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Professor Sir Mark Caulfield

Mark

Vice Principal for Health for Queen Mary’s Faculty of Medicine and Dentistry

Centre: Clinical Pharmacology and Precision Medicine

Email: m.j.caulfield@qmul.ac.uk
Telephone: +44(0) 20 7882 3403

Profile

ORCID iD: 0000-0001-9295-3594

Professor Sir Mark Caulfield is Professor of Clinical Pharmacology at Queen Mary University of London and the Vice Principal for Health for Queen Mary’s Faculty of Medicine and Dentistry.

Professor Caulfield graduated in Medicine in 1984 from the London Hospital Medical College and trained in Clinical Pharmacology at St Bartholomew’s Hospital, he developed a research programme in molecular genetics of hypertension and translational clinical research.

At Queen Mary University of London Professor Caulfield has made contributions to the discovery of genes related to blood pressure, cardiovascular health, cancer and rare diseases. His research has changed national and international guidance for high blood pressure.

He has won the Lily Prize of the British Pharmacology Society, the Bjorn Folkow Award of the European Society of Hypertension 2016 and the Franz Volhard Award of the International Society of Hypertension in 2018.

Professor Caulfield was appointed Chief Scientist for Genomics England in 2013, charged with delivery of the 100,000 Genomes Project on whole genome sequencing in rare disease, cancer and infection. He was instrumental in delivering the 100,000 Genomes Project which has delivered life-changing results for many patients. He worked with NHS England to co-create the National Genomic Test Directory, which offers equitable access for 56 million people to appropriate genomic tests.  Professor Caulfield was awarded a knighthood in 2019 for his leadership of the 100,000 Genomes Project.

He is a member of the Barts Health NHS Trust Board, the Barking, Havering and Redbridge University Hospitals NHS Trust, the MedCity Board and is the President Elect of the British Pharmacological Society

Research

Group members

NIHR Barts Biomedical Research Centre Director’s Office
Clare Birch (Executive Assistant); John Whiteley (Chief Operating Officer for the NIHR Barts Biomedical Research Centre).

Cardiovascular Genetics and Genomics
Dr Helen Warren (Lecturer); Dr Claudia Cabrera (Lecturer); Prof Mike Barnes (Director of Bioinformatics); Dr Emma Forton Macgavern (Academic Clinical Fellow); Dr Arianna Tucci (MRC Clinician Scientist); Dr Kristina Ibanez Garikano (Lecturer).

William Harvey Clinical Research Centre
Dr David Collier (Clinical Director); Dr Manish Saxena (Clinical Fellow); Dr Julian Shiel (Clinical Fellow); Marion Benford (Quality Assurance); Mike Taylor (Recruitment); Patrizia Ebano; Ania Michalska (Research Sisters).

Summary

Cardiovascular Genomics
My leadership of international research collaborations of 350 researchers from 24 countries has discovered over 1200 gene regions influencing blood pressure and generated a polygenic risk scores for hypertension published in Nature and Nature Genetics and recognised by two of the most prestigious prizes in cardiovascular research.

Genomics England
In 2013 I was asked to become Chief Scientist for Genomics England (GEL) to lead scientific strategy and delivery of the 100,000 Genomes Project. I drew on my extensive experience of collaborative working as a researcher, as an NIHR Biomedical Research Centre Director and Senior Investigator to create the vital coalition of 5000 healthcare professionals, 3400 researchers and 97,000 participants, in partnership with the NHS, to deliver the 100,000 Genomes Project on target creating the platform for a new Genomic Medicine Service (GMS).

Cardiovascular Clinical Research
I have undertaken internationally leading translational and outcomes trials research e.g. the ASCOT trial, which changed international and NICE guidance for lipid lowering and hypertension and the PATHWAY Study which changed European Guidance. From this Barts and The London now have a major clinical trials programme and a partnership with IQVIA where we coordinate and enhance clinical research across UCLP Partners Academic Health Sciences Centre.

Publications

  • Collier D, Taylor M, Godec T et al. (2024). Do more with less? Impact of personalized very low doses of amlodipine in the PERSONAL-CovidBP trial. nameOfConference


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  • Magavern EF, Deshmukh H, Asselin G et al. (2024). Pharmacogenomics of CRP response to statins: a GIST consortium study. nameOfConference


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  • Hepburn D, Hitchings AW, Wilson K et al. (2024). Importance of the UK Prescribing Safety Assessment as a component of undergraduate medical assessment. nameOfConference


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  • Magavern EF, McDermott JH, Caulfield MJ et al. (2024). CYP2C19 genetic testing for Mavacamten and ischaemic stroke treatment: What does the result mean for cardiovascular prescribers in the UK and Europe?. nameOfConference


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  • Shi S, Rubinacci S, Hu S et al. (2024). A Genomics England haplotype reference panel and imputation of UK Biobank. nameOfConference


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  • Magavern EF, Kapil V, Saxena M et al. (2024). Use of Genomics to Develop Novel Therapeutics and Personalize Hypertension Therapy. nameOfConference


  • Caulfield M (2024). Foreword. nameOfConference


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  • Magavern EF, Jacobs B, Warren H et al. (2023). CYP2C19 genotype prevalence and association with recurrent myocardial infarction in British-South Asians treated with clopidogrel. nameOfConference


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  • Magavern EF, Van Heel DA, Smedley D et al. (2023). SLCO1B1*5 is protective against non-senile cataracts in cohort prescribed statins: analysis in a British-South Asian cohort. nameOfConference


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  • Magavern EF, Hitchings A, Bollington L et al. (2024). UK Prescribing Safety Assessment (PSA): The development, implementation and outcomes of a national online prescribing assessment. nameOfConference


  • Magavern EF, Durrani F, Raza M et al. (2023). British South Asian ancestry participants views of pharmacogenomics clinical implementation and research: a thematic analysis. nameOfConference


  • Hartmann S, Yasmeen S, Jacobs BM et al. (publicationYear). ADRA2A and IRX1 are putative risk genes for Raynaud’s phenomenon. nameOfConference


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  • Xiao S, Kai Z, Murphy D et al. (2023). Functional filter for whole-genome sequencing data identifies HHT and stress-associated non-coding SMAD4 polyadenylation site variants >5 kb from coding DNA. nameOfConference


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  • Magavern EF, Team GHR, Smedley D et al. (2023). Factor V Leiden, estrogen, and multimorbidity association with venous thromboembolism in a British-South Asian cohort. nameOfConference


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  • Magavern EF, Jacobs B, Warren H et al. (2023). CYP2C19 Genotype Prevalence and Association With Recurrent Myocardial Infarction in British–South Asians Treated With Clopidogrel. nameOfConference


  • Magavern EF, van Heel DA, Team GHR et al. (2023). CYP2C19 loss‐of‐function alleles are not associated with higher prevalence of gastrointestinal bleeds in those who have been prescribed antidepressants: Analysis in a British‐South Asian cohort. nameOfConference


  • Sadeghi-Alavijeh O, Chan MMY, Moochhala SH et al. (2023). Rare variants in the sodium-dependent phosphate transporter gene SLC34A3 explain missing heritability of urinary stone disease. nameOfConference


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  • Tesi B, Boileau C, Boycott KM et al. (2023). Precision medicine in rare diseases: What is next?. nameOfConference


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  • Magavern EF, van Heel DA, Smedley D et al. (2023). SLCO1B1*5 is protective against non-senile cataracts in cohort prescribed statins: analysis in a British-South Asian cohort. nameOfConference


  • Siedlinski M, Carnevale L, Xu X et al. (2023). Genetic analyses identify brain structures related to cognitive impairment associated with elevated blood pressure. nameOfConference


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  • Magavern EF, Caulfield MJ (2023). Equal access to pharmacogenomics testing: The ethical imperative for population‐wide access in the UK NHS. nameOfConference


  • Dominiczak AF, Padmanabhan S, Caulfield M et al. (2023). Introducing Cambridge prisms: Precision medicine. nameOfConference


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  • Magavern E, Smedley D, Caulfield M (2023). Factor V Leiden and oestrogen use in the context of multiple common chronic medical conditions: Analysis in the Genes & Health British-South Asian Cohort. nameOfConference

    DOI: doi

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  • Magavern E, van Heel D, Smedley D et al. (2023). Precision prescribing would not reduce gastrointestinal bleeds associated with CYP2C19 metabolized antidepressants:: Analysis in a British-South Asian cohort. nameOfConference

    DOI: doi

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  • Wei W, Schon KR, Elgar G et al. (2022). Nuclear-embedded mitochondrial DNA sequences in 66,083 human genomes. nameOfConference


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  • Calabrese C, Pyle A, Griffin H et al. (publicationYear). Heteroplasmic mitochondrial DNA variants in cardiovascular diseases. nameOfConference


  • Lesurf R, Said A, Akinrinade O et al. (publicationYear). Whole genome sequencing delineates regulatory, copy number, and cryptic splice variants in early onset cardiomyopathy. nameOfConference


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  • Ibañez K, Polke J, Hagelstrom RT et al. (2022). Whole genome sequencing for the diagnosis of neurological repeat expansion disorders in the UK: a retrospective diagnostic accuracy and prospective clinical validation study. nameOfConference


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  • Horgan D, Borisch B, Cattaneo I et al. (publicationYear). Factors Affecting Citizen Trust and Public Engagement Relating to the Generation and Use of Real-World Evidence in Healthcare. nameOfConference


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  • Owen N, Toms M, Young RM et al. (2022). Identification of 4 novel human ocular coloboma genes ANK3, BMPR1B, PDGFRA, and CDH4 through evolutionary conserved vertebrate gene analysis. nameOfConference


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  • Trompet S, Postmus I, Warren HR et al. (publicationYear). The Pharmacogenetics of Statin Therapy on Clinical Events: No Evidence that Genetic Variation Affects Statin Response on Myocardial Infarction. nameOfConference


  • McGuigan A, Whitworth J, Andreou A et al. (2022). Multilocus Inherited Neoplasia Allele Syndrome (MINAS): an update. nameOfConference


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  • Tooze RS, Hyder Z, Calpena E et al. (2022). Evaluating the performance of a clinical genome sequencing programme for diagnosis of rare genetic disease, seen through the lens of craniosynostosis. nameOfConference

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  • Collier D, Taylor M, Godec T et al. (2022). Personalized electronic record supported optimisation when alone for patients with hypertension- pilot study for remote medical management of hypertension during the Covid-19 pandemic (personal covidBP). nameOfConference

