Dr Jianmin Chen

Profile

Dr Jianmin Chen is a Lecturer in Inflammation and Cardiovascular Medicine and Versus Arthritis Career Development Fellow at the William Harvey Research Institute, Queen Mary University of London. Jianmin attained a Doctor’s degree in Clinical Medicine from Sichuan University, China in 2012. She was awarded with a PhD scholarship for her doctoral studies in Cardiovascular Pharmacology at Queen Mary University of London from 2012 to 2016, focusing on pathophysiology and experimental treatments of sepsis-induced cardiac dysfunction. She joined Professor Mauro Perretti’s group at the William Harvey Research Institute as a postdoctoral researcher in 2017. She applies her expertise of cardiovascular research to the fields of arthritis to investigate cardiac comorbidities faced by patients with rheumatoid arthritis. In 2022 she received her Versus Arthritis UK Career Development Fellowship. Her current research aims to investigate the mechanisms for cardiomyopathy in inflammatory arthritis and explore novel therapeutic strategies.

Awards and Honours

• Bülbring Award, British Pharmacology Society
• Career Development Fellowship, Versus Arthritis UK
• European New Investigator, European Shock Society
• WHRI New Investigator Award, William Harvey Research Institute
• William Harvey Medal & Best Oral Presentation, William Harvey Research Institute New Year Celebration
• Travel Awards, conferred by Thirty-Eighth Annual Conference on Shock, 16th Congress of the European Shock Society and International Federation of Shock Congress, respectively

Links to my other profiles

• Research Gate
• LinkedIn
• Loop

Research

Group members

• Mr Ahmad Hjiej Andaloussi (PhD student)
• Mr Weifeng Bu (PhD student)
• Mr Thomas Dudley Wright (PhD student, 2^nd Supervisor)
• Dr Marilena Christoforou (Post-doctoral Fellow; PI)

Summary

Cardiovascular comorbidities contribute to around half of all deaths in patients with rheumatoid arthritis (RA), with non-ischaemic heart failure being a major cause. RA patients are particularly susceptible to a type of heart failure with preserved ejection fraction (HFpEF), which is accompanied by diastolic dysfunction. The causes of diastolic dysfunction in RA are unknown and current medications for RA have limited cardioprotective effects: the clinical unmet need for increased congestive heart failure (CHF) remains pressing. To address this unmet clinical need, we have identified a mouse model of arthritis, K/BxN F1 progeny, which recapitulates the specific diastolic dysfunction of RA patients; this is the first mouse model of inflammatory arthritis identified which shows diastolic dysfunction.

My research aims are to understand the pathophysiology of cardiac diastolic dysfunction in inflammatory arthritis and to develop novel therapeutics for this fatal side-effect of arthritis.

Ongoing projects include:

1. Identify whether cellular/molecular dysregulation contributes to the development of cardiac dysfunction by analysing immune cell infiltration, and changes in cardiac metabolism in mice with inflammatory arthritis.
2. Test the impact of both established classical anti-inflammatory and innovative pro-resolving therapeutic strategies on cardiac function and joint symptoms in mice with inflammatory arthritis.
3. Assess the translational potential of current research using samples and data obtained from RA patients.

Furthermore, I have expertise in modelling a range of both acute and chronic cardiovascular diseases in mice and rats, including inducing polymicrobial sepsis/sepsis-associated cardiac dysfunction by cecum ligation and perforation surgery in mice, haemorrhage shock in rats, myocardial ischemia/reperfusion injury and heart failure in rats. I am also interested in studying the pathophysiology and exploring novel therapeutic treatments of these disease conditions.

Publications

• Chen J, Oggero S, Cecconello C et al. (2023). The Annexin-A1 mimetic RTP-026 promotes acute cardioprotection through modulation of immune cell activation. nameOfConference

  
  

  DOI: 10.1016/j.phrs.2023.107005

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/92298
• Chen J, Austin-Williams S, O'Riordan CE et al. (2023). Formyl Peptide Receptor Type 2 Deficiency in Myeloid Cells Amplifies Sepsis-Induced Cardiac Dysfunction. nameOfConference

  
  

  DOI: 10.1159/000530284

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/85560
• Costa VV, Sugimoto MA, Hubner J et al. (publicationYear). Targeting the Annexin A1-FPR2/ALX pathway for host-directed therapy in dengue disease. nameOfConference

  
  

  DOI: 10.7554/elife.73853

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/79205
• Hamers A, Primus CP, Whitear C et al. (2022). 20‐hydroxyeicosatetraenoic acid (20‐HETE) is a pivotal endogenous ligand for TRPV1‐mediated neurogenic inflammation in the skin. nameOfConference

  
  

  DOI: 10.1111/bph.15726

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/75763
• Gee LC, Massimo G, Lau C et al. (2022). Inorganic nitrate attenuates cardiac dysfunction: roles for xanthine oxidoreductase and nitric oxide. nameOfConference

  
  

