment: What does the result mean for cardiovascular prescribers in the UK and Europe?. nameOfConference DOI: 10.1093/ehjcvp/pvae040 QMRO: qmroHref Shi S, Rubinacci S, Hu S et al. (2024). A Genomics England haplotype reference panel and imputation of UK Biobank. nameOfConference DOI: 10.1038/s41588-024-01868-7 QMRO: qmroHref Keaton JM, Kamali Z, Xie T et al. (2024). Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits. nameOfConference DOI: 10.1038/s41588-024-01714-w QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/99886 Smith CEL, Laugel-Haushalter V, Hany U et al. (2024). Biallelic variants in Plexin B2 (PLXNB2) cause amelogenesis imperfecta, hearing loss and intellectual disability. nameOfConference DOI: 10.1136/jmg-2023-109728 QMRO: qmroHref Magavern EF, Kapil V, Saxena M et al. (2024). Use of Genomics to Develop Novel Therapeutics and Personalize Hypertension Therapy. nameOfConference DOI: 10.1161/atvbaha.123.319220 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/96841 Collier DJ, Taylor M, Godec T et al. (2024). Personalized Antihypertensive Treatment Optimization With Smartphone‐Enabled Remote Precision Dosing of Amlodipine During the COVID‐19 Pandemic (PERSONAL‐CovidBP Trial). nameOfConference DOI: 10.1161/jaha.123.030749 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/95325 Seaby EG, Leggatt G, Cheng G et al. (2024). A gene pathogenicity tool “GenePy” identifies missed biallelic diagnoses in the 100,000 Genomes Project. nameOfConference DOI: 10.1016/j.gim.2024.101073 QMRO: qmroHref Sosinsky A, Ambrose J, Cross W et al. (2024). Insights for precision oncology from the integration of genomic and clinical data of 13,880 tumors from the 100,000 Genomes Cancer Programme. nameOfConference DOI: 10.1038/s41591-023-02682-0 QMRO: qmroHref Olinger E, Wilson IJ, Orr S et al. (2024). Copy-number analysis from genome sequencing data of 11,754 rare-disease parent-child trios: A model for identifying autosomal recessive human gene knockouts including a novel gene for autosomal recessive retinopathy. nameOfConference DOI: 10.1016/j.gimo.2024.101834 QMRO: qmroHref Caulfield M (2024). Foreword. nameOfConference DOI: 10.1016/b978-0-12-822951-4.00013-8 QMRO: qmroHref Magavern EF, Jacobs B, Warren H et al. (2023). CYP2C19 genotype prevalence and association with recurrent myocardial infarction in British-South Asians treated with clopidogrel. nameOfConference DOI: 10.1093/eurheartj/ehad655.2870 QMRO: qmroHref Magavern EF, Van Heel DA, Smedley D et al. (2023). SLCO1B1*5 is protective against non-senile cataracts in cohort prescribed statins: analysis in a British-South Asian cohort. nameOfConference DOI: 10.1093/eurheartj/ehad655.2869 QMRO: qmroHref Magavern EF, Hitchings A, Bollington L et al. (2024). UK Prescribing Safety Assessment (PSA): The development, implementation and outcomes of a national online prescribing assessment. nameOfConference DOI: 10.1111/bcp.15919 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/91430 Jeffries L, Mis EK, McWalter K et al. (2024). Biallelic CRELD1 variants cause a multisystem syndrome, including neurodevelopmental phenotypes, cardiac dysrhythmias, and frequent infections. nameOfConference DOI: 10.1016/j.gim.2023.101023 QMRO: qmroHref Magavern EF, Durrani F, Raza M et al. (2023). British South Asian ancestry participants views of pharmacogenomics clinical implementation and research: a thematic analysis. nameOfConference DOI: 10.1038/s41397-023-00317-8 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/91977 Hartmann S, Yasmeen S, Jacobs BM et al. (publicationYear). ADRA2A and IRX1 are putative risk genes for Raynaud’s phenomenon. nameOfConference DOI: 10.1038/s41467-023-41876-5 QMRO: qmroHref Xiao S, Kai Z, Murphy D et al. (2023). Functional filter for whole-genome sequencing data identifies HHT and stress-associated non-coding SMAD4 polyadenylation site variants >5 kb from coding DNA. nameOfConference DOI: 10.1016/j.ajhg.2023.09.005 QMRO: qmroHref Kovilakam SC, Gu M, Dunn WG et al. (2023). Prevalence and significance of DDX41 gene variants in the general population. nameOfConference DOI: 10.1182/blood.2023020209 QMRO: qmroHref Lagou V, Jiang L, Ulrich A et al. (2023). GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification. nameOfConference DOI: 10.1038/s41588-023-01462-3 QMRO: qmroHref Magavern EF, Team GHR, Smedley D et al. (2023). Factor V Leiden, estrogen, and multimorbidity association with venous thromboembolism in a British-South Asian cohort. nameOfConference DOI: 10.1016/j.isci.2023.107795 QMRO: qmroHref Magavern EF, Jacobs B, Warren H et al. (2023). CYP2C19 Genotype Prevalence and Association With Recurrent Myocardial Infarction in British–South Asians Treated With Clopidogrel. nameOfConference DOI: 10.1016/j.jacadv.2023.100573 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/90328 Magavern EF, van Heel DA, Team GHR et al. (2023). CYP2C19 loss‐of‐function alleles are not associated with higher prevalence of gastrointestinal bleeds in those who have been prescribed antidepressants: Analysis in a British‐South Asian cohort. nameOfConference DOI: 10.1111/bcp.15762 QMRO: qmroHref Niggl E, Bouman A, Briere LC et al. (2023). HNRNPC haploinsufficiency affects alternative splicing of intellectual disability-associated genes and causes a neurodevelopmental disorder. nameOfConference DOI: 10.1016/j.ajhg.2023.07.005 QMRO: qmroHref Dominik N, Magri S, Currò R et al. (2023). Normal and pathogenic variation of RFC1 repeat expansions: implications for clinical diagnosis. nameOfConference DOI: 10.1093/brain/awad240 QMRO: qmroHref Vetro A, Pelorosso C, Balestrini S et al. (2023). Stretch-activated ion channel TMEM63B associates with developmental and epileptic encephalopathies and progressive neurodegeneration. nameOfConference DOI: 10.1016/j.ajhg.2023.06.008 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/98118 Sadeghi-Alavijeh O, Chan MMY, Moochhala SH et al. (2023). Rare variants in the sodium-dependent phosphate transporter gene SLC34A3 explain missing heritability of urinary stone disease. nameOfConference DOI: 10.1016/j.kint.2023.06.019 QMRO: qmroHref Tesi B, Boileau C, Boycott KM et al. (2023). Precision medicine in rare diseases: What is next?. nameOfConference DOI: 10.1111/joim.13655 QMRO: qmroHref Graham SE, Clarke SL, Wu K-HH et al. (2023). Author Correction: The power of genetic diversity in genome-wide association studies of lipids. nameOfConference DOI: 10.1038/s41586-023-06194-2 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/92162 Magavern EF, van Heel DA, Smedley D et al. (2023). SLCO1B1*5 is protective against non-senile cataracts in cohort prescribed statins: analysis in a British-South Asian cohort. nameOfConference DOI: 10.1038/s41397-023-00307-w QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/90329 Choi D-J, Armstrong G, Lozzi B et al. (2023). The genomic landscape of familial glioma. nameOfConference DOI: 10.1126/sciadv.ade2675 QMRO: qmroHref Martins Custodio H, Clayton LM, Bellampalli R et al. (2023). Widespread genomic influences on phenotype in Dravet syndrome, a ‘monogenic’ condition. nameOfConference DOI: 10.1093/brain/awad111 QMRO: qmroHref Siedlinski M, Carnevale L, Xu X et al. (2023). Genetic analyses identify brain structures related to cognitive impairment associated with elevated blood pressure. nameOfConference DOI: 10.1093/eurheartj/ehad101 QMRO: qmroHref Jackson A, Lin S-J, Jones EA et al. (2023). Clinical, genetic, epidemiologic, evolutionary, and functional delineation of TSPEAR-related autosomal recessive ectodermal dysplasia 14. nameOfConference DOI: 10.1016/j.xhgg.2023.100186 QMRO: qmroHref Magavern EF, Caulfield MJ (2023). Equal access to pharmacogenomics testing: The ethical imperative for population‐wide access in the UK NHS. nameOfConference DOI: 10.1111/bcp.15689 QMRO: qmroHref Dominiczak AF, Padmanabhan S, Caulfield M et al. (2023). Introducing Cambridge prisms: Precision medicine. nameOfConference DOI: 10.1017/pcm.2023.7 QMRO: qmroHref Magavern E, Smedley D, Caulfield M (2023). Factor V Leiden and oestrogen use in the context of multiple common chronic medical conditions: Analysis in the Genes & Health British-South Asian Cohort. nameOfConference DOI: doi QMRO: qmroHref Magavern E, van Heel D, Smedley D et al. (2023). Precision prescribing would not reduce gastrointestinal bleeds associated with CYP2C19 metabolized antidepressants:: Analysis in a British-South Asian cohort. nameOfConference DOI: doi QMRO: qmroHref Kanoni S, Graham SE, Wang Y et al. (publicationYear). Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis. nameOfConference DOI: 10.1186/s13059-022-02837-1 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/84269 Robbe P, Ridout KE, Vavoulis DV et al. (2022). Whole-genome sequencing of chronic lymphocytic leukemia identifies subgroups with distinct biological and clinical features. nameOfConference DOI: 10.1038/s41588-022-01211-y QMRO: qmroHref Cacheiro P, Westerberg CH, Mager J et al. (publicationYear). Mendelian gene identification through mouse embryo viability screening. nameOfConference DOI: 10.1186/s13073-022-01118-7 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/82620 Yengo L, Vedantam S, Marouli E et al. (2022). A saturated map of common genetic variants associated with human height. nameOfConference DOI: 10.1038/s41586-022-05275-y QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/84268 Wei W, Schon KR, Elgar G et al. (2022). Nuclear-embedded mitochondrial DNA sequences in 66,083 human genomes. nameOfConference DOI: 10.1038/s41586-022-05288-7 QMRO: qmroHref Moreno-Ruiz N, Lao O, Aróstegui JI et al. (2022). Assessing the digenic model in rare disorders using population sequencing data. nameOfConference DOI: 10.1038/s41431-022-01191-x QMRO: qmroHref Chan MM, Sadeghi-Alavijeh O, Lopes FM et al. (publicationYear). Diverse ancestry whole-genome sequencing association study identifies TBX5 and PTK7 as susceptibility genes for posterior urethral valves. nameOfConference DOI: 10.7554/elife.74777 QMRO: qmroHref Nguyen H, Solomonson M, Palotie A et al. (2022). A first update on mapping the human genetic architecture of COVID-19. nameOfConference DOI: 10.1038/s41586-022-04826-7 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/80041 Ramdas S, Judd J, Graham SE et al. (2022). A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids. nameOfConference DOI: 10.1016/j.ajhg.2022.06.012 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/84264 Joyce KE, Onabanjo E, Brownlow S et al. (2022). Whole genome sequences discriminate hereditary hemorrhagic telangiectasia phenotypes by non-HHT deleterious DNA variation. nameOfConference DOI: 10.1182/bloodadvances.2022007136 QMRO: qmroHref Shoemark A, Griffin H, Wheway G et al. (2022). Genome sequencing reveals underdiagnosis of primary ciliary dyskinesia in bronchiectasis.. nameOfConference DOI: 10.1183/13993003.00176-2022 QMRO: qmroHref Trotman J, Armstrong R, Firth H et al. (2022). The NHS England 100,000 Genomes Project: feasibility and utility of centralised genome sequencing for children with cancer. nameOfConference DOI: 10.1038/s41416-022-01788-5 QMRO: qmroHref Calabrese C, Pyle A, Griffin H et al. (publicationYear). Heteroplasmic mitochondrial DNA variants in cardiovascular diseases. nameOfConference DOI: 10.1371/journal.pgen.1010068 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/78260 Al-Jawahiri R, Foroutan A, Kerkhof J et al. (2022). SOX11 variants cause a neurodevelopmental disorder with infrequent ocular malformations and hypogonadotropic hypogonadism and with distinct DNA methylation profile. nameOfConference DOI: 10.1016/j.gim.2022.02.013 QMRO: qmroHref Lesurf R, Said A, Akinrinade O et al. (publicationYear). Whole genome sequencing delineates regulatory, copy number, and cryptic splice variants in early onset cardiomyopathy. nameOfConference DOI: 10.1038/s41525-022-00288-y QMRO: qmroHref Baillie JK, Begg C, Clohisey Hendry S et al. (2022). Whole-genome sequencing reveals host factors underlying critical COVID-19. nameOfConference DOI: 10.1038/s41586-022-04576-6 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/80960 Ibañez K, Polke J, Hagelstrom RT et al. (2022). Whole genome sequencing for the diagnosis of neurological repeat expansion disorders in the UK: a retrospective diagnostic accuracy and prospective clinical validation study. nameOfConference DOI: 10.1016/s1474-4422(21)00462-2 QMRO: qmroHref Horgan D, Borisch B, Cattaneo I et al. (publicationYear). Factors Affecting Citizen Trust and Public Engagement Relating to the Generation and Use of Real-World Evidence in Healthcare. nameOfConference DOI: 10.3390/ijerph19031674 QMRO: qmroHref Owen N, Toms M, Young RM et al. (2022). Identification of 4 novel human ocular coloboma genes ANK3, BMPR1B, PDGFRA, and CDH4 through evolutionary conserved vertebrate gene analysis. nameOfConference DOI: 10.1016/j.gim.2021.12.014 QMRO: qmroHref Trompet S, Postmus I, Warren HR et al. (publicationYear). The Pharmacogenetics of Statin Therapy on Clinical Events: No Evidence that Genetic Variation Affects Statin Response on Myocardial Infarction. nameOfConference DOI: 10.3389/fphar.2021.679857 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/76582 McGuigan A, Whitworth J, Andreou A et al. (2022). Multilocus Inherited Neoplasia Allele Syndrome (MINAS): an update. nameOfConference DOI: 10.1038/s41431-021-01013-6 QMRO: qmroHref Tooze RS, Hyder Z, Calpena E et al. (2022). Evaluating the performance of a clinical genome sequencing programme for diagnosis of rare genetic disease, seen through the lens of craniosynostosis. nameOfConference DOI: doi QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/80152 Collier D, Taylor M, Godec T et al. (2022). Personalized electronic record supported optimisation when alone for patients with hypertension- pilot study for remote medical management of hypertension during the Covid-19 pandemic (personal covidBP). nameOfConference DOI: doi QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/95326 Balachandar S, Graves TJ, Shimonty A et al. (2022). Identification and validation of a novel pathogenic variant in GDF2 (BMP9) responsible for hereditary hemorrhagic telangiectasia and pulmonary arteriovenous malformations. nameOfConference DOI: 10.1002/ajmg.a.62584 QMRO: qmroHref Graham SE, Clarke SL, Wu K-HH et al. (2021). The power of genetic diversity in genome-wide association studies of lipids. nameOfConference DOI: 10.1038/s41586-021-04064-3 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/75769 Bacq A, Roussel D, Bonduelle T et al. (2022). Cardiac Investigations in Sudden Unexpected Death in DEPDC5‐Related Epilepsy. nameOfConference DOI: 10.1002/ana.26256 QMRO: qmroHref Pagnamenta AT, Diaz-Gonzalez F, Banos-Pinero B et al. (2022). Variable skeletal phenotypes associated with biallelic variants in PRKG2. nameOfConference DOI: 10.1136/jmedgenet-2021-108027 QMRO: qmroHref Smedley D, Smith KR, Martin AR et al. (2021). 100,000 Genomes Pilot on Rare-Disease Diagnosis in Health Care — Preliminary Report. nameOfConference DOI: 10.1056/nejmoa2035790 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/79432 Schon KR, Horvath R, Wei W et al. (publicationYear). Use of whole genome sequencing to determine genetic basis of suspected mitochondrial disorders: cohort study. nameOfConference DOI: 10.1136/bmj-2021-066288 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/89470 Best S, Lord J, Roche M et al. (2022). Molecular diagnoses in the congenital malformations caused by ciliopathies cohort of the 100,000 Genomes Project. nameOfConference DOI: 10.1136/jmedgenet-2021-108065 QMRO: qmroHref Wei Y, Papachristou N, Mueller S et al. (2021). Application of ensemble clustering and survival tree analysis for identifying prognostic clinicogenomic features in patients with colorectal cancer from the 100,000 Genomes Project. nameOfConference DOI: 10.1186/s13104-021-05789-0 QMRO: qmroHref Magavern EF, Kaski JC, Turner RM et al. (2022). Challenges in cardiovascular pharmacogenomics implementation: a viewpoint from the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy. nameOfConference DOI: 10.1093/ehjcvp/pvab063 QMRO: qmroHref Silvennoinen K, Puvirajasinghe C, Hudgell K et al. (2021). Late diagnoses of Dravet syndrome: How many individuals are we missing?. nameOfConference DOI: 10.1002/epi4.12525 QMRO: qmroHref Stark Z, Foulger RE, Williams E et al. (2021). Scaling national and international improvement in virtual gene panel curation via a collaborative approach to discordance resolution. nameOfConference DOI: 10.1016/j.ajhg.2021.06.020 QMRO: qmroHref Niemi MEK, Karjalainen J, Liao RG et al. (2021). Mapping the human genetic architecture of COVID-19. nameOfConference DOI: 10.1038/s41586-021-03767-x QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/75755 Kosmicki JA, Horowitz JE, Banerjee N et al. (2021). Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals. nameOfConference DOI: 10.1016/j.ajhg.2021.05.017 QMRO: qmroHref Chen J, Spracklen CN, Marenne G et al. (2021). The trans-ancestral genomic architecture of glycemic traits. nameOfConference DOI: 10.1038/s41588-021-00852-9 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/72348 Eales JM, Jiang X, Xu X et al. (2021). Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney. nameOfConference DOI: 10.1038/s41588-021-00835-w QMRO: qmroHref Zenner D (2021). The Barts Health NHS Trust COVID-19 cohort: characteristics, outcomes and risk scoring of patients in East London. nameOfConference DOI: 10.5588/ijtld.20.0926 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/71138 Warren H, Garofalidou T, Singh S et al. (2021). GENOME-WIDE ASSOCIATION STUDY FOR PHARMACOGENETIC RESPONSE OF BLOOD PRESURE TO BETA BLOCKER AND CALCIUM CHANNEL BLOCKER DRUGS. nameOfConference DOI: 10.1097/01.hjh.0000747404.49131.a6 QMRO: qmroHref Warren H, Traylor M, Garofalidou T et al. (2021). HYPERTENSIVE PATIENTS WITH GREATER GENETIC RISK RESPOND LESS EFFECTIVELY TO TREATMENT AND ARE MORE LIKELY TO BE TREATMENT RESISTANT. nameOfConference DOI: 10.1097/01.hjh.0000748692.85500.8c QMRO: qmroHref Magavern EF, Kaski JC, Turner RM et al. (2022). The role of pharmacogenomics in contemporary cardiovascular therapy: a position statement from the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy. nameOfConference DOI: 10.1093/ehjcvp/pvab018 QMRO: qmroHref Jones CL, Degasperi A, Grandi V et al. (publicationYear). Spectrum of mutational signatures in T-cell lymphoma reveals a key role for UV radiation in cutaneous T-cell lymphoma. nameOfConference DOI: 10.1038/s41598-021-83352-4 QMRO: qmroHref Ragoussis V, Pagnamenta AT, Haines RL et al. (2022). Using data from the 100,000 Genomes Project to resolve conflicting interpretations of a recurrent TUBB2A mutation. nameOfConference DOI: 10.1136/jmedgenet-2020-107528 QMRO: qmroHref Pagnamenta AT, Kaiyrzhanov R, Zou Y et al. (2021). An ancestral 10-bp repeat expansion in VWA1 causes recessive hereditary motor neuropathy. nameOfConference DOI: 10.1093/brain/awaa420 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/70063 Magavern EF, Warren HR, Ng FL et al. (2021). An Academic Clinician’s Road Map to Hypertension Genomics. nameOfConference DOI: 10.1161/hypertensionaha.120.14535 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/69645 Bick D, Bick SL, Dimmock DP et al. (2021). An online compendium of treatable genetic disorders. nameOfConference DOI: 10.1002/ajmg.c.31874 QMRO: qmroHref Boguslavskyi A, Tokar S, Prysyazhna O et al. (2021). Phospholemman Phosphorylation Regulates Vascular Tone, Blood Pressure, and Hypertension in Mice and Humans. nameOfConference DOI: 10.1161/circulationaha.119.040557 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/79294 Pairo-Castineira E, Clohisey S, Klaric L et al. (2021). Genetic mechanisms of critical illness in COVID-19.. nameOfConference DOI: 10.1038/s41586-020-03065-y QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/70806 Poulter JA, Gravett MSC, Taylor RL et al. (2021). New variants and in silico analyses in GRK1 associated Oguchi disease. nameOfConference DOI: 10.1002/humu.24140 QMRO: qmroHref Surendran P, Feofanova EV, Lahrouchi N et al. (2020). Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. nameOfConference DOI: 10.1038/s41588-020-00713-x QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/69571 Turner RM, Newman WG, Bramon E et al. (2020). Pharmacogenomics in the UK National Health Service: opportunities and challenges. nameOfConference DOI: 10.2217/pgs-2020-0091 QMRO: qmroHref Parry DA, Martin CA, Greene P et al. (2020). Heterozygous lamin B1 and lamin B2 variants cause primary microcephaly and define a novel laminopathy. nameOfConference DOI: 10.1038/s41436-020-00980-3 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/70067 Gallo JE, Ochoa JE, Warren HR et al. (2020). Hypertension and the roles of the 9p21.3 risk locus: Classic findings and new association data. nameOfConference DOI: 10.1016/j.ijchy.2020.100050 QMRO: qmroHref Chen Z, Yan Yau W, Jaunmuktane Z et al. (publicationYear). 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Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals. nameOfConference DOI: 10.1016/j.jacc.2019.03.519 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/62235 Wei W, Tuna S, Keogh MJ et al. (2019). Germline selection shapes human mitochondrial DNA diversity. nameOfConference DOI: 10.1126/science.aau6520 QMRO: qmroHref Marques P, Tufton N, Bhattacharya S et al. (2019). Hypertension due to a deoxycorticosterone-secreting adrenal tumour diagnosed during pregnancy. nameOfConference DOI: 10.1530/edm-18-0164 QMRO: qmroHref Gorman KM, Meyer E, Grozeva D et al. (2019). Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia. nameOfConference DOI: 10.1016/j.ajhg.2019.03.005 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/66591 Sung YJ, de las Fuentes L, Winkler TW et al. (2019). 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Comprehensive Cancer-Predisposition Gene Testing in an Adult Multiple Primary Tumor Series Shows a Broad Range of Deleterious Variants and Atypical Tumor Phenotypes. nameOfConference DOI: 10.1016/j.ajhg.2018.04.013 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/47785 Feitosa MF, Kraja AT, Chasman DI et al. (2018). Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.. nameOfConference DOI: 10.1371/journal.pone.0198166 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/41963 Williams B, MacDonald TM, Morant SV et al. (2018). Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies.. nameOfConference DOI: 10.1016/S2213-8587(18)30071-8 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/47823 BROWN MJ (2018). 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A genetic risk score is associated with statin-induced low-density lipoprotein cholesterol lowering. nameOfConference DOI: 10.2217/pgs.16.8 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/12771 Diver LA, MacKenzie SM, Fraser R et al. (2016). Common Polymorphisms at the CYP17A1 Locus Associate With Steroid Phenotype: Support for Blood Pressure Genome-Wide Association Study Signals at This Locus.. nameOfConference DOI: 10.1161/hypertensionaha.115.06925 QMRO: qmroHref Lessard S, Manning AK, Low-Kam C et al. (2016). Testing the role of predicted gene knockouts in human anthropometric trait variation. nameOfConference DOI: 10.1093/hmg/ddw055 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/12772 Burchell AE, Chan K, Ratcliffe LEK et al. (2016). Controversies Surrounding Renal Denervation: Lessons Learned From Real‐World Experience in Two United Kingdom Centers. nameOfConference DOI: 10.1111/jch.12789 QMRO: qmroHref Sharp ASP, Davies JE, Lobo MD et al. (2016). 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A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome. nameOfConference DOI: 10.7554/eLife.08648 QMRO: qmroHref Brown MJ, Williams B, Morant SV et al. (2016). Effect of amiloride, or amiloride plus hydrochlorothiazide, versus hydrochlorothiazide on glucose tolerance and blood pressure (PATHWAY-3): a parallel-group, double-blind randomised phase 4 trial. nameOfConference DOI: 10.1016/s2213-8587(15)00377-0 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/19183 Wain LV, Shrine N, Miller S et al. (2015). Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. nameOfConference DOI: 10.1016/s2213-2600(15)00283-0 QMRO: qmroHref Williams B, MacDonald TM, Morant S et al. (2015). Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial. nameOfConference DOI: 10.1016/s0140-6736(15)00257-3 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/19182 Ren M, Ng FL, Witkowska K et al. (2015). Abstract P048: Blood-Pressure Associated Variants in Natriuretic Peptide Receptor C Affect Human Vascular Smooth Muscle Cells Proliferation and Calcium Flux in Response to Angiotensin II. nameOfConference DOI: 10.1161/hyp.66.suppl_1.p048 QMRO: qmroHref Treibel TA, Zemrak F, Sado DM et al. (2015). Extracellular volume quantification in isolated hypertension - changes at the detectable limits?. nameOfConference DOI: 10.1186/s12968-015-0176-3 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/9687 Brown MJ, Williams B, MacDonald TM et al. (2015). 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Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study. nameOfConference DOI: 10.1016/s2213-2600(14)70290-5 QMRO: qmroHref Lobo MD, de Belder MA, Cleveland T et al. (2015). Joint UK societies’ 2014 consensus statement on renal denervation for resistant hypertension. nameOfConference DOI: 10.1136/heartjnl-2014-307029 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/6575 Kapil V, Khambata RS, Robertson A et al. (2015). Dietary Nitrate Provides Sustained Blood Pressure Lowering in Hypertensive Patients. nameOfConference DOI: 10.1161/hypertensionaha.114.04675 QMRO: qmroHref Wood AR, Esko T, Yang J et al. (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. nameOfConference DOI: 10.1038/ng.3097 QMRO: qmroHref Wood AR, Esko T, Yang J et al. (2014). 