    DOI: doi

  • Balachandar S, Graves TJ, Shimonty A et al. (2022). Identification and validation of a novel pathogenic variant in GDF2 (BMP9) responsible for hereditary hemorrhagic telangiectasia and pulmonary arteriovenous malformations. nameOfConference


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  • Bacq A, Roussel D, Bonduelle T et al. (2022). Cardiac Investigations in Sudden Unexpected Death in DEPDC5‐Related Epilepsy. nameOfConference


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  • Smedley D, Smith KR, Martin AR et al. (2021). 100,000 Genomes Pilot on Rare-Disease Diagnosis in Health Care — Preliminary Report. nameOfConference


  • Schon KR, Horvath R, Wei W et al. (publicationYear). Use of whole genome sequencing to determine genetic basis of suspected mitochondrial disorders: cohort study. nameOfConference


  • Best S, Lord J, Roche M et al. (2022). Molecular diagnoses in the congenital malformations caused by ciliopathies cohort of the 100,000 Genomes Project. nameOfConference


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  • Wei Y, Papachristou N, Mueller S et al. (2021). Application of ensemble clustering and survival tree analysis for identifying prognostic clinicogenomic features in patients with colorectal cancer from the 100,000 Genomes Project. nameOfConference


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  • Magavern EF, Kaski JC, Turner RM et al. (2022). Challenges in cardiovascular pharmacogenomics implementation: a viewpoint from the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy. nameOfConference


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  • Silvennoinen K, Puvirajasinghe C, Hudgell K et al. (2021). Late diagnoses of Dravet syndrome: How many individuals are we missing?. nameOfConference


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  • Stark Z, Foulger RE, Williams E et al. (2021). Scaling national and international improvement in virtual gene panel curation via a collaborative approach to discordance resolution. nameOfConference


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  • Eales JM, Jiang X, Xu X et al. (2021). Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney. nameOfConference


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  • Warren H, Garofalidou T, Singh S et al. (2021). GENOME-WIDE ASSOCIATION STUDY FOR PHARMACOGENETIC RESPONSE OF BLOOD PRESURE TO BETA BLOCKER AND CALCIUM CHANNEL BLOCKER DRUGS. nameOfConference


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  • Warren H, Traylor M, Garofalidou T et al. (2021). HYPERTENSIVE PATIENTS WITH GREATER GENETIC RISK RESPOND LESS EFFECTIVELY TO TREATMENT AND ARE MORE LIKELY TO BE TREATMENT RESISTANT. nameOfConference


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  • Magavern EF, Kaski JC, Turner RM et al. (2022). The role of pharmacogenomics in contemporary cardiovascular therapy: a position statement from the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy. nameOfConference


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  • Ragoussis V, Pagnamenta AT, Haines RL et al. (2022). Using data from the 100,000 Genomes Project to resolve conflicting interpretations of a recurrent TUBB2A mutation. nameOfConference


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  • Pagnamenta AT, Kaiyrzhanov R, Zou Y et al. (2021). An ancestral 10-bp repeat expansion in VWA1 causes recessive hereditary motor neuropathy. nameOfConference


  • Magavern EF, Warren HR, Ng FL et al. (2021). An Academic Clinician’s Road Map to Hypertension Genomics. nameOfConference


  • Bick D, Bick SL, Dimmock DP et al. (2021). An online compendium of treatable genetic disorders. nameOfConference


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  • Boguslavskyi A, Tokar S, Prysyazhna O et al. (2021). Phospholemman Phosphorylation Regulates Vascular Tone, Blood Pressure, and Hypertension in Mice and Humans. nameOfConference


  • Pairo-Castineira E, Clohisey S, Klaric L et al. (2021). Genetic mechanisms of critical illness in COVID-19.. nameOfConference


  • Poulter JA, Gravett MSC, Taylor RL et al. (2021). New variants and in silico analyses in GRK1 associated Oguchi disease. nameOfConference


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  • Turner RM, Newman WG, Bramon E et al. (2020). Pharmacogenomics in the UK National Health Service: opportunities and challenges. nameOfConference


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  • Parry DA, Martin CA, Greene P et al. (2020). Heterozygous lamin B1 and lamin B2 variants cause primary microcephaly and define a novel laminopathy. nameOfConference


  • Gallo JE, Ochoa JE, Warren HR et al. (2020). Hypertension and the roles of the 9p21.3 risk locus: Classic findings and new association data. nameOfConference


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  • Wei W, Pagnamenta AT, Gleadall N et al. (publicationYear). Author Correction: Nuclear-mitochondrial DNA segments resemble paternally inherited mitochondrial DNA in humans. nameOfConference


  • Turro E, Astle WJ, Megy K et al. (2020). Whole-genome sequencing of patients with rare diseases in a national health system. nameOfConference


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  • Raisi-Estabragh Z, McCracken C, Bethell MS et al. (2020). Greater risk of severe COVID-19 in Black, Asian and Minority Ethnic populations is not explained by cardiometabolic, socioeconomic or behavioural factors, or by 25(OH)-vitamin D status: study of 1326 cases from the UK Biobank. nameOfConference


  • Raisi-Estabragh Z, McCracken C, Bethell MS et al. (publicationYear). Greater risk of severe COVID-19 in non-White ethnicities is not explained by cardiometabolic, socioeconomic, or behavioural factors, or by 25(OH)-vitamin D status: study of 1,326 cases from the UK Biobank. nameOfConference


  • Sackley CM, Rick C, Au P et al. (2020). A multicentre, randomised controlled trial to compare the clinical and cost-effectiveness of Lee Silverman Voice Treatment versus standard NHS Speech and Language Therapy versus control in Parkinson’s disease: a study protocol for a randomised controlled trial. nameOfConference


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  • Tolchin D, Yeager JP, Prasad P et al. (2020). De Novo SOX6 Variants Cause a Neurodevelopmental Syndrome Associated with ADHD, Craniosynostosis, and Osteochondromas. nameOfConference


  • Ntalla I, Weng L-C, Cartwright JH et al. (publicationYear). Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction. nameOfConference


  • Wei W, Pagnamenta AT, Gleadall N et al. (publicationYear). Nuclear-mitochondrial DNA segments resemble paternally inherited mitochondrial DNA in humans. nameOfConference


  • Freeman TM, Wang D, Harris J et al. (2020). Genomic loci susceptible to systematic sequencing bias in clinical whole genomes. nameOfConference


  • Pleguezuelos-Manzano C, Puschhof J, Rosendahl Huber A et al. (2020). Mutational signature in colorectal cancer caused by genotoxic pks+E. coli. nameOfConference


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  • Lloyd KCK, Adams DJ, Baynam G et al. (2020). The Deep Genome Project. nameOfConference


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  • Cacheiro P, Muñoz-Fuentes V, Murray SA et al. (2020). Human and mouse essentiality screens as a resource for disease gene discovery. nameOfConference


  • Pu X, Chan K, Yang W et al. (2020). Effect of a coronary-heart-disease-associated variant of ADAMTS7 on endothelial cell angiogenesis. nameOfConference


  • Thomas ERA, Pasko D, Boustred C et al. (2020). Modelling diagnostic yield in the 100,000 Genomes Rare Disease Project using panel-based analysis and complementary approaches. nameOfConference

    DOI: doi

  • Cabrera CP, Pazoki R, Giri A et al. (2020). Multi-trait genome-wide association analysis of blood pressure identifies 45 additional loci. nameOfConference

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  • Smedley D, Abbs S, Arno G et al. (2020). The impact of the 100,000 Genomes Project on rare disease in national healthcare. nameOfConference

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  • Kasperaviciute D, Smith KR, Ibanez K et al. (2020). Validation of Clinically Relevant Variant Detection from Whole Genome Sequencing for NHS England's Genomic Medicine Service. nameOfConference

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  • Caulfield M (2019). 6 Translating genomics for clinical benefit. nameOfConference


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  • Hong Y, Nanthapisal S, Omoyinmi E et al. (publicationYear). Secondary C1q Deficiency in Activated PI3Kδ Syndrome Type 2. nameOfConference


  • Martin AR, Williams E, Foulger RE et al. (2019). PanelApp crowdsources expert knowledge to establish consensus diagnostic gene panels. nameOfConference


  • Smith KR, Bleda M, Kasperaviciute D et al. (2019). Uniparental disomy in the Rare Disease Programme of the UK's 100,000 Genomes Project. European Society of Human Genetics

    DOI: doi

  • Cabrera CP, Ng F, Nicholls HL et al. (2019). Over 1000 genetic loci influencing blood pressure with multiple systems and tissues implicated.. nameOfConference


  • Wheway G, Ambrose JC, Baple EL et al. (publicationYear). Corrigendum: Opportunities and Challenges for Molecular Understanding of Ciliopathies–The 100,000 Genomes Project. nameOfConference


  • Scott RH, Fowler TA, Caulfield M (2019). Genomic medicine: time for health-care transformation. nameOfConference


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  • Noordam R, Young WJ, Salman R et al. (2019). Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals. nameOfConference


  • Wei W, Tuna S, Keogh MJ et al. (2019). Germline selection shapes human mitochondrial DNA diversity. nameOfConference


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  • Marques P, Tufton N, Bhattacharya S et al. (2019). Hypertension due to a deoxycorticosterone-secreting adrenal tumour diagnosed during pregnancy. nameOfConference


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  • Gorman KM, Meyer E, Grozeva D et al. (2019). Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia. nameOfConference


  • Sung YJ, de las Fuentes L, Winkler TW et al. (2019). A multi-ancestry genome-wide study incorporating gene–smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. nameOfConference


  • Marouli E, Del Greco MF, Astley CM et al. (publicationYear). Mendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease. nameOfConference


  • Wheway G, Consortium GER, Mitchison HM et al. (publicationYear). Opportunities and Challenges for Molecular Understanding of Ciliopathies–The 100,000 Genomes Project. nameOfConference


  • van Setten J, Verweij N, Mbarek H et al. (2019). Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits. nameOfConference


  • McDonough CW, Warren HR, Jack JR et al. (2019). DRUG-SNP INTERACTIONS AND CARDIOVASCULAR OUTCOMES: A GENOME-WIDE META-ANALYSIS IN THE INTERNATIONAL CONSORTIUM FOR ANTIHYPERTENSIVE PHARMACOGENOMICS STUDIES.. nameOfConference

    DOI: doi

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  • Giri A, Hellwege JN, Keaton JM et al. (2019). Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. nameOfConference