  DOI: 10.1111/bph.15636

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/73324
• Chen J, Norling LV, Mesa JG et al. (2021). Annexin A1 attenuates cardiac diastolic dysfunction in mice with inflammatory arthritis. nameOfConference

  
  

  DOI: 10.1073/pnas.2020385118

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/74989
• de Gaetano M, Tighe C, Gahan K et al. (2021). Asymmetric Synthesis and Biological Screening of Quinoxaline-Containing Synthetic Lipoxin A4 Mimetics (QNX-sLXms). nameOfConference

  
  

  DOI: 10.1021/acs.jmedchem.1c00403

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/74918
• Kieswich JE, Chen J, Alliouachene S et al. (2020). Immunohistochemistry of Kidney a-SMA, Collagen 1, and Collagen 3, in A Novel Mouse Model of Reno-cardiac Syndrome.. nameOfConference

  
  

  DOI: 10.21769/bioprotoc.3751

  
  

  QMRO: qmroHref
• Chen J, Purvis GSD, Collotta D et al. (2020). RvE1 Attenuates Polymicrobial Sepsis-Induced Cardiac Dysfunction and Enhances Bacterial Clearance. nameOfConference

  
  

  DOI: 10.3389/fimmu.2020.02080

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/67161
• Aziz Q, Chen J, Moyes AJ et al. (2020). Vascular KATP channels protect from cardiac dysfunction and preserve cardiac metabolism during endotoxemia. nameOfConference

  
  

  DOI: 10.1007/s00109-020-01946-3

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/65764
• Yun Y, Chen J, Liu R et al. (2019). Long residence time adenosine A1 receptor agonists produce sustained wash-resistant antilipolytic effect in rat adipocytes. nameOfConference

  
  

  DOI: 10.1016/j.bcp.2019.03.032

  
  

  QMRO: qmroHref
• Al Zoubi S, Chen J, Murphy C et al. (publicationYear). Linagliptin Attenuates the Cardiac Dysfunction Associated With Experimental Sepsis in Mice With Pre-existing Type 2 Diabetes by Inhibiting NF-κB. nameOfConference

  
  

  DOI: 10.3389/fimmu.2018.02996

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/55015
• Kieswich JE, Chen J, Alliouachene S et al. (2018). A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain. nameOfConference

  
  

  DOI: 10.1186/s12882-018-1155-3

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/60832
• de Gaetano M, Butler E, Gahan K et al. (2019). Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms). nameOfConference

  
  

  DOI: 10.1016/j.ejmech.2018.10.049

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/52303
• Chen J, Hamers AJP, Finsterbusch M et al. (2018). Endogenously generated arachidonate-derived ligands for TRPV1 induce cardiac protection in sepsis.. nameOfConference

  
  

  DOI: 10.1096/fj.201701303R

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/50363
• Khan AI, Kapoor A, Chen J et al. (2018). The Antimalarial Drug Artesunate Attenuates Cardiac Injury in A Rodent Model of Myocardial Infarction.. nameOfConference

  
  

  DOI: 10.1097/SHK.0000000000000963

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/43663
• Purvis GSD, Chiazza F, Chen J et al. (2017). Annexin A1 attenuates microvascular complications through restoration of Akt signalling in a murine model of type 1 diabetes. nameOfConference

  
  

  DOI: 10.1007/s00125-017-4469-y

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/28601
• Johnson FL, Patel NSA, Purvis GSD et al. (2017). Inhibition of IκB Kinase at 24 Hours After Acute Kidney Injury Improves Recovery of Renal Function and Attenuates Fibrosis.. nameOfConference

  
  

  DOI: 10.1161/JAHA.116.005092

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/24783
• Martin L, Gombert A, Chen J et al. (2017). The β-d-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men.. nameOfConference

  
  

  DOI: 10.3389/fimmu.2017.00681

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/25296
• Martin L, Chen J, Zechendorf E et al. (2017). ROLE OF THE beta-D-ENDOGLUCURONIDASE HEPARANASE IN SEPTIC CARDIOMYOPATHY. European Shock Society

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Chen J, Hamers AJP, Finsterbusch M et al. (2016). ACTIVATION OF TRPV1 BY 12(S)-HPETE AND 20-HETE RELEASES CGRP AND PROTECTS THE HEART AGAINST THE CARDIAC DYSFUNCTION CAUSED BY LPS. Exp Biology 2016

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Martin LB, Zechendorf E, Chen J et al. (2016). THE SYNTHETIC ANTIMICROBIAL PEPTIDE 19-2.5 ATTENUATES SEPTIC CARDIOMYOPATHY IN A MURINE MODEL OF POLYMICROBIAL SEPSIS. Japanese Shock Society

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Chen J, Thiemermann C (2016). Selenium and Niacin for Sepsis Therapy. nameOfConference

  
  

  DOI: 10.1097/ccm.0000000000001493

  
  

  QMRO: qmroHref
• Chen J, Kieswich J, Chiazza F et al. (publicationYear). IkB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD. nameOfConference