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Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. nameOfConference DOI: 10.1038/ng.2500 QMRO: qmroHref Treibel TA, Zemrak F, White SK et al. (2013). Diffuse interstitial fibrosis in well-controlled hypertension. nameOfConference DOI: 10.1186/1532-429x-15-s1-p251 QMRO: qmroHref Treibel TA, White SK, Sado D et al. (2013). Interstitial expansion in pressure overload left ventricular hypertrophy. nameOfConference DOI: 10.1186/1532-429x-15-s1-o92 QMRO: qmroHref Alvarez-Madrazo S, MacKenzie SM, Davies E et al. (2013). Common Polymorphisms in the CYP11B1 and CYP11B2 Genes: Evidence for a Digenic Influence on Hypertension. nameOfConference DOI: 10.1161/HYPERTENSIONAHA.112.200741 QMRO: qmroHref Koettgen A, Albrecht E, Teumer A et al. (2013). Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. nameOfConference DOI: 10.1038/ng.2500 QMRO: qmroHref Berndt SI, Gustafsson S, Maegi R et al. (2013). 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Genetic Variants of Serum Uric Acid and Gout: An Analysis of > 170,000 Individuals. nameOfConference DOI: doi QMRO: qmroHref Islam M, Jafar T, Wood A et al. (2012). Genetic risk scores are associated with diabetes related traits in South Asians and provide tools for Mendelian randomization studies. nameOfConference DOI: doi QMRO: qmroHref Caulfield M (2012). Genetics of Blood Pressure. nameOfConference DOI: doi QMRO: qmroHref Surendran P, Vangjeli C, McCarthy N et al. (2012). Genome-wide association analysis identifies the MTHFR-CLCN6-NPPA-NPPB gene cluster as an important influence on BNP levels-implications for the use of BNP levels in the diagnosis and therapeutic monitoring of heart failure-an ASCOT sub study. nameOfConference DOI: doi QMRO: qmroHref Deshmukh HA, Colhoun HM, Johnson T et al. (2012). Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a). nameOfConference DOI: 10.1194/jlr.P021113 QMRO: qmroHref Saxena R, Elbers CC, Guo Y et al. (2012). Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci. nameOfConference DOI: 10.1016/j.ajhg.2011.12.022 QMRO: qmroHref Asselbergs FW, Guo Y, van Iperen EPA et al. (2012). Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci. nameOfConference DOI: 10.1016/j.ajhg.2012.08.032 QMRO: qmroHref Scott RA, Lagou V, Welch RP et al. (2012). Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. nameOfConference DOI: 10.1038/ng.2385 QMRO: qmroHref Islam M, Jafar TH, Wood AR et al. (2012). Multiple genetic variants explain measurable variance in type 2 diabetes-related traits in Pakistanis. nameOfConference DOI: 10.1007/s00125-012-2560-y QMRO: qmroHref Doyle AJ, Doyle JJ, Bessling SL et al. (2012). Mutations in the TGF-β repressor SKI cause Shprintzen-Goldberg syndrome with aortic aneurysm. nameOfConference DOI: 10.1038/ng.2421 QMRO: qmroHref McManus RJ, Caulfield M, Williams B (2012). NICE hypertension guideline 2011: evidence based evolution. nameOfConference DOI: 10.1136/bmj.e181 QMRO: qmroHref Saxena M, Collier D, Caulfield M et al. (2012). Patients with resistant hypertension warrant a trial of salt restriction before and after renal denervation (RD). nameOfConference DOI: doi QMRO: qmroHref Chan K, Ng FL, Saxena M et al. (2012). Renal denervation in resistant hypertension-a prospective case series. nameOfConference DOI: doi QMRO: qmroHref Johnson T, Gaunt TR, Newhouse SJ et al. (2011). Blood pressure loci identified with a gene-centric array.. nameOfConference DOI: 10.1016/j.ajhg.2011.10.013 QMRO: qmroHref Bown MJ, Jones GT, Harrison SC et al. (2011). Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1. nameOfConference DOI: 10.1016/j.ajhg.2011.10.002 QMRO: qmroHref Chambers JC, Zhang WH, Sehmi J et al. (2011). Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. nameOfConference DOI: 10.1038/ng.970 QMRO: qmroHref Heid IM, Jackson AU, Randall JC et al. (2011). Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. nameOfConference DOI: 10.1038/ng1111-1164a QMRO: qmroHref Williams B, Krause T, Lovibond K et al. (2011). Authors’ reply to Harding and colleagues, Taylor, Cruickshank, and El Turabi and Payne. nameOfConference DOI: 10.1136/bmj.d6506 QMRO: qmroHref Wain LV, Verwoert GC, O'Reilly PF et al. (2011). A large genome-wide association study of pulse pressure and mean arterial pressure reveals seven novel blood pressure LOCI. nameOfConference DOI: doi QMRO: qmroHref Lovibond K, Jowett S, Barton P et al. (2011). Cost-effectiveness of options for the diagnosis of high blood pressure in primary care: a modelling study. nameOfConference DOI: 10.1016/S0140-6736(11)61184-7 QMRO: qmroHref Michell AR, Bodey AR, Caulfield M (2011). Evolution, essential hypertension and the high arterial pressures in certain athletic breeds of dogs (vol 188, pg 125, 2011). nameOfConference DOI: 10.1016/j.tvjl.2011.08.015 QMRO: qmroHref Wain LV, Verwoert GC, O'Reilly PF et al. (2011). Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. nameOfConference DOI: 10.1038/ng.922 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/19185 Kooner JS, Saleheen D, Sim X et al. (2011). Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. nameOfConference DOI: 10.1038/ng.921 QMRO: qmroHref McCarthy N, Vangjeli C, Surendran P et al. (2011). PPARGC1 beta is a genetic determinant of the cardiovascular risk factor, Thromboxane A2-an Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) sub-study. nameOfConference DOI: doi QMRO: qmroHref Patel S, Ng FL, Uddin I et al. (2011). Plasma renin activity in the South Asian population-an intermediate group. nameOfConference DOI: doi QMRO: qmroHref Patel S, Ng FL, Uddin I et al. (2011). Salt intake in hypertensive patients with at or above-target blood pressures. nameOfConference DOI: doi QMRO: qmroHref Ehret G, Munroe PB, Rice K et al. (2011). Sixteen novel loci influence blood pressure and cardiovascular risk. nameOfConference DOI: doi QMRO: qmroHref International Consortium for Blood Pressure Genome-Wide Association Studies, Ehret GB, Munroe PB et al. (2011). Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.. nameOfConference DOI: 10.1038/nature10405 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/13815 Krause T, Lovibond K, Caulfield M et al. (2011). GUIDELINES Management of hypertension: summary of NICE guidance. nameOfConference DOI: 10.1136/bmj.d4891 QMRO: qmroHref Putku M, Kepp K, Org E et al. (2011). Novel polymorphic AluYb8 insertion in the WNK1 gene is associated with blood pressure variation in Europeans.. nameOfConference DOI: 10.1002/humu.21508 QMRO: qmroHref Fox ER, Young JH, Li YL et al. (2011). Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. nameOfConference DOI: 10.1093/hmg/ddr092 QMRO: qmroHref Fox ER, Young JH, Li Y et al. (2011). Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study.. nameOfConference DOI: 10.1093/hmg/ddr092 QMRO: qmroHref Hughes R, Lovibond K, Caulfield M et al. (2011). TREATING HYPERTENSION WITH FIRST-LINE THERAPIES IS CHEAPER THAN DOING NOTHING. nameOfConference DOI: 10.1097/00004872-201106001-00291 QMRO: qmroHref Johnson AD, Newton-Cheh C, Chasman DI et al. (2011). Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals.. nameOfConference DOI: 10.1161/HYPERTENSIONAHA.110.158667 QMRO: qmroHref Michell AR, Bodey AR, Caulfield M (2011). Evolution, essential hypertension and the high arterial pressures in certain athletic breeds of dogs. nameOfConference DOI: 10.1016/j.tvjl.2011.03.011 QMRO: qmroHref Peden JF, Hopewell JC, Saleheen D et al. (2011). A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. nameOfConference DOI: 10.1038/ng.782 QMRO: qmroHref Collier DJ, Poulter NR, Dahlöf B et al. (2011). Impact of amlodipine-based therapy among older and younger patients in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA).. nameOfConference DOI: 10.1097/HJH.0b013e328342c845 QMRO: qmroHref Collier DJ, Poulter NR, Dahlöf B et al. (2011). Impact of atorvastatin among older and younger patients in the Anglo-Scandinavian Cardiac Outcomes Trial Lipid-Lowering Arm.. nameOfConference DOI: 10.1097/HJH.0b013e328342c8f7 QMRO: qmroHref Lanktree MB, Guo YR, Murtaza M et al. (2011). Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. nameOfConference DOI: 10.1016/j.ajhg.2010.11.007 QMRO: qmroHref Chapman N, Chang CL, Caulfield M et al. (2011). ETHNIC VARIATIONS IN LIPID-LOWERING IN RESPONSE TO A STATIN (EVIREST): A SUBSTUDY OF THE ANGLO-SCANDINAVIAN CARDIAC OUTCOMES TRIAL (ASCOT). nameOfConference DOI: doi QMRO: qmroHref Esler MD, Krum H, Sobotka PA et al. (2010). Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. nameOfConference DOI: 10.1016/S0140-6736(10)62039-9 QMRO: qmroHref Sotoodehnia N, Isaacs A, de Bakker PIW et al. (2010). Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. nameOfConference DOI: 10.1038/ng.716 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/19344 Speliotes EK, Willer CJ, Berndt SI et al. (2010). Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.. nameOfConference DOI: 10.1038/ng.686 QMRO: qmroHref Tabara Y, Kohara K, Kita Y et al. (2010). Common variants in the ATP2B1 gene are associated with susceptibility to hypertension: the Japanese Millennium Genome Project.. nameOfConference DOI: 10.1161/HYPERTENSIONAHA.110.153429 QMRO: qmroHref Heid IM, Jackson AU, Randall JC et al. (2010). Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.. nameOfConference DOI: 10.1038/ng.685 QMRO: qmroHref Padmanabhan S, Melander O, Johnson T et al. (2010). Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension.. nameOfConference DOI: 10.1371/journal.pgen.1001177 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/19180 Allen HL, Estrada K, Lettre G et al. (2010). Hundreds of variants clustered in genomic loci and biological pathways affect human height. nameOfConference DOI: 10.1038/nature09410 QMRO: qmroHref Johnson T, Shaw-Hawkins S, Howard P et al. (2010). A novel gene locus for blood pressure variability identified by genomewide association scanning in the Anglo-Scandinavian Cardiac Outcome Trial. nameOfConference DOI: doi QMRO: qmroHref Hastie CE, Padmanabhan S, Melander O et al. (2010). Genome wide association study of blood pressure extremes identifies variant in uromodulin gene associated with hypertension. nameOfConference DOI: doi QMRO: qmroHref Collier DJ, Robson J, Scott R et al. (2010). HiLo: a health services intervention study: methods and interim results on the first 2000 patients at 1 year. nameOfConference DOI: doi QMRO: qmroHref Gupta AK, Poulter NR, Dobson J et al. (2010). Ethnic Differences in Blood Pressure Response to First and Second-Line Antihypertensive Therapies in Patients Randomized in the ASCOT Trial. nameOfConference DOI: 10.1038/ajh.2010.105 QMRO: qmroHref Teslovich TM, Musunuru K, Smith AV et al. (2010). Biological, clinical and population relevance of 95 loci for blood lipids. nameOfConference DOI: 10.1038/nature09270 QMRO: qmroHref Caulfield M (2010). The 10 minute clinical assessment. nameOfConference DOI: 10.1136/gut.2010.209874 QMRO: qmroHref Dolan E, Caulfield M, Thom S et al. (2010). AMBULATORY ARTERIAL STIFFNESS INDEX PREDICTS CARDIOVASCULAR MORBIDITY AND MORTALITY IN TREATED HYPERTENSIVE PATIENTS - AN ANGLO - SCANDINAVIAN CARDIAC OUTCOME TRIAL SUB-STUDY. nameOfConference DOI: 10.1097/01.hjh.0000378266.42404.35 QMRO: qmroHref Padmanabhan S, Melander O, Johnson T et al. (2010). GENOME WIDE ASSOCIATION STUDY OF BLOOD PRESSURE EXTREMES IDENTIFIES VARIANT IN UMOD ASSOCIATED WITH HYPERTENSION. nameOfConference DOI: 10.1097/01.hjh.0000378902.13083.3a QMRO: qmroHref Alvarez-Madrazo S, Padmanabhan S, Friel E et al. (2010). Validation of Association of Hypertension at the CYP11B1/B2 Locus in Caucasians.. nameOfConference DOI: doi QMRO: qmroHref Mancia G, Laurent S, Agabiti-Rosei E et al. (2010). European guidelines on the management of hypertension: The European Society of Hypertension position statement (2009). nameOfConference DOI: doi QMRO: qmroHref Chambers JC, Zhang WH, Lord GM et al. (2010). Genetic loci influencing kidney function and chronic kidney disease. nameOfConference DOI: 10.1038/ng.566 QMRO: qmroHref Liu JZ, Tozzi F, Waterworth DM et al. (2010). Meta-analysis and imputation refines the association of 15q25 with smoking quantity. nameOfConference DOI: 10.1038/ng.572 QMRO: qmroHref Lindgren CM, Heid IM, Randall JC et al. (2010). Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution. nameOfConference DOI: 10.1371/journal.pgen.1000508 QMRO: qmroHref Craddock N, Hurles ME, Cardin N et al. (2010). Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. nameOfConference DOI: 10.1038/nature08979 QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/14895 van der Harst P, Bakker SJL, de Boer RA et al. (2010). Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms. nameOfConference DOI: 10.1093/hmg/ddp489 QMRO: qmroHref Talmud PJ, Drenos F, Shah S et al. (2009). Gene-centric Association Signals for Lipids and Apolipoproteins Identified via the HumanCVD BeadChip. nameOfConference DOI: 10.1016/j.ajhg.2009.10.014 QMRO: qmroHref Munroe PB, Johnson T, Caulfield MJ (2009). The genetic architecture of blood pressure variation. nameOfConference DOI: 10.1007/s12170-009-0062-3 QMRO: qmroHref Mancia G, Laurent S, Agabiti-Rosei E et al. (2009). Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document. nameOfConference DOI: 10.1097/HJH.0b013e328333146d QMRO: qmroHref Vidyarthi M, Balakumar Y, Perry I et al. (2009). Hypokalaemic hypertension due to a rare cause. nameOfConference DOI: doi QMRO: qmroHref Dobson RJB, Munroe PB, Caulfield MJ et al. (publicationYear). Global sequence properties for superfamily prediction: a machine learning approach.. nameOfConference DOI: 10.2390/biecoll-jib-2009-109 QMRO: qmroHref Caulfield M (2009). Atheromatous vascular disease and ischaemic stroke in the UK. nameOfConference DOI: 10.1016/j.jdent.2009.05.018 QMRO: qmroHref Caulfield M (2009). PREDICTION OF ANTIHYPERTENSIVE RESPONSE - GENOTYPE. nameOfConference DOI: doi QMRO: qmroHref Nolte IM, Wallace C, Newhouse SJ et al. (publicationYear). Common Genetic Variation Near the Phospholamban Gene Is Associated with Cardiac Repolarisation: Meta-Analysis of Three Genome-Wide Association Studies. nameOfConference DOI: 10.1371/journal.pone.0006138 QMRO: qmroHref Sõber S, Org E, Kepp K et al. (publicationYear). Targeting 160 Candidate Genes for Blood Pressure Regulation with a Genome-Wide Genotyping Array. nameOfConference DOI: 10.1371/journal.pone.0006034 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/12218 Org E, Eyheramendy S, Juhanson P et al. (2009). Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations. nameOfConference DOI: 10.1093/hmg/ddp135 QMRO: qmroHref Caulfield MJ, Bochud M, Global BP Gen (2009). EIGHT BLOOD PRESSURE LOCI IDENTIFIED BY A GENOME-WIDE ASSOCIATION STUDY OF 34,433 PEOPLE OF EUROPEAN ANCESTRY. nameOfConference DOI: doi QMRO: qmroHref Lindgren CM, Heid IM, Randall JC et al. (2009). Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution. nameOfConference DOI: 10.1371/journal.pgen.1000508 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/19181 Newton-Cheh C, Johnson T, Gateva V et al. (2009). Genome-wide association study identifies eight loci associated with blood pressure. nameOfConference DOI: 10.1038/ng.361 QMRO: qmroHref Kolz M, Johnson T, Sanna S et al. (2009). Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations. nameOfConference DOI: 10.1371/journal.pgen.1000504 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/19172 Newhouse S, Farrall M, Wallace C et al. (2009). 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Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. nameOfConference DOI: 10.1038/ng.287 QMRO: qmroHref JENKINS BJ, CAULFIELD MJ, FOWLER CG et al. (1988). Reappraisal of the Role of Radical Radiotherapy and Salvage Cystectomy in the Treatment of Invasive (T2/T3) Bladder Cancer. nameOfConference DOI: 10.1111/j.1464-410x.1988.tb04362.x QMRO: qmroHref Ostergren J, Poulter NR, Sever PS et al. (2008). The Anglo-Scandinavian Cardiac Outcomes Trial: blood pressure-lowering limb: effects in patients with type II diabetes. nameOfConference DOI: 10.1097/HJH.0b013e328310e0d9 QMRO: qmroHref Samani NJ, Braund PS, Erdmann J et al. (2008). The novel genetic variant predisposing to coronary artery disease in the region of the PSRC1 and CELSR2 genes on chromosome 1 associates with serum cholesterol. nameOfConference DOI: 10.1007/s00109-008-0387-2 QMRO: qmroHref Keating BJ, Tischfield S, Murray SS et al. (2008). Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies. nameOfConference DOI: 10.1371/journal.pone.0003583 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/19174 Gupta AK, Poulter NR, Eldridge S et al. (2008). Ethnic differences in blood pressure response to atenolol and amlodipine monotherapy and to add on diuretic and ACE inhibitor dual therapy in hypertensive patients from UK in ASCOT-BPLA. nameOfConference DOI: doi QMRO: qmroHref Huq SM, Oldapo MNJ, Wang Y et al. (2008). High glucose and low lactate: a metabolic signature of hypertension in human serum?. nameOfConference DOI: doi QMRO: qmroHref Caulfield MJ, Munroe PB, O'Neill D et al. (2008). SLC2A9 Is a High-Capacity Urate Transporter in Humans. nameOfConference DOI: 10.1371/journal.pmed.0050197 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/12221 Brown MJ, Newhouse S, Wallace C et al. (2008). 