  • Brazel DM, Jiang Y, Hughey JM et al. (2018). Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use. nameOfConference


  • Evangelou E, Warren HR, Mosen-Ansorena D et al. (2018). Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.. nameOfConference


  • Collier DJ, Juhasz A, Agabiti‐Rosei E et al. (2018). Efficacy and safety of azilsartan medoxomil/chlortalidone fixed‐dose combination in hypertensive patients uncontrolled on azilsartan medoxomil alone: A randomized trial. nameOfConference


  • Allix-Béguec C, Arandjelovic I, Bi L et al. (2018). Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing. nameOfConference


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  • Evangelou E, Warren HR, Mosen-Ansorena D et al. (2018). Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. nameOfConference


  • Sosinsky A, Murugaesu N, Hamblin A et al. (2018). 19P 100,000 Genomes Project: Cancer programme. nameOfConference


    QMRO: qmroHref
  • Ng FL, Warren HR, Caulfield MJ (2018). Hypertension genomics and cardiovascular prevention.. nameOfConference


  • Sosinsky A, Antoniou P, Ambrose J et al. (2018). Abstract 434: 100,000 Genomes Project: Cancer program. nameOfConference


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  • Williams B, MacDonald TM, Morant SV et al. (2018). Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies.. nameOfConference


  • Thomas ERA, Devereau A, Brittain H et al. (2018). Widespread uptake of the Human Phenotype Ontology (HPO) in the National Health Service (NHS) in England as part of the 100,000 Genomes Project. european society human genetics

    DOI: doi

  • Munroe PB, Jahangir SNS, Caulfield MJ (2018). Genetics and Genomics of Systemic Hypertension. nameOfConference


  • Shovlin CL, Nur F, St Prix MS et al. (2018). Hereditary haemorrhagic telangiectasia and the 100,000 genomes project. nameOfConference

    DOI: doi

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  • Turcot V, Lu Y, Highland HM et al. (2018). Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. nameOfConference


  • Pazoki R, Dehghan A, Evangelou E et al. (2018). Genetic Predisposition to High Blood Pressure and Lifestyle Factors. nameOfConference


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  • McCarthy NS, Vangjeli C, Surendran P et al. (2018). Genetic variants in PPARGC1B and CNTN4 are associated with thromboxane A2 formation and with cardiovascular event free survival in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). nameOfConference


  • MacDonald TM, Williams B, Webb DJ et al. (2017). Combination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double-Blind Randomized Controlled Trial.. nameOfConference


  • Liu DJ, Peloso GM, Yu H et al. (2017). Exome-wide association study of plasma lipids in >300,000 individuals. nameOfConference


  • Ren M, Ng FL, Warren HR et al. (2018). The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle. nameOfConference


  • Kraja AT, Cook JP, Warren HR et al. (2017). New Blood Pressure–Associated Loci Identified in Meta-Analyses of 475 000 Individuals. nameOfConference


  • Warren HR, Evangelou E, Cabrera CP et al. (2017). Corrigendum: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.. nameOfConference


  • Song C, Burgess S, Eicher JD et al. (2017). Causal effect of plasminogen activator inhibitor type 1 on coronary heart disease. nameOfConference


  • Dale CE, Fatemifar G, Palmer TM et al. (2017). Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus. nameOfConference


  • Lian F, Caulfield MJ (2017). Status and future of genomics in blood pressure. nameOfConference


  • MUNROE PB, Caulfield M, Stirrups K et al. (2017). Discovery of novel heart rate-associated loci using the exome chip. nameOfConference


  • Warren HR, Evangelou E, Cabrera CP et al. (2017). Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.. nameOfConference


  • Marouli E, Graff M, Medina-Gomez C et al. (2017). Rare and low-frequency coding variants alter human adult height.. nameOfConference


  • Ng FL, Boedtkjer E, Witkowska K et al. (2017). Increased NBCn1 expression, Na+/HCO3- co-transport and intracellular pH in human vascular smooth muscle cells with a risk allele for hypertension.. nameOfConference


  • Caulfield M (2017). The 100,000 Genomes Project Transforming Healthcare. nameOfConference

    DOI: doi

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  • Noordam R, Sitlani CM, Avery CL et al. (2016). A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.. nameOfConference


  • Carss KJ, Arno G, Erwood M et al. (2017). Comprehensive Rare Variant Analysis via Whole-Genome Sequencing to Determine the Molecular Pathology of Inherited Retinal Disease. nameOfConference


  • MUNROE PB (2016). Trans-ancestry meta-analyses identify novel rare and common variants associated with blood pressure and hypertension. nameOfConference


  • Ng FL, Boedtkjer E, Ye S et al. (2016). LBOS 02-04 BLOOD PRESSURE-ASSOCIATED POLYMORPHISMS IN SLC4A7 (SODIUM/BICARBONATE CO-TRANSPORTER NBCn1) ARE LINKED TO GENE EXPRESSION AND INTRACELLULAR pH REGULATION. nameOfConference


  • Postmus I, Warren HR, Trompet S et al. (2016). Meta-analysis of genome-wide association studies of HDL cholesterol response to statins.. nameOfConference


  • Ng F, Bødtkjer E, Caulfield MJ et al. (2016). [OP.7C.02] BLOOD PRESSURE-ASSOCIATED POLYMORPHISMS IN SLC4A7 (SODIUM/BICARBONATE CO-TRANSPORTER NBCN1) ARE LINKED WITH GENE EXPRESSION AND INTRACELLULAR PH REGULATION. nameOfConference


  • Ren M, Ng F, Witkowska K et al. (2016). [OP.7C.08] BLOOD-PRESSURE ASSOCIATED VARIANTS IN NPR3 AFFECT HUMAN VASCULAR SMOOTH MUSCLE CELLS PROLIFERATION AND CALCIUM RESPONSE TO ANGIOTENSIN II. nameOfConference


  • Zhang R, Witkowska K, Afonso Guerra-Assunção J et al. (2016). A blood pressure-associated variant of the SLC39A8 gene influences cellular cadmium accumulation and toxicity.. nameOfConference


  • Kanoni S, Masca NGD, Stirrups KE et al. (2016). Analysis with the exome array identifies multiple new independent variants in lipid loci. nameOfConference


  • Yang W, Ng FL, Chan K et al. (2016). Coronary-Heart-Disease-Associated Genetic Variant at the COL4A1/COL4A2 Locus Affects COL4A1/COL4A2 Expression, Vascular Cell Survival, Atherosclerotic Plaque Stability and Risk of Myocardial Infarction. nameOfConference


  • Bodea CA, Neale BM, Ripke S et al. (2016). A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies. nameOfConference


    QMRO: qmroHref
  • Leusink M, der Zee AHM-V, Ding B et al. (2016). A genetic risk score is associated with statin-induced low-density lipoprotein cholesterol lowering. nameOfConference


  • Diver LA, MacKenzie SM, Fraser R et al. (2016). Common Polymorphisms at the CYP17A1 Locus Associate With Steroid Phenotype: Support for Blood Pressure Genome-Wide Association Study Signals at This Locus.. nameOfConference


    QMRO: qmroHref
  • Lessard S, Manning AK, Low-Kam C et al. (2016). Testing the role of predicted gene knockouts in human anthropometric trait variation. nameOfConference


  • Burchell AE, Chan K, Ratcliffe LEK et al. (2016). Controversies Surrounding Renal Denervation: Lessons Learned From Real‐World Experience in Two United Kingdom Centers. nameOfConference


    QMRO: qmroHref
  • Sharp ASP, Davies JE, Lobo MD et al. (2016). Renal artery sympathetic denervation: observations from the UK experience. nameOfConference


  • Pattaro C, Teumer A, Gorski M et al. (publicationYear). Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. nameOfConference


  • Ng FL, Boedtkjer E, Ye S et al. (2016). Blood pressure-associated polymorphisms in SLC4A7 (sodium/bicarbonate co-transporter NBCn1) are linked to gene expression and intracellular pH (pHi) regulation. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Evangelou E, Warren H, Cabrera C et al. (2016). UK Biobank GWAS Identifies over 100 Novel Variants Associated with Blood Pressure. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Doyle JJ, Doyle AJ, Wilson NK et al. (2015). A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Williams B, Morant SV et al. (2016). Effect of amiloride, or amiloride plus hydrochlorothiazide, versus hydrochlorothiazide on glucose tolerance and blood pressure (PATHWAY-3): a parallel-group, double-blind randomised phase 4 trial. nameOfConference


  • Wain LV, Shrine N, Miller S et al. (2015). Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. nameOfConference


    QMRO: qmroHref
  • Williams B, MacDonald TM, Morant S et al. (2015). Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial. nameOfConference


  • Ren M, Ng FL, Witkowska K et al. (2015). Abstract P048: Blood-Pressure Associated Variants in Natriuretic Peptide Receptor C Affect Human Vascular Smooth Muscle Cells Proliferation and Calcium Flux in Response to Angiotensin II. nameOfConference


    QMRO: qmroHref
  • Treibel TA, Zemrak F, Sado DM et al. (2015). Extracellular volume quantification in isolated hypertension - changes at the detectable limits?. nameOfConference


  • Brown MJ, Williams B, MacDonald TM et al. (2015). Comparison of single and combination diuretics on glucose tolerance (PATHWAY-3): protocol for a randomised double-blind trial in patients with essential hypertension. nameOfConference


  • MacDonald TM, Williams B, Caulfield M et al. (2015). Monotherapy versus dual therapy for the initial treatment of hypertension (PATHWAY-1): a randomised double-blind controlled trial. nameOfConference


    QMRO: qmroHref
  • Williams B, MacDonald TM, Caulfield M et al. (2015). Prevention And Treatment of Hypertension With Algorithm-based therapy (PATHWAY) number 2: protocol for a randomised crossover trial to determine optimal treatment for drug-resistant hypertension. nameOfConference


    QMRO: qmroHref
  • Joshi PK, Esko T, Mattsson H et al. (2015). Directional dominance on stature and cognition in diverse human populations. nameOfConference


  • Juhasz A, Collier D, Caulfield M et al. (2015). Achievement of Blood Pressure Targets and Safety of Azilsartan Medoxomil/Chlorthalidone Fixed Dose Combination versus Azilsartan Medoxomil in Hypertensive Patients Uncontrolled on Monotherapy. nameOfConference


    QMRO: qmroHref
  • Khanji M, Balawon A, Boubertakh R et al. (2015). LB01.07. nameOfConference