  
  

  DOI: 10.1681/ASN.2015060670

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/12841
• Chen J, Hamers AJP, Finsterbusch M et al. (2016). Activation of TRPV1 by 12(s)-HpETE and 20-HETE Releases CGRP and Protects the Heart Against the Cardiac Dysfunction Caused by LPS. Exp Biology (FASEB) 2016

  
  

  DOI: 10.1096/fasebj.30.1_supplement.306.4

  
  

  QMRO: qmroHref
• Zhang W, Zhao X, Xiao Y et al. (2016). The association of depressed angiogenic factors with reduced capillary density in the Rhesus monkey model of myocardial ischemia. nameOfConference

  
  

  DOI: 10.1039/c5mt00332f

  
  

  QMRO: qmroHref
• Chen J, Kieswich J, Chiazza F et al. (2015). THE CARDIAC DYSFUNCTION CAUSED BY SEPSIS IN ANIMALS WITH CHRONIC KIDNEY DISEASE IS ATTENUATED BY INHIBITING IκB KINASE. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Gobbetti T, Coldewey SM, Chen J et al. (2014). Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis. nameOfConference

  
  

  DOI: 10.1073/pnas.1410938111

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/6704
• Chen J, Chiazza F, Collino M et al. (publicationYear). Gender Dimorphism of the Cardiac Dysfunction in Murine Sepsis: Signalling Mechanisms and Age-Dependency. nameOfConference

  
  

  DOI: 10.1371/journal.pone.0100631

  
  

  QMRO: https://uat2-qmro.qmul.ac.uk/xmlui/handle/123456789/12540
• Chen J, Chiazza F, Collino M et al. (2014). GENDER DIMORPHISM OF THE CARDIAC DYSFUNCTION IN SEPSIS. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Chen J, Kieswich J, Yaqoob MM et al. (2014). PRE-EXISTING CHRONIC KIDNEY DISEASE WORSENS MYOCARDIAL DYSFUNCTION CAUSED BY SEPSIS IN MICE. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Sun X, Cai J, Fan X et al. (publicationYear). Decreases in Electrocardiographic R-Wave Amplitude and QT Interval Predict Myocardial Ischemic Infarction in Rhesus Monkeys with Left Anterior Descending Artery Ligation. nameOfConference

  
  

  DOI: 10.1371/journal.pone.0071876

  
  

  QMRO: qmroHref
• Hafner S, Wepler M, McCook O et al. (2013). EFFECTS OF THE PPAR-β/δ AGONIST GW0742 ON RENAL INFLAMMATION AND KIDNEY TISSUE INJURY DURING RESUSCITATED PORCINE SEPTIC SHOCK. nameOfConference

  
  

  DOI: doi

  
  

  QMRO: qmroHref
• Xie Y, Chen J, Han P et al. (2012). Immunohistochemical detection of differentially localized up-regulation of lysyl oxidase and down-regulation of matrix metalloproteinase-1 in rhesus monkey model of chronic myocardial infarction. nameOfConference

  
  

  DOI: 10.1258/ebm.2012.012070

  
  

  QMRO: qmroHref

Collaborators

Internal 

• Prof Mauro Perretti (Sponsor of VA Fellowship, WHRI)
• Dr Dianne Cooper (Sponsor of VA Fellowship, WHRI)
• Dr Lucy Norling (WHRI)
• Prof Federica Marelli-Berg (WHRI)
• Dr Nay Aung (Digital Environment Research Institute (DERI) Dr Dunja Aksentijevic (WHRI)
• Dr Myles Lewis (WHRI)
• Prof Steffen Peterson (WHRI)
• Dr Trinidad Montero-Melendez (WHRI)
• Prof Christoph Thiemermann (WHRI)

International Collaborators

• Dr Andreas Margraf (Ludwig-Maximilians University Munich)

Industry Collaborators

• Dr John Lupisella (Bristol-Myers Squibb)
• Dr Ricardo Garcia (Bristol-Myers Squibb)
• Dr Thomas Jonassen (ResoTher Pharma)
• Dr Samra Sanni (ResoTher Pharma)

Versus Arthritis Research Partner

• Mr Robin Brittain

News

• PhD studentship grant awarded to Dr Jianmin Chen. How can we treat heart problems in patients with rheumatoid arthritis? (Heart Research UK), May 2023
• Jianmin Chen, The female researchers of Heart Research UK (Heart Research UK), March 2023
• New model could improve treatment of rheumatoid arthritis patients with cardiac disease (Queen Mary University of London), September 2021

Teaching

• MRes research project supervisor and lecturer: MRes Cardiac and Vascular Medicine - Inflammation: Cellular and Vascular Aspects (WHRM922)
• Bsc research project supervisor: BSc Pharmacology - Research Project in Pharmacology (BMD670)
• PBL tutor (MBBS)
• OSCE examiner (MBBS)

Disclosures

No disclosures.