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Common variants in the gene underlying type 2 Bartter syndrome are associated with blood pressure in the general population - The results of the genetic scan in the GRAPHIC (genetic regulation of arterial pressure of humans in the community) study. nameOfConference DOI: doi QMRO: qmroHref Loos RJF, Lindgren CM, Li SX et al. (2008). Common variants near MC4R are associated with fat mass, weight and risk of obesity. nameOfConference DOI: 10.1038/ng.140 QMRO: qmroHref Weedon MN, Lango H, Lindgren CM et al. (2008). Genome-wide association analysis identifies 20 loci that influence adult height. nameOfConference DOI: 10.1038/ng.121 QMRO: qmroHref Johnston L, Caulfield M, Savage M et al. (1999). NESTEGG: detecting new genes that influence fetal and childhood growth. nameOfConference DOI: 10.1111/j.1651-2227.1999.tb14424.x QMRO: qmroHref Sever PS, Poulter NR, Dahlof B et al. (2008). The Anglo-Scandinavian Cardiac Outcomes Trial lipid lowering arm: extended observations 2 years after trial closure. nameOfConference DOI: 10.1093/eurheartj/ehm583 QMRO: qmroHref Johnston L, Ester W, Koelega AH et al. (2008). Analysis of GDF5-UQCC polymorphism with height in NESTEGG SGA and ISS subjects. nameOfConference DOI: doi QMRO: qmroHref Dobson RJB, Munroe PB, Mein CA et al. (2008). Combining protein-protein interaction (PPI) network and sequence attributes for predicting hypertension related proteins. nameOfConference DOI: 10.1007/978-3-540-70600-7_28 QMRO: qmroHref Doblado M, Munroe PB, O'Neill D et al. (2008). Functional studies identify a glucose transporter SLC2A9 as a novel urate transporter. nameOfConference DOI: doi QMRO: qmroHref Wallace C, Newhouse SJ, Braund P et al. (2008). 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Effects of torcetrapib in patients at high risk for coronary events. nameOfConference DOI: 10.1056/NEJMoa0706628 QMRO: qmroHref Thomson W, Barton A, Ke X et al. (2007). Rheumatoid arthritis association at 6q23. nameOfConference DOI: 10.1038/ng.2007.32 QMRO: qmroHref Newport M, Sirugo G, Lyons E et al. (2007). Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. nameOfConference DOI: 10.1038/ng.2007.17 QMRO: qmroHref HITMAN GA, Todd JA, Samani NJ et al. (2007). Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.. nameOfConference DOI: 10.1038/ng.2007.17 QMRO: qmroHref Wallace C, Dobson RJ, Munroe PB et al. (2007). Information capture using SNPs from HapMap and whole-genome chips differs in a sample of inflammatory and cardiovascular gene-centric regions from genome-wide estimates.. nameOfConference DOI: 10.1101/gr.5996407 QMRO: qmroHref Padmanabhan S, Davies E, MacKenzie SM et al. (2007). Association of the CYP11B1 and CYP11B2 gene polymorphisms with hypertension in the British Genetics of Hypertension case-control study. nameOfConference DOI: doi QMRO: qmroHref Newhouse S, Wallace C, Hoti M et al. (2007). Association of the WNK1 gene with essential hypertension, blood pressure variability and serum and urine electrolytes. nameOfConference DOI: doi QMRO: qmroHref Collier DJ, Davies LC, Bernardi L et al. (2007). Baroreceptor function changes with differing blood pressure treatment during the anglo-scandinavian cardiac outcomes trial: principal results from the cardiac autonomic reflex assessment trial (CARAT). nameOfConference DOI: doi QMRO: qmroHref Padmanabhan S, Menni C, Delles C et al. (2007). Urinary albumin excretion in hypertensive siblings in the British Genetics of Hypertension study. nameOfConference DOI: doi QMRO: qmroHref Marcano ACB, Burke B, Gungadoo J et al. (2007). Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension. nameOfConference DOI: 10.1136/jmg.2007.049718 QMRO: qmroHref Burton PR, Clayton DG, Cardon LR et al. (2007). Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. nameOfConference DOI: 10.1038/nature05911 QMRO: qmroHref Collier D, Davies L, Bernardi L et al. (2007). Baroreceptor function changes with differing blood pressure treatment during the Anglo-Scandinavian Cardiac Outcomes Trial: Principal results from the Cardiac Autonomic Reflex Assessment Trial (CARAT). nameOfConference DOI: doi QMRO: qmroHref Collier D, Arunachalam G, Johnston A et al. (2007). Continuing reduction of microalbuminuria and proteinuria during follow-up for the Anglo-Scandinavian Cardiac Outcomes Trial dominance of duration and blood pressure over other effects. nameOfConference DOI: doi QMRO: qmroHref Zeggini E, Weedon MN, Lindgren CM et al. (2007). Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.. nameOfConference DOI: 10.1126/science.1142364 QMRO: qmroHref Brown M, Boon N, Brooks N et al. (2007). Medical training in the UK: sleepwalking to disaster. nameOfConference DOI: 10.1016/s0140-6736(07)60754-5 QMRO: qmroHref (2007). Babies, pre-eclamptic mothers and grandparents: a three-generation phenotyping study. nameOfConference DOI: 10.1097/hjh.0b013e32803fb634 QMRO: qmroHref Brown M, Boon N, Brooks N et al. (2007). Modernising Medical Careers, Medical Training Application Service, and the Postgraduate Medical Education and Training Board: time for the emperors to don their clothes. nameOfConference DOI: 10.1016/S0140-6736(07)60459-0 QMRO: qmroHref Burke B, Gungadoo J, Marçano ACB et al. (2007). Chapter 36 Monogenic Forms of Human Hypertension. nameOfConference DOI: 10.1016/b978-0-323-03961-1.50039-8 QMRO: qmroHref Burke B, Gungadoo J, Marçano ACB et al. (2007). Monogenic Forms of Human Hypertension. nameOfConference DOI: 10.1016/B978-0-323-03961-1.50039-8 QMRO: qmroHref Barr M, MacKenzie SM, Friel EC et al. (2007). Polymorphic variation in the 11 beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency. nameOfConference DOI: 10.1161/01.HYP.0000249904.93940.7a QMRO: qmroHref CAULFIELD M, BOULOUX P, MUNROE P (1997). Progress in Determining the Genes for Hypertension, Insulin Resistance, and Dyslipidemiaa. nameOfConference DOI: 10.1111/j.1749-6632.1997.tb51826.x QMRO: qmroHref Mancia G, De Backer G, Dominiczak A et al. (2007). †2007 Guidelines for the management of arterial hypertension1. nameOfConference DOI: 10.1093/eurheartj/ehm236 QMRO: qmroHref Sever P, Dahlöf B, Poulter N et al. (2006). Potential synergy between lipid-lowering and blood-pressure-lowering in the Anglo-Scandinavian Cardiac Outcomes Trial. nameOfConference DOI: 10.1093/eurheartj/ehl403 QMRO: qmroHref Collier DJ, Caulfield MJ, Poulter NR et al. (2006). Did older or younger patients benefit more from amlodipine based vs atenolol based therapy in ASCOT-BPLA?. nameOfConference DOI: doi QMRO: qmroHref Delles C, Braga-Marcano AC, Munroe PB et al. (2006). Association between variants of the human GSTM gene family and hypertension. nameOfConference DOI: doi QMRO: qmroHref Padmanabhan S, Hastie CE, Wallace C et al. (2006). Familial atherosclerotic disease and hypertension localised to chromosome 7p in the British genetics of hypertension study. nameOfConference DOI: doi QMRO: qmroHref Ostergren J, Sever P, Poulter N et al. (2006). The Anglo-Scandinavian Cardiac Outcomes Trial: Blood pressure-lowering limb (ASCOT-BPLA): effects in patients with type 2 diabetes. nameOfConference DOI: doi QMRO: qmroHref Wallace C, Xue M-Z, Newhouse SJ et al. (2006). Linkage analysis using co-phenotypes in the BRIGHT study reveals novel potential susceptibility loci for hypertension.. nameOfConference DOI: 10.1086/506370 QMRO: qmroHref Munroe PB, Wallace C, Xue M-Z et al. (2006). Increased support for linkage of a novel locus on chromosome 5q13 for essential hypertension in the British Genetics of Hypertension Study.. nameOfConference DOI: 10.1161/01.HYP.0000228324.74255.f1 QMRO: qmroHref (2007). Corrigendum. nameOfConference DOI: 10.1093/eurheartj/ehl453 QMRO: qmroHref Padmanabhan S, Wallace C, McBride MW et al. (2006). Genomewide linkage analysis for loci affecting electrocardiographic LV mass. nameOfConference DOI: doi QMRO: qmroHref Delles C, Marcano ACB, Munroe PB et al. (2006). Variants of the human mu type glutathione-s-transferase (GSTM) gene family are associated with hypertension. nameOfConference DOI: doi QMRO: qmroHref Dobson RJ, Munroe PB, Caulfield MJ et al. (2006). Predicting deleterious nsSNPs: an analysis of sequence and structural attributes.. nameOfConference DOI: 10.1186/1471-2105-7-217 QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/19176 Bell JT, Wallace C, Dobson R et al. (2006). Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension. nameOfConference DOI: 10.1093/hmg/ddl058 QMRO: qmroHref Padmanabhan S, Wallace C, Munroe PB et al. (2006). Chromosome 2p shows significant linkage to antihypertensive response in the British Genetics of Hypertension Study.. nameOfConference DOI: 10.1161/01.HYP.0000197947.62601.9d QMRO: qmroHref Padmanabhan S, Wallace C, Munroe PB et al. (2006). Chromosome 2p shows significant linkage to antihypertensive response in the British genetics of hypertension study. nameOfConference DOI: 10.1161/01.HYP.0000197947.62601.9d QMRO: qmroHref Binder A, Garcia E, Wallace C et al. (2006). Haplotypes of the beta-2 adrenergic receptor associate with high diastolic blood pressure in the Caerphilly prospective study. nameOfConference DOI: 10.1097/01.hjh.0000209983.28735.33 QMRO: qmroHref Tobin MD, Raleigh SM, Newhouse S et al. (2005). Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population. nameOfConference DOI: 10.1161/CIRCULATIONHA.105.555474 QMRO: qmroHref Padmanabhan S, Wallace C, Munroe PB et al. (2005). Chromosome 2p shows genome wide significant linkage to of anti-hypertensive medication response in the British genetics of hypertension (BRIGHT) study.. nameOfConference DOI: doi QMRO: qmroHref Wallace C, Xue MZ, Dobson R et al. (2005). Loci on chromosomes 5p and 20q are linked to multiple hypertension phenotypes in the BRItish genetics of Hypertension (BRIGHT) study. nameOfConference DOI: doi QMRO: qmroHref Padmanabhan S, Munroe PB, Brown M et al. (2005). Chromosome 2p shows genome wide significant linkage to anti-hypertensive medication response in the British genetics hypertension (BRIGHT) study. nameOfConference DOI: doi QMRO: qmroHref Munroe PB, Wallace C, Mein C et al. (2005). Enhanced support for linkage to chromosome 5q13.1 and hypertension in the British Genetics of Hypertension (BRIGHT) study.. nameOfConference DOI: doi QMRO: qmroHref Wallace C, Xue MZ, Dobson R et al. (2005). Loci on chromosomes 5p and 20q are linked to multiple hypertension phenotypes in the BRItish Genetics of HyperTension (BRIGHT) study. nameOfConference DOI: doi QMRO: qmroHref Xue MZ, Wallace C, Dobson R et al. (2005). Variants and haplotypes of the angiotensinogen gene are associated with hypertension in the Caerphilly Prospective Study. nameOfConference DOI: doi QMRO: qmroHref Dahlof B, Sever PS, Poulter NR et al. (2005). Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. nameOfConference DOI: 10.1016/S0140-6736(05)67185-1 QMRO: qmroHref Poulter NR, Wedel H, Dahlof B et al. (2005). Role of blood pressure and other variables in the differential cardiovascular event rates noted in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA). nameOfConference DOI: 10.1016/S0140-6736(05)67186-3 QMRO: qmroHref (publicationYear). Epidemiology of Hypertension. nameOfConference DOI: 10.1201/b14127-7 QMRO: qmroHref Newhouse SJ, Wallace C, Dobson R et al. (2005). Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study.. nameOfConference DOI: 10.1093/hmg/ddi187 QMRO: qmroHref Marcano ACB, Onipinla AK, Caulfield MJ et al. (2005). Recent advances in the identification of genes for human hypertension.. nameOfConference DOI: 10.1586/14779072.3.4.733 QMRO: qmroHref Consortium G (2005). Disentangling Fetal and Maternal Susceptibility for Pre-Eclampsia: A British Multicenter Candidate-Gene Study. nameOfConference DOI: 10.1086/431245 QMRO: qmroHref Sever PS, Poulter NR, Dahlof B et al. (2005). Reduction in cardiovascular events with atorvastatin in 2,532 patients with type 2 diabetes: Anglo-Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm (ASCOT-LLA). nameOfConference DOI: 10.2337/diacare.28.5.1151 QMRO: qmroHref Mein CA, Caulfield MJ, Munroe PB (2005). Selection of candidate genes in hypertension.. nameOfConference DOI: 10.1385/1-59259-850-1:107 QMRO: qmroHref Munroe PB, Dobson R, Pembroke J et al. (2004). The MRC BRIGHT study: Demographic and biochemical characteristics of the sibling-pair resource. nameOfConference DOI: doi QMRO: qmroHref Lee YW, Oh VMS, Garcia E et al. (2004). Haplotypes of the beta 2-adrenegic receptor gene are associated with essential hypertension in a Singaporean Chinese population. nameOfConference DOI: 10.1097/00004872-200411000-00012 QMRO: qmroHref Newhouse S, Dobson R, Wallace C et al. (2004). No association of the WNK1 gene with essential hypertension in the MRC BRIGHT study. nameOfConference DOI: 10.1097/00004872-200406002-00740 QMRO: qmroHref Mein CA, Caulfield MJ, Dobson RJ et al. (2004). Genetics of essential hypertension. nameOfConference DOI: doi QMRO: qmroHref Mein CA, Caulfield MJ, Dobson RJ et al. (2004). Genetics of essential hypertension.. nameOfConference DOI: 10.1093/hmg/ddh078 QMRO: qmroHref Sever PS, Dahlof B, Poulter NR et al. (2004). Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial - Lipid lowering arm (ASCOT-LLA): A multicentre randomised controlled trial. nameOfConference DOI: 10.2165/00003495-200464002-00005 QMRO: qmroHref Caulfield M, Munroe P, Pembroke J et al. (2003). Genome-wide mapping of human loci for essential hypertension. nameOfConference DOI: 10.1016/j.accreview.2003.08.046 QMRO: qmroHref Newhouse SJ, Garcia E, Caulfield M et al. (2003). Haplotype structure of the WNK1 gene and association studies in hypertensive populations. nameOfConference DOI: doi QMRO: qmroHref Kübler W (2003). Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesteroal concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial—Lipid Lowering Arm (ASCOL-LLA): a multicentre randomised controlled trial. nameOfConference DOI: 10.1007/s00392-003-0967-7 QMRO: qmroHref Wilson S, Johnston A, Robson J et al. (2003). Comparison of methods to identify individuals at increased risk of coronary disease from the general population.. nameOfConference DOI: 10.1136/bmj.326.7404.1436 QMRO: qmroHref Caulfield M, Munroe P, Pembroke J et al. (2003). Genome-wide mapping of human loci for essential hypertension.. nameOfConference DOI: 10.1016/S0140-6736(03)13722-1 QMRO: qmroHref Sever PS, Dahlof B, Poulter NR et al. (2003). Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial. nameOfConference DOI: 10.1016/S0140-6736(03)12948-0 QMRO: qmroHref Wilson S, Johnston A, Collier DJ et al. (2003). Feasibility of enrolling patients to hypertension outcome trials based on an assessment of their cardiovascular risk. nameOfConference DOI: doi QMRO: qmroHref Wilson S, Johnston A, Robson J et al. (2003). Predicting coronary risk in the general population--is it necessary to measure high-density lipoprotein cholesterol?. nameOfConference DOI: 10.1097/01.hjr.0000060844.48106.ff QMRO: qmroHref Knight J, Munroe PB, Pembroke JC et al. (2003). Human chromosome 17 in essential hypertension.. nameOfConference DOI: 10.1046/j.1469-1809.2003.t01-1-00002.x QMRO: qmroHref Garcia EA, Newhouse S, Caulfield MJ et al. (2003). Genes and hypertension.. nameOfConference DOI: 10.2174/1381612033454513 QMRO: qmroHref Garcia EA, Aristizabal D, McEwen J et al. (2002). Guanine nucleotide binding 3 (GNB3) haplotype analysis in the Venecia-Colombia Latin-American blood pressure study.. nameOfConference DOI: doi QMRO: qmroHref Wilson S, Johnston A, Robson J et al. (2002). Should we measure high density lipoprotein cholesterol in people with hypertension?. nameOfConference DOI: doi QMRO: qmroHref Caulfield M, Pembroke J, Dominiczak A et al. (2002). The MRC British Genetics of Hypertension Study - Genome-wide screen results. nameOfConference DOI: doi QMRO: qmroHref Wilson S, Johnston A, Robson J et al. (2002). OR-4: Who should have their cholesterol measured? A comparison of selective cholesterol screening methods. nameOfConference DOI: 10.1016/s0895-7061(02)02284-7 QMRO: qmroHref Collier DJ, Martin TA, Angell-James JE et al. (2002). P-334: Gender differences in carotid sinus baroreceptor reflexes in healthy young normal subjects and in ASCOT patients with treated essential hypertension. nameOfConference DOI: 10.1016/s0895-7061(02)02685-7 QMRO: qmroHref Chapman JN, Kirby P, Caulfield MC et al. (2001). Cardiovascular risk factors in a cohort of 30 000 high-risk men and women in the UK: Cross-sectional, retrospective and prospective studies of screenees for the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). nameOfConference DOI: 10.1038/sj.jhh.1001078 QMRO: qmroHref Metherell LA, Akker SA, Munroe PB et al. (2001). Pseudoexon activation as a novel mechanism for disease resulting in atypical growth-hormone insensitivity.. nameOfConference DOI: 10.1086/323266 QMRO: qmroHref O'Brien E, McInnes GT, Stanton A et al. (2001). Ambulatory blood pressure monitoring and 24-h blood pressure control as predictors of outcome in treated hypertensive patients. nameOfConference DOI: 10.1038/sj.jhh.1001076 QMRO: qmroHref Sever PS, Dahlof B, Poulter NR et al. (2001). Anglo-Scandinavian Cardiac Outcomes Trial: a brief history, rationale and outline protocol. nameOfConference DOI: 10.1038/sj.jhh.1001212 QMRO: qmroHref Collier DJ, Bernardi L, Angell-James JE et al. (2001). Baroreflex sensitivity and heart rate variability as predictors of cardiovascular outcome in hypertensive patients with multiple risk factors for coronary