  • Zhang R, Witkowska K, Ng F et al. (2015). LB03.08. nameOfConference


  • Ren M, Ng F, Witkowska K et al. (2015). PP.LB03.07. nameOfConference


    QMRO: qmroHref
  • Yousaf N, Low WY, Onipinla A et al. (2015). Differences between disease-associated endoplasmic reticulum aminopeptidase 1 (ERAP1) isoforms in cellular expression, interactions with tumour necrosis factor receptor 1 (TNF-R1) and regulation by cytokines. nameOfConference


    QMRO: qmroHref
  • Poulter NR, Prabhakaran D, Caulfield M (2015). Hypertension. nameOfConference


    QMRO: qmroHref
  • Huffman JE, Albrecht E, Teumer A et al. (publicationYear). Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans. nameOfConference


  • Padmanabhan S, Caulfield M, Dominiczak AF (2015). Genetic and Molecular Aspects of Hypertension. nameOfConference


  • Mega JL, Stitziel NO, Smith JG et al. (2015). Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials. nameOfConference


    QMRO: qmroHref
  • Kapil V, Khambata RS, Robertson A et al. (2015). Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: A randomized, phase 2, double-blind, placebo-controlled study. nameOfConference


  • Locke AE, Kahali B, Berndt SI et al. (2015). Genetic studies of body mass index yield new insights for obesity biology. nameOfConference


  • Shungin D, Winkler TW, Croteau-Chonka DC et al. (2015). New genetic loci link adipose and insulin biology to body fat distribution. nameOfConference


  • Cabrera CP, Ng FL, Warren HR et al. (2015). Exploring hypertension genome‐wide association studies findings and impact on pathophysiology, pathways, and pharmacogenetics. nameOfConference


    QMRO: qmroHref
  • Ren M, Ng FL, Witkowska K et al. (2015). Blood-pressure associated variants in NPR3 affect human vascular smooth muscle cells proliferation and calcium response to angiotensin II. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Witkowska K, Ren M, Caulfield M (2015). Chapter 23 Genetic Markers in Prediction of Cardiovascular Disease. nameOfConference


    QMRO: qmroHref
  • Witkowska K, Ren M, Caulfield M (2015). Genetic Markers in Prediction of Cardiovascular Disease. nameOfConference


    QMRO: qmroHref
  • Zhang R, Witkowska K, Ng FL et al. (2015). Hypertension related variant of SLC39A8 gene influences cadmium uptake and cell toxicity. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Warren H, Sever P, Poulter N et al. (2015). Pharmacogenetic GWAS meta-analysis of response to antihypertensive drugs. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Warren H, Sever P, Poulter N et al. (2015). Pharmacogenetic Meta-Analysis of Response to Antihypertensive Drugs within ASCOT. nameOfConference

    DOI: doi

  • Rautanen A, Mills TC, Gordon AC et al. (2015). Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study. nameOfConference


    QMRO: qmroHref
  • Lobo MD, de Belder MA, Cleveland T et al. (2015). Joint UK societies’ 2014 consensus statement on renal denervation for resistant hypertension. nameOfConference


  • Kapil V, Khambata RS, Robertson A et al. (2015). Dietary Nitrate Provides Sustained Blood Pressure Lowering in Hypertensive Patients. nameOfConference


    QMRO: qmroHref
  • Wood AR, Esko T, Yang J et al. (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. nameOfConference


    QMRO: qmroHref
  • Wood AR, Esko T, Yang J et al. (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. nameOfConference


  • Moyes AJ, Khambata RS, Villar I et al. (2014). Endothelial C-type natriuretic peptide maintains vascular homeostasis.. nameOfConference


  • Postmus I, Trompet S, Deshmukh HA et al. (2014). Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. nameOfConference


  • Arking DE, Pulit SL, Crotti L et al. (2014). Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.. nameOfConference


  • Hoggart CJ, Venturini G, Mangino M et al. (publicationYear). Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index. nameOfConference


    QMRO: qmroHref
  • Ganesh SK, Chasman DI, Larson MG et al. (2014). Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations. nameOfConference


    QMRO: qmroHref
  • Ganesh SK, Chasman DI, Larson MG et al. (2014). Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations.. nameOfConference


    QMRO: qmroHref
  • Mancia G, van Zwieten PA (publicationYear). ANTIHYPERTENSIVE TREATMENT STRATEGIES. nameOfConference


    QMRO: qmroHref
  • Padmanabhan S, Caulfield M, Dominiczak AF (publicationYear). GENETIC BASIS OF BLOOD PRESSURE AND HYPERTENSION. nameOfConference


    QMRO: qmroHref
  • Rapsomaniki E, Timmis A, George J et al. (2014). Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people.. nameOfConference


    QMRO: qmroHref
  • Tragante V, Barnes MR, Ganesh SK et al. (2014). Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci.. nameOfConference


  • Saxena M, Jain A, Mathur A et al. (2014). Early reduction in blood pressure and heart rate variability following multielectrode radio-frequency renal denervation in medicines intolerant patients. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Mahajan A, Go MJ, Zhang W et al. (2014). Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. nameOfConference


    QMRO: qmroHref
  • Burchell A, Chan K, Ratcliffe L et al. (2014). Highly variable response to renal denervation for resistant hypertension - real world experience from 2 UK centres. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Caulfield M (2014). Home Blood Pressure Monitoring: New Evidence for an Expanded Role. nameOfConference


  • Postmus I, Trompet S, Warren HR et al. (2014). Pharmacogenetic GWAS meta-analysis of LDL cholesterol response to statins. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Dobson RJB, Munroe PB, Caulfield MJ et al. (2014). Protein interaction networks associated with cardiovascular disease and cancer: exploring the effect of bias on shared network properties. nameOfConference


    QMRO: qmroHref
  • Thorgeirsson TE, Gudbjartsson DF, Sulem P et al. (2013). A common biological basis of obesity and nicotine addiction. nameOfConference


    QMRO: qmroHref
  • Yadav S, Cotlarciuc I, Munroe PB et al. (2013). Genome-wide analysis of blood pressure variability and ischemic stroke.. nameOfConference


    QMRO: qmroHref
  • Shah T, Engmann J, Dale C et al. (publicationYear). Correction: Population Genomics of Cardiometabolic Traits: Design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium. nameOfConference


    QMRO: qmroHref
  • Shah T, Engmann J, Dale C et al. (2013). Population Genomics of Cardiometabolic Traits: Design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium. nameOfConference


  • Caulfield M (2013). Advances in genomics of blood pressure—time for translation. nameOfConference


    QMRO: qmroHref
  • Hu Y-J, Berndt SI, Gustafsson S et al. (2013). Meta-analysis of Gene-Level Associations for Rare Variants Based on Single-Variant Statistics. nameOfConference


    QMRO: qmroHref
  • Ganesh SK, Tragante V, Guo W et al. (2013). Loci influencing blood pressure identified using a cardiovascular gene-centric array. nameOfConference


    QMRO: qmroHref
  • Randall JC, Winkler TW, Kutalik Z et al. (2013). Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits. nameOfConference


  • Hall AS, Newby DE, Gale CP et al. (2013). 027 THE IMPACT OF STRATEGIC UK NATIONAL HEALTH SERVICE (NHS) FUNDING ON THE PATIENT RECRUITMENT TO ‘ATHEROTHROMBOSIS’ RESEARCH STUDIES. THE UK NHS ATHEROTHROMBOSIS RESEARCH NETWORK. nameOfConference


    QMRO: qmroHref
  • Pu X, Xiao Q, Kiechl S et al. (2013). YIA3: ADAMTS7 CLEAVAGE AND VASCULAR SMOOTH MUSCLE CELL MIGRATION IS AFFECTED BY A CORONARY ARTERY DISEASE ASSOCIATED VARIANT. nameOfConference


    QMRO: qmroHref
  • Munroe PB, Barnes MR, Caulfield MJ (2013). Advances in blood pressure genomics.. nameOfConference


    QMRO: qmroHref
  • Ghosh SM, Kapil V, Fuentes-Calvo I et al. (2013). Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential.. nameOfConference


    QMRO: qmroHref
  • Huertas-Vazquez A, Nelson CP, Guo X et al. (2013). Novel Loci Associated with Increased Risk of Sudden Cardiac Death in the Context of Coronary Artery Disease. nameOfConference


    QMRO: qmroHref
  • Ehret GB, Caulfield MJ (2013). Genes for blood pressure: an opportunity to understand hypertension. nameOfConference


    QMRO: qmroHref
  • Pu X, Xiao Q, Kiechl S et al. (2013). ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant. nameOfConference


    QMRO: qmroHref
  • Pu X, Xiao Q, Kiechl S et al. (2013). ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant.. nameOfConference


    QMRO: qmroHref
  • Vimaleswaran KS, Berry DJ, Lu C et al. (2013). Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts. nameOfConference


    QMRO: qmroHref
  • Köttgen A, Albrecht E, Teumer A et al. (2013). Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. nameOfConference


    QMRO: qmroHref
  • Treibel TA, Zemrak F, White SK et al. (2013). Diffuse interstitial fibrosis in well-controlled hypertension. nameOfConference


    QMRO: qmroHref
  • Treibel TA, White SK, Sado D et al. (2013). Interstitial expansion in pressure overload left ventricular hypertrophy. nameOfConference


    QMRO: qmroHref
  • Alvarez-Madrazo S, MacKenzie SM, Davies E et al. (2013). Common Polymorphisms in the CYP11B1 and CYP11B2 Genes: Evidence for a Digenic Influence on Hypertension. nameOfConference


    QMRO: qmroHref
  • Koettgen A, Albrecht E, Teumer A et al. (2013). Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. nameOfConference


    QMRO: qmroHref
  • Berndt SI, Gustafsson S, Maegi R et al. (2013). Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. nameOfConference


    QMRO: qmroHref
  • Ganesh SK, Tragante V, Guo W et al. (2013). Loci influencing blood pressure identified using a cardiovascular gene-centric array. nameOfConference


    QMRO: qmroHref
  • Robinson PJ, Ng FL, Lobo MD et al. (2013). Phaeochromocytoma-paraganglioma syndrome presenting as a para-renal mass: A case report. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Postmus I, Trompet S, Warren H et al. (2013). Pharmacogenetic GWAS Meta-Analysis of LDL Cholesterol Response to Statins. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Huang C, Ng F, Kapil V et al. (2013). Prognostic significance of short term blood pressure variability in a tertiary referral centre population. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • O'Byrne S, Caulfield M (1998). Genetics of Hypertension. nameOfConference


    QMRO: qmroHref
  • Eyre S, Bowes J, Diogo D et al. (2012). High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. nameOfConference


    QMRO: qmroHref
  • Jostins L, Ripke S, Weersma RK et al. (2012). Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease. nameOfConference


    QMRO: qmroHref
  • Guo Y, Lanktree MB, Taylor KC et al. (2013). Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals. nameOfConference


    QMRO: qmroHref
  • Motterle A, Pu X, Wood H et al. (2012). Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells.. nameOfConference


    QMRO: qmroHref
  • Scott RA, Lagou V, Welch RP et al. (2012). Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. nameOfConference


    QMRO: qmroHref
  • Okada Y, Sim X, Go MJ et al. (2012). Meta-analysis identifies multiple loci associated with kidney function–related traits in east Asian populations. nameOfConference


    QMRO: qmroHref
  • Lanktree MB, Guo Y, Murtaza M et al. (2012). Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. nameOfConference


    QMRO: qmroHref
  • Louis-Dit-Picard H, Barc J, Trujillano D et al. (2012). Erratum: KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron. nameOfConference


    QMRO: qmroHref
  • Saxena R, Elbers CC, Guo Y et al. (2012). Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci. nameOfConference


    QMRO: qmroHref
  • Dastani Z, Hivert M-F, Timpson N et al. (2012). Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals. nameOfConference


    QMRO: qmroHref
  • Angelakopoulou A, Shah T, Sofat R et al. (2012). Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration.. nameOfConference


    QMRO: qmroHref
  • Salvi E, Kutalik Z, Glorioso N et al. (2012). Genomewide association study using a high-density single nucleotide polymorphism array and case-control design identifies a novel essential hypertension susceptibility locus in the promoter region of endothelial NO synthase.. nameOfConference


    QMRO: qmroHref
  • Motterle A, Xiao Q, Kiechl S et al. (2012). Influence of matrix metalloproteinase-12 on fibrinogen level.. nameOfConference


    QMRO: qmroHref
  • Louis-Dit-Picard H, Barc J, Trujillano D et al. (2012). KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron. nameOfConference


    QMRO: qmroHref
  • Maller JB, McVean G, Byrnes J et al. (2012). Bayesian refinement of association signals for 14 loci in 3 common diseases. nameOfConference


    QMRO: qmroHref
  • Choi H, Plenge RM, Koettgen A et al. (2012). Genetic Variants of Serum Uric Acid and Gout: An Analysis of > 170,000 Individuals. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Islam M, Jafar T, Wood A et al. (2012). Genetic risk scores are associated with diabetes related traits in South Asians and provide tools for Mendelian randomization studies. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Caulfield M (2012). Genetics of Blood Pressure. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Surendran P, Vangjeli C, McCarthy N et al. (2012). Genome-wide association analysis identifies the MTHFR-CLCN6-NPPA-NPPB gene cluster as an important influence on BNP levels-implications for the use of BNP levels in the diagnosis and therapeutic monitoring of heart failure-an ASCOT sub study. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Deshmukh HA, Colhoun HM, Johnson T et al. (2012). Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a). nameOfConference


    QMRO: qmroHref
  • Saxena R, Elbers CC, Guo Y et al. (2012). Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci. nameOfConference


    QMRO: qmroHref
  • Asselbergs FW, Guo Y, van Iperen EPA et al. (2012). Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci. nameOfConference


    QMRO: qmroHref
  • Scott RA, Lagou V, Welch RP et al. (2012). Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. nameOfConference


    QMRO: qmroHref
  • Islam M, Jafar TH, Wood AR et al. (2012). Multiple genetic variants explain measurable variance in type 2 diabetes-related traits in Pakistanis. nameOfConference


    QMRO: qmroHref
  • Doyle AJ, Doyle JJ, Bessling SL et al. (2012). Mutations in the TGF-β repressor SKI cause Shprintzen-Goldberg syndrome with aortic aneurysm. nameOfConference


    QMRO: qmroHref
  • McManus RJ, Caulfield M, Williams B (2012). NICE hypertension guideline 2011: evidence based evolution. nameOfConference


    QMRO: qmroHref
  • Saxena M, Collier D, Caulfield M et al. (2012). Patients with resistant hypertension warrant a trial of salt restriction before and after renal denervation (RD). nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Chan K, Ng FL, Saxena M et al. (2012). Renal denervation in resistant hypertension-a prospective case series. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Johnson T, Gaunt TR, Newhouse SJ et al. (2011). Blood pressure loci identified with a gene-centric array.. nameOfConference


    QMRO: qmroHref
  • Bown MJ, Jones GT, Harrison SC et al. (2011). Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1. nameOfConference


    QMRO: qmroHref
  • Chambers JC, Zhang WH, Sehmi J et al. (2011). Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. nameOfConference


    QMRO: qmroHref
  • Heid IM, Jackson AU, Randall JC et al. (2011). Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. nameOfConference


    QMRO: qmroHref
  • Williams B, Krause T, Lovibond K et al. (2011). Authors’ reply to Harding and colleagues, Taylor, Cruickshank, and El Turabi and Payne. nameOfConference


    QMRO: qmroHref
  • Wain LV, Verwoert GC, O'Reilly PF et al. (2011). A large genome-wide association study of pulse pressure and mean arterial pressure reveals seven novel blood pressure LOCI. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Lovibond K, Jowett S, Barton P et al. (2011). Cost-effectiveness of options for the diagnosis of high blood pressure in primary care: a modelling study. nameOfConference


    QMRO: qmroHref
  • Michell AR, Bodey AR, Caulfield M (2011). Evolution, essential hypertension and the high arterial pressures in certain athletic breeds of dogs (vol 188, pg 125, 2011). nameOfConference


    QMRO: qmroHref
  • Wain LV, Verwoert GC, O'Reilly PF et al. (2011). Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. nameOfConference


  • Kooner JS, Saleheen D, Sim X et al. (2011). Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. nameOfConference


    QMRO: qmroHref
  • McCarthy N, Vangjeli C, Surendran P et al. (2011). PPARGC1 beta is a genetic determinant of the cardiovascular risk factor, Thromboxane A2-an Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) sub-study. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Patel S, Ng FL, Uddin I et al. (2011). Plasma renin activity in the South Asian population-an intermediate group. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Patel S, Ng FL, Uddin I et al. (2011). Salt intake in hypertensive patients with at or above-target blood pressures. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Ehret G, Munroe PB, Rice K et al. (2011). Sixteen novel loci influence blood pressure and cardiovascular risk. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • International Consortium for Blood Pressure Genome-Wide Association Studies, Ehret GB, Munroe PB et al. (2011). Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.. nameOfConference


  • Krause T, Lovibond K, Caulfield M et al. (2011). GUIDELINES Management of hypertension: summary of NICE guidance. nameOfConference


    QMRO: qmroHref
  • Putku M, Kepp K, Org E et al. (2011). Novel polymorphic AluYb8 insertion in the WNK1 gene is associated with blood pressure variation in Europeans.. nameOfConference


    QMRO: qmroHref
  • Fox ER, Young JH, Li YL et al. (2011). Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. nameOfConference


    QMRO: qmroHref
  • Fox ER, Young JH, Li Y et al. (2011). Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study.. nameOfConference


    QMRO: qmroHref
  • Hughes R, Lovibond K, Caulfield M et al. (2011). TREATING HYPERTENSION WITH FIRST-LINE THERAPIES IS CHEAPER THAN DOING NOTHING. nameOfConference


    QMRO: qmroHref
  • Johnson AD, Newton-Cheh C, Chasman DI et al. (2011). Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals.. nameOfConference


    QMRO: qmroHref
  • Michell AR, Bodey AR, Caulfield M (2011). Evolution, essential hypertension and the high arterial pressures in certain athletic breeds of dogs. nameOfConference


    QMRO: qmroHref
  • Peden JF, Hopewell JC, Saleheen D et al. (2011). A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. nameOfConference


    QMRO: qmroHref
  • Collier DJ, Poulter NR, Dahlöf B et al. (2011). Impact of amlodipine-based therapy among older and younger patients in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA).. nameOfConference


    QMRO: qmroHref
  • Collier DJ, Poulter NR, Dahlöf B et al. (2011). Impact of atorvastatin among older and younger patients in the Anglo-Scandinavian Cardiac Outcomes Trial Lipid-Lowering Arm.. nameOfConference


    QMRO: qmroHref
  • Lanktree MB, Guo YR, Murtaza M et al. (2011). Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. nameOfConference


    QMRO: qmroHref
  • Chapman N, Chang CL, Caulfield M et al. (2011). ETHNIC VARIATIONS IN LIPID-LOWERING IN RESPONSE TO A STATIN (EVIREST): A SUBSTUDY OF THE ANGLO-SCANDINAVIAN CARDIAC OUTCOMES TRIAL (ASCOT). nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Esler MD, Krum H, Sobotka PA et al. (2010). Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. nameOfConference


    QMRO: qmroHref
  • Sotoodehnia N, Isaacs A, de Bakker PIW et al. (2010). Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. nameOfConference


  • Speliotes EK, Willer CJ, Berndt SI et al. (2010). Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.. nameOfConference


    QMRO: qmroHref
  • Tabara Y, Kohara K, Kita Y et al. (2010). Common variants in the ATP2B1 gene are associated with susceptibility to hypertension: the Japanese Millennium Genome Project.. nameOfConference


    QMRO: qmroHref
  • Heid IM, Jackson AU, Randall JC et al. (2010). Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.. nameOfConference


    QMRO: qmroHref
  • Padmanabhan S, Melander O, Johnson T et al. (2010). Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension.. nameOfConference


  • Allen HL, Estrada K, Lettre G et al. (2010). Hundreds of variants clustered in genomic loci and biological pathways affect human height. nameOfConference


    QMRO: qmroHref
  • Johnson T, Shaw-Hawkins S, Howard P et al. (2010). A novel gene locus for blood pressure variability identified by genomewide association scanning in the Anglo-Scandinavian Cardiac Outcome Trial. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Hastie CE, Padmanabhan S, Melander O et al. (2010). Genome wide association study of blood pressure extremes identifies variant in uromodulin gene associated with hypertension. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Collier DJ, Robson J, Scott R et al. (2010). HiLo: a health services intervention study: methods and interim results on the first 2000 patients at 1 year. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Gupta AK, Poulter NR, Dobson J et al. (2010). Ethnic Differences in Blood Pressure Response to First and Second-Line Antihypertensive Therapies in Patients Randomized in the ASCOT Trial. nameOfConference