disease.. nameOfConference DOI: 10.1038/sj.jhh.1001077 QMRO: qmroHref Chapman JN, Kirby P, Caulfield MC et al. (2001). Cardiovascular risk factors in a cohort of 30,000 high-risk men and women in the UK: cross-sectional, retrospective and prospective studies of screenees for the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). nameOfConference DOI: 10.1038/sj.jhh.1001078 QMRO: qmroHref Kirby PL, Caulfield MC, Collier DJ et al. (2001). Differential response to amlodipine and atenolol mono-therapy for hypertension by ethnic group.. nameOfConference DOI: 10.1038/sj.jhh.1001080 QMRO: qmroHref Poulter NR, Caulfield M, Feder G (2001). Ethnic variations in response to a statin (EVIREST). nameOfConference DOI: 10.1038/sj.jhh.1001213 QMRO: qmroHref Wilson S, Collier D, Johnston A et al. (2001). Evaluation of cardiovascular risk equations using the ASCOT cohort.. nameOfConference DOI: 10.1038/sj.jhh.1001084 QMRO: qmroHref White PC, Agarwal AK, Li AR et al. (2001). Possible association but no linkage of the HSD11B2 gene encoding the kidney isozyme of 11 beta-hydroxysteroid dehydrogenase to hypertension in Black people. nameOfConference DOI: 10.1046/j.1365-2265.2001.01314.x QMRO: qmroHref Sever PS, Dahlof B, Poulter NR et al. (2001). Rationale, design, methods and baseline demography of participants of the Anglo-Scandinavian cardiac outcomes trial. nameOfConference DOI: 10.1097/00004872-200106000-00020 QMRO: qmroHref Sever PS, Dahlöf B, Poulter NR et al. (2001). Anglo-Scandinavian cardiac outcomes trial: A brief history, rationale and outline protocol. nameOfConference DOI: 10.1038/sj.jhh.1001212 QMRO: qmroHref Caulfield MJ (2001). Genes for common diseases. nameOfConference DOI: 10.1046/j.1365-2125.2001.01343.x QMRO: qmroHref Knight J, Gardner G, Clark A et al. (2000). Investigation of chromosome 17q as a locus for human essential hypertension in African Caribbeans. nameOfConference DOI: 10.1038/sj.jhh.1001025 QMRO: qmroHref Munroe PB, Caulfield MJ (2000). Genetics of hypertension. nameOfConference DOI: 10.1016/s0959-437x(00)00081-2 QMRO: qmroHref Munroe PB, Knight J, Caulfield MJ (2000). 1990-2000: progress in determining high blood pressure genes.. nameOfConference DOI: doi QMRO: qmroHref Caulfield M, Papp J, Pembroke J et al. (2000). A new tool for checks of data precision within the MRC British genetics of hypertension study. nameOfConference DOI: doi QMRO: qmroHref Munroe P, Sandhu M, Jadhav D et al. (2000). No association of the epithelial sodium channel beta-subunit T594M variant with essential hypertension in an African Caribbean population. nameOfConference DOI: doi QMRO: qmroHref Munroe PB, Strautnieks SS, Farrall M et al. (1998). Absence of Linkage of the Epithelial Sodium Channel to Hypertension in Black Caribbeans*. nameOfConference DOI: 10.1016/s0895-7061(98)00092-2 QMRO: qmroHref Caulfield M, Cafferkey M (1998). Gene therapy: The possibilities and the problems. nameOfConference DOI: doi QMRO: qmroHref Brand E, Chatelain N, Keavney B et al. (1998). Evaluation of the Angiotensinogen Locus in Human Essential Hypertension. nameOfConference DOI: 10.1161/01.hyp.31.3.725 QMRO: qmroHref Brand E, Chatelain N, de Bruijn T et al. (1997). 1.P.377 Evaluation of the angiotensinogen locus in human essential hypertension: An European study. nameOfConference DOI: 10.1016/s0021-9150(97)88556-5 QMRO: qmroHref Kotanko P, Binder A, Tasker J et al. (1997). Essential hypertension in African Caribbeans associates with a variant of the beta2-adrenoceptor.. nameOfConference DOI: 10.1161/01.hyp.30.4.773 QMRO: qmroHref Munroe PB, Strautnieks SS, Farrall M et al. (1997). Investigation of the epithelial sodium channel (hENaC) as a candidate gene for essential hypertension (EH) in African Caribbeans. nameOfConference DOI: 10.1016/s0895-7061(97)88661-x QMRO: qmroHref Daniel H, Munroe P, Kamdar S et al. (1997). The atrial natriuretic peptide gene and essential hypertension in African-Caribbeans from St Vincent and the Grenadines. nameOfConference DOI: 10.1038/sj.jhh.1000389 QMRO: qmroHref Caulfield M, Lavender P, Newell-Price J et al. (1996). Angiotensinogen in human essential hypertension.. nameOfConference DOI: 10.1161/01.hyp.28.6.1123 QMRO: qmroHref Caulfield M, Newell-Price J (1995). The angiotensin converting enzyme gene in cardiovascular disease.. nameOfConference DOI: 10.1136/hrt.74.3.207 QMRO: qmroHref Munroe PB, Daniel HI, Farrall M et al. (1995). Absence of genetic linkage between polymorphisms of the insulin receptor gene and essential hypertension.. nameOfConference DOI: doi QMRO: qmroHref Caulfield M, Lavender P, Newell-Price J et al. (1995). Linkage of the angiotensinogen gene locus to human essential hypertension in African Caribbeans.. nameOfConference DOI: 10.1172/jci118111 QMRO: qmroHref Mattu R, Needham E, Galton D et al. (1995). The Ace I/D Polymorphism Identifies Cad in Low Risk Welsh Subjects. nameOfConference DOI: 10.1042/cs088001pa QMRO: qmroHref Mattu RK, Needham EWA, Galton DJ et al. (1995). A DNA variant at the angiotensin-converting enzyme gene locus associates with coronary artery disease in the Caerphilly Heart Study.. nameOfConference DOI: 10.1161/01.cir.91.2.270 QMRO: qmroHref Caulfield M, Lavender P, Newell-Price J et al. (1994). 2 Linkage of the angiotensinogen gene to human essential hypertension in African Caribbeans. nameOfConference DOI: 10.1097/00004872-199411000-00015 QMRO: qmroHref Brown MJ, Clayton D (1994). Linkage of the Angiotensinogen Gene to Essential Hypertension. nameOfConference DOI: 10.1056/nejm199410203311615 QMRO: qmroHref Mattu RK, Needham EWA, Caulfield M et al. (1994). Association of the ACE I/D polymorphism with CAD in a Welsh population. nameOfConference DOI: 10.1016/0021-9150(94)93841-5 QMRO: qmroHref Kamdar S, Daniel H, Fogarty P et al. (1994). ACE insertion/deletion (I/D) polymorphism in Vincentian African Caribbeans with essential hypertension.. nameOfConference DOI: doi QMRO: qmroHref Munroe PB, Johnston A, Duke VM et al. (1994). Investigation of lipoprotein lipase (LPL) as a candidate gene for dyslipidaemic hypertension.. nameOfConference DOI: doi QMRO: qmroHref Daniel HI, Munroe PB, Lawson M et al. (1994). Investigation of the renin gene as a putative locus for essential hypertension (EH) in Vincentian African Caribbeans.. nameOfConference DOI: doi QMRO: qmroHref Caulfield M, Lavender P, Farrall M et al. (1994). Linkage of the Angiotensinogen Gene to Essential Hypertension. nameOfConference DOI: 10.1056/nejm199406093302301 QMRO: qmroHref Munroe PB, Caulfield M, Daniel H et al. (1993). Analysis of the insulin receptor RsaI polymorphism in essential hypertension. nameOfConference DOI: doi QMRO: qmroHref Raveendran R, Heybroek W, Caulfield M et al. (1992). Indomethacin and Protein Binding of Methotrexate. nameOfConference DOI: 10.1177/096032719201100411 QMRO: qmroHref Raveendran R, Heybroek WM, Caulfield M et al. (1992). Protein binding of indomethacin, methotrexate and morphine in patients with cancer.. nameOfConference DOI: doi QMRO: qmroHref Saleh S, Caulfield M, Lledo P et al. (1990). Debrisoquine-type genetic polymorphism differences in medifoxamine pharmacokinetics. nameOfConference DOI: 10.1016/0014-2999(90)93953-n QMRO: qmroHref Caulfield MJ, Dilkes MG, Iles RK et al. (1990). Rapid diagnosis of testicular choriocarcinoma by urinary pregnancy tests. nameOfConference DOI: 10.1016/0140-6736(90)92761-6 QMRO: qmroHref Heybroek WM, Caulfield M, Johnston A et al. (1990). Automatic on-line extraction coupled with electrochemical detection as an improved method for the HPLC co-analysis of codeine and morphine in plasma and gastric juice. nameOfConference DOI: 10.1016/0731-7085(90)80163-j QMRO: qmroHref CAULFIELD MJ, DILKES MG, ILES RK et al. (1990). RAPID DIAGNOSIS OF TESTICULAR CHORIOCARCINOMA BY URINARY PREGNANCY TESTS. nameOfConference DOI: doi QMRO: qmroHref Bouloux P-MG, Caulfield M, Lawson M et al. (1989). A study of Xho 1 polymorphisms of the human proatrial natriuretic peptide gene in essential hypertension. nameOfConference DOI: 10.1097/00004872-198911000-00013 QMRO: qmroHref Blandy JP, Jenkins BJ, Fowler CG et al. (1988). Radical radiotherapy and salvage cystectomy for T2/3 cancer of the bladder.. nameOfConference DOI: doi QMRO: qmroHref Sponsors IQVIA (formerly Quintiles) British Heart Foundation National Institute for Health and Care Research CollaboratorsInternal Prof Patricia Munroe Prof Amrita Ahluwalia Prof Adrian Hobbs Prof Steffen Petersen Prof Chris Thiemermann Prof Adam Timmis Prof Costantino Pitzalis Dr Mel Lobo News £6.5m grant to launch new heart disease Biomedical Research Centre, Queen Mary University of London, September 2016 Blood pressure measured at home, BBC, August 2011 Back to top