    QMRO: qmroHref
  • Teslovich TM, Musunuru K, Smith AV et al. (2010). Biological, clinical and population relevance of 95 loci for blood lipids. nameOfConference


    QMRO: qmroHref
  • Caulfield M (2010). The 10 minute clinical assessment. nameOfConference


    QMRO: qmroHref
  • Dolan E, Caulfield M, Thom S et al. (2010). AMBULATORY ARTERIAL STIFFNESS INDEX PREDICTS CARDIOVASCULAR MORBIDITY AND MORTALITY IN TREATED HYPERTENSIVE PATIENTS - AN ANGLO - SCANDINAVIAN CARDIAC OUTCOME TRIAL SUB-STUDY. nameOfConference


    QMRO: qmroHref
  • Padmanabhan S, Melander O, Johnson T et al. (2010). GENOME WIDE ASSOCIATION STUDY OF BLOOD PRESSURE EXTREMES IDENTIFIES VARIANT IN UMOD ASSOCIATED WITH HYPERTENSION. nameOfConference


    QMRO: qmroHref
  • Alvarez-Madrazo S, Padmanabhan S, Friel E et al. (2010). Validation of Association of Hypertension at the CYP11B1/B2 Locus in Caucasians.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Mancia G, Laurent S, Agabiti-Rosei E et al. (2010). European guidelines on the management of hypertension: The European Society of Hypertension position statement (2009). nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Chambers JC, Zhang WH, Lord GM et al. (2010). Genetic loci influencing kidney function and chronic kidney disease. nameOfConference


    QMRO: qmroHref
  • Liu JZ, Tozzi F, Waterworth DM et al. (2010). Meta-analysis and imputation refines the association of 15q25 with smoking quantity. nameOfConference


    QMRO: qmroHref
  • Lindgren CM, Heid IM, Randall JC et al. (2010). Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution. nameOfConference


    QMRO: qmroHref
  • Craddock N, Hurles ME, Cardin N et al. (2010). Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. nameOfConference


  • van der Harst P, Bakker SJL, de Boer RA et al. (2010). Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms. nameOfConference


    QMRO: qmroHref
  • Talmud PJ, Drenos F, Shah S et al. (2009). Gene-centric Association Signals for Lipids and Apolipoproteins Identified via the HumanCVD BeadChip. nameOfConference


    QMRO: qmroHref
  • Munroe PB, Johnson T, Caulfield MJ (2009). The genetic architecture of blood pressure variation. nameOfConference


    QMRO: qmroHref
  • Mancia G, Laurent S, Agabiti-Rosei E et al. (2009). Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document. nameOfConference


    QMRO: qmroHref
  • Vidyarthi M, Balakumar Y, Perry I et al. (2009). Hypokalaemic hypertension due to a rare cause. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Dobson RJB, Munroe PB, Caulfield MJ et al. (publicationYear). Global sequence properties for superfamily prediction: a machine learning approach.. nameOfConference


    QMRO: qmroHref
  • Caulfield M (2009). Atheromatous vascular disease and ischaemic stroke in the UK. nameOfConference


    QMRO: qmroHref
  • Caulfield M (2009). PREDICTION OF ANTIHYPERTENSIVE RESPONSE - GENOTYPE. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Nolte IM, Wallace C, Newhouse SJ et al. (publicationYear). Common Genetic Variation Near the Phospholamban Gene Is Associated with Cardiac Repolarisation: Meta-Analysis of Three Genome-Wide Association Studies. nameOfConference


    QMRO: qmroHref
  • Sõber S, Org E, Kepp K et al. (publicationYear). Targeting 160 Candidate Genes for Blood Pressure Regulation with a Genome-Wide Genotyping Array. nameOfConference


  • Org E, Eyheramendy S, Juhanson P et al. (2009). Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations. nameOfConference


    QMRO: qmroHref
  • Caulfield MJ, Bochud M, Global BP Gen (2009). EIGHT BLOOD PRESSURE LOCI IDENTIFIED BY A GENOME-WIDE ASSOCIATION STUDY OF 34,433 PEOPLE OF EUROPEAN ANCESTRY. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Lindgren CM, Heid IM, Randall JC et al. (2009). Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution. nameOfConference


  • Newton-Cheh C, Johnson T, Gateva V et al. (2009). Genome-wide association study identifies eight loci associated with blood pressure. nameOfConference


    QMRO: qmroHref
  • Kolz M, Johnson T, Sanna S et al. (2009). Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations. nameOfConference


  • Newhouse S, Farrall M, Wallace C et al. (2009). Polymorphisms in the WNK1 Gene Are Associated with Blood Pressure Variation and Urinary Potassium Excretion. nameOfConference


  • Dolan E, Stanton AV, Thom S et al. (2009). Ambulatory blood pressure monitoring predicts cardiovascular events in treated hypertensive patients - an Anglo-Scandinavian cardiac outcomes trial substudy. nameOfConference


    QMRO: qmroHref
  • Collier DJ, Stride TJ, He S et al. (2009). Impact of Lifestyle Changes During Five Years of Drug Treatment in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Mancia G, Laurent S, Agabiti-Rosei E et al. (2009). Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document. nameOfConference


    QMRO: qmroHref
  • Willer CJ, Speliotes EK, Loos RJF et al. (2009). Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. nameOfConference


    QMRO: qmroHref
  • JENKINS BJ, CAULFIELD MJ, FOWLER CG et al. (1988). Reappraisal of the Role of Radical Radiotherapy and Salvage Cystectomy in the Treatment of Invasive (T2/T3) Bladder Cancer. nameOfConference


    QMRO: qmroHref
  • Ostergren J, Poulter NR, Sever PS et al. (2008). The Anglo-Scandinavian Cardiac Outcomes Trial: blood pressure-lowering limb: effects in patients with type II diabetes. nameOfConference


    QMRO: qmroHref
  • Samani NJ, Braund PS, Erdmann J et al. (2008). The novel genetic variant predisposing to coronary artery disease in the region of the PSRC1 and CELSR2 genes on chromosome 1 associates with serum cholesterol. nameOfConference


    QMRO: qmroHref
  • Keating BJ, Tischfield S, Murray SS et al. (2008). Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies. nameOfConference


  • Gupta AK, Poulter NR, Eldridge S et al. (2008). Ethnic differences in blood pressure response to atenolol and amlodipine monotherapy and to add on diuretic and ACE inhibitor dual therapy in hypertensive patients from UK in ASCOT-BPLA. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Huq SM, Oldapo MNJ, Wang Y et al. (2008). High glucose and low lactate: a metabolic signature of hypertension in human serum?. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Caulfield MJ, Munroe PB, O'Neill D et al. (2008). SLC2A9 Is a High-Capacity Urate Transporter in Humans. nameOfConference


  • Brown MJ, Newhouse S, Wallace C et al. (2008). Systematic analysis of 123 candidate genes reveals two novel genes for hypertension. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Hoti M, Newhouse S, Clayton D et al. (2008). WNK1 - functional analyses of variants associated with blood pressure and essential hypertension. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Hoti M, Newhouse S, Clayton D et al. (2008). WNK1-functional analyses of variants associated with blood pressure and essential hypertension. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Delles C, Padmanabhan S, Lee WK et al. (2008). Glutathione S-transferase variants and hypertension. nameOfConference


    QMRO: qmroHref
  • Tobin MD, Tomaszewski M, Braund PS et al. (2008). Common variants in genes underlying monogenic hypertension and hypotension and blood pressure in the general population. nameOfConference


    QMRO: qmroHref
  • Tomaszewski M, Tobin MD, Braund PS et al. (2008). Common variants in the gene underlying type 2 Bartter syndrome are associated with blood pressure in the general population - The results of the genetic scan in the GRAPHIC (genetic regulation of arterial pressure of humans in the community) study. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Loos RJF, Lindgren CM, Li SX et al. (2008). Common variants near MC4R are associated with fat mass, weight and risk of obesity. nameOfConference


    QMRO: qmroHref
  • Weedon MN, Lango H, Lindgren CM et al. (2008). Genome-wide association analysis identifies 20 loci that influence adult height. nameOfConference


    QMRO: qmroHref
  • Johnston L, Caulfield M, Savage M et al. (1999). NESTEGG: detecting new genes that influence fetal and childhood growth. nameOfConference


    QMRO: qmroHref
  • Sever PS, Poulter NR, Dahlof B et al. (2008). The Anglo-Scandinavian Cardiac Outcomes Trial lipid lowering arm: extended observations 2 years after trial closure. nameOfConference


    QMRO: qmroHref
  • Johnston L, Ester W, Koelega AH et al. (2008). Analysis of GDF5-UQCC polymorphism with height in NESTEGG SGA and ISS subjects. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Dobson RJB, Munroe PB, Mein CA et al. (2008). Combining protein-protein interaction (PPI) network and sequence attributes for predicting hypertension related proteins. nameOfConference


    QMRO: qmroHref
  • Doblado M, Munroe PB, O'Neill D et al. (2008). Functional studies identify a glucose transporter SLC2A9 as a novel urate transporter. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Wallace C, Newhouse SJ, Braund P et al. (2008). Genome-wide association study identifies genes for biomarkers of cardiovascular disease: Serum urate and dyslipiclemia. nameOfConference


    QMRO: qmroHref
  • Freel EM, Ingram M, Friel EC et al. (2007). Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study. nameOfConference


    QMRO: qmroHref
  • Wallace C, Newhouse SJ, Braund P et al. (2007). Discovery of novel genes for serum urate and low-density lipoprotein cholesterol - Two biomarkers of cardiovascular disease. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Newhouse SJ, Wallace C, Hoti M et al. (2007). Novel associations of the Wnk1 gene with risk for essential hypertension and electrolyte homeostasis. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Barter PJ, Caulfield M, Eriksson M et al. (2007). Effects of torcetrapib in patients at high risk for coronary events. nameOfConference


    QMRO: qmroHref
  • Thomson W, Barton A, Ke X et al. (2007). Rheumatoid arthritis association at 6q23. nameOfConference


    QMRO: qmroHref
  • Newport M, Sirugo G, Lyons E et al. (2007). Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. nameOfConference


    QMRO: qmroHref
  • HITMAN GA, Todd JA, Samani NJ et al. (2007). Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.. nameOfConference


    QMRO: qmroHref
  • Wallace C, Dobson RJ, Munroe PB et al. (2007). Information capture using SNPs from HapMap and whole-genome chips differs in a sample of inflammatory and cardiovascular gene-centric regions from genome-wide estimates.. nameOfConference


    QMRO: qmroHref
  • Padmanabhan S, Davies E, MacKenzie SM et al. (2007). Association of the CYP11B1 and CYP11B2 gene polymorphisms with hypertension in the British Genetics of Hypertension case-control study. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Newhouse S, Wallace C, Hoti M et al. (2007). Association of the WNK1 gene with essential hypertension, blood pressure variability and serum and urine electrolytes. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Collier DJ, Davies LC, Bernardi L et al. (2007). Baroreceptor function changes with differing blood pressure treatment during the anglo-scandinavian cardiac outcomes trial: principal results from the cardiac autonomic reflex assessment trial (CARAT). nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Padmanabhan S, Menni C, Delles C et al. (2007). Urinary albumin excretion in hypertensive siblings in the British Genetics of Hypertension study. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Marcano ACB, Burke B, Gungadoo J et al. (2007). Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension. nameOfConference


    QMRO: qmroHref
  • Burton PR, Clayton DG, Cardon LR et al. (2007). Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. nameOfConference


    QMRO: qmroHref
  • Collier D, Davies L, Bernardi L et al. (2007). Baroreceptor function changes with differing blood pressure treatment during the Anglo-Scandinavian Cardiac Outcomes Trial: Principal results from the Cardiac Autonomic Reflex Assessment Trial (CARAT). nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Collier D, Arunachalam G, Johnston A et al. (2007). Continuing reduction of microalbuminuria and proteinuria during follow-up for the Anglo-Scandinavian Cardiac Outcomes Trial dominance of duration and blood pressure over other effects. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Zeggini E, Weedon MN, Lindgren CM et al. (2007). Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.. nameOfConference


    QMRO: qmroHref
  • Brown M, Boon N, Brooks N et al. (2007). Medical training in the UK: sleepwalking to disaster. nameOfConference


    QMRO: qmroHref
  • (2007). Babies, pre-eclamptic mothers and grandparents: a three-generation phenotyping study. nameOfConference


    QMRO: qmroHref
  • Brown M, Boon N, Brooks N et al. (2007). Modernising Medical Careers, Medical Training Application Service, and the Postgraduate Medical Education and Training Board: time for the emperors to don their clothes. nameOfConference


    QMRO: qmroHref
  • Burke B, Gungadoo J, Marçano ACB et al. (2007). Chapter 36 Monogenic Forms of Human Hypertension. nameOfConference


    QMRO: qmroHref
  • Burke B, Gungadoo J, Marçano ACB et al. (2007). Monogenic Forms of Human Hypertension. nameOfConference


    QMRO: qmroHref
  • Barr M, MacKenzie SM, Friel EC et al. (2007). Polymorphic variation in the 11 beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency. nameOfConference


    QMRO: qmroHref
  • CAULFIELD M, BOULOUX P, MUNROE P (1997). Progress in Determining the Genes for Hypertension, Insulin Resistance, and Dyslipidemiaa. nameOfConference


    QMRO: qmroHref
  • Mancia G, De Backer G, Dominiczak A et al. (2007). †2007 Guidelines for the management of arterial hypertension1. nameOfConference


    QMRO: qmroHref
  • Sever P, Dahlöf B, Poulter N et al. (2006). Potential synergy between lipid-lowering and blood-pressure-lowering in the Anglo-Scandinavian Cardiac Outcomes Trial. nameOfConference


    QMRO: qmroHref
  • Collier DJ, Caulfield MJ, Poulter NR et al. (2006). Did older or younger patients benefit more from amlodipine based vs atenolol based therapy in ASCOT-BPLA?. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Delles C, Braga-Marcano AC, Munroe PB et al. (2006). Association between variants of the human GSTM gene family and hypertension. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Padmanabhan S, Hastie CE, Wallace C et al. (2006). Familial atherosclerotic disease and hypertension localised to chromosome 7p in the British genetics of hypertension study. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Ostergren J, Sever P, Poulter N et al. (2006). The Anglo-Scandinavian Cardiac Outcomes Trial: Blood pressure-lowering limb (ASCOT-BPLA): effects in patients with type 2 diabetes. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Wallace C, Xue M-Z, Newhouse SJ et al. (2006). Linkage analysis using co-phenotypes in the BRIGHT study reveals novel potential susceptibility loci for hypertension.. nameOfConference


    QMRO: qmroHref
  • Munroe PB, Wallace C, Xue M-Z et al. (2006). Increased support for linkage of a novel locus on chromosome 5q13 for essential hypertension in the British Genetics of Hypertension Study.. nameOfConference


    QMRO: qmroHref
  • (2007). Corrigendum. nameOfConference


    QMRO: qmroHref
  • Padmanabhan S, Wallace C, McBride MW et al. (2006). Genomewide linkage analysis for loci affecting electrocardiographic LV mass. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Delles C, Marcano ACB, Munroe PB et al. (2006). Variants of the human mu type glutathione-s-transferase (GSTM) gene family are associated with hypertension. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Dobson RJ, Munroe PB, Caulfield MJ et al. (2006). Predicting deleterious nsSNPs: an analysis of sequence and structural attributes.. nameOfConference


  • Bell JT, Wallace C, Dobson R et al. (2006). Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension. nameOfConference


    QMRO: qmroHref
  • Padmanabhan S, Wallace C, Munroe PB et al. (2006). Chromosome 2p shows significant linkage to antihypertensive response in the British Genetics of Hypertension Study.. nameOfConference


    QMRO: qmroHref
  • Padmanabhan S, Wallace C, Munroe PB et al. (2006). Chromosome 2p shows significant linkage to antihypertensive response in the British genetics of hypertension study. nameOfConference


    QMRO: qmroHref
  • Binder A, Garcia E, Wallace C et al. (2006). Haplotypes of the beta-2 adrenergic receptor associate with high diastolic blood pressure in the Caerphilly prospective study. nameOfConference


    QMRO: qmroHref
  • Tobin MD, Raleigh SM, Newhouse S et al. (2005). Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population. nameOfConference


    QMRO: qmroHref
  • Padmanabhan S, Wallace C, Munroe PB et al. (2005). Chromosome 2p shows genome wide significant linkage to of anti-hypertensive medication response in the British genetics of hypertension (BRIGHT) study.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Wallace C, Xue MZ, Dobson R et al. (2005). Loci on chromosomes 5p and 20q are linked to multiple hypertension phenotypes in the BRItish genetics of Hypertension (BRIGHT) study. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Padmanabhan S, Munroe PB, Brown M et al. (2005). Chromosome 2p shows genome wide significant linkage to anti-hypertensive medication response in the British genetics hypertension (BRIGHT) study. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Munroe PB, Wallace C, Mein C et al. (2005). Enhanced support for linkage to chromosome 5q13.1 and hypertension in the British Genetics of Hypertension (BRIGHT) study.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Wallace C, Xue MZ, Dobson R et al. (2005). Loci on chromosomes 5p and 20q are linked to multiple hypertension phenotypes in the BRItish Genetics of HyperTension (BRIGHT) study. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Xue MZ, Wallace C, Dobson R et al. (2005). Variants and haplotypes of the angiotensinogen gene are associated with hypertension in the Caerphilly Prospective Study. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Dahlof B, Sever PS, Poulter NR et al. (2005). Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. nameOfConference


    QMRO: qmroHref
  • Poulter NR, Wedel H, Dahlof B et al. (2005). Role of blood pressure and other variables in the differential cardiovascular event rates noted in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA). nameOfConference


    QMRO: qmroHref
  • (publicationYear). Epidemiology of Hypertension. nameOfConference


    QMRO: qmroHref
  • Newhouse SJ, Wallace C, Dobson R et al. (2005). Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study.. nameOfConference


    QMRO: qmroHref
  • Marcano ACB, Onipinla AK, Caulfield MJ et al. (2005). Recent advances in the identification of genes for human hypertension.. nameOfConference


    QMRO: qmroHref
  • Consortium G (2005). Disentangling Fetal and Maternal Susceptibility for Pre-Eclampsia: A British Multicenter Candidate-Gene Study. nameOfConference


    QMRO: qmroHref
  • Sever PS, Poulter NR, Dahlof B et al. (2005). Reduction in cardiovascular events with atorvastatin in 2,532 patients with type 2 diabetes: Anglo-Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm (ASCOT-LLA). nameOfConference


    QMRO: qmroHref
  • Mein CA, Caulfield MJ, Munroe PB (2005). Selection of candidate genes in hypertension.. nameOfConference


    QMRO: qmroHref
  • Munroe PB, Dobson R, Pembroke J et al. (2004). The MRC BRIGHT study: Demographic and biochemical characteristics of the sibling-pair resource. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Lee YW, Oh VMS, Garcia E et al. (2004). Haplotypes of the beta 2-adrenegic receptor gene are associated with essential hypertension in a Singaporean Chinese population. nameOfConference


    QMRO: qmroHref
  • Newhouse S, Dobson R, Wallace C et al. (2004). No association of the WNK1 gene with essential hypertension in the MRC BRIGHT study. nameOfConference


    QMRO: qmroHref
  • Mein CA, Caulfield MJ, Dobson RJ et al. (2004). Genetics of essential hypertension. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Mein CA, Caulfield MJ, Dobson RJ et al. (2004). Genetics of essential hypertension.. nameOfConference


    QMRO: qmroHref
  • Sever PS, Dahlof B, Poulter NR et al. (2004). Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial - Lipid lowering arm (ASCOT-LLA): A multicentre randomised controlled trial. nameOfConference


    QMRO: qmroHref
  • Caulfield M, Munroe P, Pembroke J et al. (2003). Genome-wide mapping of human loci for essential hypertension. nameOfConference


    QMRO: qmroHref
  • Newhouse SJ, Garcia E, Caulfield M et al. (2003). Haplotype structure of the WNK1 gene and association studies in hypertensive populations. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Wilson S, Johnston A, Robson J et al. (2003). Comparison of methods to identify individuals at increased risk of coronary disease from the general population.. nameOfConference


    QMRO: qmroHref
  • Caulfield M, Munroe P, Pembroke J et al. (2003). Genome-wide mapping of human loci for essential hypertension.. nameOfConference


    QMRO: qmroHref
  • Sever PS, Dahlof B, Poulter NR et al. (2003). Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial. nameOfConference


    QMRO: qmroHref
  • Wilson S, Johnston A, Collier DJ et al. (2003). Feasibility of enrolling patients to hypertension outcome trials based on an assessment of their cardiovascular risk. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Wilson S, Johnston A, Robson J et al. (2003). Predicting coronary risk in the general population--is it necessary to measure high-density lipoprotein cholesterol?. nameOfConference


    QMRO: qmroHref
  • Knight J, Munroe PB, Pembroke JC et al. (2003). Human chromosome 17 in essential hypertension.. nameOfConference


    QMRO: qmroHref
  • Garcia EA, Newhouse S, Caulfield MJ et al. (2003). Genes and hypertension.. nameOfConference


    QMRO: qmroHref
  • Garcia EA, Aristizabal D, McEwen J et al. (2002). Guanine nucleotide binding 3 (GNB3) haplotype analysis in the Venecia-Colombia Latin-American blood pressure study.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Wilson S, Johnston A, Robson J et al. (2002). Should we measure high density lipoprotein cholesterol in people with hypertension?. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Caulfield M, Pembroke J, Dominiczak A et al. (2002). The MRC British Genetics of Hypertension Study - Genome-wide screen results. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Wilson S, Johnston A, Robson J et al. (2002). OR-4: Who should have their cholesterol measured? A comparison of selective cholesterol screening methods. nameOfConference


    QMRO: qmroHref
  • Collier DJ, Martin TA, Angell-James JE et al. (2002). P-334: Gender differences in carotid sinus baroreceptor reflexes in healthy young normal subjects and in ASCOT patients with treated essential hypertension. nameOfConference


    QMRO: qmroHref
  • Chapman JN, Kirby P, Caulfield MC et al. (2001). Cardiovascular risk factors in a cohort of 30 000 high-risk men and women in the UK: Cross-sectional, retrospective and prospective studies of screenees for the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). nameOfConference


    QMRO: qmroHref
  • Metherell LA, Akker SA, Munroe PB et al. (2001). Pseudoexon activation as a novel mechanism for disease resulting in atypical growth-hormone insensitivity.. nameOfConference


    QMRO: qmroHref
  • O'Brien E, McInnes GT, Stanton A et al. (2001). Ambulatory blood pressure monitoring and 24-h blood pressure control as predictors of outcome in treated hypertensive patients. nameOfConference


    QMRO: qmroHref
  • Sever PS, Dahlof B, Poulter NR et al. (2001). Anglo-Scandinavian Cardiac Outcomes Trial: a brief history, rationale and outline protocol. nameOfConference


    QMRO: qmroHref
  • Collier DJ, Bernardi L, Angell-James JE et al. (2001). Baroreflex sensitivity and heart rate variability as predictors of cardiovascular outcome in hypertensive patients with multiple risk factors for coronary disease.. nameOfConference


    QMRO: qmroHref
  • Chapman JN, Kirby P, Caulfield MC et al. (2001). Cardiovascular risk factors in a cohort of 30,000 high-risk men and women in the UK: cross-sectional, retrospective and prospective studies of screenees for the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). nameOfConference


    QMRO: qmroHref
  • Kirby PL, Caulfield MC, Collier DJ et al. (2001). Differential response to amlodipine and atenolol mono-therapy for hypertension by ethnic group.. nameOfConference


    QMRO: qmroHref
  • Poulter NR, Caulfield M, Feder G (2001). Ethnic variations in response to a statin (EVIREST). nameOfConference


    QMRO: qmroHref
  • Wilson S, Collier D, Johnston A et al. (2001). Evaluation of cardiovascular risk equations using the ASCOT cohort.. nameOfConference


    QMRO: qmroHref
  • White PC, Agarwal AK, Li AR et al. (2001). Possible association but no linkage of the HSD11B2 gene encoding the kidney isozyme of 11 beta-hydroxysteroid dehydrogenase to hypertension in Black people. nameOfConference


    QMRO: qmroHref
  • Sever PS, Dahlof B, Poulter NR et al. (2001). Rationale, design, methods and baseline demography of participants of the Anglo-Scandinavian cardiac outcomes trial. nameOfConference


    QMRO: qmroHref
  • Sever PS, Dahlöf B, Poulter NR et al. (2001). Anglo-Scandinavian cardiac outcomes trial: A brief history, rationale and outline protocol. nameOfConference


    QMRO: qmroHref
  • Caulfield MJ (2001). Genes for common diseases. nameOfConference


    QMRO: qmroHref
  • Knight J, Gardner G, Clark A et al. (2000). Investigation of chromosome 17q as a locus for human essential hypertension in African Caribbeans. nameOfConference


    QMRO: qmroHref
  • Munroe PB, Caulfield MJ (2000). Genetics of hypertension. nameOfConference


    QMRO: qmroHref
  • Munroe PB, Knight J, Caulfield MJ (2000). 1990-2000: progress in determining high blood pressure genes.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Caulfield M, Papp J, Pembroke J et al. (2000). A new tool for checks of data precision within the MRC British genetics of hypertension study. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Munroe P, Sandhu M, Jadhav D et al. (2000). No association of the epithelial sodium channel beta-subunit T594M variant with essential hypertension in an African Caribbean population. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Munroe PB, Strautnieks SS, Farrall M et al. (1998). Absence of Linkage of the Epithelial Sodium Channel to Hypertension in Black Caribbeans*. nameOfConference


    QMRO: qmroHref
  • Caulfield M, Cafferkey M (1998). Gene therapy: The possibilities and the problems. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Brand E, Chatelain N, Keavney B et al. (1998). Evaluation of the Angiotensinogen Locus in Human Essential Hypertension. nameOfConference


    QMRO: qmroHref
  • Brand E, Chatelain N, de Bruijn T et al. (1997). 1.P.377 Evaluation of the angiotensinogen locus in human essential hypertension: An European study. nameOfConference


    QMRO: qmroHref
  • Kotanko P, Binder A, Tasker J et al. (1997). Essential hypertension in African Caribbeans associates with a variant of the beta2-adrenoceptor.. nameOfConference


    QMRO: qmroHref
  • Munroe PB, Strautnieks SS, Farrall M et al. (1997). Investigation of the epithelial sodium channel (hENaC) as a candidate gene for essential hypertension (EH) in African Caribbeans. nameOfConference


    QMRO: qmroHref
  • Daniel H, Munroe P, Kamdar S et al. (1997). The atrial natriuretic peptide gene and essential hypertension in African-Caribbeans from St Vincent and the Grenadines. nameOfConference


    QMRO: qmroHref
  • Caulfield M, Lavender P, Newell-Price J et al. (1996). Angiotensinogen in human essential hypertension.. nameOfConference


    QMRO: qmroHref
  • Caulfield M, Newell-Price J (1995). The angiotensin converting enzyme gene in cardiovascular disease.. nameOfConference


    QMRO: qmroHref
  • Munroe PB, Daniel HI, Farrall M et al. (1995). Absence of genetic linkage between polymorphisms of the insulin receptor gene and essential hypertension.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Caulfield M, Lavender P, Newell-Price J et al. (1995). Linkage of the angiotensinogen gene locus to human essential hypertension in African Caribbeans.. nameOfConference


    QMRO: qmroHref
  • Mattu R, Needham E, Galton D et al. (1995). The Ace I/D Polymorphism Identifies Cad in Low Risk Welsh Subjects. nameOfConference


    QMRO: qmroHref
  • Mattu RK, Needham EWA, Galton DJ et al. (1995). A DNA variant at the angiotensin-converting enzyme gene locus associates with coronary artery disease in the Caerphilly Heart Study.. nameOfConference


    QMRO: qmroHref
  • Caulfield M, Lavender P, Newell-Price J et al. (1994). 2 Linkage of the angiotensinogen gene to human essential hypertension in African Caribbeans. nameOfConference


    QMRO: qmroHref
  • Brown MJ, Clayton D (1994). Linkage of the Angiotensinogen Gene to Essential Hypertension. nameOfConference


    QMRO: qmroHref
  • Mattu RK, Needham EWA, Caulfield M et al. (1994). Association of the ACE I/D polymorphism with CAD in a Welsh population. nameOfConference


    QMRO: qmroHref
  • Kamdar S, Daniel H, Fogarty P et al. (1994). ACE insertion/deletion (I/D) polymorphism in Vincentian African Caribbeans with essential hypertension.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Munroe PB, Johnston A, Duke VM et al. (1994). Investigation of lipoprotein lipase (LPL) as a candidate gene for dyslipidaemic hypertension.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Daniel HI, Munroe PB, Lawson M et al. (1994). Investigation of the renin gene as a putative locus for essential hypertension (EH) in Vincentian African Caribbeans.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Caulfield M, Lavender P, Farrall M et al. (1994). Linkage of the Angiotensinogen Gene to Essential Hypertension. nameOfConference


    QMRO: qmroHref
  • Munroe PB, Caulfield M, Daniel H et al. (1993). Analysis of the insulin receptor RsaI polymorphism in essential hypertension. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Raveendran R, Heybroek W, Caulfield M et al. (1992). Indomethacin and Protein Binding of Methotrexate. nameOfConference


    QMRO: qmroHref
  • Raveendran R, Heybroek WM, Caulfield M et al. (1992). Protein binding of indomethacin, methotrexate and morphine in patients with cancer.. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Saleh S, Caulfield M, Lledo P et al. (1990). Debrisoquine-type genetic polymorphism differences in medifoxamine pharmacokinetics. nameOfConference


    QMRO: qmroHref
  • Caulfield MJ, Dilkes MG, Iles RK et al. (1990). Rapid diagnosis of testicular choriocarcinoma by urinary pregnancy tests. nameOfConference


    QMRO: qmroHref
  • Heybroek WM, Caulfield M, Johnston A et al. (1990). Automatic on-line extraction coupled with electrochemical detection as an improved method for the HPLC co-analysis of codeine and morphine in plasma and gastric juice. nameOfConference


    QMRO: qmroHref
  • CAULFIELD MJ, DILKES MG, ILES RK et al. (1990). RAPID DIAGNOSIS OF TESTICULAR CHORIOCARCINOMA BY URINARY PREGNANCY TESTS. nameOfConference

    DOI: doi

    QMRO: qmroHref
  • Bouloux P-MG, Caulfield M, Lawson M et al. (1989). A study of Xho 1 polymorphisms of the human proatrial natriuretic peptide gene in essential hypertension. nameOfConference


    QMRO: qmroHref
  • Blandy JP, Jenkins BJ, Fowler CG et al. (1988). Radical radiotherapy and salvage cystectomy for T2/3 cancer of the bladder.. nameOfConference

    DOI: doi

    QMRO: qmroHref

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